Navigation Links
New mouse model for testing cancer drugs
Date:7/19/2011

FRANKFURT. Only one in twenty cancer drugs makes its way from the laboratory to become an approved pharmaceutical product. The majority of new agents are only shown to be unsuitable in the later phases of clinical development which would explain the exorbitantly high development costs of 500 to 600 million euros per new cancer drug. In order to recognize at an earlier stage which side effects are associated with the use of new cancer drugs, a research group under the guidance of the Goethe University has developed a new mouse model. In cooperation with the companies Bayer Schering Pharma AG and Taconic Artemis GmbH, the researchers were the first to simulate drug-induced inhi-bition what is currently one of the most attractive target genes for new cancer drugs. They were able to demonstrate that, as a result of this, the rapid division of cancer cells was prevented while healthy cells were hardly affected. This study has been published in the current issue of the prestigious journal, Nature Communications.

The cancer gene, polo-like kinase 1 (Plk1), which is currently the subject of intense investigation, plays a central role in cell division. However, up to now, it has not been possible with classical mouse model to investigate what would happen if this gene were to be silenced in adult animals since the latter is indispensable to embryonic de-velopment. The researchers working together with Prof. Klaus Strebhardt from the Centre for Gynecology and Obstetrics at Frankfurt's University Hospital thus devised a method of silencing the gene at any point during the lifetime of the new transgenic mouse. To this end, they expressed short RNAs with a length of 20 to 22 base pairs in the cells of the mice. These short RNAs prevent the information which is read by the cancer gene from being converted into proteins. This method known as RNA interfe-rence was further developed by the researchers into an inducible system: The design is such that the expres
'/>"/>

Contact: Prof. Klaus Strebhardt
Strebhardt@em.uni-frankfurt.de
49-696-301-6894
Goethe University Frankfurt
Source:Eurekalert

0

GOOD

Page: 1 2 3

Related medicine news :

1. Human Stem Cells Used to Fix Damaged Mouse Heart
2. Mouse Study Uncovers the Roots of Gray Hair
3. Mouse Study Reveals How Smoking Helps Keep People Thin
4. Apples Help Keep Muscles Strong, Mouse Study Finds
5. Scientists create humanized mouse model for hepatitis C
6. Pitt researchers build a better mouse model to study depression
7. Mouse study turns fat-loss/longevity link on its head
8. Fox Chase researchers report that naproxen reduces tumors in a mouse model of colon cancer
9. Sleeping through danger: the dormouse approach to survival
10. Mouse Sperm Successfully Grown in Lab, Researchers Say
11. Mouse cancer genome unveils genetic errors in human cancers
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/24/2013)... week is National EMS Week, which recognizes and honors ... emergency care and to improve health communications in communities. ... the public that all can play a role in ... and a very important one. According to the American ... can triple a victim’s chance of survival. , Fortunately ...
(Date:5/24/2013)... FRIDAY, May 24 (HealthDay News) -- Patients hospitalized for ... if they,re admitted on Mondays or in the morning, ... of stay are highest among heart failure patients admitted ... researchers, who are scheduled to present their findings Saturday ... Failure Association of the European Society of Cardiology. ...
(Date:5/24/2013)... (PRWEB) May 24, 2013 KC and Monica ... Title Sponsors for FreeRide836. Their oldest sons, Kyle and Austin ... Tracey Russell family and several professional kiteboarders. , KC Craichy ... project. "This has miraculously come together such that virtually everyone ... to participate." , 20 kite boarders will meet at Matheson ...
(Date:5/24/2013)... research suggests a link between sleep duration and ... additional hour someone with insomnia sleeps is associated ... of moderate or high risk of suicide, according ... "We were surprised by the strength of ... study author, Linden Oliver, clinical research coordinator for ...
(Date:5/24/2013)... Portland, OR (PRWEB) May 24, 2013 ... and Sustainable Cards, major competitors in sustainable card ... awareness of using forest materials as a sustainable ... committee is to identify industry challenges and increase ... gift card programs to support the reduction of ...
Breaking Medicine News(10 mins):Health News:Acadian Medics Reunite with Miracle Baby 2Health News:Monday Best Time for Hospitalization With Heart Failure, Study Says 2Health News:FreeRide836 Sponsor Living Fuel, The Leader in Superfood Nutrition, Announces Kiteboard Launch For This Sunday To Raise Money For Orphans In Africa 2Health News:FreeRide836 Sponsor Living Fuel, The Leader in Superfood Nutrition, Announces Kiteboard Launch For This Sunday To Raise Money For Orphans In Africa 3Health News:Sleep Duration Linked to Suicidal Thoughts in People With Insomnia 2Health News:Making Gift Cards Greener- Competitors Combine Efforts to Educate and Empower Merchants 2Health News:Making Gift Cards Greener- Competitors Combine Efforts to Educate and Empower Merchants 3
... single-institution study of its kind has found few complications ... to remove the prostate. Men in this study received ... indicated their cancer had recurred. Researchers ... and Minnesota suggest that patients and their physicians should ...
... Epigenetics of Common Human Disease has been chosen as ... Institutes of Health (NIH) grant for Centers of Excellence ... $16.8 million over five years. "We,re grateful ... understanding how epigenetic control affects disease," says the center,s ...
... higher, research finds , MONDAY, Sept. 28 (HealthDay News) ... the autoimmune condition called antiphospholipid syndrome are at greatly ... risk is even higher when these women smoke or ... syndrome occurs when autoantibodies attach to cell membranes and ...
... be serious, study finds , MONDAY, Sept. 28 (HealthDay ... skin lesions that are harmless in most cases but ... a new study suggests. , Researchers examined 320 people ... Of those, 7.5 percent developed skin lesions as a ...
... isn,t clear, researchers say , , MONDAY, Sept. 28 ... a 26 percent increased risk of developing atrial fibrillation, ... The overall incidence of atrial fibrillation was 3.6 percent ... for people without the metabolic condition was only 2.5 ...
... have used nanomaterials to develop a microchip sensitive enough ... patient,s cancer so that the disease can be detected ... reported Sept. 27 in Nature Nanotechnology heralds ... "This remarkable innovation is an indication that the ...
Cached Medicine News:Health News:Mayo researchers find few side effects from radiation treatment given after prostate cancer surgery 2Health News:Mayo researchers find few side effects from radiation treatment given after prostate cancer surgery 3Health News:Autoimmune Disorder Linked to Stroke, Heart Attack in Women 2Health News:Irregular Heartbeat Risk Higher in Women With Type 2 Diabetes 2Health News:Irregular Heartbeat Risk Higher in Women With Type 2 Diabetes 3Health News:U of T researchers create microchip that can detect type and severity of cancer 2
(Date:5/23/2013)... , May 23, 2013  Texas, premier physician ... deliver doctors the survival tools they need to provide ... in today,s health care marketplace. "I am ... save local practices," said Stephen L. Brotherton ... (TMA). " Texas doctors are determined ...
(Date:5/23/2013)... 23, 2013   Direct to implant, or ... an appropriate option for many women with BRCA ... their breast cancer risk, or with breast cancer. ... and a second surgery to insert permanent implants, ... surgery as mastectomy can be a medically and ...
(Date:5/23/2013)...  BioElectronics Corporation (OTC Pink: BIEL), the maker of ... FDA panel meeting for non-thermal shortwave diathermy: ... Therapy Meeting was held on May 21, 2013 in ... of the meeting was very narrow, in that the ... the application of non-thermal shortwave diathermy for the treatment ...
Breaking Medicine Technology:TMA Launches Physician Services Organization for Patient Care 2TMA Launches Physician Services Organization for Patient Care 3TMA Launches Physician Services Organization for Patient Care 4Direct to Implant ("One Step") Mastectomy Breast Reconstruction Reduces Number of Surgeries and Time to Final Cosmetic Results 2Direct to Implant ("One Step") Mastectomy Breast Reconstruction Reduces Number of Surgeries and Time to Final Cosmetic Results 3BioElectronics and Pulsed Shortwave Therapy Make Progress 2
... Data presented,today at a major medical meeting found ... five days is as,effective as standard therapy of ... of complicated urinary tract infections,(cUTI) and acute pyelonephritis ... LEVAQUIN in the,U.S., presented the data during a ...
... Pressure in Obese and,Non-Obese Hypertensive Patients, CHICAGO, ... today presented positive data from two clinical,studies ... selective beta,1-blocker with vasodilating properties currently under ... (FDA) for the treatment of,hypertension. Data from ...
Cached Medicine Technology:Five Days of LEVAQUIN(R) as Effective as 10 Days of Ciprofloxacin,in Complicated Urinary Tract Infections and Acute Pyelonephritis 2Five Days of LEVAQUIN(R) as Effective as 10 Days of Ciprofloxacin,in Complicated Urinary Tract Infections and Acute Pyelonephritis 3Five Days of LEVAQUIN(R) as Effective as 10 Days of Ciprofloxacin,in Complicated Urinary Tract Infections and Acute Pyelonephritis 4Data Presented at ASH Demonstrate Nebivolol Lowers Blood Pressure,as Long-Term Monotherapy and in Combination Therapy 2Data Presented at ASH Demonstrate Nebivolol Lowers Blood Pressure,as Long-Term Monotherapy and in Combination Therapy 3Data Presented at ASH Demonstrate Nebivolol Lowers Blood Pressure,as Long-Term Monotherapy and in Combination Therapy 4
... Quebec Colony Counter allows the user to quickly ... models allows for digital counting or manual counting. ... standard lens increasing magnification to 3.0X. The adjustable ... be raised or lowered. The lens also rotates ...
The Accucount 1000 is designed to automatically count macroscopic objects in a field displaying totals on a highly visible digital readout....
... is a Accelerated Bacterial Enumeration System. Bacterial ... of colonies found by the volume dispensed ... A logarithmically decreasing volume of sample is ... Petri dish in an Archimedes spiral. The ...
... automated genetic analysis system. This system automatically ... linear polyacrylamide (LPA) gel, denatures and loads ... analyzes the data. Software tools let you ... automated data assessment. All to ensure unprecedented ...
Medicine Products: