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New opportunities to treat bowel cancer
Date:7/8/2013

s p53, inactivating their ability to suppress cancer progression.

"Understanding the genetic makeup of different colorectal cancer subtypes will guide therapeutic decision making in the future" says Professor Allan Bradley, senior author from the Wellcome Trust Sanger Institute. "Our ability to engineer specific genetic alterations in mice allows us to study the function of cancer genes and to model specific cancer subtypes at an organismal level. Such mouse models are also invaluable for testing anticancer drugs before using them in clinical trials".

The team tested a wide range of existing and candidate drugs for their ability to slow down or prevent growth of mouse colon cancer and human colon cancer cells, finding several highly effective approaches. These were tested individually or in combination with one another to find the most powerful therapies.

Mice with the Braf-associated colon cancer had very similar therapeutic responses to those of BRAF-associated cancer cells from patients with colon cancer, highlighting the effectiveness of mice in preclinical cancer research.

The team found multiple drugs and drug combinations that were effective against human colon cancer cells. These are promising results for alternative second- or third-line treatments after resistance to the first round of treatment against this occurs.

"Our results illustrate the power of combining genomic information with large-scale drug screening to provide new targeted treatment strategies for patients with specific cancer subtypes," says Dr Ultan McDermott, author from the Wellcome Trust Sanger Institute.


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Contact: Aileen Sheehy
press.office@sanger.ac.uk
44-012-234-96928
Wellcome Trust Sanger Institute
Source:Eurekalert

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