Navigation Links
New model of skin cancer provides insights on second-most common type of cancer
Date:12/10/2009

PHILADELPHIA Scientists at the University of Pennsylvania School of Medicine have developed a new model of skin cancer based on the knowledge that a common cancer-related molecule called Src kinase is activated in human skin-cancer samples.

"Our previous work demonstrated that Src kinases are activated in human squamous cell carcinomas of the skin. We modeled these observations by increasing the expression of the gene Fyn, a member of Src family of proteins, in mouse skin," explains senior author John T. Seykora M.D., Ph.D, assistant professor of Dermatology. In addition, prior work by the Seykora lab on a related protein called Srcasm, discovered by him in 2002, suggested that Srcasm may function as an anti-oncogene, a molecule that keeps others in check in order to control cell growth.

In this proof-of-principle study, published this month in Cancer Research, the authors found that genetically engineered mice expressing a K14-Fyn transgene develop precancerous lesions and invasive squamous cell carcinomas (SCCs) spontaneously in 5 to 8 weeks. Skin SCCs are the second most common form of cancer, with greater than 250,000 cases annually in the US, leading to approximately 2,500 deaths.

This study demonstrates that Fyn is a potent oncogene in skin. When Srcasm levels are raised in the mouse skin cancer model, tumor formation is dramatically inhibited showing that Srcasm functions as an anti-oncogene.

The findings highlight an important relationship between Fyn and SrcasmFyn encourages growth, while Srcasm inhibits it. "When this system malfunctions, it's like stepping on the gas and taking off the brakes on cell growth," explains Seykora. "Adding Srcasm back to the system lowers Fyn levels and restores order."

Analysis of human skin tumor samples confirmed that Srcasm levels are decreased and Src kinase activity is increased. The authors conclude that one potential means of combating skin cancer
'/>"/>

Contact: Karen Kreeger
karen.kreeger@uphs.upenn.edu
215-349-5658
University of Pennsylvania School of Medicine
Source:Eurekalert  

Page: 1 2

Related medicine news :

1. Measuring and modeling blood flow in malaria
2. Massachusetts Model Tobacco Cessation Benefit Spurs Unprecedented Drop in Smoking Rates, Heart Attacks, Asthma, and Birth Complications
3. New Series of Podcasts Highlight Supermodel's "Life-altering" Experience to Raise Awareness of Fibroid Treatment Options
4. Drexel Universitys Eleventh Street Health Services Recognized as National Model of Innovative Health Care
5. Health Integrated Announces Turnkey Model of Care Program for Special Needs Health Plans
6. Dramatic Settlement Sets National Model for H1N1 Hospital Safety Measures
7. NovaBays Aganocides Show Penetration and Efficacy in a Pre-Clinical Infected Human Nail Model of Onychomycosis
8. Pittsburgh Partners Launch Promising Family-Centered Care Model: Special Focus on Promoting Parental Well-Being and Healthy Child Development
9. UC San Diego researchers reverse pulmonary arterial hypertension in mouse models
10. General anesthetics lead to learning disabilities in animal models
11. New mathematical model more accurately diagnoses acute heart failure in emergency rooms
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
New model of skin cancer provides insights on second-most common type of cancer
(Date:10/1/2014)... New research suggests the adage that encourages people to ... target when it comes to exercise. When walking, staying ... distance to it appear shorter and help people walk ... compares this technique to walking while looking around the ... quality of exercise. , "People are less interested in ...
(Date:10/1/2014)... Lifeinsurance-policy.com has released a new blog post explaining ... smokers. , Smoking will always have a negative impact ... best method to find affordable coverage. Insurance brokerage websites ... , Whole life insurance premiums will be fixed ... coverage is permanent, the initial rates are very ...
(Date:10/1/2014)... Join the more than 80 golfers who already ... ever charity golf tournament to benefit Project HEAL, a not-for-profit ... cannot afford treatment. The tournament will be held Monday, Oct. ... , The day-long event starts with 10:30 a.m. check-in and ... will begin at 5 p.m. and will include an auction ...
(Date:10/1/2014)... City, NJ (PRWEB) October 01, 2014 Diet ... with their intentions to lose weight and their dieting attempts ... unhealthy, fatty foods. Including hormone diet treatments into ... only allows patients to see fast and effective weight loss ... and begin forming healthy habits to maintain their weight for ...
(Date:10/1/2014)... Dar, Ethiopia, at the occasion of the Leishmaniasis ... 150 African and international leishmaniasis experts, results of ... efficacy monitoring plan, carried out by MSF, ... and Ethiopia, were presented to key decision makers ... of kala-azar with the combination of Sodium Stibogluconate ...
Breaking Medicine News(10 mins):Health News:Keeping your eyes on the prize can help with exercise, NYU study finds 2Health News:Keeping your eyes on the prize can help with exercise, NYU study finds 3Health News:Affordable Whole Life Insurance Premiums for Smokers! 2Health News:Project HEAL Benefit Golf Tournament Gaining Momentum 2Health News:Project HEAL Benefit Golf Tournament Gaining Momentum 3Health News:Diet Doc Announces Their New Version of the Hormone Diet Plan to Target, Attack and Burn Fat Without Dangerous Side Effects 2Health News:Diet Doc Announces Their New Version of the Hormone Diet Plan to Target, Attack and Burn Fat Without Dangerous Side Effects 3Health News:Diet Doc Announces Their New Version of the Hormone Diet Plan to Target, Attack and Burn Fat Without Dangerous Side Effects 4Health News:Results of large-scale roll out of combination treatment for kala-azar in Eastern Africa 2
... Marketer Spiegel Brands and Shasun USA, One of ... Producers of Ibuprofen, Have Signed Multi-Year ... Management,Services Inc., (OTC Bulletin Board: BPOM), a full-service ... today,announced that Spiegel Brands, Inc., Chicago, the women,s ...
... since 1998, announces recent additions to womenshealthchannel.com. These new features ... as teen pregnancy with each other and with ... ... (PRWEB) July 2, 2008 -- Womenshealthchannel.com , a physician-developed ...
... October 24-26, 2008 at the Catholic Institute in Toulouse, France. Investigators ... applications and prospective issues in an interactive and collaborative meeting from ... for details. , ... Carmel, IN (PRWEB) July 2, ...
... clinicians should understand and consider the economic impact of ... a report appearing in the July/August issue of ... journal of the American Cancer Society. The report says ... clinicians to be aware of the relative costs and ...
... equivalent of 300 human genomes in just over six months. ... letters of genetic code that will be read by researchers ... health and disease. Scientists will be able to answer questions ... will be transformed. , The amount of data is ...
... Health,Systems, Inc. (Amex: ADK ), an Ohio based ... the refinancing of three assisted,living properties in Ohio., ... assisted living,properties located in Springfield, Ohio and Hearth & ... property located in Urbana, Ohio.,Both entities are limited liability ...
Cached Medicine News:Health News:BPO Management Services Wins Two New Information Technology Outsourcing Contracts 2Health News:BPO Management Services Wins Two New Information Technology Outsourcing Contracts 3Health News:Womenshealthchannel Enhancements Support Pregnant Teens 2Health News:Womenshealthchannel Enhancements Support Pregnant Teens 3Health News:Womenshealthchannel Enhancements Support Pregnant Teens 4Health News:Womenshealthchannel Enhancements Support Pregnant Teens 5Health News:2008 International Federation of Adipose Therapeutics and Science (IFATS) Conference Date Set 2Health News:2008 International Federation of Adipose Therapeutics and Science (IFATS) Conference Date Set 3Health News:Report says clinicians should consider economic impact of new interventions 2Health News:15 human genomes each week 2Health News:15 human genomes each week 3Health News:AdCare Health Systems, Inc. Announces the Refinancing of Three Assisted Living Properties in Ohio 2
(Date:10/1/2014)... 1, 2014  Dyadic International, Inc. ("Dyadic") (OTCQX: ... proprietary technology used to develop and produce enzymes ... biopharmaceuticals, and industrial enzymes industries, today announced the ... Bioenergy for commercial scale production of Abengoa,s proprietary ... developed under Abengoa,s license agreement with Dyadic. ...
(Date:10/1/2014)... NEW YORK , October 1, 2014 ... and service provider for the medical industries, announced today the expansion ... New York City . genae Americas was incorporated ... is strategically centered in one of the highest concentrations of medical ... Philippe Kassab , President at genae Americas. "The expansion of genae ...
(Date:10/1/2014)... Oct. 1, 2014  Varian Medical Systems (NYSE: ... results for the fourth quarter of fiscal year 2014 ... 22, 2014.  The news release will be followed by ... p.m. PT.  The news release and a link to ... company website at: www.varian.com/investor .  To access the ...
Breaking Medicine Technology:Dyadic International Reports Licensing Payment For Commercial-Scale Production Of C1-Based Cellulase Enzymes 2Dyadic International Reports Licensing Payment For Commercial-Scale Production Of C1-Based Cellulase Enzymes 3genae Opens Offices in New York City 2Varian Medical Systems Schedules Fourth Quarter FY2014 News Release and Conference Call 2
Designed for forefoot relief and healing. This shoe has a unique wedge outsole and a soft nylon upper. We also added the hi-top upper to keep the foot held back and reduce slippage. Available in five...
... Cronin, Inc. is a ... Footwear, Orthopedic Softgoods, and ... Our products are of ... available in the USA ...
Resilient insole has a series of removable hexagons for tailored pressure relief....
... controlling range of motion of the elbow., ... for its lower extremity bracing solutions, in ... have benefitted from our custom and post-operative ... Series post-operative elbow braces come in single ...
Medicine Products: