Navigation Links
New model suggests feared side effect of Alzheimer's drugs is unlikely
Date:6/17/2010

The first trial of a new model for testing Alzheimer's treatments has reassured researchers that a promising class of drugs does not exacerbate the disease if treatment is interrupted.

Scientists at Washington University School of Medicine in St. Louis and Merck & Co. Inc studied the effects of a class of drugs known as gamma secretase inhibitors. Researchers had worried that these drugs might cause a build-up of proteins linked to Alzheimer's disease and that this build-up could be unleashed in a surge when patients went off the medications. But the new study suggests that they do not.

"This is important because it eases some concerns that have been raised about this potentially useful class of medications," says senior author Randall Bateman, MD, a Washington University neurologist who treats patients at Barnes-Jewish Hospital.

The findings appeared recently in The Journal of Neuroscience.

Gamma secretase inhibitors block proteins involved in the creation of amyloid beta, the main ingredient of Alzheimer's plaques. Patients cannot continuously take these drugs because nonstop inhibition of the gamma secretase enzyme has harmful side effects. One study had revealed that when physicians temporarily halted used of the inhibitors in humans, amyloid beta levels in the blood surged. An animal study suggested cessation of treatment also led to an amyloid beta increase in the brain. Researchers have been watching for similar effects in current human clinical trials of gamma secretase inhibitors.

The new study used a technique for measuring production and clearance of amyloid beta developed by Bateman and his colleagues at Washington University. It was the first time stable-isotope-labeling kinetics (SILK) was used in primates.

In a preliminary assessment of normal amyloid beta production and clearance rates, scientists found that the amyloid beta turnover in the subjects, a group of rhesus macaques, was 10
'/>"/>

Contact: Michael C. Purdy
purdym@wustl.edu
314-286-0122
Washington University School of Medicine
Source:Eurekalert

Page: 1 2

Related medicine news :

1. University of Pennsylvania: Contrary to popular models, sugar is not burned by self-control tasks
2. Solid tumor modeling focus of workshops
3. PivotPoint Doubles Down on Business Process Modeling with Advanced BPMN 2 + UML 2 Training
4. NYU College of Dentistry, Penn State develop new model for investigating tobacco/oral cancer link
5. Jenny McCarthy - Actress, Activist, and Model - Dedicates bforacure's ‘breasts are beautiful' to Help Raise Money for Breast Cancer Charities
6. Same disease, different stem cell models
7. Wyatt Matas & Associates Releases White Paper on Future Home Healthcare Business Model
8. Super Fitness Bikini Model Mega-Mogul Jennifer Nicole Lee Goes Global, British TV Appearance, QVC London May 12th Sharing Top Fitness Products
9. Former USAA President and Leading, Industry Expert Launch Contact-Center Management Company Featuring Innovative Business Model
10. Second volume of groundbreaking Emerging Model Organisms series is released
11. Global Premiere: Jennifer Nicole Lee, Super Fitness Model & Mega Brand, Reveals Ab Circle Mini on HSN's World Launch
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/30/2014)... 30, 2014 Decene is an ... chain of ten carbon atoms with one double ... of 1-decenes. It can be used as a ... to produce epoxides, amines, oxo alcohols, synthetic lubricants, ... Early buyers will receive 10% customization on this ...
(Date:7/30/2014)... 2014 (HealthDay News) -- Medical costs for chronic obstructive ... than $32 billion each year, according to new research ... The yearly financial toll of COPD (which includes ... estimated $49 billion by 2020. "For the first ... provide state public health practitioners with estimates of the ...
(Date:7/30/2014)... The global digital pathology market was valued at an estimated ... a CAGR of 11.8%, to reach an estimated $437 million ... and is expected to continue to rise in the coming ... software enable pathologists to be efficient and this leads to ... American market was valued at $128.9 million and accounted for ...
(Date:7/30/2014)... (July 30, 2014) With the advent of non-surgical ... popular science and researchers must work to ensure ... of stroke rehabilitation. A new study out today ... shift in perspective and suggests that chronically stimulating ... promote stroke motor recovery, for example by restoring ...
(Date:7/30/2014)... Rhode Island Hospital researchers have found that ... significantly reduce depression and other symptoms in informal ... with dementia. The study is published online in ... & Dementia . , "Those caring for people ... are often under a great deal of pressure," ...
Breaking Medicine News(10 mins):Health News:Europe 1-decene Market is Expected to Reach 251.7 thousand MT in 2018 - New Report by MicroMarket Monitor 2Health News:Europe 1-decene Market is Expected to Reach 251.7 thousand MT in 2018 - New Report by MicroMarket Monitor 3Health News:Europe 1-decene Market is Expected to Reach 251.7 thousand MT in 2018 - New Report by MicroMarket Monitor 4Health News:Annual COPD Costs To Hit $49 Billion by 2020: CDC 2Health News:Global Digital Pathology Market To See 11.8% CAGR to 2018 Says a New Research Report Available at ReportsnReports.com 2Health News:Global Digital Pathology Market To See 11.8% CAGR to 2018 Says a New Research Report Available at ReportsnReports.com 3Health News:Global Digital Pathology Market To See 11.8% CAGR to 2018 Says a New Research Report Available at ReportsnReports.com 4Health News:Global Digital Pathology Market To See 11.8% CAGR to 2018 Says a New Research Report Available at ReportsnReports.com 5Health News:Neuro researchers advocate for a shift in thinking for stroke rehabilitation 2Health News:Study: Telephone support program beneficial for caregivers of those with dementia 2
... a nationwide increase in the incidence of injuries as a ... researchers at the Johns Hopkins Bloomberg School of Public Health ... for injuries from lawn mowing which is regarded to be ... spring. , The research also pointed out to ...
... evaluate the safety of using the amalgam fillings that contain ... health risk in children // , bringing much respite not ... to foodconsumer.org. The studies were conducted independently, one in Europe ... same conclusion about the health risks of dental amalgam in ...
... health ministry of China has reported bird flu infection in a ... and pneumonia // on 1st April has been admitted to a ... confirms the presence of bird flu infection, it would mark the ... nation. ,Since 2003, nearly 194 people have been known ...
... Health officials declared on Tuesday in Guwahati that, at least ... northeast India and another 25,000 have fallen sick from the ... Assam state government announced that since the beginning of April, ... two districts in the eastern part of the state Lakhmipur ...
... study titled 'Search for Diabetes in Youth' has highlighted the ... points out to the importance of keeping a constant vigil ... prevent the associated complications. The results of the study have ... official journal of the Juvenile Diabetes Research Foundation. ...
... earn for meeting specific targets like children's vaccinations. While there ... ?250,000.// ,The elevation in GP’s pay is after the ... as GPs historically earned less than hospital doctors, and trainee ... the perceived high workload and a responsibility for 24-hour cover. ...
Cached Medicine News:Health News:Nationwide Increase In Lawn Mowing Injuries 2Health News:Dental Amalgam Doesn't Pose Health Risks In Children 2Health News:Dental Amalgam Doesn't Pose Health Risks In Children 3Health News:Dental Amalgam Doesn't Pose Health Risks In Children 4Health News:14% Of Pune Population Diabetic: Children Most Affected 2
(Date:7/30/2014)...  Decision Resources Group finds that ... imaging system market will be significantly driven by ... computed tomography and magnetic resonance imaging with nuclear ... the need for higher-quality imaging to satisfy more ... spur preclinical imaging system sales. Other ...
(Date:7/30/2014)... YORK and KISSING, Germany ... and distributor of a single use and computer-assisted ("robotic") ... (Homi) Shamir , a worldwide recognized medical device executive, ... Mr. Shamir is a highly respected global ... recent assignment he served as President and Chief Executive ...
(Date:7/30/2014)... 30, 2014  DigiPath, Inc. (OTCBB and OTCQB: DIGP), ... the cannabis testing and education markets, announced today that ... affairs not previously disclosed or, to its knowledge, any ... action. "We have noticed unusual price and ... trading days," said Steve Barbee , CEO of ...
Breaking Medicine Technology:Growing Popularity of Multimodality Imaging Will Drive the Preclinical Animal Research Imaging System Market 2invendo medical Appoints Nachum (Homi) Shamir To The Company's Board Of Directors 2invendo medical Appoints Nachum (Homi) Shamir To The Company's Board Of Directors 3DigiPath No New Corporate Developments 2
... (Nasdaq CM: INSM), a biopharmaceutical company, will host a ... AM ET, to discuss its financial results for the ... quarterly financial results press release before the market opens ... the live conference call, please dial 800-901-5213 (U.S. callers) ...
... Pharmaceuticals, Inc. (Nasdaq: ALXA ) announced today that ... 31, 2012, on Thursday, May 10, 2012, following the close ... investor conference call and live webcast to discuss the financial ... Time / 2:00 p.m. Pacific Time on the same date. The ...
Cached Medicine Technology:Insmed to Host 2012 First Quarter Earnings Conference Call 2Insmed to Host 2012 First Quarter Earnings Conference Call 3Alexza to Announce 2012 First Quarter Financial Results on Thursday, May 10, 2012 2Alexza to Announce 2012 First Quarter Financial Results on Thursday, May 10, 2012 3
For use with Snap-In Snap-Out-II tip inserts. Available in five styles, the Snap-In Snap-Out-II Laparoscopic Instrument Handles offer the broadest range available....
For use with Snap-In Snap-Out-II tip inserts. Available in five styles, the Snap-In Snap-Out-II Laparoscopic Instrument Handles offer the broadest range available....
Inquire...
Inquire...
Medicine Products: