Navigation Links
New paper describes important advance in imaging of cell death
Date:1/29/2010

For quite some time, the "Holy Grail" in medical imaging has been the development of an effective method to image cell death as a means to intervene early in diseases and rapidly determine the effectiveness of treatments. A new paper by researchers at the University of Notre Dame and the Washington University School of Medicine describes important progress in using a synthetic probe to target dead and dying cells in mammary and prostate tumors in living animals.

Bradley D. Smith, Emil T. Hofman Professor of Chemistry and Biochemistry at Notre Dame, points out that the group of researchers had previously discovered that synthetic zinc (II)-dipicolylamine (Zn-DPA) coordination complexes can selectively target the outer surfaces of anionic (negatively charged) cell membranes. Furthermore, fluorescent versions of these Zn-DPA complexes act as imaging probes that can distinguish dead and dying mammalian cells from healthy cells in a cell culture and also selectively target bacteria in contaminated samples.

The researchers also recently demonstrated that a fluorescent near-infrared probe referred to as PSS-794 can be used to image bacterial infections in mice, indicating that PSS-794 has a notable ability to selectively target anionic cells in living animals.

In the new paper, the researchers describe a significant expansion of the animal imaging capability of PSS-794 by showing that it can target the anionic dead and dying cells within tumors in rat and mouse models. The research is an important step toward the development of optical imaging probes that could determine, noninvasively, the amount and type of cell death in tumors. Such imaging techniques could help clinicians accurately determine the grade of tumors and the stage of cancers, as well as to measure the effectiveness of treatments.

The researchers also believe that analogous probes can be developed that would allow for deep tissue imaging of cancers in humans.

Smith points out that although the study focused on mammary and prostate tumors, imaging of cell death is broadly useful for treatment of numerous conditions, including cardiovascular disease, neurology, renal disease and even transplant rejection.


'/>"/>

Contact: Bradley Smith
smith.115@nd.edu
574-631-8632
University of Notre Dame
Source:Eurekalert

Related medicine news :

1. New Paperback Dating Advice Book, Love in 90 Days, Reveals 16 Men's Dead-End Dating Patterns and What To Do About Them
2. Scantronix and ePaperlessSolutions Form Key Partnership
3. Diabetes and Pre-Diabetes Accounted for $218 Billion in Costs in 2007, Health Affairs Paper Demonstrates
4. New Concord Coalition Paper Discusses End Game Fiscal Considerations for Health Care Reform
5. New White Paper Details Best Practices of an Occupational Hearing Conservation Program: US Airways
6. Amilpar - Press Release - Commercial Papers
7. PeopleStreme Human Capital Releases 'New Trends in Performance Management - 2010' Whitepaper
8. The Paper Tiger Document Management and Filing System Software Announces "Windows 7 Compatibility"
9. Case Western Reserve researchers new pathway discovery published as Paper of the Week
10. Kendall Hunt Authors Earn NAGC “Paper of the Year” Award
11. New White Paper Details Six Common Bad Assumptions About Hearing Protection
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/19/2017)... ... January 19, 2017 , ... Bill Howe Plumbing, Heating ... the American Heart Association; “Howe” Healthy is Your Heart Drawing Contest The ... active. Each year, Bill Howe Plumbing, Heating & Air receives over 600 entries. The ...
(Date:1/19/2017)... Marriottsville, MD (PRWEB) , ... January 19, 2017 , ... ... launched six new clients into the US market. , Over the past 20 years ... the past 4 weeks SFI has launched six new clients into the US market. ...
(Date:1/19/2017)... Georgia (PRWEB) , ... January 19, 2017 , ... ... Surgeons hosts the Atlanta Breast Surgery Symposium, a conference where hundreds of surgeons ... advancements in breast surgery. Covering topics from cosmetic breast augmentation to ...
(Date:1/18/2017)... ... 2017 , ... A recent video posting of a new fidget product gathered ... fidgeting to relieve stress and anxiety. No one was more surprised than Think ... just completed a successful Kickstarter campaign raising $67,000 on the popular crowdfunding platform. ...
(Date:1/18/2017)... (PRWEB) , ... January 18, 2017 , ... ... manage it from the number one doctor-recommended OTC antiperspirant, Certain Dri. , Excessive ... go untreated. , Certain Dri created this infographic to explain the seven types ...
Breaking Medicine News(10 mins):
(Date:1/19/2017)... CLEVELAND , Jan. 19, 2017 ViewRay, ... (DFG), a federal institution supporting research in ... installation and patient treatments at the University Clinic Heidelberg ... The MRIdian Linac program will be headed ... who also heads radiation oncology at the German Cancer ...
(Date:1/19/2017)... Calif. , Jan. 19, 2017   Science ... is excited to announce that the first five ... Biology  (RP:CB) have been published in eLife today. ... project represents the first practical evaluation of reproducibility ... in reproducible studies. Unlike other assessments of reproducibility, ...
(Date:1/19/2017)... -- New Review of Safinamide - ... and Motor Complications in Mid- to Late-stage Parkinson,s ... ... C Warren Olanow , ... 2-15, http://www.touchneurology.com/articles/safinamide-new-therapeutic-option-address-motor-symptoms-and-motor-complications-mid-late Published recently ...
Breaking Medicine Technology: