Navigation Links
New papers identify a microRNA that drives both cancer onset and metastasis
Date:7/3/2013

BOSTON -- A mere 25 years ago, noncoding RNAs were considered nothing more than "background noise" in the overall genomic landscape. Now, two new studies reveal that one of these tiny noncoding molecules microRNA-22 plays an outsized role in two types of cancer.

Reported on-line today in the journals Cell and Cell Stem Cell, the two papers demonstrate in mouse models that miR-22 drives both the onset and spread of breast cancer, as well as the onset of blood cancer. The findings, led by investigators at Beth Israel Deaconess Medical Center (BIDMC), further suggest that inhibition of miR-22 through a "decoy" method offers a novel therapeutic option for treating hematological malignancies.

"This is the first time that a microRNA has been shown to drive both cancer initiation and metastasis in a mouse model," explains senior author Pier Paolo Pandolfi, MD, PhD, Scientific Director of the Cancer Center at BIDMC and the George Reisman Professor of Medicine at Harvard Medical School. "It's amazing that, by itself, this one little microRNA can trigger cancer in two different organs, perhaps in many more, and in the case of breast cancer, can also promote metastasis."

Although many advances have been made in identifying the genetic causes of some cancers, it has become apparent that changes in the primary DNA sequence alone cannot explain the many steps that are necessary to turn a normal cell into a cancer cell. As these new papers confirm, epigenetic modifications which occur apart from changes in the underlying DNA sequences and include DNA methylation and histone modification have now been recognized as playing integral roles in cancer.

"Our discovery is exciting for several reasons," says Pandolfi. "Mechanistically, we have revealed one way in which microRNAs can fundamentally reconfigure the way that DNA is read. Our findings show that miR-22 triggers an epigenetic 're-wiring,' if you will, which represses th
'/>"/>

Contact: Bonnie Prescott
bprescot@bidmc.harvard.edu
617-667-7306
Beth Israel Deaconess Medical Center
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. AVT Announces Three Peer-Reviewed Papers Now Available
2. Study finds newspapers have changed coverage of ice hockey concussions over last quarter-century
3. Obesity coverage in black newspapers is mostly negative, MU study finds
4. Book Banning: The Illinois Department of Corrections Bans The Cannabis Papers by “Publius”
5. Original research papers on acute cardiovascular care: ESC launches EHJ-ACVC
6. New optical metrics can identify patients on fast track to decreased vision
7. Researchers Identify New Genes Linked to the Origins of Alzheimer’s, Says Cure Alzheimers Fund
8. Researchers identify master coordinator for aortic rupture
9. Moffitt Cancer Center researchers identify genetic variants predicting aggressive prostate cancers
10. Scientists at UMass Medical School identify neurons that control feeding behavior in Drosophila
11. Genetic variations may help identify best candidates for preventive breast cancer drugs
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/26/2014)... 26, 2014 “Many people become overwhelmed ... injury claim issues and phone calls with insurance companies,” ... article featuring their free eBook on pedestrian and ... on pedestrian and bicycle auto accident claims assures the ... capable of professionally handling their case while they focus ...
(Date:12/25/2014)... The microscopy market is estimated ... reach $5,756.0 million by 2019. Optical microscopy is ... electron microscopes product segment is expected to show ... Rising focus on nanotechnology, technological advancements, and increasing ... market. , Get Full Copy of Report @ ...
(Date:12/25/2014)... York (PRWEB) December 25, 2014 Product ... DePuy ASR hip recall ( http://www.consumerinjurylawyers.com/DePuy/ ) continue to ... According to an Order issued in the U.S. District ... Court will convene an open conference on January 7, ... United States Courthouse in West Palm Beach, Florida. The ...
(Date:12/25/2014)... Recently, BellasDress has launched its Christmas ... BellasDress has chosen their best-selling lace wedding dresses, vintage ... holiday season. , Now, BellasDress.com features popular women’s ... at discount prices. The business hopes everyone can have ... , “All our elegant products are made with ...
(Date:12/25/2014)... HealthDay Reporter WEDNESDAY, Dec. 24, 2014 (HealthDay ... receive effective, less expensive care from a clinic that functions ... of dedicated health care professionals, a new study shows. ... either hospitalization or a trip to the emergency room when ... the University of Texas in Houston versus usual care, according ...
Breaking Medicine News(10 mins):Health News:Guide to Handling Pedestrian and Bicycle Accidents Released By The Jones Firm, Featured in Recent Article 2Health News:Microscopy Market Hit to $5,756.0 Million by 2019 - New Research Report by MarketsandMarkets 2Health News:Microscopy Market Hit to $5,756.0 Million by 2019 - New Research Report by MarketsandMarkets 3Health News:Microscopy Market Hit to $5,756.0 Million by 2019 - New Research Report by MarketsandMarkets 4Health News:Federal Court Overseeing DePuy ASR Hip Lawsuit Set to Convene Conference in January, Bernstein Liebhard LLP Reports 2Health News:Federal Court Overseeing DePuy ASR Hip Lawsuit Set to Convene Conference in January, Bernstein Liebhard LLP Reports 3Health News:BellasDress.com’s Christmas Sale: Trendy Wedding Dresses With Big Discounts 2Health News:Coordinated Care Through 'Medical Home' Best for Chronically Ill Kids: Study 2Health News:Coordinated Care Through 'Medical Home' Best for Chronically Ill Kids: Study 3
... measure against breast cancer, saves lives and reduces medical costs. ... online in CANCER , a peer-reviewed journal of the ... of tamoxifen to prevent cancer can sufficiently compensate for its ... have an increased risk of developing breast cancer. Research ...
... - Breast cancer tumors take numerous paths to resist ... a crucial crossroads may restore a tumor,s vulnerability to ... Cancer Center report on line at Nature Medicine ... shrinks previously resistant tumors by cutting off at least ...
... By Dennis Thompson HealthDay Reporter , FRIDAY, March ... of radiation as a present and serious environmental health concern ... to affect nearly every home in the country. But ... estimated 21,000 lung cancer deaths every year, according to the ...
... For rodent pups, bonding with mom isn,t hard-wired in ... of life, which is achieved by their maturing sense ... by learning to identify mother, siblings, and home. ... an associate Professor of Neuroscience at the University of ...
... , FRIDAY, March 11 (HealthDay News) -- Taking aspirin ... mostly in people at increased risk for the disease ... their blood, according to a new study. Previous ... other nonsteroidal anti-inflammatory drugs (NSAIDs) have a reduced risk ...
... FRIDAY, March 11 (HealthDay News) -- Adults infected with HIV ... increased risk for bone fractures compared to the general population, ... bone mineral density is common in people with HIV, but ... group of patients. In this study, researchers compared rates ...
Cached Medicine News:Health News:Taking tamoxifen to prevent breast cancer can save lives and money 2Health News:Combination overcomes breast cancer resistance to herceptin 2Health News:Combination overcomes breast cancer resistance to herceptin 3Health News:Invisible and Odorless, Radon Poses Risks to Lungs 2Health News:Invisible and Odorless, Radon Poses Risks to Lungs 3Health News:Invisible and Odorless, Radon Poses Risks to Lungs 4Health News:Mouse nose nerve cells mature after birth, allowing bonding, recognition with mother 2Health News:Aspirin May Protect Against Colorectal Cancer -- But Only in Certain People 2Health News:Adults With HIV at Increased Risk of Bone Fractures, Study Finds 2
(Date:12/24/2014)... and RALEIGH, N.C. , Dec. 23, ... International plc (NASDAQ: ENDP ) (TSX: ENL), ... ) announced today that they have submitted a New ... the U.S. Food and Drug Administration (FDA).  Buprenorphine HCl ... pain severe enough to require daily, around-the-clock, long-term opioid ...
(Date:12/22/2014)... --Research and Markets ( http://www.researchandmarkets.com/research/h3xm6q/us ) has ... Glucose Market" report to their offering. ... insight focuses on the developments in the self-monitoring blood ... . Reimbursement analysis and the effects of competitive bidding ... 73 SMBG meters have been performed, based on the ...
(Date:12/22/2014)... , Dec. 22, 2014 Swedish Orphan ... today announced that the Committee for Medicinal Products for ... has adopted a positive opinion for the use of ... men with Peyronie,s disease with a palpable plaque and ... start of therapy. The use of Xiapex ...
Breaking Medicine Technology:Endo Pharmaceuticals and BioDelivery Sciences Announce NDA Submission for Buprenorphine HCl Buccal Film for the Management of Moderate to Severe Chronic Pain 2Endo Pharmaceuticals and BioDelivery Sciences Announce NDA Submission for Buprenorphine HCl Buccal Film for the Management of Moderate to Severe Chronic Pain 3Endo Pharmaceuticals and BioDelivery Sciences Announce NDA Submission for Buprenorphine HCl Buccal Film for the Management of Moderate to Severe Chronic Pain 4Endo Pharmaceuticals and BioDelivery Sciences Announce NDA Submission for Buprenorphine HCl Buccal Film for the Management of Moderate to Severe Chronic Pain 5US Self-monitoring Blood Glucose Market 2Sobi's Xiapex receives positive opinion by CHMP for the treatment of Peyronie's disease 2Sobi's Xiapex receives positive opinion by CHMP for the treatment of Peyronie's disease 3Sobi's Xiapex receives positive opinion by CHMP for the treatment of Peyronie's disease 4Sobi's Xiapex receives positive opinion by CHMP for the treatment of Peyronie's disease 5Sobi's Xiapex receives positive opinion by CHMP for the treatment of Peyronie's disease 6
... 16 When 76-year old Cumming resident, ... worst. Raised in the carnival and a self professed hobo for ... to his other illnesses, Smith felt limited in his choices for ... Radiation Oncologist with Radiotherapy Centers of Georgia - ...
... of Prematurity , , , ... June 16 The widespread use of fertility drugs, not just high-tech laboratory procedures, ... birth in the United States , experts said today at the March of Dimes ... , Working with experts from ...
Cached Medicine Technology:Cumming Radiation Oncologist Performs First Stereotactic Body Radiation Therapy in Forsyth County 2Cumming Radiation Oncologist Performs First Stereotactic Body Radiation Therapy in Forsyth County 3Cumming Radiation Oncologist Performs First Stereotactic Body Radiation Therapy in Forsyth County 4Fertility Drugs Contribute Heavily to Multiple Births 2Fertility Drugs Contribute Heavily to Multiple Births 3
Triangular shaped tips. Marked for 5 mm and 10 mm tucks. Round knurled handle with polished finish....
Angled shafts with 9 mm scaled jaws. 1 mm teeth on one jaw fit into holes on the other jaw. Slide lock and serrated handle with polished finish. Right....
Shafts angled 45 degrees, 10 mm from tip to bend. 1 x 2 teeth. Serrated handle with polished finish. Most popular size or model....
Straight shafts with 5.5 mm tying platform and 1 mm crisscross serrated tips. Wide serrated handle with polished finish....
Medicine Products: