Navigation Links
New model of skin cancer provides insights on second-most common type of cancer
Date:12/10/2009

PHILADELPHIA Scientists at the University of Pennsylvania School of Medicine have developed a new model of skin cancer based on the knowledge that a common cancer-related molecule called Src kinase is activated in human skin-cancer samples.

"Our previous work demonstrated that Src kinases are activated in human squamous cell carcinomas of the skin. We modeled these observations by increasing the expression of the gene Fyn, a member of Src family of proteins, in mouse skin," explains senior author John T. Seykora M.D., Ph.D, assistant professor of Dermatology. In addition, prior work by the Seykora lab on a related protein called Srcasm, discovered by him in 2002, suggested that Srcasm may function as an anti-oncogene, a molecule that keeps others in check in order to control cell growth.

In this proof-of-principle study, published this month in Cancer Research, the authors found that genetically engineered mice expressing a K14-Fyn transgene develop precancerous lesions and invasive squamous cell carcinomas (SCCs) spontaneously in 5 to 8 weeks. Skin SCCs are the second most common form of cancer, with greater than 250,000 cases annually in the US, leading to approximately 2,500 deaths.

This study demonstrates that Fyn is a potent oncogene in skin. When Srcasm levels are raised in the mouse skin cancer model, tumor formation is dramatically inhibited showing that Srcasm functions as an anti-oncogene.

The findings highlight an important relationship between Fyn and SrcasmFyn encourages growth, while Srcasm inhibits it. "When this system malfunctions, it's like stepping on the gas and taking off the brakes on cell growth," explains Seykora. "Adding Srcasm back to the system lowers Fyn levels and restores order."

Analysis of human skin tumor samples confirmed that Srcasm levels are decreased and Src kinase activity is increased. The authors conclude that one potential means of combating skin cancer would be to inhibit Src kinases and/or increase Srcasm levels.

This work may have broader relevance as Src kinases are one of the longest studied oncogenes and are activated in many types of human cancer, including colon and breast cancer. This study provides insight into how Src kinases are activated in human cancers. Further study of this model may provide insights into treating carcinomas that have increased Src kinase activity

Future work will involve determining how Srcasm levels are decreased in skin tumors to promote cell growth. In addition, topical compounds will be tested using this model to determine if they may be useful in treating skin cancer in people.


'/>"/>

Contact: Karen Kreeger
karen.kreeger@uphs.upenn.edu
215-349-5658
University of Pennsylvania School of Medicine
Source:Eurekalert  

Related medicine news :

1. Measuring and modeling blood flow in malaria
2. Massachusetts Model Tobacco Cessation Benefit Spurs Unprecedented Drop in Smoking Rates, Heart Attacks, Asthma, and Birth Complications
3. New Series of Podcasts Highlight Supermodel's "Life-altering" Experience to Raise Awareness of Fibroid Treatment Options
4. Drexel Universitys Eleventh Street Health Services Recognized as National Model of Innovative Health Care
5. Health Integrated Announces Turnkey Model of Care Program for Special Needs Health Plans
6. Dramatic Settlement Sets National Model for H1N1 Hospital Safety Measures
7. NovaBays Aganocides Show Penetration and Efficacy in a Pre-Clinical Infected Human Nail Model of Onychomycosis
8. Pittsburgh Partners Launch Promising Family-Centered Care Model: Special Focus on Promoting Parental Well-Being and Healthy Child Development
9. UC San Diego researchers reverse pulmonary arterial hypertension in mouse models
10. General anesthetics lead to learning disabilities in animal models
11. New mathematical model more accurately diagnoses acute heart failure in emergency rooms
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
New model of skin cancer provides insights on second-most common type of cancer
(Date:12/2/2016)... ... December 02, 2016 , ... On Dec. 2, 2016, CURE® magazine will ... Diego honoring the 2016 MPN Heroes—eight individuals who have made a difference in the ... beyond the standard of care, demonstrating leadership within the MPN community and/or a commitment ...
(Date:12/2/2016)... ... 2016 , ... Center for Autism and Related Disorders (CARD) Portland today announced ... disorder (ASD) and other developmental disabilities. The group, which is being launched with the ... the opportunity to share stories and advice, seek help, and continue their education on ...
(Date:12/2/2016)... ... December 02, 2016 , ... Dr. Raffi Hovsepian, a ... in the 2016 “Guide to America’s Top Plastic Surgeons” for seven consecutive years. ... their education, experience, and professional associations. , One the most frequently honored ...
(Date:12/2/2016)... Cleveland, OH (PRWEB) , ... December 02, 2016 ... ... provider of veterinarian diagnostic imaging systems and the first company to ... Robot With a Heart at their tradeshow booth # 941 for the American ...
(Date:12/2/2016)... ... December 02, 2016 , ... Clarify Health ... has raised $6.0 million in an initial round of funding. The round was ... and their caregivers can receive far better care through the application of the ...
Breaking Medicine News(10 mins):
(Date:12/2/2016)... GARDENS, N.Y. , Dec. 2, 2016  LifeVac, ... will be included in the Emergency Response Training and ... are very excited to have LifeVac become part of ... Lih , Founder and CEO of LifeVac. "Having an ... LifeVac safely and effectively will help leverage our efforts ...
(Date:12/2/2016)... , Dec. 2, 2016  PipelineRx, a leading medication ... be offering demonstrations of its SaaS-based telepharmacy platform, ... Health-System Pharmacists 2016 Midyear Clinical Meeting and Exhibition, ... . With nearly 300 hospital clients nationally, the ... technology designed to dramatically improve pharmacy operations, enhance ...
(Date:12/2/2016)... AMARILLO, Texas , Dec. 2, 2016  Maxor National ... its acquisition of Pharmaceutical Specialties, Inc. ("PSI").  The combination of ... and Georgia -based PSI bring together both ... patients, physicians, manufacturers, and payers an industry-leading specialty pharmacy. ... , ...
Breaking Medicine Technology: