Navigation Links
New opportunities to treat bowel cancer
Date:7/8/2013

s p53, inactivating their ability to suppress cancer progression.

"Understanding the genetic makeup of different colorectal cancer subtypes will guide therapeutic decision making in the future" says Professor Allan Bradley, senior author from the Wellcome Trust Sanger Institute. "Our ability to engineer specific genetic alterations in mice allows us to study the function of cancer genes and to model specific cancer subtypes at an organismal level. Such mouse models are also invaluable for testing anticancer drugs before using them in clinical trials".

The team tested a wide range of existing and candidate drugs for their ability to slow down or prevent growth of mouse colon cancer and human colon cancer cells, finding several highly effective approaches. These were tested individually or in combination with one another to find the most powerful therapies.

Mice with the Braf-associated colon cancer had very similar therapeutic responses to those of BRAF-associated cancer cells from patients with colon cancer, highlighting the effectiveness of mice in preclinical cancer research.

The team found multiple drugs and drug combinations that were effective against human colon cancer cells. These are promising results for alternative second- or third-line treatments after resistance to the first round of treatment against this occurs.

"Our results illustrate the power of combining genomic information with large-scale drug screening to provide new targeted treatment strategies for patients with specific cancer subtypes," says Dr Ultan McDermott, author from the Wellcome Trust Sanger Institute.


'/>"/>

Contact: Aileen Sheehy
press.office@sanger.ac.uk
44-012-234-96928
Wellcome Trust Sanger Institute
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Telesoft the Subject of a Strengths, Weaknesses, Opportunities, and Threats Report
2. Newly Released Continuing Education Courses Provide Physical and Occupational Therapy Professionals With Opportunities To Expand Skill Sets
3. Critical Acclaim Pouring in for Killing Ideas: You Can Kill an Idea, You Can’t Kill an Opportunity by Dr. Pam Henderson: Book Shows Companies How to Maximize Growth Through BIG Opportunities
4. AGA presents cutting-edge research and new learning opportunities at DDW® 2013
5. Large genomic study identifies endometrial cancer subtypes, treatment opportunities
6. New Career Opportunities Appear in the Emerging Semi Permanent Make-up Market with Long-Time-Liner®’s Semi Permanent Make-up Training Courses
7. Extracellular vesicles may open new opportunities for brain cancer diagnosis and treatment
8. Laser Die-Cutting Creates New Opportunities for Acrylic Photo Gifts
9. General Plastics Announces Global Distribution Opportunities
10. Lice Happens Now Offering "Lousy" Franchise Opportunities
11. MMS Group Explores New Opportunities for Placing Healthcare Contractors
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/22/2015)... Liberty University has received accreditation for its resident Clinical ... for Accreditation of Counseling & Related Educational Programs (CACREP). ... & Family Studies , is under the leadership of Dr. ... Behavioral Sciences. Prior to the formation of the new school, ...
(Date:1/22/2015)... Padre Murphy's and Owner Tom Boyle in ... Player Health Alliance (PPHA). The PPHA's passion for others' ... including NFL greats, treated for obstructive sleep apnea (OSA) has ... the cause in the valley. The most recent plans for ...
(Date:1/22/2015)... AngelWeddingDress, the premier women’s dress supplier, has ... View website of AngelWeddingDress.com to find more ... dresses online for a bridal party. AngelWeddingDress offers a ... them. Its maternity wedding dresses are specially designed for ...
(Date:1/22/2015)... Autocarinsurancebest.com has released a new blog post explaining ... policy . , Auto insurance quotes help many drivers ... longer necessary to call an agent or visit an agency ... a single website: http://autocarinsurancebest.com/ . , Every business who ...
(Date:1/22/2015)... Calif. (PRWEB) January 22, 2015 ... Susan Bonilla (D-Concord) and Kristin Olsen (R-Modesto) were ... their leadership in advancing biotechnology, biomedical science, medical ... and Olsen each received the “2014 Life Sciences ...
Breaking Medicine News(10 mins):Health News:Liberty University's Resident Master’s Counseling Program Receives CACREP Accreditation 2Health News:Padre Murphy's Holds NFL Retired Players Association Party Star Studded Event With Bud Light and Pro Player Health Alliance Sponsoring 2Health News:Padre Murphy's Holds NFL Retired Players Association Party Star Studded Event With Bud Light and Pro Player Health Alliance Sponsoring 3Health News:AngelWeddingDress Has Recently Released Its Collection Of 2015 Maternity Wedding Dresses 2Health News:Commercial Auto Insurance Provides Several Important Features! 2Health News:California Biomedical Community Honors Senator Holly Mitchell, Assemblymembers Susan Bonilla & Kristin Olsen 2Health News:California Biomedical Community Honors Senator Holly Mitchell, Assemblymembers Susan Bonilla & Kristin Olsen 3
... Health Care Purchasing,Initiatives, WASHINGTON, Nov. 6 ... hospital improvement initiative, The Leapfrog,Hospital Rewards Program ... hospitals for improvements in quality and resource,utilization. ... includes a,standardized measure set and scoring methodology, ...
... MINNEAPOLIS, Nov. 6 Consumers are looking beyond,Vitamin ... cold and flu season.,With the variety of supplements ... supplements in order to choose effective,products., Paul ... University,of Minnesota and Director of Nutrition Research, Botanic ...
... CITY, Nov. 6 "In a remarkable turn of ... cosmetics, women around the,country have been applying a stretch-mark ... lines, wrinkles and crows, feet." Five years ago, these,words ... in the cosmetic,industry: a little-known American stretch-mark cream called,StriVectin-SD(R) ...
... that are Tasty and Healthy, WICHITA, Kan., Nov. 6 ... three things: fun, family and food. With so many,parties to ... can be,difficult to maintain your overall health and nutrition while ... FranklinCovey Holiday Stress Survey, more than 75,percent of respondents didn,t ...
... Nationwide School Grant Program Begins Its Third Year; Over $600,000 ... ... author and chef, is,looking for a few good moms -- those devoted ... and the makers of,Hidden Valley(R) Salad Dressings will host a Love Your ...
... Z Williams and Dr Christopher G Williams, both with Park Meadows Cosmetic ... local hospital to bring DIEP Flap breast reconstruction to Colorado patients. ... ... being diagnosed with breast cancer every year, new alternatives to breast ...
Cached Medicine News:Health News:The Leapfrog Group Launches Updated Hospital Rewards Program 2Health News:The Leapfrog Group Launches Updated Hospital Rewards Program 3Health News:Beyond Vitamin C 2Health News:Happy Birthday, StriVectin! The Skin Cream that Revolutionized the Anti-Aging Market 2Health News:Happy Birthday, StriVectin! The Skin Cream that Revolutionized the Anti-Aging Market 3Health News:Navigating Holiday Taste Temptations 2Health News:Navigating Holiday Taste Temptations 3Health News:Chef Art Smith, Moms and Schools Partner to Teach Kids to Love Their Veggies 2Health News:Chef Art Smith, Moms and Schools Partner to Teach Kids to Love Their Veggies 3Health News:Chef Art Smith, Moms and Schools Partner to Teach Kids to Love Their Veggies 4Health News:Chef Art Smith, Moms and Schools Partner to Teach Kids to Love Their Veggies 5Health News:Two Colorado Surgeons Become Pioneers In Microsurgical DIEP Flap Breast Reconstruction 2Health News:Two Colorado Surgeons Become Pioneers In Microsurgical DIEP Flap Breast Reconstruction 3
(Date:1/23/2015)... all-time hits leader, is the new spokesperson for the topical ... announced. "Pete,s a Hall of Famer in our ... with Myoflex," said Ducere Pharma Chief Executive Officer Chris ... across all generations. The passion and intensity that Pete brought ...
(Date:1/23/2015)... Fla. , Jan. 23, 2015  iMD Companies, Inc. (ICBU) ... to increase market share and grab a foothold in the ... influence, production capabilities and a presence in the sector, and ... facilitate the growth of hemp and medical marijuana, iMD is ...
(Date:1/23/2015)... Jan. 23, 2015   Leatt Corporation  (OTCQB: LEAT), a ... for all forms of sports, including extreme motor sports, ... announced today that the UISP Lega Motociclismo Lombardia, an ... riders to wear a neck brace during its racing ...
Breaking Medicine Technology:Pete Rose bets on Myoflex to relieve aches and pains 2iMD Companies Poised to Make Impact in Multi-Billion Dollar Medical Marijuana Sector With Recent Investments and Strategic Partnerships 2Leatt Announces Neck Braces Now Required For Motocross/Minicross Racing In Italy 2Leatt Announces Neck Braces Now Required For Motocross/Minicross Racing In Italy 3
... concave seats and standard-sized backrests with ... seats, backrests, armrests, and casters and ... for the following environments: industry, education, ... care and office. • With reinforced ...
... Basic ergonomic chairs with concave seats ... • Select options like seats, backrests, ... BTN/1Q-CAB chairs are recommended for the ... room, static control, health care and ...
... Basic ergonomic chairs with concave seats ... • Select options like seats, backrests, ... BTN/1Q-CAB chairs are recommended for the ... room, static control, health care and ...
... concave seats and standard-sized backrests with ... seats, backrests, armrests, and casters and ... for the following environments: industry, education, ... care and office. • With cast ...
Medicine Products: