Navigation Links
New pain relief targets discovered
Date:4/17/2014

Scientists have identified new pain relief targets that could be used to provide relief from chemotherapy-induced pain. BBSRC-funded researchers at King's College London made the discovery when researching how pain occurs in nerves in the periphery of the body.

Dr Marzia Malcangio said: "We have been investigating and identifying mechanisms underlying pain generation and our findings could help chemotherapy patients who suffer pain related side effects."

One potential side effect of some chemotherapy drugs (such as vincristine) is damage to nerves. This is particularly prominent in hands and feet as the drugs affect nerves in the periphery of the body. This causes pain which doctors treat with painkillers. However, some people find that the pain persists.

Dr Malcangio's team investigated why the chemotherapy drugs were causing pain in hope to solve the problem. The used mice in the study because mice given the chemotherapy drug also experienced pain in their nerve extremities (such as their hind-paws).

By studying the mice, they found that the pain was caused by the mouse's own immune system responding to damaged blood vessels.

Dr Marzia Malcangio explained: "The chemotherapy drug was found to cause damage to blood vessels around the nerves. When this happened, immune cells leave the blood flow and enter the nerve to help reduce the inflammation, but they also activate pain. Chemicals released naturally by the immune cells were activating the nerves and producing pain."

To try to prevent the pain, researchers looked at ways of stopping the immune cells entering the nerve. They identified receptors on the outside of the immune cells that could be targeted to stop their exit from blood, constituting new types of pain treatment.

Dr Marzia Malcangio added: "We have discovered that the pain responses are caused by local activation of pain nerves by immune cells and that this could be prevented. Our result can be exploited to produce drugs that, given in combination with treatment, may limit the pain experienced by patients during chemotherapy cycles."

Professor Jackie Hunter, BBSRC Chief Executive said: "This BBSRC CASE studentship has enabled a mutually beneficial research collaboration between academia and industry. Understanding the biological mechanisms of pain, using this mouse model, could lead to new types of pain management."


'/>"/>

Contact: Chris Melvin
chris.melvin@bbsrc.ac.uk
01-793-414-694
Biotechnology and Biological Sciences Research Council
Source:Eurekalert  

Related medicine news :

1. Botox Offers Little Relief for Migraine, Study Finds
2. Study Explores Distractions Role in Pain Relief
3. Spider-Phobes May Get Quick Relief
4. The W3 Project Receives Support from Doulton for Emergency Relief Efforts
5. Deep Brain Stimulation May Offer Longer-Term Relief for Parkinsons
6. Back Pain Relief4Life Announces $47 Program
7. Vygone Introduces A New Zapper For Effective Relief From Herpes Virus Related Skin Problems
8. Relief for Migraine Sufferers as The Life House Offers New Findings, Free Consults
9. Vertebroplasty reportedly provides better pain relief and function
10. Generic drugs key to US overseas HIV relief
11. Standard radiation therapy dose provides pain relief for painful heel spurs
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
New pain relief targets discovered
(Date:10/13/2017)... ... October 13, 2017 , ... The International Association of ... of excellence for the field of eating disorders, announces the opening of early ... in Orlando, Florida at the Omni Resort at ChampionsGate. , The ...
(Date:10/13/2017)... , ... October 13, 2017 , ... Many families have ... many long-term care insurance companies have a waiver for care if the client has ... period, when the family pays for care, is often waived, so the benefits from ...
(Date:10/13/2017)... ... October 13, 2017 , ... Talented host, actor ... on sciatica in a new episode of "Success Files," which is an award-winning ... innovation and investigates each subject in-depth with passion and integrity. , Sciatica occurs ...
(Date:10/12/2017)... ... 12, 2017 , ... CitiDent and San Francisco dentists, Dr. ... Oventus O2Vent technology. As many as 18 million Americans are estimated to suffer ... Oral appliances can offer significant relief to about 75 percent of people with ...
(Date:10/12/2017)... ... October 12, 2017 , ... Asante, a ... health care, have expanded their existing home health joint venture through an agreement, ... been operating a joint venture home health company with Asante, delivering clinically integrated ...
Breaking Medicine News(10 mins):
(Date:10/7/2017)... Texas , Oct. 6, 2017   Provista, ... with more than $100 billion in purchasing power, today ... news and information. The Newsroom is the ... and industry trends, infographics, expert bios, news releases, slideshows ... having access to a wealth of resources at their ...
(Date:10/2/2017)... FLINT, Mich. , Oct. 2, 2017 ... acquired 8th Day Software and Consulting, LLC , ... 8th Day Software, based in Tennessee ... Management LLC. 8th Day expands EnvoyHealth,s service offerings for ... product development. "In ...
(Date:9/28/2017)... , Sept. 28, 2017 Hill-Rom Holdings, Inc. ... earnings conference call and webcast on Friday, November 3, ... (EDT) and ending at approximately 8:30 a.m. (CDT) / ... the company,s 2017 financial performance and guidance for 2018, ... initiatives to enhance operational performance, and long-range financial outlook ...
Breaking Medicine Technology: