Navigation Links
New modeling of brain's circuitry may bring better understanding of Parkinson's disease
Date:9/27/2011

INDIANAPOLIS Researchers from the School of Science at Indiana University-Purdue University Indianapolis have developed a mathematical model of the brain's neural circuitry that may provide a better understanding of how and why information is not transmitted correctly in the brains of Parkinson's disease patients. This knowledge may eventually help scientists and clinicians correct these misfires.

Work led by Leonid L. Rubchinsky, Ph.D., associate professor of mathematical sciences in the School of Science at IUPUI, examines the exchange of electric signals within the Parkinson affected brain, demonstrating that repetitious, overlapped firing of neurons can lead to waves of overly synchronized brain activity. A report on the model appears in the September 2011 issue of the journal Chaos: An Interdisciplinary Journal of Nonlinear Science, a publication of the American Institute of Physics.

"This mathematical model of the brain's circuitry provides insight that we could not obtain from animal or human brains in experimental or clinical studies. With this new modeling we, and others, can now better study the mechanisms of information transmission in the Parkinsonian brain both how the mechanisms work and how they fail. We can also learn about the properties of the cells that are responsible. All this knowledge is critical to the eventual development of therapies to correct defective transmissions found in the brains of those with Parkinson's disease," said Rubchinsky, who is affiliated with the Center for Mathematical Modeling and Computational Sciences in the School of Science at IUPUI.

Parkinson's disease is a progressive disorder causing degeneration of neurons in the substantia nigra, a region of the brain which produces the chemical dopamine. Symptoms of Parkinson's disease include tremor, rigidity or stiffness, slowness of movement and impaired balance and coordination. Approximately 60,000 new cases are diagnosed annually in the United States according to the National Institutes of Health. Currently there is no cure for Parkinson's disease.

"Technically we have the tools needed for deep brain stimulation stimulators, long lasting batteries and implantable chips but we don't have the algorithms the formulas and other mathematical tools necessary to know what we are trying to stimulate and how. Our model, and others that will follow, should make deep brain stimulation a feasible therapy for Parkinson's disease within the next decade," said Rubchinsky, who is also a researcher with the Stark Neurosciences Research Institute at the IU School of Medicine.


'/>"/>

Contact: Cindy Fox Aisen
caisen@iupui.edu
317-274-7722
Indiana University-Purdue University Indianapolis School of Science
Source:Eurekalert  

Related medicine news :

1. Hunk Calendar Photographer Resurrects Erotic Male Modeling Club and Launches Provocative E-exhibition
2. PivotPoint Doubles Down on Business Process Modeling with Advanced BPMN 2 + UML 2 Training
3. Solid tumor modeling focus of workshops
4. Tutorial addresses multi-cell, multi-scale modeling
5. INFORMS health care conference highlights increased role of math modeling in health systems
6. Modeling disparities may help with cervical cancer prevention
7. Pro Athletes Brains React at Olympic Speed
8. iPhone Memory Aid for Scatterbrains, Aging Baby Boomers and Busy, Forgetful People
9. MessageSolution First in the Market to Offer All-in-One, Integrated Cloud-Based Archiving for Email, File Systems and SharePoint at Novell BrainShare 2010
10. Scientists Tweak Subjects Brains to Alter Their Moral Choices
11. SharpBrains Launches First Brain Fitness Innovation Awards to Recognize Neuroplasticity Pioneers
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
New modeling of brain's circuitry may bring better understanding of Parkinson's disease
(Date:4/28/2017)... ... April 28, 2017 , ... Woolsy Corporation ... supplements, through its Nova Skin Sciences division, recently announced the launch of Allumière ... with the power of an anti-aging concentrate. , Anogeissus Leiocarpa Bark ...
(Date:4/28/2017)... ... April 28, 2017 , ... Semrock’s highly popular SearchLight ... online modeling resource for fluorescence microscopists and optical system designers, enabling The Right ... years spanning the globe, SearchLight has become a tremendously popular tool for the ...
(Date:4/27/2017)... ... April 27, 2017 , ... The Incentive Research Foundation ... A Nudge Guide," a groundbreaking analysis of how behavioral economics can be applied ... immediately to IRR programs, the report highlights proven behavioral economics approaches and the ...
(Date:4/27/2017)... ... April 27, 2017 , ... The American Brain Foundation ... Leadership in Neurology Award (PLINA). The couple joins a prestigious list of past ... Walter Mondale, actor Michael J. Fox and former U.S. Attorney General Janet Reno. ...
(Date:4/27/2017)... ... ... Goodcents Deli Fresh Subs announced a franchise expansion agreement today including three new ... first new location will open at the corner of 27th and Randolph in Lincoln, ... this fall. And the third location is in the process of being identified. ...
Breaking Medicine News(10 mins):
(Date:4/24/2017)... 24, 2017 Solentim, the developer of ... addition of a major new product line called ... The VIPS has been developed for automatically seeding ... as part of the process to generate clonally-derived ... and more reliable solution when compared to traditional ...
(Date:4/20/2017)... DUBLIN , April 20, 2017 ... the "Global Biosimilar Pipeline and Market Prospects: Addressing ... report to their offering. ... "Global Biosimilar Pipeline and Market ... by Design" provides an in-depth assessment of the current ...
(Date:4/20/2017)... AMSTERDAM , April 20, 2017  AbbVie ... that 99 percent (n=145/146) of chronic hepatitis C ... 4, 5 or 6 and compensated cirrhosis (Child-Pugh ... post-treatment (SVR 12 ) with its investigational, pan-genotypic ... rates were seen following 12 weeks of ...
Breaking Medicine Technology: