Researchers at Winship Cancer Institute of Emory University have identified a new function for a gene that normally prevents the development of cancer.
Scientists had known that the gene, which encodes a protein called p14 ARF, works inside the cell to control proliferation and division. A team led by Erwin Van Meir, PhD, discovered that p14 ARF also regulates tumor-induced angiogenesis, the process by which growing cancers attract new blood vessels.
The findings, published in the Journal of Clinical Investigation, provide insight into how cancers form and progress, communicate with surrounding vascular cells and could guide the development of new therapies to fight tumors whose growth is driven by loss of p14 ARF.
Van Meir is professor of neurosurgery and hematology & medical oncology at Emory University School of Medicine and Winship Cancer Institute. Abdessamad Zerrouqi, PhD, research associate, is the first author of the paper.
Pinning down the new function for p14 ARF was a several-year detective investigation for Zerrouqi. The gene was a slippery target because growing cells in culture tend to lose or silence it, he says. P14 ARF is not turned on in most tissues of the body, but is activated in response to aberrant growth signals.
The gene encoding p14 ARF is mutated or silenced in many types of cancers, including most gliomas, the most common brain cancer in adults. People who inherit mutations affecting this gene develop "melanoma-astrocytoma syndrome," with increased occurrence of both types of tumors. ARF stands for "alternate reading frame" because the DNA sequence overlaps with another protein that is read out of step in comparison to ARF.
Previous research had linked the function of p14 ARF to another gene, p53, which is also frequently mutated in cancers. P53 is known as "guardian of the genome" because it shuts down cell division in response to DNA damage.
Zerrouqi says severa
|Contact: Lynne Anderson|