Navigation Links
New model of ALS is based on human cells from autopsied tissue
Date:8/11/2011

By isolating cells from patients' spinal tissue within a few days after death, researchers funded by the National Institutes of Health have developed a new model of the paralyzing disease amyotrophic lateral sclerosis (ALS). They found that during the disease, cells called astrocytes become toxic to nerve cells a result previously found in animal models but not in humans. The new model could be used to investigate many more questions about ALS, also known as Lou Gehrig's disease.

ALS can run in families, but in the majority of cases, it is sporadic, with no known cause. The researchers derived astrocytes from patients who had succumbed to either type of ALS, and found that the cells secrete toxic factors that cause nerve cells to degenerate. A similar mechanism has been found in mouse models of ALS.

"The mouse models capture a type of familial ALS that accounts for only 2 percent of all cases. The field has begged for new disease models that can provide a clear window into sporadic ALS," said senior author Brian Kaspar, Ph.D., an investigator at the Nationwide Children's Research Institute (NCRI) in Columbus, Ohio. His collaborators were Jerry Mendell, M.D., director of NCRI's Center for Gene Therapy, and Arthur Burghes, Ph.D., a professor of molecular and cellular biochemistry at Ohio State University in Columbus. Drs. Kaspar and Mendell also hold faculty positions at Ohio State.

The research is reported in Nature Biotechnology and was funded in part by NIH's National Institute of Neurological Disorders and Stroke (NINDS), including a $1.7 million stimulus grant made possible by the American Recovery and Reinvestment Act.

ALS is characterized by the death of motor neurons, which are muscle-controlling nerve cells in the spinal cord. As these neurons die, the body's voluntary muscles weaken and waste away. Death within five years of diagnosis is common. The only approved treatment, riluzole, extends life exp
'/>"/>

Contact: Daniel Stimson
stimsond@ninds.nih.gov
301-496-5751
NIH/National Institute of Neurological Disorders and Stroke
Source:Eurekalert

Page: 1 2 3 4

Related medicine news :

1. Celebrity Trainer and Super Fitness Model Jennifer Nicole Lee on HSN with #1 Secret Six Pack Abs Secret, Ab Circle Pro
2. Hunk Calendar Photographer Resurrects Erotic Male Modeling Club and Launches Provocative E-exhibition
3. Dolphins could be ideal model to study human cervical cancer, UF veterinarians say
4. David Anderson to discuss what model organisms can teach us about emotion
5. Rate Regulation for Health Insurance: Obama Administration Should Look to CAs Model Law Which Has Saved Drivers $62 Billion Since 1988
6. GE Healthcare, Intel and Mayo Clinic explore new models of health care delivery
7. Rapamycin rescues learning, memory in Alzheimers mouse model
8. Ghrelin mitigates liver fibrosis in animal models; regulates human fibrosis
9. A novel in vitro model for light-induced wound healing
10. Hard to Treat Diseases (HTDS) Collagenna Skin Care Business Model and Chilean Update
11. Choice of Derek H. Lee as Chief Financial and Corporate Development Officer Strengthens Talaris Advisors' Portfolio Design Business Model
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/3/2015)... Plano, Texas (PRWEB) June 03, 2015 ... Intelligence and Analytics solutions, today announced the launch ... Studio EXtensions (DSX) for SAP® BusinessObjects™ Design Studio. ... embed additional visualization capabilities and advanced functionalities into ... of the DSX suite, Visual BI is adding ...
(Date:6/3/2015)... 03, 2015 Sitting at a computer ... in the back, neck, shoulders and/or wrists. This can ... In addition, recent research links sitting for long periods ... diseases. Fortunately, three inventors from Oakville, Ontario, are offering ... desk. , They have developed a prototype for a ...
(Date:6/3/2015)... GA (PRWEB) June 03, 2015 Fourroux ... in Duluth, GA will celebrate its grand opening with ... , The first prosthetic center of its kind in ... their family unmatched care and outcomes through use of ... Watson, CPO & CEO of Fourroux Prosthetics, states, “Our ...
(Date:6/3/2015)... TX (PRWEB) June 03, 2015 ... independent freestanding emergency rooms in the United States, announced ... Potranco facility in late June. , “I am ... in Texas with a new facility in the San ... Director of First Choice Emergency Room. , First ...
(Date:6/3/2015)... 03, 2015 Foot and Ankle ... Casey Friske ( Clarksville Division ) was recently ... Symposium of Advanced Wound Care (SAWC) and the American ... Dan Davis. The Conference was held on April ... Center in San Antonio, TX. , Dr. Casey ...
Breaking Medicine News(10 mins):Health News:Visual BI Launches Second Release for its Design Studio EXtensions (DSX) for SAP® BusinessObjects™ Design Studio 2Health News:Visual BI Launches Second Release for its Design Studio EXtensions (DSX) for SAP® BusinessObjects™ Design Studio 3Health News:Adjustable Height Tabletop Unit Invented by Three InventHelp® Clients (TOR-9278) 2Health News:Fourroux Prosthetics Atlanta to Have Grand Opening Gala & Ribbon Cutting Ceremony 2Health News:First Choice Emergency Room to Open New Facility in San Antonio, Texas 2Health News:Foot and Ankle Specialists of the Mid-Atlantic, LLC Receives Award at the Spring 2015 Symposium of Advanced Wound Care Conference 2
... , SUNDAY, April 11 (HealthDay News) -- It,s easy to help ... according to the Alliance for a Healthier Generation. , For starters, ... active. And you can share the fun and health benefits, ... children to get on their bicycles, roller skates or blades and ...
... ... YHC magazine on April 25. , ... (Vocus) April 10, 2010 -- The Khanna institute to attend the YHC Health Expo ... CA 91361, , , , ,Khanna Institute of LASIK & Refractive surgery, an eye surgery ...
... ... York, announces the ten-year anniversary of his involvement with the Smiles for Life program. This ... directly to charities. , ... Lake, New York (Vocus) April 10, 2010 -- A dentist in a small community in ...
... ... send the equivalent of 10,000 laser targeted marketing postcards to all of your patient,s ... ... Traffic releases the easiest chiropractic marketing can be done right now in the ...
... ... presented by psychologist Paul G. Swingle, illustrates the use of neurotherapy in treating patients ... ADD, ADHD, epilepsy, stroke, learning disorders, traumatic brain injury, depression, fibromyalgia, and autistic spectrum ... ...
... ARBOR, Mich. Noting that the organization,s research "has touched ... nation," the National Cancer Institute (NCI) has renewed the Southwest ... funding package over that period expected to exceed $120 million. ... briefing by Group Executive Officer Anne F. Schott, M.D., and ...
Cached Medicine News:Health News:Khanna Institute of Vision and Your Health Connection Spring Expo 2Health News:Khanna Institute of Vision and Your Health Connection Spring Expo 3Health News:Ballston Lake Cosmetic Dentist Excited about 10th Year Participating in Smiles for Life Program 2Health News:Ballston Lake Cosmetic Dentist Excited about 10th Year Participating in Smiles for Life Program 3Health News:Chiropractic Traffic CEO Matt Prados Releases the Easiest and Fastest Free Chiropractic Marketing Method Known to Man 2Health News:Psychologist and Author Paul G. Swingle Talks about his Approach to Treating Depression and Mood Disorders in Online Forum 2Health News:Psychologist and Author Paul G. Swingle Talks about his Approach to Treating Depression and Mood Disorders in Online Forum 3Health News:SWOG cancer trials network awarded over $120 million in NCI grants 2
(Date:6/3/2015)... 3, 2015 According to ... Peripheral Vascular Devices Market (Embolic Protection, Chronic Total ... Grafts, IVC Filters, Stents, Balloons and Accessories) - ... Cardiology and Peripheral Vascular Devices Market is expected ... a CAGR of 7.4% from 2014 to 2019. ...
(Date:6/3/2015)... Conn. , June 3, 2015  SurgiQuest®, ... innovative access technologies for minimally invasive surgery (MIS) ... AirSeal® System in over 250,000 procedures.  Adoption has ... procedures over last year, driven by the company,s ... as well as geographic expansion to over 45 ...
(Date:6/3/2015)... PillPack, the pharmacy that simplifies medication management, today announced ... led by CRV with participation from Accel Partners, Atlas ... be used to fuel growth, accelerate the hiring of ... markets. "In the last two years, we,ve ... folks absolutely love," says TJ Parker, PharmD, CEO of ...
Breaking Medicine Technology:The Interventional Cardiology and Peripheral Vascular Devices Market Worth $26.72 Billion by 2019 2The Interventional Cardiology and Peripheral Vascular Devices Market Worth $26.72 Billion by 2019 3The Interventional Cardiology and Peripheral Vascular Devices Market Worth $26.72 Billion by 2019 4Rapid Procedure Growth With SurgiQuest's AirSeal System 2PillPack Raises $50 Million to Build Retail Footprint and Accelerate Growth 2PillPack Raises $50 Million to Build Retail Footprint and Accelerate Growth 3
... 15, 2010 Menicon Co., Ltd. has announced its ... for Optimed,s CAPTIV8 communication services and i-Vue content-driven digital ... obtained exclusive distribution rights for Optimed,s products in Japan ... ) "First of all, I would like ...
... PRINCETON, N.J., Nov. 15, 2010 BioWa, Inc. announced ... with Agensys, Inc., an affiliate of Tokyo based Astellas ... ® Technology platform for the purpose of identifying ... "We are extremely pleased about our Agreement with ...
Cached Medicine Technology:Menicon Expands Partnership with Optimed in North America 2BioWa Announces License of POTELLIGENT® Technology to Agensys 2
... protease secreted by the kidney, plays ... system. The renin-angiotensin system regulates blood ... retention by the kidney. Renin is ... including decreased intravascular volume and decreased ...
... polypeptide hormones which belong to the ... TGF- superfamily is a large group ... many aspects of development, reproductive function ... incude TGF-s, bone morphogenetic proteins, growth ...
... Human Insulin-like Growth Factor Binding Protein-1 ... the liver, which specifically binds and modulates ... The role of IGFBP-1 has not been ... regulation suggests that IGFBP-1 may be involved ...
... Human Insulin-like growth factor binding protein-2 ... (further IGFBPs have been proposed) which specifically ... and IGF-II. The binding affinity of IGFBP-2 ... higher than for IGF-I [1], suggesting a ...
Medicine Products: