Navigation Links
New old drug fights colon cancer

A new Tel Aviv University drug, based on an older generation antibiotic, may provide doctors with an effective and innovative method of treating colon cancer in both its incipient and full-blown stages ― and minimize the need for painful, uncomfortable colonoscopies and surgical polyp removal.

Dr. Rina Rosin-Arbesfeld of TAU's Sackler School of Medicine has shown in preclinical studies that a common antibiotic can suppress the growth of colon cancer polyps in mice. Her aim is to reformulate the drug for use as a preventative therapy ― or, in stronger doses, in combination with chemotherapy and radiation to fight existing cancers until they're gone. The current formulation reduced the size of the polyps in about 80% of the mice she studied, and on average the animals lived 30% longer than those who were not given the antibiotic.

"My experience shows that colon cancer is particularly aggressive," says Dr. Rosin-Arbesfeld. "Our new drug may be able to slow down polyp growth so that it never manifests to full-blown colon cancer." She is currently preparing the results of her recent study for an upcoming issue of the journal Gut.

Taking genes to the repair shop

The antibiotic acts in a genetic fashion. In diseases like cystic fibrosis (CF) and muscular dystrophy, antibiotics from the aminiglycoside family can repair damaged or mutated DNA. For her new study, Dr. Rosin-Arbesfeld looked at a closely-related but less toxic family of antibiotics from the Macrolide family that achieves the same therapeutic results.

Dr. Rosin-Arbesfeld focused on a gene associated with colorectal cancer, the APC gene, and noticed that the mutation types in colorectal cancer are similar to those in the CF gene. Noting that old generation antibiotics are effective in fighting CF, she studied its effects on colon cancer as well. She found that the drug partially repaired faulty genes in mice with colon cancer. Benefits from using old generation and out of circulation antibiotics means that the new therapy will not interfere with current antibiotics used for today's bacterial infections.

At first she thought about using the antibiotic as a preventative therapy, but later investigated its efficacy in treating full-blown cancer and found it similarly effective.

A fast track to getting the drug to market

Ramot, TAU's commercial transfer company, has filed for a patent for the new use, and because the antibiotic has already been on the market, Dr. Rosin-Arbesfeld expects the new drug could be developed quickly. The preclinical results are encouraging and Ramot is currently talking with potential partners to bring this drug to experimental trials in humans, a critical step before it can be made more widely available.

"For many years it's been known that a specific family of antibiotics does more than kill bacteria," says Dr. Rosin-Arbesfeld. "They affect biological systems in the body and repair mutated genes. In directing my work towards the treatment of cancer, I can help save lives."


Contact: George Hunka
American Friends of Tel Aviv University

Related medicine news :

1. Bay Medical Fights Healthcare-Associated Infections by Improving Hand Hygiene 300%
2. Irish Joe McCreedy Defends Title, Fights for New One With Superhydration From AquaHydrate, First High Performance Sports Water
3. Biotransformed blueberry juice fights fat and diabetes
4. New Precision Radiation Treatment System Fights Cancer
5. Most Americans Continue to Support Moving Ahead With Health Care Reform Now Despite Town Hall Fights and Ad Campaigns
6. Indoor Tanning Association Fights Back Against Media Hype over Tanning Beds
7. New Drug Fights Anthrax Toxin
8. New Cancer Drug Fights Tumors in Those With BRCA Mutations
9. Researchers at Case Western Reserve discover a new way the body fights fungal infection
10. New Insights Show Ginseng Fights Inflammation
11. New Discovery Shows Ancient Herb Fights Inflammation
Post Your Comments:
Related Image:
New old drug fights colon cancer
(Date:12/1/2015)... (PRWEB) , ... December 01, 2015 , ... With ... footage, and with full control over customization, the possibilities are truly endless, all with ... position randomization, overlay depth position, vertical flip, horizontal flip, depth of field and more, ...
(Date:11/30/2015)... ... November 30, 2015 , ... Third Molar ... that it has officially launched a sleek, mobile-ready and user-centric redesigned website. , ... new website clearly outlines the benefits that its SEO services provide to dentists ...
(Date:11/30/2015)... ... December 01, 2015 , ... The National Association of ... its VIP Woman of the Year Circle. She is recognized with this prestigious distinction ... exclusively for professional women, boasting more than 850,000 members and over 200 operating Local ...
(Date:11/30/2015)... ... 30, 2015 , ... Until now, the St. Louis Fetal Care Institute ... of Myelomeningocele Study) trial. One of these exclusion criteria was a BMI above 34.9. ... to 24.9 is considered normal, 25 - 29.9 is overweight and above 30 is ...
(Date:11/30/2015)... ... November 30, 2015 , ... ... . The directory is specialized and only includes chiropractic clinics in the US. ... competent and trustworthy alternative health practitioner when back pain sets in. When people ...
Breaking Medicine News(10 mins):
(Date:11/30/2015)... 2015  Kevin Smith has been appointed Chief ... pioneer in wireless monitoring of vital signs.  As ... , Mr. Smith will be responsible for the ... He will also directly oversee partnering with US ... for SensiumVitals, the first early warning detection device ...
(Date:11/30/2015)... 2015  PTS Diagnostics, the U.S.-based manufacturer of point-of-care ... A1CNow ® systems, and PTS Detect™ cotinine systems, ... that will propel the company into the mHealth market. ... Europe . The technology is a system that ... smartphones and tablets, and uses test strip technology already ...
(Date:11/30/2015)... Wash. and ST. LOUIS ... Express Scripts (NASDAQ: ESRX ) today announced an ... The partnership, which began in 1999, will now extend ... --> After evaluating pharmacy benefit manager ... concluded that Express Scripts continues to offer the best ...
Breaking Medicine Technology: