Navigation Links
New multi-use device can shed light on oxygen intake

WEST LAFAYETTE, Ind. - A fiber-optic sensor created by a team of Purdue University researchers that is capable of measuring oxygen intake rates could have broad applications ranging from plant root development to assessing the effectiveness of chemotherapy drugs.

The self-referencing optrode, developed in the lab of Marshall Porterfield, an associate professor of agricultural and biological engineering, is non-invasive, can deliver real-time data, holds a calibration for the sensor's lifetime and doesn't consume oxygen like traditional sensors that can compete with the sample being measured. A paper on the device was released on the early online version of the journal The Analyst this week.

"It's very sensitive in terms of the biological specimens we can monitor," Porterfield said. "We don't only measure oxygen concentration, we measure the flux. That's what's important for biologists."

Mohammad Rameez Chatni, a doctoral student in Porterfield's lab, said the sensor could be used broadly across disciplines. Testing included tumor cells, fish eggs, spinal cord material and plant roots.

Cancerous cells typically intake oxygen at higher rates than healthy cells, Chatni said. Measuring how a chemotherapy drug affects oxygen intake in both kinds of cells would tell a researcher whether the treatment was effective in killing tumors while leaving healthy cells unaffected.

Plant biologists might be interested in the sensor to measure oxygen intake of a genetically engineered plant's roots to determine its ability to survive in different types of soil.

"This tool could have applications in biomedical science, agriculture, material science. It's going across all disciplines," Chatni said.

The sensor is created by heating an optical fiber and pulling it apart to create two pointed optrodes about 15 microns in diameter, about one-tenth the size of a human hair. A membrane containing a fluorescent dye is placed on the tip of an optrode.

Oxygen binds to the fluorescent dye. When a blue light is passed through the optrode, the dye emits red light back. The complex analysis of that red light reveals the concentration of oxygen present at the tip of the optrode.

The optrode is oscillated between two points, one just above the surface of the sample and another a short distance away. Based on the difference in the oxygen concentrations, called flux, the amount of oxygen being taken in by the sample is calculated.

It's the intake, or oxygen transportation, that Porterfield said is important to understand.

"Just knowing the oxygen concentration in or around a sample will not necessarily correlate to the underlying biological processes going on," he said.

Porterfield said future work will focus on altering the device to measure things such as sodium and potassium intake as well. The National Science Foundation funded the research.


Contact: Brian Wallheimer
Purdue University

Related medicine news :

1. Cohera Medical Receives ISO 13485 Certification: Company Meets International Standards for Design, Development and Manufacturing of Medical Devices
2. New device could more effectively alleviate menstrual cramp pain
3. New device finds early signs of eye disease in preemies
4. FDA Awards Three Grants Designed to Stimulate Development of Pediatric Medical Devices
5. Health Robotics Continues Global Expansion Into Oceania With Device Technologies Australias Strategic Partnership
6. Medical Device Manufacturer MRPC Awarded ISO 13485 Certification
7. Zargis Receives FDA Clearance for Signal X6 Telemedicine Device; OK Allows Delivery to US Army
8. Worlds First Emergency Medical Information Franchise Launches GPS Tracking Device
9. For Medical Device Makers, Free Webinar, Implementing QA Automation.
10. Sono-Tek Announces its Largest Ever Sales of MediCoat Stent Coating Systems to a Leading Global Medical Device Manufacturer
11. American Scientific Resources Acquires Intellectual Property to Worlds Only FDA Approved Home Needle Destruction Device
Post Your Comments:
Related Image:
New multi-use device can shed light on oxygen intake
(Date:10/13/2017)... Calif. (PRWEB) , ... October 13, 2017 , ... Many ... dementia. However, many long-term care insurance companies have a waiver for care if the ... 90-day elimination period, when the family pays for care, is often waived, so the ...
(Date:10/13/2017)... ... October 13, 2017 , ... Ellevate Network, the leading ... to advocate for action towards gender equality at their inaugural Summit in New York ... globe, and reached a social audience of over 3 million. To watch the Mobilize ...
(Date:10/13/2017)... Abilene, Texas (PRWEB) , ... October 13, 2017 , ... ... publication this week that explains one of the most popular and least understood books ... seems like cryptic and puzzling descriptions that have baffled scholars for centuries. Many have ...
(Date:10/13/2017)... ... October 13, 2017 , ... Coveros, a leader in agile ... a contract by the Center for Medicare and Medicaid Services (CMS). The Enterprise ... use of Agile methodologies in a consistent and high value manner across CMS ...
(Date:10/13/2017)... ... October 13, 2017 , ... “America On The Brink”: the Christian history of ... Brink” is the creation of published author, William Nowers. Captain Nowers and his ... veteran, he spent thirty years in the Navy. Following his career as a ...
Breaking Medicine News(10 mins):
(Date:9/27/2017)... and NEW YORK , Sept. 27, 2017 /PRNewswire/ ... health and big data solutions, today announced that its MyDario product is ... your local TV listings for when The Dr. Oz Show airs in ... The nine-time ... month. ...
(Date:9/22/2017)... Md. , Sept. 22, 2017  As the ... Republican Senators Bill Cassidy (R-LA) and ... Information notes that the medical device industry is in ... medical device tax, the 2.3% excise tax on medical ... But they also want covered patients, increased visits and ...
(Date:9/18/2017)... ALLENTOWN , Pa. and KALAMAZOO, Mich. ... Allentown, Penn. , and OptiMed Specialty Pharmacy ... a business partnership to offer a strategic hub service ... PMD Healthcare,s highly sought-after personal spirometer, Spiro PD 2.0, ... A spirometer is a medical device used ...
Breaking Medicine Technology: