Navigation Links
New neuroimaging study identifies 'brain signature' for cigarette cravings
Date:12/18/2007

PHILADELPHIA A new brain imaging study by researchers in the Abramson Cancer Center of the University of Pennsylvania shows that cigarette cravings in smokers who are deprived of nicotine are linked with increased activation in specific regions of the brain. Using a novel method of measuring brain blood flow developed by John Detre, MD, associate professor of Neurology at Penn, this study is the first to show how abstinence from nicotine produces brain activation patterns that relate to urges to smoke. The findings, to be published in the December 19, 2007, issue of The Journal of Neuroscience, make an important contribution to understanding smoking urges, a key risk factor for relapse, at the brain level.

According to Caryn Lerman, PhD, Director of the Transdisciplinary Tobacco Use Research Center and senior author of the paper, and colleagues John Detre, MD, and Ze Wang, PhD, cravings are a hallmark of drug dependence, including nicotine dependence. There have been several brain imaging studies showing how subjects respond to visual, smoking-related cues, such as a picture of a cigarette or of someone smoking, said Lerman. However, less is known about the neural basis of urges that arise naturally as a result of nicotine deprivation. This study was designed help fill this research gap.

This joint research effort between Penns Transdisciplinary Tobacco Use Research Center and the Center for Functional Neuroimaging, used MRI arterial spin labeled (ASL) technology. ASL, a non-invasive technique for the measurement of cerebral blood flow (CBF) in the brain, was used to compare resting CBF across two scanning sessions which varied by length of periods of abstinence from smoking. Fifteen regular smokers were included in the study. Each participant was scanned in a resting state on two separate occasions: participants smoked a cigarette within an hour of the one scan, and abstained from smoking overnight for the other scan.

The findings indicate that abstinence-induced, unprovoked cravings to smoke are associated with increased activation in brain regions important in attention, behavioral control, memory, and reward. The craving assessments used in our study predict relapse in smoking cessation treatment, said Lerman. If validated in larger studies, these results may have important clinical implications. For example, perfusion MRI may aid in the identification of smokers at increased risk for relapse who may require more intensive therapy.


'/>"/>

Contact: Olivia Fermano
Olivia.Fermano@uphs.upenn.edu
215-349-5653
University of Pennsylvania School of Medicine
Source:Eurekalert

Related medicine news :

1. Penn study finds pro-death proteins required to regulate healthy immune function
2. New study shows promise in reducing surgical risks associated with surgical bleeding
3. Study, meta-analysis examine factors associated with death from heatstroke
4. Study suggests loss of 2 types of neurons -- not just 1 -- triggers Parkinsons symptoms
5. Study says COPD testing is not measuring up
6. Preclinical study suggests organ-transplant drug may aid in lupus fight
7. Ability to cope with stress can increase good cholesterol in older white men, study finds
8. High alcohol consumption increases stroke risk, Tulane study says
9. Mailman School of Public Health study examines link between racial discrimination and substance use
10. Pitt study finds inequality in tobacco advertising
11. Stanford study highlights cost-effective method of lowering heart disease risks
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/23/2017)... ... ... Old School Labs™, makers of the wildly popular all-natural sports supplements based ... its growing team of brand ambassadors. The Olympia top finisher and former Big 12 ... year was able to turn professional, participating in the 2013 NPC USA Championships in ...
(Date:1/23/2017)... ... ... a story of love and redemption, hope and uncertainty as a girl makes her ... Inn at the Mill” is the creation of published author, Lois Kulp, who was born ... Berks County on Crow Hill. The inn, the mill and "Post Yokel" are ...
(Date:1/23/2017)... ... ... “Life Under Blankets”: an entrancing story about one woman's travels through ... the creation of published author, Kimberly Mitchell, who earned her bachelor’s degree in English ... pursue a master’s degree in education in the field of curriculum and instruction. Kimberly’s ...
(Date:1/22/2017)... (PRWEB) , ... January 22, 2017 , ... Phytocéane invites ... isolated from the rest of the world with ZANZIBAR MILKY CREAM. Inspired by the ... key ingredients like Virgin Coconut Oil and moisturizing vegetal coral to create this gentle, ...
(Date:1/22/2017)... ... 2017 , ... Medical lab testing through hospitals and other traditional ... test will take days to arrive to the end customer, having to travel through ... their lab tests, bypassing the cost and delay of traditional means. Now all employees ...
Breaking Medicine News(10 mins):
(Date:1/21/2017)... ResMed (NYSE: RMD ), BMC ( ... Florida ) today announced they have agreed on a global ... be permitted to sell their existing products in exchange for royalty ... to 3B to close the Florida litigation ... of liability or wrongdoing by any party. The ...
(Date:1/21/2017)...  Faruqi & Faruqi, LLP, a leading national securities law ... (NASDAQ: KMPH ) of the federal securities class ... directors and underwriters of the Company,s April 16, 2015 Initial ... plaintiff. The lawsuit has been filed in the ... Johnson County on behalf of all those who ...
(Date:1/20/2017)... Research and Markets has announced the ... and Future" report to their offering. ... This research service on the global ... and provides a snapshot of the key participants in the market. ... provided from 2016 to 2020. The market is expected to grow ...
Breaking Medicine Technology: