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New national clinical trials network for neurological disorders to foster cutting-edge treatments
Date:9/12/2012

iece was the strength in the coordination and collaboration of the investigators," Dr. Kaufmann said. "UT Southwestern also is built on solid basic science enterprise and has translational research capacity. This really was a very good fit."

NeuroNEXT's first clinical trial is designed to identify biomarkers for spinal muscular atrophy (SMA), a motor-neuron disease that causes progressive weakness and respiratory disease. It is the most common genetic cause of death in infants, and those with the most aggressive form of the disease often die before they are 2 years old. There currently is no effective treatment or cure.

UT Southwestern's participation in the trial includes Dr. Susan Iannaccone, a NeuroNEXT co-principal investigator who treats one of the nation's largest populations of spinal muscular atrophy patients. In 2000, she set up one of the disease's first national clinical trial groups, which was expanded from five sites to 15 through two rounds of funding from the National Institutes of Health.

Although successful, that earlier network required expensive and time-consuming planning and execution, said Dr. Iannaccone, professor of pediatrics and of neurology and neurotherapeutics at UT Southwestern. Centralizing those efforts through NeuroNEXT, she said, will allow investigators to focus on research and treatment.

"This means the future is brighter for our patients," said Dr. Iannaccone, who also is director of pediatric neurology at Children's Medical Center. "The faster you can test drugs, the faster you can find out if they work."


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Contact: Jeff Carlton
jeffrey.carlton@utsouthwestern.edu
214-648-3404
UT Southwestern Medical Center
Source:Eurekalert  

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