Navigation Links
New mouse model helps explain gene discovery in congenital heart disease
Date:6/26/2012

Scientists now have clues to how a gene mutation discovered in families affected with congenital heart disease leads to underdevelopment of the walls that separate the heart into four chambers. A Nationwide Children's Hospital study appearing in PLoS Genetics suggests that abnormal development of heart cells during embryogenesis may be to blame.

When babies are born with a hole in their heart (either between the upper or lower chambers), they have a septal defect, the most common form of congenital heart disease. Although it's not clear what causes all septal defects, genetic studies primarily utilizing large families have led to the discovery of several causative genes.

Vidu Garg, MD, the study's lead author, previously reported that a single nucleotide change in the GATA4 gene in humans causes atrial and ventricular septal defects along with pulmonary valve stenosis. In mice, the GATA4 gene has been shown to be necessary for normal heart development and its deletion leads to abnormal heart development.

"While GATA4 has been shown to be important for several critical processes during early heart formation, the mechanism for the heart malformations found in humans with the mutation we previously reported is not well understood," said Dr. Garg, a pediatric cardiologist in The Heart Center and principal investigator in the Center for Cardiovascular and Pulmonary Research at The Research Institute at Nationwide Children's Hospital.

To better characterize the mutation, Dr. Garg and colleagues generated a mouse model harboring the same human disease-causing mutation. They saw heart abnormalities in the mice that were consistent with those seen in humans with GATA4 mutations. Upon further examination, they found that the mutant protein leads to functional deficits in the ability for heart cells to increase in number during embryonic development.

"Our findings suggest that cardiomyocyte proliferation deficits coul
'/>"/>

Contact: Mary Ellen Peacock
maryellen.peacock@nationwidechildrens.org
614-355-0495
Nationwide Children's Hospital
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Mouse Study Hints at New Path for Diabetes Treatment
2. This mousetrap may save lives
3. Its Not Just What You Eat, Its When You Eat, Mouse Study Finds
4. Belly Membrane May Regulate Immune System, Mouse Study Finds
5. Mouse Study Suggests Certain Fats Could Trigger Crohns, Colitis
6. Researchers develop a new cell and animal model of inflammatory breast cancer
7. Model for breast cancer rehab featured in supplement to ACS journal, Cancer
8. Research shows efficacy of treatment model developed at Women & Infants
9. HHS enlists Archimedes Inc. to expand governments use of health care modeling
10. Modeling the demise of migrating brain tumor cells
11. Super Models Line Up to Walk The Catwalk and Celebrate Vogue's Fashion Night Out in LA
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/30/2015)... Chicago, Ill. (PRWEB) May 30, 2015 ... academicians were recognized by their peers as the 2015 ... hosted by OncLive® at the Chicago Illuminating Company last ... panel of eminent oncologists for landmark achievements in translational ... has changed the course of cancer treatment. , Honorees ...
(Date:5/30/2015)... 2015 Thousands of aesthetic industry professionals ... sponsored by the American Society for Aesthetic Plastic Surgery ... was Zeltiq, the parent company of one of the ... With blazing growth, the one-of-a-kind device just sold its ... is currently in the news for gaining the FDA’s ...
(Date:5/30/2015)... 30, 2015 On Thursday, May ... Charles Simone and Dr. Evan Alley both of ... the Mesothelioma Experts’ series. The interview was part ... centers of excellence. Drs. Simone and Alley were ... Hesdorffer, with whom they discussed the mesothelioma program ...
(Date:5/30/2015)... Industry, CA (PRWEB) May 30, 2015 ... technology and foreign travelers who experienced OGAWA products while ... in the U.S. , A leader in the ... is a cutting-edge designer, researcher, developer and manufacturer of ... longevity and superior craftsmanship of their products, health enthusiasts ...
(Date:5/30/2015)... Cyclist Barry Haarde will commence his ... 2015: Piles of Miles” near San Francisco, California ... and encourage individuals to support needy hemophilic children ... Life supports nearly 1,200 impoverished children and adults ... sponsorships, scholarships and micro-enterprise grants. Hemophilia is a ...
Breaking Medicine News(10 mins):Health News:OncLive’s 2015 Giant of Cancer Care™ Awards Announced 2Health News:OncLive’s 2015 Giant of Cancer Care™ Awards Announced 3Health News:OncLive’s 2015 Giant of Cancer Care™ Awards Announced 4Health News:Dr. Paul Vitenas Meets with Zeltiq President and CEO in Montreal 2Health News:Dr. Paul Vitenas Meets with Zeltiq President and CEO in Montreal 3Health News:Interview with Mesothelioma Experts, Drs. Simone and Alley Now Available on Demand 2Health News:Award-winning OGAWA Massage Chairs Finally Available for purchase in North America. 2Health News:Award-winning OGAWA Massage Chairs Finally Available for purchase in North America. 3Health News:Barry Haarde Cycles 4,000 Miles Across the USA for Hemophilia 2
... placenta may damage blood vessels in women with preeclampsia ... to life-threatening increases in high blood pressure after 20 ... substances called "microparticles" released by the placenta damage maternal ... by Seth Guller, sought to detect whether specific proteins ...
... mutation that causes X-linked mental retardation for which there ... study. ,Investigators F. Lucy Raymond, ... Sanger Institute, UK describe the ZDHHC9 gene found in ... point of entirely losing function. ,"ZDHHC9 ...
... A new calibration technique that involves measuring the distance ... help facial plastic surgeons// use computer imaging software, according ... facial proportions has been studied for centuries by architects, ... information in the article. It is essential for plastic ...
... who treat them have incorporated spirituality into the recovery ... how spirituality changes during recovery, or how those changes ... quest for sobriety. ,Now, a new study ... Center sheds light on this phenomenon. In the March ...
... developed a malaria-resistant mosquito, a step that might one day ... millions// of lives around the world. ,When ... higher survival rate than nonresistant ones, meaning they could eventually ... a report in Tuesday's issue of Proceedings of the National ...
... by the National Aeronautics and Space Administration (NASA) has ... has been thinning// since early 1990s. ,Aerosols ... naturally, originating from volcanoes, dust storms, forest and grassland ... tend to cause cooling of the Earth's surface immediately ...
Cached Medicine News:Health News:Severe Mental Retardation Gene Mutation Identified 2Health News:Computer Imaging Assists With Facial Reconstructive Surgery 2Health News:Spirituality Increases as Alcoholics Recover 2Health News:Spirituality Increases as Alcoholics Recover 3Health News:Malaria-resistant Mosquito Developed 2
(Date:5/30/2015)... TOKYO , May 30, 2015  Astellas Pharma ... a Phase 1/2 trial on the safety, tolerability and ... patients with relapsed or refractory (R/R) acute myeloid leukemia ... the American Society of Clinical Oncology,s (ASCO) annual meeting ... is a receptor tyrosine kinase inhibitor of FLT3 and ...
(Date:5/30/2015)... Tex. , May 30, 2015 ... on fulfilling the promise of precision medicine, today ... that demonstrate the utility of Caris Molecular Intelligence®, ... facilitating comparisons between tumors that share histological features. ... the American Society of Clinical Oncology (ASCO) in ...
(Date:5/29/2015)... 2015  Excite Medical was established by its President, ... Excite Medical, under the leadership of Mr. Musallam ... a solid track record of providing unparalleled service and ... base.  Photo - http://photos.prnewswire.com/prnh/20150529/219412 ... been possible, in large part, due to Mr. ...
Breaking Medicine Technology:Astellas Announces Preliminary Phase 1/2 Safety, Tolerability And Efficacy Data For ASP2215 In Patients With Relapsed Or Refractory Acute Myeloid Leukemia (AML) 2Astellas Announces Preliminary Phase 1/2 Safety, Tolerability And Efficacy Data For ASP2215 In Patients With Relapsed Or Refractory Acute Myeloid Leukemia (AML) 3Caris Molecular Intelligence Multi-Platform Tumor Profiling Facilitates Comparisons between Tumors that Share Histological Features 2Caris Molecular Intelligence Multi-Platform Tumor Profiling Facilitates Comparisons between Tumors that Share Histological Features 3Caris Molecular Intelligence Multi-Platform Tumor Profiling Facilitates Comparisons between Tumors that Share Histological Features 4Caris Molecular Intelligence Multi-Platform Tumor Profiling Facilitates Comparisons between Tumors that Share Histological Features 5Caris Molecular Intelligence Multi-Platform Tumor Profiling Facilitates Comparisons between Tumors that Share Histological Features 6
... laser beam is delivered through an ultra thin ... the operator full freedom of movement when performing ... with a wide range of handpieces. Handpieces ... mm and 16 mm. Straight and angled ...
These are the Reusable Components (minus cannula), to be used with the VersaStep™ Plus Reposable Short System....
... VERSASTEP™ Plus Short Instrument for ... ,The VERSASTEP™ Plus Short ... Length is a unique endoscopic ... in laparoscopic procedures. It is ...
... Autosuture™ Blunt Tip Trocar consists of a ... a valve body assembly. , ,The ... valve and seal to prevent gas leakage ... Autosuture™ Blunt Tip Trocar includes built-in converters ...
Medicine Products: