Navigation Links
New model of ALS is based on human cells from autopsied tissue
Date:8/11/2011

By isolating cells from patients' spinal tissue within a few days after death, researchers funded by the National Institutes of Health have developed a new model of the paralyzing disease amyotrophic lateral sclerosis (ALS). They found that during the disease, cells called astrocytes become toxic to nerve cells a result previously found in animal models but not in humans. The new model could be used to investigate many more questions about ALS, also known as Lou Gehrig's disease.

ALS can run in families, but in the majority of cases, it is sporadic, with no known cause. The researchers derived astrocytes from patients who had succumbed to either type of ALS, and found that the cells secrete toxic factors that cause nerve cells to degenerate. A similar mechanism has been found in mouse models of ALS.

"The mouse models capture a type of familial ALS that accounts for only 2 percent of all cases. The field has begged for new disease models that can provide a clear window into sporadic ALS," said senior author Brian Kaspar, Ph.D., an investigator at the Nationwide Children's Research Institute (NCRI) in Columbus, Ohio. His collaborators were Jerry Mendell, M.D., director of NCRI's Center for Gene Therapy, and Arthur Burghes, Ph.D., a professor of molecular and cellular biochemistry at Ohio State University in Columbus. Drs. Kaspar and Mendell also hold faculty positions at Ohio State.

The research is reported in Nature Biotechnology and was funded in part by NIH's National Institute of Neurological Disorders and Stroke (NINDS), including a $1.7 million stimulus grant made possible by the American Recovery and Reinvestment Act.

ALS is characterized by the death of motor neurons, which are muscle-controlling nerve cells in the spinal cord. As these neurons die, the body's voluntary muscles weaken and waste away. Death within five years of diagnosis is common. The only approved treatment, riluzole, extends life exp
'/>"/>

Contact: Daniel Stimson
stimsond@ninds.nih.gov
301-496-5751
NIH/National Institute of Neurological Disorders and Stroke
Source:Eurekalert

0

GOOD

Page: 1 2 3 4

Related medicine news :

1. Celebrity Trainer and Super Fitness Model Jennifer Nicole Lee on HSN with #1 Secret Six Pack Abs Secret, Ab Circle Pro
2. Hunk Calendar Photographer Resurrects Erotic Male Modeling Club and Launches Provocative E-exhibition
3. Dolphins could be ideal model to study human cervical cancer, UF veterinarians say
4. David Anderson to discuss what model organisms can teach us about emotion
5. Rate Regulation for Health Insurance: Obama Administration Should Look to CAs Model Law Which Has Saved Drivers $62 Billion Since 1988
6. GE Healthcare, Intel and Mayo Clinic explore new models of health care delivery
7. Rapamycin rescues learning, memory in Alzheimers mouse model
8. Ghrelin mitigates liver fibrosis in animal models; regulates human fibrosis
9. A novel in vitro model for light-induced wound healing
10. Hard to Treat Diseases (HTDS) Collagenna Skin Care Business Model and Chilean Update
11. Choice of Derek H. Lee as Chief Financial and Corporate Development Officer Strengthens Talaris Advisors' Portfolio Design Business Model
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/25/2013)... make great companions for senior citizens, but elderly people who ... more likely to crash than those who never drive with ... 2,000 licensed drivers aged 70 and older. The nearly 700 ... with their pet in the car. Among those who ... as high as among those who never drove with their ...
(Date:5/25/2013)... Dallas, TX (PRWEB) May 25, 2013 ... between those who are carrying excessive weight and their ... that for many, simply losing weight can naturally relieve ... Medicine found that improvement in sleep quality was significantly ... this six month study dated November 6th, ...
(Date:5/25/2013)... York, NY (PRWEB) May 25, 2013 On ... that many people do not wish to discuss or plan ... in life. FuneralFinancials.com released a Must-Do List ... , 1. Funeral Financials recommends, “Creating a personal fact sheet.” ... used to organize financial information and personal data. It ...
(Date:5/25/2013)... By working diligently for months on this ... the 2012 Lamborghini Aventador into their well-built fitments database. ... the list of vehicles lined by SizeItUp for the ... to thrill automobile lovers in the year 2013. ... the 2012 Lamborghini Aventador comes with extraordinarily spacious cabin ...
(Date:5/25/2013)... 2013 Many orthodontists have thought about ... exactly that cloud is. Most people would naturally ... to provide their cloud service and support would own ... service they're selling, they'd be wrong. Cloud providers ... secure, redundant facility that houses servers and related equipment ...
Breaking Medicine News(10 mins):Health News:Seniors More Likely to Crash When Driving With Pet: Study 2Health News:hCGTreatments / Diet Doc hCG Diets & Weight Loss Plans Offers Newly Improved hCG Diet Plans Capable of Delivering Better Sleep 2Health News:FuneralFinancials.com Releases Last Wishes Must-Do List 2Health News:Rim Fitments Provider SizeItUp Launches The Database Integration For The 2012 Lamborghini Aventador 2Health News:Cirrus Ortho Launches Cloud Computing for Orthodontic Industry That is Unlike Any Other 2
... from rejecting a fetus may also play an important ... by the immune system, allowing them to spread in ... Center in Philadelphia found that the metastatic cancer cells ... produce enough of the protein, IDO, to essentially wall-off ...
... When They Release,Studies Based on a Methodology of Google ... Association,s (ATRA) and the Center for Medicine in the ... at best.,ATRA and CMPI should be ashamed to issue ... searches., Follow the money for this study: tort ...
... joins Jenny Craig to relay the message of a healthy ... ... the,nation,s leading authorities on weight management, held a press conference,today at the Beverly ... client. The Oscar-nominated,singer and actress will be the focal point of a new ...
... diet plans by providing recipes, shopping lists and nutrition tracking ... help support ... DaVita Inc., a,leading provider of dialysis services for those diagnosed ... Inc. (Nasdaq:,DIET), leveraging the power of the Internet to bring ...
... mice, researchers have found that the bodys immune system can ... molecule comes from a protein found in all cells of ... only when it is present on the surface of cells ... as histone H4, signals the immune system to respond to ...
... as a mere folk remedy for relieving urinary tract ... Thanks to Prof. Itzhak Ofek, a researcher at Tel ... knows that science supports the folklore. Prof. Ofek,s ... decades shows that its juice indeed combats urinary tract ...
Cached Medicine News:Health News:Jefferson scientists find protein helps pancreatic cancer cells evade immune system and spread 2Health News:Jefferson scientists find protein helps pancreatic cancer cells evade immune system and spread 3Health News:Statement from AAJ President Kathleen Flynn Peterson on ATRA's Latest Attack on Civil Justice Attorneys 2Health News:Queen Latifah Brings in the New Year with a Healthy Resolution 2Health News:Nation's Leading Dialysis Provider - DaVita - Partners with eDiets(R) to Launch One-of-a-Kind Diet Helper Online Nutrition and Meal Planning Tool for Late-Stage Kidney Disease Patients and Caregivers 2Health News:Nation's Leading Dialysis Provider - DaVita - Partners with eDiets(R) to Launch One-of-a-Kind Diet Helper Online Nutrition and Meal Planning Tool for Late-Stage Kidney Disease Patients and Caregivers 3Health News:Common molecule notifies immune system of prostate cancer 2Health News:Common molecule notifies immune system of prostate cancer 3Health News:Cranberries really are a miracle cure for women 2Health News:Cranberries really are a miracle cure for women 3
(Date:5/23/2013)... 23, 2013  The need to add tissue ... was highlighted prominently at the 108 th ... in San Diego.  According to SonaCare Medical, a ... (HIFU) technology, the need for image-guided technologies to ... to consider minimally invasive ablative treatments, was addressed ...
(Date:5/23/2013)... 2013  Every day, their baby stopped breathing, his collapsed ... April and Bryan Gionfriddo watched helplessly, ... "Quite a few doctors said he had a good ... April Gionfriddo , about her now 20-month-old son, Kaiba. ... we would take it and run with it." ...
(Date:5/23/2013)... BEDFORD, Mass. , May 23, 2013 /PRNewswire/ ... HOLX ), a leading developer, manufacturer and ... surgical products, with an emphasis on serving the ... first large-scale observational study in a U.S. clinical ... mammography technology (breast tomosynthesis) with conventional 2D mammography ...
Breaking Medicine Technology:Need for Image Guided Minimally Invasive Ablative Treatments Featured Prominently at American Urological Association (AUA) Annual Meeting 2Need for Image Guided Minimally Invasive Ablative Treatments Featured Prominently at American Urological Association (AUA) Annual Meeting 3Need for Image Guided Minimally Invasive Ablative Treatments Featured Prominently at American Urological Association (AUA) Annual Meeting 4Need for Image Guided Minimally Invasive Ablative Treatments Featured Prominently at American Urological Association (AUA) Annual Meeting 5Need for Image Guided Minimally Invasive Ablative Treatments Featured Prominently at American Urological Association (AUA) Annual Meeting 6Baby's life saved with groundbreaking 3D printed device from U-M that restored his breathing 2Baby's life saved with groundbreaking 3D printed device from U-M that restored his breathing 3Baby's life saved with groundbreaking 3D printed device from U-M that restored his breathing 4First Large-Scale Population-Based Study in the U.S. Shows Hologic's 3D Mammography (Breast Tomosynthesis) Significantly Reduces Recall Rates While Simultaneously Improving Cancer Detection 2First Large-Scale Population-Based Study in the U.S. Shows Hologic's 3D Mammography (Breast Tomosynthesis) Significantly Reduces Recall Rates While Simultaneously Improving Cancer Detection 3First Large-Scale Population-Based Study in the U.S. Shows Hologic's 3D Mammography (Breast Tomosynthesis) Significantly Reduces Recall Rates While Simultaneously Improving Cancer Detection 4
... 2011 International Isotopes Inc (OTC Bulletin Board: ... of the Company,s general business status, particularly, the year to ... to discuss progress of its ongoing plans for the depleted ... General Business Update. When: Wednesday, September ...
... LUTHERVILLE, Md., Sept. 12, 2011 The National ... nonprofit organization that facilitates cooperation between law enforcement, ... in the prevention and investigation of drug diversion ... to a survey by the Substance Abuse and ...
Cached Medicine Technology:International Isotopes Inc Announces Conference Call to Give an Update on the Company's General Business Status 2
IR Autoflow Single Chamber Water-Jacketed CO2 Incubator...
US Autoflow Single Chamber Stackable Water-Jacketed CO2/O2 Inc....
...
Listeria Enrichment Broth...
Medicine Products: