Navigation Links
New old drug fights colon cancer

A new Tel Aviv University drug, based on an older generation antibiotic, may provide doctors with an effective and innovative method of treating colon cancer in both its incipient and full-blown stages ― and minimize the need for painful, uncomfortable colonoscopies and surgical polyp removal.

Dr. Rina Rosin-Arbesfeld of TAU's Sackler School of Medicine has shown in preclinical studies that a common antibiotic can suppress the growth of colon cancer polyps in mice. Her aim is to reformulate the drug for use as a preventative therapy ― or, in stronger doses, in combination with chemotherapy and radiation to fight existing cancers until they're gone. The current formulation reduced the size of the polyps in about 80% of the mice she studied, and on average the animals lived 30% longer than those who were not given the antibiotic.

"My experience shows that colon cancer is particularly aggressive," says Dr. Rosin-Arbesfeld. "Our new drug may be able to slow down polyp growth so that it never manifests to full-blown colon cancer." She is currently preparing the results of her recent study for an upcoming issue of the journal Gut.

Taking genes to the repair shop

The antibiotic acts in a genetic fashion. In diseases like cystic fibrosis (CF) and muscular dystrophy, antibiotics from the aminiglycoside family can repair damaged or mutated DNA. For her new study, Dr. Rosin-Arbesfeld looked at a closely-related but less toxic family of antibiotics from the Macrolide family that achieves the same therapeutic results.

Dr. Rosin-Arbesfeld focused on a gene associated with colorectal cancer, the APC gene, and noticed that the mutation types in colorectal cancer are similar to those in the CF gene. Noting that old generation antibiotics are effective in fighting CF, she studied its effects on colon cancer as well. She found that the drug partially repaired faulty genes in mice with colon cancer. Benefits from using old generation and out of circulation antibiotics means that the new therapy will not interfere with current antibiotics used for today's bacterial infections.

At first she thought about using the antibiotic as a preventative therapy, but later investigated its efficacy in treating full-blown cancer and found it similarly effective.

A fast track to getting the drug to market

Ramot, TAU's commercial transfer company, has filed for a patent for the new use, and because the antibiotic has already been on the market, Dr. Rosin-Arbesfeld expects the new drug could be developed quickly. The preclinical results are encouraging and Ramot is currently talking with potential partners to bring this drug to experimental trials in humans, a critical step before it can be made more widely available.

"For many years it's been known that a specific family of antibiotics does more than kill bacteria," says Dr. Rosin-Arbesfeld. "They affect biological systems in the body and repair mutated genes. In directing my work towards the treatment of cancer, I can help save lives."


Contact: George Hunka
American Friends of Tel Aviv University

Related medicine news :

1. Bay Medical Fights Healthcare-Associated Infections by Improving Hand Hygiene 300%
2. Irish Joe McCreedy Defends Title, Fights for New One With Superhydration From AquaHydrate, First High Performance Sports Water
3. Biotransformed blueberry juice fights fat and diabetes
4. New Precision Radiation Treatment System Fights Cancer
5. Most Americans Continue to Support Moving Ahead With Health Care Reform Now Despite Town Hall Fights and Ad Campaigns
6. Indoor Tanning Association Fights Back Against Media Hype over Tanning Beds
7. New Drug Fights Anthrax Toxin
8. New Cancer Drug Fights Tumors in Those With BRCA Mutations
9. Researchers at Case Western Reserve discover a new way the body fights fungal infection
10. New Insights Show Ginseng Fights Inflammation
11. New Discovery Shows Ancient Herb Fights Inflammation
Post Your Comments:
Related Image:
New old drug fights colon cancer
(Date:11/24/2015)... , ... November 24, 2015 , ... ... the Business Action on Health Awards, bestowed annually to the world’s best corporate-supported ... commended companies at Global Health Council’s Landscape Symposium held in Washington D.C and ...
(Date:11/24/2015)... ... 2015 , ... The OSHA Training Center at Chabot-Las ... in Northern California, is calling on retail employers to implement safety measures to ... volume of sales and shoppers rapidly expands, retailers are strongly encouraged to develop ...
(Date:11/24/2015)... ... , ... There’s nothing better than giving the gift of green this holiday ... , This year, gardens are popping up in the most unexpected places. A variety ... Gardens’ African Keyhole Garden Bed ($499) , Water conscious gardeners – and that should ...
(Date:11/24/2015)... ... November 24, 2015 , ... Wireless Analytics, an ... announced new 24-hour weekday support capability. The “all hours” offering was introduced ... international customers, and to enhance after-hours support available in the US. , Available ...
(Date:11/24/2015)... ... , ... Take the audience on a journey with TransFrame Cloud from Pixel Film ... images without ever setting a single keyframe in Final Cut Pro X. Design smooth and ... to change the angle and depth of field to create a unique viewing perspective. , ...
Breaking Medicine News(10 mins):
(Date:11/24/2015)... Nov. 24, 2015  Figure 1, a free mobile-first ... medical cases, has launched a new completely redesigned web ... version allows radiologists, who work primarily on a desktop, ... engage with its radiologist user base, Figure 1 is ... North America (RSNA) Annual Meeting. ...
(Date:11/24/2015)... , Nov. 24, 2015  Family Rentals, a ... announced the launch of their newly designed, mobile-responsive ... --> Logo ... --> --> Now, renting essential ... and vacation, just got a whole lot easier ...
(Date:11/24/2015)... -- The uptake of recently approved and pipeline premium products ... market growth to 2021, says GBI Research . ... for Type 1 Diabetes Mellitus (T1DM), will be a key driver of ... --> The uptake of recently approved and pipeline premium ... of market growth to 2021, says GBI Research ...
Breaking Medicine Technology: