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New optical metrics can identify patients on 'fast track' to decreased vision
Date:6/24/2013

to predict the rate of decline in visual acuity during that time. The goal was to see whether any of the image quality or other metrics could predict which patients would have faster than usual age-related declines in vision.

Overall, the average change in visual acuity during follow-up was loss of 1.6 letters on the standard eye chart. That was consistent with the expected age-related decline.

However, a subgroup of 50 patients had larger changes in visual acuity during follow-up. In this group the average change was loss of 3.4 letters.

Three Significant Predictors of Faster Age-Related Visual Decline

With adjustment for other factors, three optical measures predicted a larger change in visual acuity. These included one optical quality measure ("trefoil"), one measure of optical light scatter ("point spread function entropy"), and one measure of lens clouding (posterior subcapsular cataract).

Together, these three measures accounted for 32 percent of the change in visual acuity in patients with larger-than-expected change in visual acuity. Older age explained at additional two percent of the change.

For the overall sample of 148 eyes, the same factors explained 15 percent of the change in visual acuity. In these slower-changing eyes, older age was the most important predictor.

Advanced optical quality metrics can detect a wide range of minor imperfections in the visual performance of the eye. Computerized WFE analysis is becoming more widely available to detect these subtle vision defects, for example, as part of LASIK and corneal surgery.

The new study suggests that some of these WFE-based metrics may be useful in predicting which patients will have more rapid than usual age-related decline in visual acuity. "Correlations like those found here in fast changing eyes allow the identification of those at risk of being on a fast track to acuity loss," Dr Koenig and coauthors conclude.
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Contact: Connie Hughes
connie.hughes@wolterskluwer.com
Wolters Kluwer Health
Source:Eurekalert

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