Navigation Links
New nanoparticles make blood clots visible
Date:2/2/2011

gh bismuth for it to be seen by the spectral CT scanner.

"Each nanoparticle is carrying a million atoms of bismuth," Lanza says. Since CT is a relatively insensitive imaging technique, this sheer quantity of metal is necessary for the particles to be visible to the scanner.

But bismuth is a toxic heavy metal, Pan says. It can't be injected into the body on its own. Instead, Pan used a compound made of bismuth atoms attached to fatty acid chains that can't come apart in the body. He then dissolved this compound in a detergent and encapsulated the mixture in a phospholipid membrane. Much like oil droplets suspended in a shaken vinaigrette, these particles self-assemble with the bismuth compound at the core.

As Pan showed in a mouse model, the design of the nanoparticles also allows the body to break them apart and release the inner bismuth compound in a safe form.

Once the nanoparticles carried enough bismuth to be visible to the scanner, Pan added a molecule to the particles' surface that seeks out a protein called fibrin. Fibrin is common in blood clots but is not found elsewhere in the vasculature.

"If you're having a heart attack, the lining of your coronary artery has ruptured, and a clot is forming to repair it," Lanza says. "But that clot is starting to narrow the vessel so blood can't get by. Now we have a nanoparticle that will see that clot."

A spectral CT image with the bismuth nanoparticles targeted to fibrin will provide the same information as a traditional black and white CT image, but the fibrin in any blood clots will show up in a color, such as yellow or green, solving the problem of calcium interference common to traditional CT scanners.

The spectral CT scanner used in this study is still a prototype instrument, developed by Philips Research in Hamburg, Germany. The nanoparticles have only been tested in rabbits and other animal models, but early results show success in distinguishing bl
'/>"/>

Contact: Julia Evangelou Strait
straitj@wustl.edu
314-286-0141
Washington University School of Medicine
Source:Eurekalert  

Page: 1 2 3

Related medicine news :

1. Special sugar, nanoparticles combine to detect cholera toxin
2. Delivering a potent cancer drug with nanoparticles can lessen side effects
3. Einstein-Montefiore researcher will test nanoparticles against pancreatic cancer
4. Iron oxide nanoparticles becoming tools for brain tumor imaging and treatment
5. With magnetic nanoparticles, scientists remotely control neurons and animal behavior
6. Curcumin nanoparticles open up resistant cancers
7. Novel nanoparticles prevent radiation damage
8. Attacking cancer cells with hydrogel nanoparticles
9. Using gold nanoparticles to hit cancer where it hurts
10. Shoo fly: Catnip oil repels bloodsucking flies
11. Researchers discover root cause of blood vessel damage in diabetes
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
New nanoparticles make blood clots visible
(Date:9/4/2015)... , ... September 04, 2015 , ... Yisrayl Hawkins, Pastor and Overseer at The House ... are prophetic details involving the Pope’s upcoming trip to the United States. , Yisrayl lays ... his role with the Vatican and society is. Yisrayl also provides the meaning of his ...
(Date:9/3/2015)... (PRWEB) , ... September 03, 2015 , ... While bariatric ... to the best practices when preparing for a bariatric procedure, some patients have been ... Apart from the basic instructions typical for many types of surgery that should be ...
(Date:9/3/2015)... ... September 03, 2015 , ... The ... the Academy of Integrative Health & Medicine (AIHM) Interprofessional Fellowship in Integrative Health ... Low Dog, MD, an internationally renowned educator, physician and thought leader in integrative ...
(Date:9/3/2015)... ... September 03, 2015 , ... DriButts, a non-profit organization ... Slingshot® Product Development Group to manufacture a long-lasting reusable diaper for warm weather ... plans to bring 600 DriButts Diapers to rural areas of Haiti during a ...
(Date:9/3/2015)... (PRWEB) , ... September 03, 2015 , ... ... Spouse/Caregiver Scholarship applications are open for spring 2016. Scholarships are awarded two times ... Hope For The Warriors® is a national nonprofit dedicated to restoring a sense ...
Breaking Medicine News(10 mins):Health News:Yisrayl Hawkins Writes Open Letter to Pope Francis In Light of Approaching U.S. Visit 2Health News:Dr. Feiz and Associates Answer August's ‘Patient Submitted Question of the Month’: “How Can I Prepare for Weight Loss Surgery” 2Health News:Oregon Collaborative for Integrative Medicine Partners with AIHM on First Interprofessional Fellowship 2Health News:Oregon Collaborative for Integrative Medicine Partners with AIHM on First Interprofessional Fellowship 3Health News:DriButts Diapers Rely on Slingshot Help in Haiti 2Health News:DriButts Diapers Rely on Slingshot Help in Haiti 3Health News:Hope For The Warriors Spouse/Caregiver Scholarships Now Open for Spring 2016 2
... , INDIANAPOLIS , Jan. 14 Eli ... it will provide donations of medicines and money for victims of ... . , "The current situation in Haiti is ... of the Lilly Foundation. "The significant number of casualties and widespread ...
... are failing to advise people with medical conditions that ... get behind the wheel, according to research from the ... School have found many healthcare professionals are failing to ... visual impairment if they are not fit to drive. ...
... they intended to cause harm, survey finds , THURSDAY, Jan. 14 ... percent of girls aged 12 to 17 were involved in serious ... , "These findings are alarming," SAMHSA administrator Pamela S. Hyde said ... reaching girls at risk and teaching them how to resolve problems ...
... The 2009 David ... children in New England and the Dominican Republic with access to the pediatric critical care ... ... Classic netted more than $225,000 for the David Ortiz Children’s Fund , providing children ...
... ... the devastating earthquake that struck Haiti yesterday. , ... (PRWEB) January 14, 2010 -- The Haiti ... the urgent need that the Haitian people have for medical care, housing, and other ...
... , Volunteers to honor Dr. King,s memory ... WASHINGTON , Jan. 14 American Red Cross and ... canvass neighborhoods in more than 40 cities across the country for ... year on January 18—the day Dr. King,s birthday is commemorated. ...
Cached Medicine News:Health News:Lilly Sends Relief to Haiti Earthquake Victims 2Health News:Health care professionals failing to tell patients they are not fit to drive 2Health News:David Ortiz Celebrity Golf Classic Nets More than $225,000 for Children in Need 2Health News:David Ortiz Celebrity Golf Classic Nets More than $225,000 for Children in Need 3Health News:Haiti Foundation Against Poverty Launches New Fundraising Drive to Help Victims of Earthquake 2Health News:American Red Cross and HOPE worldwide Partner for MLK Day of Service 2Health News:American Red Cross and HOPE worldwide Partner for MLK Day of Service 3
(Date:9/3/2015)... , Sept. 3, 2015 ... devices market? Which areas are going to grow at ... potential revenues to 2025, assessing data, trends, opportunities and ... tables, charts, and graphs. Discover the most lucrative areas ... new study lets you assess forecasted sales at overall ...
(Date:9/3/2015)... 3,  2015 About artificial organs ... which are implanted or integrated into individuals ... include artificial heart, kidney, pancreas, and cochlear ... polysulfone, and porous polypropylene), biologics, ceramics, and ... These organs are incorporated with different technologies ...
(Date:9/3/2015)... 2015  WellCare Health Plans, Inc. (NYSE: WCG ... vice president and chief financial officer, is scheduled to ... on Wednesday, September 9, 2015, at 9:25 a.m. Eastern ... In addition, a replay of the webcast will be ... the live broadcast and the replay will be available ...
Breaking Medicine Technology:Ophthalmic Devices Market Forecast 2015-2025: Future Prospects for Leading Companies in Vision Care, Surgical, Diagnostic & Monitoring Devices 2Ophthalmic Devices Market Forecast 2015-2025: Future Prospects for Leading Companies in Vision Care, Surgical, Diagnostic & Monitoring Devices 3Ophthalmic Devices Market Forecast 2015-2025: Future Prospects for Leading Companies in Vision Care, Surgical, Diagnostic & Monitoring Devices 4Global Artificial Organ Market 2015-2019 2
... heels of launching its enhanced Lilly for Better Health ... introduces the Lilly Health Channel on YouTube – ... employee and community outreach efforts, health innovation, Lilly programs and ... spotlight issues like the growing rate of diabetes ...
... SAN JOSE, Calif., Sept. 8, 2011 Sanmina-SCI ... manufacturing solutions company making some of the world,s ... today announced that its Kenosha, Wisconsin, facility has ... manufacturing. Achieving this certification recognizes Sanmina-SCI,s world-class manufacturing ...
Cached Medicine Technology:Lilly Health Channel Debuts on YouTube 2Sanmina-SCI Kenosha, Wisconsin Facility Awarded ISO 13485 Certification for Medical Devices 2Sanmina-SCI Kenosha, Wisconsin Facility Awarded ISO 13485 Certification for Medical Devices 3
... is a national reference laboratory and a ... development. ARUP offers an extensive test menu ... in clinical and anatomic pathology. Owned by ... include more than half of the nation's ...
... ARUP Laboratories is a national reference ... laboratory research and development. ARUP offers an ... unique medical tests in clinical and anatomic ... ARUP Laboratories' clients include more than half ...
... a national reference laboratory and a worldwide ... ARUP offers an extensive test menu of ... clinical and anatomic pathology. Owned by the ... more than half of the nation's university ...
... reference laboratory and a worldwide leader in ... an extensive test menu of highly complex ... anatomic pathology. Owned by the University of ... half of the nation's university teaching hospitals ...
Medicine Products: