Navigation Links
New model taps tiny, common tropical fish for large-scale drug screening to combat Cushing disease
Date:5/10/2011

LOS ANGELES (May 9, 2011) A common, tiny tropical fish plays a key role in a new model for Cushing disease, giving researchers a powerful tool to conduct extensive searches for effective treatments for this serious hormonal disorder, testing up to 300 drugs weekly.

The model published online on May 2 by the Proceedings of the National Academy of Sciences -- was created in the laboratory of Shlomo Melmed, MD, dean of the medical faculty at Cedars-Sinai Medical Center, by his research team led by Ning-Ai Liu, MD, PhD.

They introduced into striped zebrafish the freshwater translucent tropical Danio rario -- the "pituitary tumor transforming gene" discovered in Melmed's lab in 1997. This caused the zebrafish to develop features of Cushing disease including: high levels of the stress-related hormone cortisol; diabetes; and heart disease. These zebrafish then were bred with fish that bear green fluorescent markers, allowing researchers to visualize in the resulting hybrids how drugs interact with the Cushing's disease pituitary tumors.

"This new model for Cushing disease means that we can more rapidly and effectively identify drugs that could be successful in fighting these tumors," Melmed said. "With no current drug therapies and limited options available to Cushing patients, it is our hope that our research will enable medical advances that will revolutionize how this disease is treated."

Cushing Disease often is caused by a pituitary tumor that triggers overproduction of a hormone, which, in turn, stimulates the adrenal gland to overproduce cortisol, affecting nearly every area of the body including the regulation of blood pressure and metabolism. This leads to serious health problems, including diabetes, hypertension, osteoporosis, obesity (especially with a distinctive moon face and fatty tissue deposits in the midsection, upper back and between the shoulders) and cardiovascular disease.

There are no appro
'/>"/>

Contact: Nicole White
nicole.white@cshs.org
310-423-5215
Cedars-Sinai Medical Center
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Model developed to improve combination vaccine accessibility worldwide
2. INFORMS health care conference highlights increased role of math modeling in health systems
3. Virtual lung models set to personalize asthma and COPD treatment
4. New scientific model tracks form of ovarian cancer to origins in fallopian tube
5. Controversial TOFT theory of cancer versus SMT model: Authors do battle in BioEssays
6. Biochemist uses computer models to study protein involved with cancer, aging and chronic disease
7. Fox Chase researchers report that naproxen reduces tumors in a mouse model of colon cancer
8. Researchers publish molecular disease model for melanoma
9. Inclusion of falls history shown to enhance accuracy of fracture risk assessment models
10. Models Photos May Spur Mixed Messages About Body Image
11. US health care reforms should use model developed by Queens University professor
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/1/2015)... ... August 01, 2015 , ... Lume Wellness creators Alex, Robert, and ... download on the Apple AppStore. , The app is designed to track various ... as a tool to view personal health and use this information for positive behavior ...
(Date:7/31/2015)... Santa Rosa, CA (PRWEB) , ... July 31, ... ... been posted by High Times magazine. What are the STASH awards? The ... celebrate advances made by the cannabis-cultivation community as well as tried-and-true products that ...
(Date:7/31/2015)... Santa Clara, CA (PRWEB) , ... August 01, 2015 , ... Super Bowl 50 ... The National Football League’s biggest day each year is the Super Bowl. In the ... buildup that takes place from the host venue. The 2016 Super Bowl game will mark ...
(Date:7/31/2015)... ... 31, 2015 , ... Last week, the Mesothelioma Applied Research ... be accessed by visiting http://www.curemeso.org/store . , “Our new store features a ... whenever a product is purchased, the Meso Foundation receives a $5.00 donation,” said ...
(Date:7/31/2015)... ... 31, 2015 , ... Jacksonville-based drug and alcohol rehabilitation center, ... Center. The medical community, social workers, law enforcement, and government officials are all ... the effort to better understand and combat sex trafficking. Lead by sex trafficking ...
Breaking Medicine News(10 mins):Health News:Lume Wellness Launches Health and Fitness Tracker iPhone App 2Health News:The High Times S.T.A.S.H. Awards Are in, Guess Who Took Home the Prize for “Best Grow System” 2Health News:Cheap 2016 Super Bowl Tickets at Levi's Stadium: Ticket Down Slashes Ticket Prices on Super Bowl 50 Tickets in Santa Clara, CA at Levi's Stadium 2Health News:Mesothelioma Organization Launches New Store 2Health News:Mesothelioma Organization Launches New Store 3Health News:Lakeview Health Links Sex Trafficking and Addiction in Special Jacksonville Educational Workshop 2Health News:Lakeview Health Links Sex Trafficking and Addiction in Special Jacksonville Educational Workshop 3
... Men may be far less likely than women to see a ... effort, a Loyola University physician says. Men generally die ... cancer, stroke and AIDS. But a U.S. survey found that women ... on a regular basis. For many men, seeing a doctor ...
... of medicine and director of the rheumatology division ... with colleagues from the medical center for rheumatoid ... and the blogosphere to discuss advances in the ... can be viewed at: , http://coe.musculoskeletaldisease.webdev.nyumc.org/research/whats-up-with-ra-webinar ...
... By Steven Reinberg HealthDay Reporter , THURSDAY, ... Administration is calling for new warning labels on a class ... medications may raise the risk of developing an aggressive form ... agency said the drugs involved include popular medications sold under ...
... reports suggest that boys and girls with attention deficit ... their vulnerability to substance use problems, say the researchers ... Finland. A total of 1545 Finnish adolescents ... and classroom teachers using standardized rating scales at age ...
... Kathleen Doheny HealthDay Reporter , THURSDAY, June ... (HRT), if tailored to an individual woman,s needs, appears ... scheduled for release Friday at the World Congress on ... compelling that young, healthy women do quite well and ...
... Amanda Gardner HealthDay Reporter , THURSDAY, June 9 ... smokers thin has gotten new support from a study in ... into new drugs to control weight gain. It,s always ... but this new research does open up interesting possibilities. ...
Cached Medicine News:Health News:Men Urged to Lead by Example and See a Doctor Regularly 2Health News:NYU Langone rheumatologists share insight with online RA community 2Health News:Drugs for Enlarged Prostate May Raise Risk of Aggressive Cancer 2Health News:Drugs for Enlarged Prostate May Raise Risk of Aggressive Cancer 3Health News:Experts Say Hormone Replacement Generally Safe in Short-Term 2Health News:Experts Say Hormone Replacement Generally Safe in Short-Term 3Health News:Mouse Study Reveals How Smoking Helps Keep People Thin 2
(Date:7/31/2015)... , July 31, 2015 Today, the ... (NABP ® ) issued a report urging greater ... action is taken against websites illegally selling medications ... Drug Outlet Identification Program Progress Report for State ... thousands of websites illegally distribute medications and ...
(Date:7/31/2015)... , July 31, 2015 The Physician-Patient ... release on July 28, 2015, "Surviving Your Hospital ... Fundraising for Patient Safety." A sentence ... should read: "PPAHS is a member ... on Opioids. For more information on the National Coalition ...
(Date:7/31/2015)... CHICAGO , July 31, 2015 ... Market by Product (Moist Heat, Dry Heat, Ethylene Oxide, Filtration, ... & End User (Hospitals, Pharmaceuticals) - Global Forecast to 2020", ... reach around USD 6.1 Billion by 2020, at a CAGR ... 242 market data T ables and ...
Breaking Medicine Technology:NABP Stresses Need for Accountability in Enforcing Internet Policies to Protect the Public From Illegal Online Drug Sellers 2NABP Stresses Need for Accountability in Enforcing Internet Policies to Protect the Public From Illegal Online Drug Sellers 3Sterilization Equipment Market is Expected to Reach USD 6.1 Billion by 2020 2Sterilization Equipment Market is Expected to Reach USD 6.1 Billion by 2020 3Sterilization Equipment Market is Expected to Reach USD 6.1 Billion by 2020 4
... with 48-week boceprevir-based ... combination therapy ... N.J., Aug. 4 Schering-Plough,Corporation (NYSE: SGP ) today reported top-line ... its investigational,oral hepatitis C protease inhibitor. The analysis showed a high rate ...
... Sanofi,Pasteur, the vaccines division of sanofi-aventis Group, ... the United,States for the 2008-2009 season. The first ... week following marketing clearance of the,2008-2009 formulation by ... 14, 2008., Vaccine shipments to health-care providers ...
Cached Medicine Technology:Top-Line Results of Boceprevir Phase II Study Showed High Rate of Sustained Response (SVR) in Genotype 1 Treatment-Naive Hepatitis C Patients 2Top-Line Results of Boceprevir Phase II Study Showed High Rate of Sustained Response (SVR) in Genotype 1 Treatment-Naive Hepatitis C Patients 3Top-Line Results of Boceprevir Phase II Study Showed High Rate of Sustained Response (SVR) in Genotype 1 Treatment-Naive Hepatitis C Patients 4Top-Line Results of Boceprevir Phase II Study Showed High Rate of Sustained Response (SVR) in Genotype 1 Treatment-Naive Hepatitis C Patients 5Top-Line Results of Boceprevir Phase II Study Showed High Rate of Sustained Response (SVR) in Genotype 1 Treatment-Naive Hepatitis C Patients 6Top-Line Results of Boceprevir Phase II Study Showed High Rate of Sustained Response (SVR) in Genotype 1 Treatment-Naive Hepatitis C Patients 7Top-Line Results of Boceprevir Phase II Study Showed High Rate of Sustained Response (SVR) in Genotype 1 Treatment-Naive Hepatitis C Patients 8Top-Line Results of Boceprevir Phase II Study Showed High Rate of Sustained Response (SVR) in Genotype 1 Treatment-Naive Hepatitis C Patients 9Sanofi Pasteur Shipping First Doses of Influenza Vaccine for the 2008-2009 Season in the US 2Sanofi Pasteur Shipping First Doses of Influenza Vaccine for the 2008-2009 Season in the US 3Sanofi Pasteur Shipping First Doses of Influenza Vaccine for the 2008-2009 Season in the US 4Sanofi Pasteur Shipping First Doses of Influenza Vaccine for the 2008-2009 Season in the US 5
... ARUP Laboratories is a national reference laboratory ... research and development. ARUP offers an extensive ... medical tests in clinical and anatomic pathology. ... Laboratories' clients include more than half of ...
... is a national reference laboratory and a ... development. ARUP offers an extensive test menu ... in clinical and anatomic pathology. Owned by ... include more than half of the nation's ...
... national reference laboratory and a worldwide leader ... offers an extensive test menu of highly ... and anatomic pathology. Owned by the University ... than half of the nation's university teaching ...
... is a national reference laboratory and a ... development. ARUP offers an extensive test menu ... in clinical and anatomic pathology. Owned by ... include more than half of the nation's ...
Medicine Products: