Navigation Links
New oncogene gives valuable insight into hepatocellular tumors in humans
Date:4/23/2009

Copenhagen, Denmark, Thursday 23 April: The first identification of GP130 somatic activating mutations* in human tumours was announced today at EASL 2009, the Annual Meeting of the European Association for the Study of Liver Disease in Copenhagen, Denmark.

Identification of recurrent somatic mutation activating GP130 in inflammatory hepatocellular tumours reveals a new pathway of tumourigenesis in humans, according to researchers. This finding reinforces the role of inflammation in hepatocarcinogenesis and particularly in the malignant transformation of hepatocellular adenomas (HCA). Moreover, GP130 mutations will enable the refinement of the molecular classification of hepatocellular tumors in humans.

Inflammatory hepatocellular adenomas (IHCA) are benign liver tumours defined by the presence of inflammatory infiltrates and by an over-expression of inflammatory proteins. IHCA are usually developed in women and their occurrence is frequently associated with obesity and alcohol intake. Recently, somatic mutations were identified that activated GP130 in 60% of IHCA (Rebouissou et al, Nature, 2009), thus defining GP130 as a new oncogene in human tumours. This study aimed to evaluate frequency of GP130 mutations in a wide series of tumours.

Dr Jessica Zucman-Rossi of Inserm U674, Paris, France, who led the study, said: "This exciting advance means we now have a novel means of further investigating the development pathway of hepatocellular tumours as well as a new tool in the classification of hepatocellular tumours. It is an important step forward in our understanding of hepatocarcinogenesis and the future management of this disease."

Researchers in this study screened a series of 400 well-characterised hepatocellular tumours including hepatocellular adenomas, carcinomas, hepatocholangio-carcinoma, fibrolamellar carcinomas and intra-hepatic cholangiocarcinomas. 100 tumours from different organs were also collected. To search for mutations, GP130 exons were screened in all samples and the function of 7 different mutants was analysed in HEP3B.

A somatic mutation was identified in 65% of the IHCA including 24 different small in-frame deletions or duplications. A spectrum of mutations shows that mutations clearly target the IL-6 binding site in GP130. Also demonstrated was the fact that the expression of the most frequent GP130 mutants in HEP3B cells activates STAT3 in absence of IL-6. The researchers searched for possible interaction and cooperation of GP130 activation with other pathways altered in hepatocellular adenoma. HNF1α inactivation and gp130 activation were mutually exclusive in HCA (P< 10-4). By contrast, in half of the -catenin activating HCA, a GP130-activating mutation was identified. For two IHCA associated with a malignant transformation, both an activating gp130 and -catenin mutations were found. Further, analysis of 220 hepatocellular carcinomas revealed rare GP130 alterations in all cases accompanied by -catenin-activating mutations, suggesting a cooperative effect of these signalling pathways in the malignant transformation of hepatocytes.


'/>"/>

Contact: Camilla Dormer
easlpressoffice@cohnwolfe.com
44-787-619-0439
European Association for the Study of the Liver
Source:Eurekalert

Related medicine news :

1. MicroRNA controls expression of oncogenes
2. Colon Cancer Oncogene Discovered
3. Blocking Oncogene Can Stop Spread of Ovarian Cancer
4. Oncogene inhibits tumor suppressor to promote cancer: Study links B-RAF and LKB1
5. Online Epidemic Gives Clues to Bird Flu Spread
6. Welch Foundation gives $1.6 million for drug discovery research
7. 24 Hour Fitness Gives The Biggest Loser High-Tech Upgrade
8. New Technology at Unitrin Direct Gives Customers an Alternative to Waiting
9. Ancient mechanism for coping with stresses also gives cancer a boost
10. What gives us sunburn protects crayfish against bacteria
11. Bellevue Dentist Gives a Thumbs Up to Britney Spears Smile
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/13/2016)... ... 13, 2016 , ... Valentine’s Day is nearly upon us, and most singles ... great outfit, flawless hair, and a sparkling personality are all well and good, but ... night at home with Rover. (Actually, man’s best friend might not even want to ...
(Date:2/13/2016)... ... February 13, 2016 , ... Many individuals looking to lead a healthy lifestyle ... reasons. IsoPasta by Isolator Fitness has delved into this niche allowing those giving ... high-carb repercussions. IsoPasta has 30 grams of protein and only 7 grams of ...
(Date:2/13/2016)... ... February 13, 2016 , ... The producers of Enterprises TV are ... The increasingly modern world of instantaneous consumption proves very convenient for businesses. With new ... oil and coal, which pollutes our air, water, and soil. It can also threaten ...
(Date:2/13/2016)... ... February 13, 2016 , ... Christie Medical Holdings, Inc. presented ... a VeinViewer® Vision vein finder for the nursing school simulation lab. ... and draw blood, combining technology with traditional technique. , “VeinViewer is a wonderful ...
(Date:2/13/2016)... (PRWEB) , ... February 13, 2016 , ... In the ... forward. They’ll groom themselves to perfection, go out of their way to be romantic, ... – just take a look at any online dating profile. , A recent ...
Breaking Medicine News(10 mins):
(Date:2/12/2016)... FRAMINGHAM, Mass. , Feb. 12, 2016   ... scheduled a conference call and webcast to discuss its ... December 31, 2015, on Thursday, February 25, 2016 at ... financial results prior to the conference call and webcast.  ... the company,s financial results, highlights from the fourth quarter ...
(Date:2/12/2016)...  Memorial Hermann Health System has teamed up with ... bring a one-of-a-kind experience to pediatric patients at ... as 360-degree video and Google Cardboard, Howard was able ... giving the patients and their families an unexpected, and ... on video . Memorial Hermann IRONMAN ...
(Date:2/12/2016)... SEOUL, South Korea , Feb. 12, 2016 ... today announced they will form a partnership to ... medicine in cancer. The goal of the collaboration ... with Macrogen,s high-throughput Next Generation Sequencing capabilities toward ... Laboratory Improvement Amendments (CLIA) of 1988 by the ...
Breaking Medicine Technology: