Navigation Links
New pain relief targets discovered
Date:4/17/2014

Scientists have identified new pain relief targets that could be used to provide relief from chemotherapy-induced pain. BBSRC-funded researchers at King's College London made the discovery when researching how pain occurs in nerves in the periphery of the body.

Dr Marzia Malcangio said: "We have been investigating and identifying mechanisms underlying pain generation and our findings could help chemotherapy patients who suffer pain related side effects."

One potential side effect of some chemotherapy drugs (such as vincristine) is damage to nerves. This is particularly prominent in hands and feet as the drugs affect nerves in the periphery of the body. This causes pain which doctors treat with painkillers. However, some people find that the pain persists.

Dr Malcangio's team investigated why the chemotherapy drugs were causing pain in hope to solve the problem. The used mice in the study because mice given the chemotherapy drug also experienced pain in their nerve extremities (such as their hind-paws).

By studying the mice, they found that the pain was caused by the mouse's own immune system responding to damaged blood vessels.

Dr Marzia Malcangio explained: "The chemotherapy drug was found to cause damage to blood vessels around the nerves. When this happened, immune cells leave the blood flow and enter the nerve to help reduce the inflammation, but they also activate pain. Chemicals released naturally by the immune cells were activating the nerves and producing pain."

To try to prevent the pain, researchers looked at ways of stopping the immune cells entering the nerve. They identified receptors on the outside of the immune cells that could be targeted to stop their exit from blood, constituting new types of pain treatment.

Dr Marzia Malcangio added: "We have discovered that the pain responses are caused by local activation of pain nerves by immune cells and that this could be prevented. Our result can be exploited to produce drugs that, given in combination with treatment, may limit the pain experienced by patients during chemotherapy cycles."

Professor Jackie Hunter, BBSRC Chief Executive said: "This BBSRC CASE studentship has enabled a mutually beneficial research collaboration between academia and industry. Understanding the biological mechanisms of pain, using this mouse model, could lead to new types of pain management."


'/>"/>

Contact: Chris Melvin
chris.melvin@bbsrc.ac.uk
01-793-414-694
Biotechnology and Biological Sciences Research Council
Source:Eurekalert  

Related medicine news :

1. Botox Offers Little Relief for Migraine, Study Finds
2. Study Explores Distractions Role in Pain Relief
3. Spider-Phobes May Get Quick Relief
4. The W3 Project Receives Support from Doulton for Emergency Relief Efforts
5. Deep Brain Stimulation May Offer Longer-Term Relief for Parkinsons
6. Back Pain Relief4Life Announces $47 Program
7. Vygone Introduces A New Zapper For Effective Relief From Herpes Virus Related Skin Problems
8. Relief for Migraine Sufferers as The Life House Offers New Findings, Free Consults
9. Vertebroplasty reportedly provides better pain relief and function
10. Generic drugs key to US overseas HIV relief
11. Standard radiation therapy dose provides pain relief for painful heel spurs
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
New pain relief targets discovered
(Date:9/22/2017)... ... 2017 , ... On Sunday, September 24, hundreds will gather at Flo Jo ... considered the fastest woman of all time. Flo Jo passed away from complications ... the National Anthem. Mary was a contestant on the 2012 season of America’s ...
(Date:9/22/2017)... (PRWEB) , ... September 22, 2017 , ... ... assembles Passive House buildings, and Richard Pedranti Architect (RPA), a full-service ... from the strategic partner’s Solsken Line of Model Homes . Independently, Ecocor ...
(Date:9/22/2017)... ... September 22, 2017 , ... SABRE is ... Sweepstakes.,  , Molli C., a graduate student from Sonora, California, who will begin ... at St. Thomas University in Miami, Florida, was selected from a pool of ...
(Date:9/22/2017)... ... ... “Cursed with a Curse: The Truth about Tithing”: a ... when breaking free from this misconception. “Cursed with a Curse: The Truth about ... Christian Faith Publishing, Lysa M. Harrison’s new book is a powerful and thought-provoking ...
(Date:9/22/2017)... ... 2017 , ... "Success Files," a short- and long-form documentary ... a disease estimated to affect the lives of more than 5 million Americans ... a leading voice in the fight for cure and research into the disease, ...
Breaking Medicine News(10 mins):
(Date:9/22/2017)... -- As the latest Obamacare repeal effort moves is debated, ... and Lindsey Graham (R-SC) medical device market ... is in an odd place.  The industry wants repeal ... on medical device sales passed along with the Affordable ... visits and hospital customers with the funding to invest ...
(Date:9/18/2017)... , Sept. 18, 2017 EpiVax, ... of bioinformatics and immune engineering, today announced ... influenza A (H7N9) vaccine. ... to seasonal influenza and presents a challenge ... prior exposure to be effective. Using state-of-the-art ...
(Date:9/9/2017)... Sept. 8, 2017 ... MRI Unit coming to Washington DC ... When: Tuesday, September 12 th – Monday, September 18 th ... offering free MRI brain scans to the public.Where:  ... parked at 501 K Street NW, Washington, D.C.What:BTF brings its nationwide initiative, ...
Breaking Medicine Technology: