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New monoclonal antibody inhibits tumor growth in advanced solid tumors in phase I clinical trial
Date:11/6/2012

tumour and blood samples), including durable inhibition of TWEAK, inhibition of signalling pathways controlled by Fn14, and inhibition of tumour cell proliferation."

Study investigators from four leading cancer research centres in Denmark, The Netherlands and Canada are recruiting patients to the trial, particularly those with advanced metastatic melanoma expressing Fn14. "These results are encouraging and support additional studies of RG7212 in combination with other treatments," said Dr Lassen.

Professor Stefan Sleijfer, the scientific chair of the EORTC-NCI-AACR Symposium, from Erasmus University Medical Centre (The Netherlands), commented: "Fn14 is a novel target for treatment in cancer. In view of these data, this drug certainly deserves further studies in Fn14 expressing tumours."


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Contact: Emma Mason
wordmason@mac.com
ECCO-the European CanCer Organisation
Source:Eurekalert

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