Navigation Links
New pathway found for regulation of blood vessel growth in cancer
Date:3/1/2012

Researchers at Winship Cancer Institute of Emory University have identified a new function for a gene that normally prevents the development of cancer.

Scientists had known that the gene, which encodes a protein called p14 ARF, works inside the cell to control proliferation and division. A team led by Erwin Van Meir, PhD, discovered that p14 ARF also regulates tumor-induced angiogenesis, the process by which growing cancers attract new blood vessels.

The findings, published in the Journal of Clinical Investigation, provide insight into how cancers form and progress, communicate with surrounding vascular cells and could guide the development of new therapies to fight tumors whose growth is driven by loss of p14 ARF.

Van Meir is professor of neurosurgery and hematology & medical oncology at Emory University School of Medicine and Winship Cancer Institute. Abdessamad Zerrouqi, PhD, research associate, is the first author of the paper.

Pinning down the new function for p14 ARF was a several-year detective investigation for Zerrouqi. The gene was a slippery target because growing cells in culture tend to lose or silence it, he says. P14 ARF is not turned on in most tissues of the body, but is activated in response to aberrant growth signals.

The gene encoding p14 ARF is mutated or silenced in many types of cancers, including most gliomas, the most common brain cancer in adults. People who inherit mutations affecting this gene develop "melanoma-astrocytoma syndrome," with increased occurrence of both types of tumors. ARF stands for "alternate reading frame" because the DNA sequence overlaps with another protein that is read out of step in comparison to ARF.

Previous research had linked the function of p14 ARF to another gene, p53, which is also frequently mutated in cancers. P53 is known as "guardian of the genome" because it shuts down cell division in response to DNA damage.

Zerrouqi says severa
'/>"/>

Contact: Lynne Anderson
virginia.l.anderson@emory.edu
404-778-5452
Emory University
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Molecular pathways linked to sex, age affect outcomes in lung cancer
2. Defective signaling pathway sheds light on cystic fibrosis
3. Scientists Discover Molecular Pathway for Organ Tissue Regeneration and Repair
4. Arsenic exposure activates an oncogenic signaling pathway; leads to increased cancer risk
5. Different signaling pathways of cholangiocarcinoma
6. Welsh Tree LLC Proudly Presents the Release of the Celtic Pathways CD by Jason Evans, in Time for Saint Patrick's Day
7. Cellular pathway could provide evidence of how cancer and obesity are linked
8. Newly identified proteins critical to FA pathway DNA repair function
9. Targeting cell pathway may prevent relapse of leukemia
10. Space Coast Cancer Center Selects Via Oncology™ Pathways to Advance Evidence-Based Cancer Care
11. A single protein regulates 2 immune pathways
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/2/2014)... News) -- The quality of Americans, diets has improved ... the rich and poor is growing, a new study ... to date that the extensive efforts by many groups ... some payoff, but it also indicates that these efforts ... doctoral student in the department of nutrition at the ...
(Date:9/2/2014)... Amy Norton HealthDay Reporter , ... want to lose weight and boost their heart health, cutting ... a new study suggests. In a small clinical trial ... a low-carbohydrate diet lost more weight over a year than ... bigger improvements in their cholesterol and triglyceride levels, the research ...
(Date:9/2/2014)... Philadelphia, PA (PRWEB) September 02, 2014 ... Magee Rehabilitation Hospital returns on September 19 at The ... Hill, Pennsylvania. Over the past 25 years, the Classic, ... more than $12 million for programs and services designed ... at Magee Rehabilitation Hospital. , “The Segal Classic ...
(Date:9/2/2014)... 02, 2014 North America Resectoscopes ... Market Outlook to 2020? provides key market data ... provides value, in millions of US dollars, volume ... within market segments –,     Rigid ... Reusable) Electrodes and Bipolar (Disposable and Reusable) Electrodes). ...
(Date:9/2/2014)... 02, 2014 Humility of Mary Health Partners ... at St. Elizabeth Health Center, 1044 Belmont Ave. , The ... more than 200 common health problems as well as tips ... injury, and advice on when to seek medical attention. ... in the Youngstown Room; the evening session runs from 5:30 ...
Breaking Medicine News(10 mins):Health News:Quality of U.S. Diet Improves, Slightly 2Health News:Low-Carb Beats Low-Fat for Weight Loss, Heart Health: Study 2Health News:Low-Carb Beats Low-Fat for Weight Loss, Heart Health: Study 3Health News:The 25th Jerry Segal Classic Returns to Benefit Patients of Magee Rehabilitation Hospital 2Health News:North America Resectoscopes & Bronchoscopes Market (Revenue, Volume & Company Share) to 2020 Report Available at MarketOptimizer.org 2Health News:North America Resectoscopes & Bronchoscopes Market (Revenue, Volume & Company Share) to 2020 Report Available at MarketOptimizer.org 3Health News:North America Resectoscopes & Bronchoscopes Market (Revenue, Volume & Company Share) to 2020 Report Available at MarketOptimizer.org 4Health News:HMHP Offers ‘Health at Home’ Workshop 2
... health problems outside the lungs, researchers say , , WEDNESDAY, ... and long-term toxic effects on the heart and blood ... cause death, a new report says. , The ... issue of the Journal of the American College ...
... Physician Accuracy And ... Reduces Radiation Exposure for Patients, AUSTIN, Texas, Aug. ... Institute (TCAI) at St. David,s Medical Center became,the first ... -- an enhancement to the state-of-the art Hansen Robotic ...
... ("Assurant"),(NYSE: AIZ ), a premier provider of ... that Jane Meyer,has been appointed senior vice president, ... vice president, organizational development and,corporate communications effective immediately. ... and Mr. Walker will continue to report to ...
... Daily Dietary Supplements to Introduce Fashion Week ... Survival Kit at Verrier Runway Show, ... its,first-ever fashion partnership with breakout designer Ashleigh Verrier to,promote "Style ... healthy beauty during one of the most exciting and fast-paced,fashion ...
... the National Institutes of Health (NIH) have found a mechanism ... the development of autoimmune disease when turned off. The findings ... of autoimmunity and could also have implications for the development ... as cancer and HIV. The study paper appears online today ...
... strength, agility tied to brain damage, even in the ... -- Physical frailty among the elderly may be linked ... patients develop dementia, new research reveals. , The finding, ... the notion that motor impairment in the elderly is ...
Cached Medicine News:Health News:Air Pollution Can Damage Heart, Blood Vessels, Too 2Health News:Texas Cardiac Arrhythmia Institute at St. David's Medical Center First in the Nation to Use a New Generation of Medical Robots for Complex Electrophysiology Mapping Procedures 2Health News:Texas Cardiac Arrhythmia Institute at St. David's Medical Center First in the Nation to Use a New Generation of Medical Robots for Complex Electrophysiology Mapping Procedures 3Health News:Assurant Announces Two Executive Appointments 2Health News:VIACTIV(R) Partners With Rising Fashion Label Verrier to Launch 'Style and Strength for Life' Health Initiative at Fall Fashion Week 2008 2Health News:VIACTIV(R) Partners With Rising Fashion Label Verrier to Launch 'Style and Strength for Life' Health Initiative at Fall Fashion Week 2008 3Health News:NIH scientists find a novel mechanism that controls the development of autoimmunity 2Health News:Physical Frailty Could Predict Alzheimer's Disease 2Health News:Physical Frailty Could Predict Alzheimer's Disease 3
(Date:9/2/2014)... SEATTLE , Sept. 2, 2014 /PRNewswire/ ... company committed to the development and commercialization ... today announced an update on corporate and ... structure, commitment for future funding, ongoing clinical ... In corporate news, Chief Executive Officer ...
(Date:9/2/2014)... , Sept. 2, 2014  MEI Pharma, Inc. ... focused on the clinical development of novel therapies ... enrollment in a randomized Phase II clinical trial ... combination with azacitidine in patients with previously untreated ... placebo-controlled, double-blind study enrolled a total of 108 ...
(Date:9/2/2014)... Sept. 2, 2014 Isis Pharmaceuticals, Inc. (NASDAQ: ... three drugs in its lipid franchise were highlighted in ... (ESC) Congress in Barcelona Spain . ... designed to provide effective and safe therapeutic options to ... of one commercialized drug and several other drugs in ...
Breaking Medicine Technology:VentiRx Pharmaceuticals Provides Corporate and Clinical Update 2VentiRx Pharmaceuticals Provides Corporate and Clinical Update 3MEI Pharma Completes Enrollment In Randomized Phase II Clinical Trial Of Pracinostat In Front Line Myelodysplastic Syndrome 2MEI Pharma Completes Enrollment In Randomized Phase II Clinical Trial Of Pracinostat In Front Line Myelodysplastic Syndrome 3MEI Pharma Completes Enrollment In Randomized Phase II Clinical Trial Of Pracinostat In Front Line Myelodysplastic Syndrome 4Drugs from Isis' Lipid Franchise Highlighted at European Society of Cardiology Congress 2014 2Drugs from Isis' Lipid Franchise Highlighted at European Society of Cardiology Congress 2014 3Drugs from Isis' Lipid Franchise Highlighted at European Society of Cardiology Congress 2014 4Drugs from Isis' Lipid Franchise Highlighted at European Society of Cardiology Congress 2014 5
... ... Dysmenorrhea Pain Medication, HOBOKEN, N.J., June 18 A ... periods,affecting millions of women each year, can be reduced naturally ... maritime,pine tree. The multi- center field study, published in the ...
... the Need for Testosterone Screening in At-Risk ... ... from a 12-month,international, multi-center study showed that treatment for low,testosterone with ... and sexual function among,hypogonadal men with Type 2 diabetes and/or Metabolic ...
Cached Medicine Technology:New Study: Pine Bark Significantly Reduces Menstrual Pain 2New Study: Pine Bark Significantly Reduces Menstrual Pain 3Novel Testosterone Gel Significantly Improves Insulin Sensitivity and Sexual Function in Hypogonadal Men With Type 2 Diabetes and Metabolic Syndrome 2Novel Testosterone Gel Significantly Improves Insulin Sensitivity and Sexual Function in Hypogonadal Men With Type 2 Diabetes and Metabolic Syndrome 3
... is a national reference laboratory and a ... development. ARUP offers an extensive test menu ... in clinical and anatomic pathology. Owned by ... include more than half of the nation's ...
... Laboratories is a national reference laboratory and ... and development. ARUP offers an extensive test ... tests in clinical and anatomic pathology. Owned ... clients include more than half of the ...
... is a national reference laboratory and a ... development. ARUP offers an extensive test menu ... in clinical and anatomic pathology. Owned by ... include more than half of the nation's ...
... national reference laboratory and a worldwide leader ... offers an extensive test menu of highly ... and anatomic pathology. Owned by the University ... than half of the nation's university teaching ...
Medicine Products: