Navigation Links
New paper describes important advance in imaging of cell death
Date:1/29/2010

For quite some time, the "Holy Grail" in medical imaging has been the development of an effective method to image cell death as a means to intervene early in diseases and rapidly determine the effectiveness of treatments. A new paper by researchers at the University of Notre Dame and the Washington University School of Medicine describes important progress in using a synthetic probe to target dead and dying cells in mammary and prostate tumors in living animals.

Bradley D. Smith, Emil T. Hofman Professor of Chemistry and Biochemistry at Notre Dame, points out that the group of researchers had previously discovered that synthetic zinc (II)-dipicolylamine (Zn-DPA) coordination complexes can selectively target the outer surfaces of anionic (negatively charged) cell membranes. Furthermore, fluorescent versions of these Zn-DPA complexes act as imaging probes that can distinguish dead and dying mammalian cells from healthy cells in a cell culture and also selectively target bacteria in contaminated samples.

The researchers also recently demonstrated that a fluorescent near-infrared probe referred to as PSS-794 can be used to image bacterial infections in mice, indicating that PSS-794 has a notable ability to selectively target anionic cells in living animals.

In the new paper, the researchers describe a significant expansion of the animal imaging capability of PSS-794 by showing that it can target the anionic dead and dying cells within tumors in rat and mouse models. The research is an important step toward the development of optical imaging probes that could determine, noninvasively, the amount and type of cell death in tumors. Such imaging techniques could help clinicians accurately determine the grade of tumors and the stage of cancers, as well as to measure the effectiveness of treatments.

The researchers also believe that analogous probes can be developed that would allow for deep tissue imaging of cancers in humans.

Smith points out that although the study focused on mammary and prostate tumors, imaging of cell death is broadly useful for treatment of numerous conditions, including cardiovascular disease, neurology, renal disease and even transplant rejection.


'/>"/>

Contact: Bradley Smith
smith.115@nd.edu
574-631-8632
University of Notre Dame
Source:Eurekalert

Related medicine news :

1. New Paperback Dating Advice Book, Love in 90 Days, Reveals 16 Men's Dead-End Dating Patterns and What To Do About Them
2. Scantronix and ePaperlessSolutions Form Key Partnership
3. Diabetes and Pre-Diabetes Accounted for $218 Billion in Costs in 2007, Health Affairs Paper Demonstrates
4. New Concord Coalition Paper Discusses End Game Fiscal Considerations for Health Care Reform
5. New White Paper Details Best Practices of an Occupational Hearing Conservation Program: US Airways
6. Amilpar - Press Release - Commercial Papers
7. PeopleStreme Human Capital Releases 'New Trends in Performance Management - 2010' Whitepaper
8. The Paper Tiger Document Management and Filing System Software Announces "Windows 7 Compatibility"
9. Case Western Reserve researchers new pathway discovery published as Paper of the Week
10. Kendall Hunt Authors Earn NAGC “Paper of the Year” Award
11. New White Paper Details Six Common Bad Assumptions About Hearing Protection
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/13/2016)... ... February 13, 2016 , ... ... Nursing with an in-kind gift of a VeinViewer® Vision vein finder ... learn how to start an IV and draw blood, combining technology with traditional ...
(Date:2/12/2016)... ... February 12, 2016 , ... Mystic Buddha Publishing House ... Blue SKies Buddha, the biography of Rama - Dr. Frederick Lenz. , ... the love of a Buddhist teacher for teaching and helping others. Valentine’s Day ...
(Date:2/12/2016)... Church, VA (PRWEB) , ... February 12, 2016 ... ... Store?, Feb. 29, 2016 — 1:30 p.m. – 3:00 p.m. EST, http://www.fdanews.com/fixeddosecombination ... issue in the life cycle of pharmaceutical products, garnering increased attention from all ...
(Date:2/12/2016)... Wis. (PRWEB) , ... February 12, 2016 , ... ... second Lean Leadership Series at Zuckerberg San Francisco General Hospital on April 5-7. ... practice new behaviors and create new habits. The workshops cover a broad range ...
(Date:2/12/2016)... ... 2016 , ... The Jones Agency, a family owned insurance company with offices ... cooperative charity drive with the Tarrant Area Food Bank in the hopes of alleviating ... in need, the Tarrant County Food Bank offers hope and security to the one ...
Breaking Medicine News(10 mins):
(Date:2/11/2016)... The primary goal of this research is ... the usage of liquid biopsy. Key information the survey ... Timeframe of liquid biopsy adoption amidst future users - ... type - Sample inflow to conduct liquid biopsy tests ... and so on. - Correlation analysis of sample type ...
(Date:2/11/2016)... Laboratory glassware and plasticware include ... may range from microscope slides to large storage boxes ... borosilicate glass because of its low weight and resistance ... started gaining popularity over the past decade when it ... with plastic in several applications due to its resistance ...
(Date:2/11/2016)... 2016  Governor Andrew M. Cuomo today announced a ... throughout Western New York . This ... Polytechnic Institute, includes a major expansion of Athenex,s North ... Buffalo , as well as the creation of ... Dunkirk . The combined projects are expected ...
Breaking Medicine Technology: