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New model may simplify high-dose radiosurgery planning
Date:9/2/2010

ancers more quickly and make these high-dose therapies available to cancer patients much sooner, Mayr says.

Fractionated low-dose therapy causes cumulative damage to tumor cells during the many weeks of exposure, while causing minimal damage to hardier normal cells. Patients, however, must return repeatedly to the hospital for many weeks to complete their treatment.

High-dose therapy has become possible because of advances in computer and radiation technology. It uses multiple beams of radiation that conform tightly to a tumor's shape. They converge on the cancer to deliver higher total radiation levels, while sparing normal tissues. This kills more tumor cells per treatment, so far fewer treatments are needed overall.

The new study, published recently in the journal Science Translational Medicine, tested the gLQ Model in cell and animal models, and is expected to be evaluated soon in clinical trials.

"Our Generalized LQ Model determines appropriate radiation levels across the entire wide spectrum of doses, from low and high, and from many to very few treatments, which is a new approach," Mayr says.


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Contact: Darrell E. Ward
Darrell.Ward@osumc.edu
614-293-3737
Ohio State University Medical Center
Source:Eurekalert

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