Navigation Links
New model of skin cancer provides insights on second-most common type of cancer
Date:12/10/2009

PHILADELPHIA Scientists at the University of Pennsylvania School of Medicine have developed a new model of skin cancer based on the knowledge that a common cancer-related molecule called Src kinase is activated in human skin-cancer samples.

"Our previous work demonstrated that Src kinases are activated in human squamous cell carcinomas of the skin. We modeled these observations by increasing the expression of the gene Fyn, a member of Src family of proteins, in mouse skin," explains senior author John T. Seykora M.D., Ph.D, assistant professor of Dermatology. In addition, prior work by the Seykora lab on a related protein called Srcasm, discovered by him in 2002, suggested that Srcasm may function as an anti-oncogene, a molecule that keeps others in check in order to control cell growth.

In this proof-of-principle study, published this month in Cancer Research, the authors found that genetically engineered mice expressing a K14-Fyn transgene develop precancerous lesions and invasive squamous cell carcinomas (SCCs) spontaneously in 5 to 8 weeks. Skin SCCs are the second most common form of cancer, with greater than 250,000 cases annually in the US, leading to approximately 2,500 deaths.

This study demonstrates that Fyn is a potent oncogene in skin. When Srcasm levels are raised in the mouse skin cancer model, tumor formation is dramatically inhibited showing that Srcasm functions as an anti-oncogene.

The findings highlight an important relationship between Fyn and SrcasmFyn encourages growth, while Srcasm inhibits it. "When this system malfunctions, it's like stepping on the gas and taking off the brakes on cell growth," explains Seykora. "Adding Srcasm back to the system lowers Fyn levels and restores order."

Analysis of human skin tumor samples confirmed that Srcasm levels are decreased and Src kinase activity is increased. The authors conclude that one potential means of combating skin cancer
'/>"/>

Contact: Karen Kreeger
karen.kreeger@uphs.upenn.edu
215-349-5658
University of Pennsylvania School of Medicine
Source:Eurekalert  

Page: 1 2

Related medicine news :

1. Measuring and modeling blood flow in malaria
2. Massachusetts Model Tobacco Cessation Benefit Spurs Unprecedented Drop in Smoking Rates, Heart Attacks, Asthma, and Birth Complications
3. New Series of Podcasts Highlight Supermodel's "Life-altering" Experience to Raise Awareness of Fibroid Treatment Options
4. Drexel Universitys Eleventh Street Health Services Recognized as National Model of Innovative Health Care
5. Health Integrated Announces Turnkey Model of Care Program for Special Needs Health Plans
6. Dramatic Settlement Sets National Model for H1N1 Hospital Safety Measures
7. NovaBays Aganocides Show Penetration and Efficacy in a Pre-Clinical Infected Human Nail Model of Onychomycosis
8. Pittsburgh Partners Launch Promising Family-Centered Care Model: Special Focus on Promoting Parental Well-Being and Healthy Child Development
9. UC San Diego researchers reverse pulmonary arterial hypertension in mouse models
10. General anesthetics lead to learning disabilities in animal models
11. New mathematical model more accurately diagnoses acute heart failure in emergency rooms
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
New model of skin cancer provides insights on second-most common type of cancer
(Date:12/25/2014)... updated its blog to provide professional shopping tips on wedding and ... LunaDress.co.uk come with big discounts, up to 80 percent off. , ... to be a most exciting memory and can show off a ... a wedding. On the updated fashion blog, ladies can now find ... day . , Going out with friends to a party is ...
(Date:12/25/2014)... 25, 2014 (HealthDay News) -- Overeating is common during the ... in moderation, an expert says. "Don,t arrive at a ... if you know you,ll be attending a party, but deprivation ... lead dietitian at Northern Westchester Hospital in Mount Kisco, N.Y., ... eat healthy during the day and even to have a ...
(Date:12/25/2014)... December 25, 2014 AngelWeddingDress.com tries its ... the online realm. Today, the business has introduced its ... site-wide prom dress promotion. , The new prom outfits ... and every dress lover. They are specially designed for ... prom dresses should visit its website before Jan. ...
(Date:12/25/2014)... Aliso Viejo, California (PRWEB) December 25, 2014 ... the release of ProFire 5k. A fully customizable business ... X . , “Adding the ProFire 5k business tool, ... style” Said Christina Austin, CEO of Pixel Film Studios. ... the look and style to add professionalism to a ...
(Date:12/25/2014)... 2014 Parker & Sons, Inc. an ... and affordable quality regarding heating, cooling and plumbing services ... 2014 by the “Queen of Clean” for impressive contractor ... impressive reputation over the years for providing outstanding quality ... of contractor services for both homeowners and businesses. Linda ...
Breaking Medicine News(10 mins):Health News:LunaDress Provides Professional Tips On Shopping Wedding And Prom Dresses 2Health News:Angelweddingdress 2015 Prom Dresses Online Now 2Health News:Announcing a new ProFire 5k plugin from Pixel Film Studios for Final Cut Pro X Professionals 2Health News:Parker & Sons Announces Recognition In 2014 By The “Queen Of Clean” For Impressive Contractor Services In Arizona 2Health News:Parker & Sons Announces Recognition In 2014 By The “Queen Of Clean” For Impressive Contractor Services In Arizona 3
... has significantly contributed to progress in the fight against ... American Association for Cancer Research (AACR) at its 2008 ... San Diego, Calif. , A series of ... and largest professional organization representing cancer scientists from the ...
... Blue Shield companies designate Blue Distinction Centers,for Complex and ... of ongoing efforts,to raise the overall quality of healthcare ... expanding the Blue Distinction(R),designation., Today, Blue Cross and ... Blue Distinction Centers for Complex and Rare Cancers across ...
... York Stock Exchange Bell-Ringing, Shafallah Center Celebration and ... Web, Highlight Global Awareness Initiative, NEW YORK, March ... today announced a series of international,events to mark the ... effort to heighten awareness about a disorder,affecting millions of ...
... EaglePicher,Medical Power, a leading supplier of batteries ... Joseph (Joe) Marotta has,joined the company as vice ... position, Mr. Marotta will be responsible for the ... customer,development initiatives. EaglePicher,s medical division has seen tremendous,growth ...
... VALENCIA, Calif., March 11 TriMed, Inc., a ... has,announced that the United States Court of Appeals ... court,s summary judgment in its patent infringement,suit against ... Stryker,s accused device contains "precisely the same structure",shown ...
... 11 InforMedix Holdings,Inc. (OTC Bulletin Board: ... has engaged,Murdock Capital Partners to provide Capital ... in New York City, is a 16 ... advice, counsel, and assistance,regarding financial matters, including ...
Cached Medicine News:Health News:Leading researchers honored for progress in cancer prevention, detection and treatment 2Health News:Leading researchers honored for progress in cancer prevention, detection and treatment 3Health News:Leading researchers honored for progress in cancer prevention, detection and treatment 4Health News:Leading researchers honored for progress in cancer prevention, detection and treatment 5Health News:Leading researchers honored for progress in cancer prevention, detection and treatment 6Health News:Leading researchers honored for progress in cancer prevention, detection and treatment 7Health News:Blue Cross and Blue Shield's Blue Distinction(R) Designation Improves Healthcare by Focusing on Quality 2Health News:Blue Cross and Blue Shield's Blue Distinction(R) Designation Improves Healthcare by Focusing on Quality 3Health News:Blue Cross and Blue Shield's Blue Distinction(R) Designation Improves Healthcare by Focusing on Quality 4Health News:Autism Speaks to Celebrate World Autism Awareness Day with Day-Long Series of International Events on April 2 2Health News:Autism Speaks to Celebrate World Autism Awareness Day with Day-Long Series of International Events on April 2 3Health News:Autism Speaks to Celebrate World Autism Awareness Day with Day-Long Series of International Events on April 2 4Health News:EaglePicher Medical Power Names Joseph Marotta Vice President of Sales and Marketing 2Health News:Court of Appeals Reverses Lower Court Decision in Favor of TriMed, Inc. Patent Infringement Case 2Health News:InforMedix Retains Murdock Capital Partners 2Health News:InforMedix Retains Murdock Capital Partners 3Health News:InforMedix Retains Murdock Capital Partners 4
(Date:12/24/2014)... December 24, 2014 ... Global Disposable Syringe Industry of 178 pages ... business intelligence library. The 2014 ... Industry is a professional and deep research ... overview analysis, the report introduces Disposable Syringe ...
(Date:12/24/2014)... 2014  The American Diabetes Association is recommending ... people with diabetes and that all people with ... statins, in keeping with recent changes to guidelines ... College of Cardiology (ACC) and American Heart Association ... recent changes to the Association,s annual revised Standards ...
(Date:12/24/2014)...  Medical Science Liaisons play a large role in ... medical device industry and key stakeholders, the role of ... as the device industry relies on them to build ... benchmarking firm, Best Practices, LLC, one area where Medical ... by harnessing new technology to enable education. Online conferences ...
Breaking Medicine Technology:World Disposable Syringe Market 2014 Report: China and Regional Analysis 2World Disposable Syringe Market 2014 Report: China and Regional Analysis 3World Disposable Syringe Market 2014 Report: China and Regional Analysis 4World Disposable Syringe Market 2014 Report: China and Regional Analysis 5New Standards of Care Provide Guidelines for Statin Use for People with Diabetes to Prevent Heart Disease 2New Standards of Care Provide Guidelines for Statin Use for People with Diabetes to Prevent Heart Disease 3New Standards of Care Provide Guidelines for Statin Use for People with Diabetes to Prevent Heart Disease 4Role of Medical Science Liaisons Evolving in Medical Device Sector 2
... Corporation (Nasdaq: VOLC ), a leading developer and ... to enhance the treatment of coronary and peripheral vascular disease, ... increased 35 percent over revenues in the same period a ... $9.6 million year-over-year as it reported net income of $5.6 ...
... 3, 2010 Covance Inc. (NYSE: CVD ) ... 2010, which included a GAAP loss of $0.49 per diluted ... non-cash impairment charge related to a write-down of preclinical assets, ... from favorable income tax resolutions in the quarter. Excluding these ...
Cached Medicine Technology:Volcano Reports 35 Percent Increase in Third Quarter Revenues; Records $9.6 Million Improvement in Year-Over-Year GAAP Profitability 2Volcano Reports 35 Percent Increase in Third Quarter Revenues; Records $9.6 Million Improvement in Year-Over-Year GAAP Profitability 3Volcano Reports 35 Percent Increase in Third Quarter Revenues; Records $9.6 Million Improvement in Year-Over-Year GAAP Profitability 4Volcano Reports 35 Percent Increase in Third Quarter Revenues; Records $9.6 Million Improvement in Year-Over-Year GAAP Profitability 5Volcano Reports 35 Percent Increase in Third Quarter Revenues; Records $9.6 Million Improvement in Year-Over-Year GAAP Profitability 6Volcano Reports 35 Percent Increase in Third Quarter Revenues; Records $9.6 Million Improvement in Year-Over-Year GAAP Profitability 7Volcano Reports 35 Percent Increase in Third Quarter Revenues; Records $9.6 Million Improvement in Year-Over-Year GAAP Profitability 8Volcano Reports 35 Percent Increase in Third Quarter Revenues; Records $9.6 Million Improvement in Year-Over-Year GAAP Profitability 9Covance Reports Third Quarter Financial Results and Takes Actions to Strengthen Future Performance 2Covance Reports Third Quarter Financial Results and Takes Actions to Strengthen Future Performance 3Covance Reports Third Quarter Financial Results and Takes Actions to Strengthen Future Performance 4Covance Reports Third Quarter Financial Results and Takes Actions to Strengthen Future Performance 5Covance Reports Third Quarter Financial Results and Takes Actions to Strengthen Future Performance 6Covance Reports Third Quarter Financial Results and Takes Actions to Strengthen Future Performance 7Covance Reports Third Quarter Financial Results and Takes Actions to Strengthen Future Performance 8Covance Reports Third Quarter Financial Results and Takes Actions to Strengthen Future Performance 9Covance Reports Third Quarter Financial Results and Takes Actions to Strengthen Future Performance 10Covance Reports Third Quarter Financial Results and Takes Actions to Strengthen Future Performance 11Covance Reports Third Quarter Financial Results and Takes Actions to Strengthen Future Performance 12Covance Reports Third Quarter Financial Results and Takes Actions to Strengthen Future Performance 13
... designed to address customer requests for another ... even wider range of clinical applications in ... flow imaging with super-high frame rates to ... a wealth of technological innovations that enhance ...
... In the Innova™ 4100, the ... X-ray system for angiographic imaging, ... piece, non tiled Digital Detector ... reliably provide high resolution imaging ...
... you perform exams from cardiac to angio. ... no compromises. An ideal 31 centimeters square, ... of cardiovascular and interventional imaging. With a ... variety of vascular and interventional procedures. The ...
... vasopressin (AVP), also known as Antidiurectic Hormone ... is transported via exonal flow to the ... AVP secretion is regulated by changes in ... respond to alterations in blood volume or ...
Medicine Products: