Navigation Links
New nanoparticles make blood clots visible
Date:2/2/2011

gh bismuth for it to be seen by the spectral CT scanner.

"Each nanoparticle is carrying a million atoms of bismuth," Lanza says. Since CT is a relatively insensitive imaging technique, this sheer quantity of metal is necessary for the particles to be visible to the scanner.

But bismuth is a toxic heavy metal, Pan says. It can't be injected into the body on its own. Instead, Pan used a compound made of bismuth atoms attached to fatty acid chains that can't come apart in the body. He then dissolved this compound in a detergent and encapsulated the mixture in a phospholipid membrane. Much like oil droplets suspended in a shaken vinaigrette, these particles self-assemble with the bismuth compound at the core.

As Pan showed in a mouse model, the design of the nanoparticles also allows the body to break them apart and release the inner bismuth compound in a safe form.

Once the nanoparticles carried enough bismuth to be visible to the scanner, Pan added a molecule to the particles' surface that seeks out a protein called fibrin. Fibrin is common in blood clots but is not found elsewhere in the vasculature.

"If you're having a heart attack, the lining of your coronary artery has ruptured, and a clot is forming to repair it," Lanza says. "But that clot is starting to narrow the vessel so blood can't get by. Now we have a nanoparticle that will see that clot."

A spectral CT image with the bismuth nanoparticles targeted to fibrin will provide the same information as a traditional black and white CT image, but the fibrin in any blood clots will show up in a color, such as yellow or green, solving the problem of calcium interference common to traditional CT scanners.

The spectral CT scanner used in this study is still a prototype instrument, developed by Philips Research in Hamburg, Germany. The nanoparticles have only been tested in rabbits and other animal models, but early results show success in distinguishing bl
'/>"/>

Contact: Julia Evangelou Strait
straitj@wustl.edu
314-286-0141
Washington University School of Medicine
Source:Eurekalert  

Page: 1 2 3

Related medicine news :

1. Special sugar, nanoparticles combine to detect cholera toxin
2. Delivering a potent cancer drug with nanoparticles can lessen side effects
3. Einstein-Montefiore researcher will test nanoparticles against pancreatic cancer
4. Iron oxide nanoparticles becoming tools for brain tumor imaging and treatment
5. With magnetic nanoparticles, scientists remotely control neurons and animal behavior
6. Curcumin nanoparticles open up resistant cancers
7. Novel nanoparticles prevent radiation damage
8. Attacking cancer cells with hydrogel nanoparticles
9. Using gold nanoparticles to hit cancer where it hurts
10. Shoo fly: Catnip oil repels bloodsucking flies
11. Researchers discover root cause of blood vessel damage in diabetes
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
New nanoparticles make blood clots visible
(Date:9/3/2014)... 03, 2014 "What can you say about ... "Margaret and Hillary," Book Eight in the Margaret of ... published by Wyston Books, Inc . These novels narrate ... in the richest town in America. , In this thriller, ... helps to investigate a student’s murder plot. Her fears increase ...
(Date:9/2/2014)... Autumn is well under way and famous review ... with worldwide people. Recently, it has made a ... http://secure.hostgator.com/~affiliat/cgi-bin/affiliates/clickthru.cgi?id=seohosts ), Arvixe, and Bluehost are the best ... 2002 HostGator has been known as a top ... reliability remains with it today. It is offering ...
(Date:9/2/2014)... today,s concentrated pot might be risky business for ... University. The study is the first to demonstrate ... THC. , Psychology professor Rebecca Craft showed ... are at least 30 percent more sensitive than ... active ingredient in cannabis. Females also develop tolerance ...
(Date:9/2/2014)... 2014 http://topcreatinemonohydrate.com/ , a ... obtain the latest information about muscle and fitness ... focuses mainly on testosterone and creatine ... their workout capacity and improve their athletic performance. ... Creatine Monohydrate, Muscle Advance Creatine is one of ...
(Date:9/2/2014)... Illinois (PRWEB) September 02, 2014 ... Chief Executive Officer and Chief Information Officer Strategy ... Carlton Chicago. , Becker's Hospital Review Chief Executive ... together hospital and health system Chief Executive Officers, ... hospital and health system executives through high-quality ...
Breaking Medicine News(10 mins):Health News:Town Locked Down After Bombing and Murders in "Margaret and Hillary" - New Book Eight in the Margaret of Greenwich(R) Young Adult Series by R. L. Rhyse 2Health News:Top10BestSEOHosting.com Celebrates The Coming Of Autumn And Release Reseller Hosting Suppliers Of 2014 2Health News:Estrogen increases cannabis sensitivity 2Health News:Estrogen increases cannabis sensitivity 3Health News:Creatine Monohydrate Reviews Site TopCreatineMonohydrate.com Announces its Launch 2Health News:Becker's Healthcare Announces Hospital CEO and CIO Strategy Roundtables 2Health News:Becker's Healthcare Announces Hospital CEO and CIO Strategy Roundtables 3Health News:Becker's Healthcare Announces Hospital CEO and CIO Strategy Roundtables 4
... An article appearing in the January issue of The Journal ... cancers (GISTs) are likely to be ineffective for// patients with ... reported by investigators at the Mayo Clinic Cancer Center, who ... help patients with high grade renal cell carcinoma. "While this ...
... are developing a hands-free frame, which may help stroke patients ... ,Stroke is a leading cause of adult disability in England ... ,Existing frames require the person to hold them ... cannot use these, and often need two people to support ...
... Research Center has reported that maintaining the current recommended ... of cardiovascular disease. The researcher has asked the ... patients less than the recommended levels by aggressive blood ... is used to monitor the average amount of blood ...
... way of treating psychological disorders. Carl Rogers introduced this technique ... lot of questions about this technique. But it was one ... patients from a different perspective. ,It was contradictory ... this therapy is not widely accepted by many psychologists. ...
... can do to people. High-fat diets cause many patients' problems. ... to know what they consume. ,Now, new rules on ... trans fats, which plug arteries, and have been linked to ... ,Trans fats are a result of manufacturers adding hydrogen ...
... or obese have a greater risk of developing Alzheimer’s, the ... researchers // has claimed. ,The research team ... Cowan University in Western Australia - say that being obese ... have found a link between body mass index (BMI) and ...
Cached Medicine News:Health News:New Gastric Cancer Drug Unlikely to Benefit Kidney Cancer Patients 2Health News:Food labels to include information on trans fats in US 2Health News:Food labels to include information on trans fats in US 3Health News:Obesity could lead to Alzheimer's 2
(Date:9/2/2014)...  Reportlinker.com announces that a new market research report ... and Taiwanese Markets for Minimally Invasive Spinal Devices ... The market for MIS spinal devices in the ... at a fast pace, albeit at different rates in ... China , where MIS spinal fusion ...
(Date:9/2/2014)... , Sept. 2, 2014 The Pharmaceutical Care ... benefit managers (PBMs), today filed a lawsuit in ... new Iowa law that restricts ... for the state,s employers and consumers.  ... by severely restricting the use of Maximum Allowable Cost ...
(Date:9/2/2014)... 2, 2014  XBiotech announced today interim results ... in the US for its anti-cancer agent Xilonix™. ... therapy, is being evaluated in advanced colorectal cancer ... The primary endpoint of the study is overall ... a control population provided only palliative therapy for ...
Breaking Medicine Technology:Chinese and Taiwanese Markets for Minimally Invasive Spinal Devices 2Chinese and Taiwanese Markets for Minimally Invasive Spinal Devices 3Chinese and Taiwanese Markets for Minimally Invasive Spinal Devices 4Chinese and Taiwanese Markets for Minimally Invasive Spinal Devices 5Chinese and Taiwanese Markets for Minimally Invasive Spinal Devices 6Chinese and Taiwanese Markets for Minimally Invasive Spinal Devices 7Chinese and Taiwanese Markets for Minimally Invasive Spinal Devices 8Chinese and Taiwanese Markets for Minimally Invasive Spinal Devices 9Lawsuit Challenges Iowa Health Mandate that Forces Employers to Pay More for Prescription Drugs 2XBiotech Halts Study, Reports Positive Phase III Results with Antibody Therapy for Cancer 2
... SEOUL, South Korea, Feb. 16, 2012   ,The ... the largest health care provider festival, is ... This Exhibition, for enhancing a national ... of hospital-related industry, is hosted by Korea ...
... Therapeutics, Inc. (NASDAQ: HALO ) today announced the ... its common stock, including 1,020,000 shares sold pursuant to the ... underwriter. All of the shares were offered by Halozyme at ... proceeds to Halozyme from this offering were approximately $81.8 million, ...
Cached Medicine Technology:To Take a Glance Cutting Edge Medicine Equipment! 'The 28th International Medical & Hospital Equipment Show' 2To Take a Glance Cutting Edge Medicine Equipment! 'The 28th International Medical & Hospital Equipment Show' 3Halozyme Announces Exercise in Full of Over-Allotment Option and Completion of Public Offering of Stock 2Halozyme Announces Exercise in Full of Over-Allotment Option and Completion of Public Offering of Stock 3
... synergy T-EP Developed in collaboration with ... and an exceptionally high standard of ... Multimedia technology and design expertise to ... 2, 5 or 10-channel Medelec Synergy ...
Neuropack Sigma MEB-5500 series evoked potential measuring system is a compact, portable, all-in-one unit....
The Nicolet Bravo is a Multi-application system that can configure to meet the needs of neurophysiology deparent....
... of the MYOHANDY family are probably ... MYOQUICK - SystemPLUS line. Based on ... systems of the ISA 100x EP ... ISA 1002 EP) , 4 channels ...
Medicine Products: