Navigation Links
New model may simplify high-dose radiosurgery planning
Date:9/2/2010

COLUMBUS, Ohio There is yet no straightforward way to determine the optimal dose level and treatment schedules for high-dose radiation therapies such as stereotactic radiation therapy, used to treat brain and lung cancer, or for high-dose brachytherapy for prostate and other cancers.

Radiation oncologists at the Ohio State University Comprehensive Cancer Center-Arthur G. James Cancer Hospital and Richard J. Solove Research Institute (OSUCCC-James) may have solved the problem by developing a new mathematical model that encompasses all dose levels.

Typically, radiation therapy for cancer is given in daily, low doses spread over many weeks. Oncologists often calculate the schedules for these fractionated, low-dose treatment courses using a mathematical model called the linear-quadratic (LQ) Model. The same calculation model is used to evaluate radiation response, interpret clinical data and guide clinical trials.

"Unfortunately the LQ Model doesn't work well for high-dose radiation therapy," says co-author Dr. Nina Mayr, professor of radiation oncology at the OSUCCC-James. "Our study resolves this problem by modifying the current method to develop the Generalized LQ (gLQ) Model that covers all dose levels and schedules."

If verified clinically, the Generalized gLQ Model could guide the planning of dose and schedules needed for the newer radiosurgery and stereotactic radiation therapy and high-dose brachytherapy procedures that are increasingly used for cancer patients, she says.

"Developing proper radiation dose schedules for these promising high-dose treatments is very challenging," Mayr says. "Typically, it involves phase I dose-finding studies and a long, cumbersome process that allows only gradual progression from the pre-clinical and clinical trial stages to broader clinical practice."

The new gLQ Model could allow oncologists to design radiation dose schedules more efficiently, help researchers conduct clinical trials for specific cancers more quickly and make these high-dose therapies available to cancer patients much sooner, Mayr says.

Fractionated low-dose therapy causes cumulative damage to tumor cells during the many weeks of exposure, while causing minimal damage to hardier normal cells. Patients, however, must return repeatedly to the hospital for many weeks to complete their treatment.

High-dose therapy has become possible because of advances in computer and radiation technology. It uses multiple beams of radiation that conform tightly to a tumor's shape. They converge on the cancer to deliver higher total radiation levels, while sparing normal tissues. This kills more tumor cells per treatment, so far fewer treatments are needed overall.

The new study, published recently in the journal Science Translational Medicine, tested the gLQ Model in cell and animal models, and is expected to be evaluated soon in clinical trials.

"Our Generalized LQ Model determines appropriate radiation levels across the entire wide spectrum of doses, from low and high, and from many to very few treatments, which is a new approach," Mayr says.


'/>"/>

Contact: Darrell E. Ward
Darrell.Ward@osumc.edu
614-293-3737
Ohio State University Medical Center
Source:Eurekalert

Related medicine news :

1. Treatment for S. aureus skin infection works in mouse model
2. Rheumatoid arthritis signaling protein reverses Alzheimers disease in mouse model
3. Scientists develop the first model for investigating the origins of testicular cancer in humans
4. QualEDIx Announces the Launch of the Nation's Only Managed Service Model for HIPAA 5010 and ICD-10 Testing
5. Mathematical models for breast cancer detection with microwave tomography are cheaper and less risky
6. Cancer stem cells are not 1 size fits all, lung cancer models show
7. New research model of human prostate cancer shows cancer development
8. Mona Pearl On Growth Models - Past, Present and Future: Where do Middle Market Companies Go For Global Expansion Expertise?
9. Prize-winning budgeting model aims for more effective marketing spending
10. New model suggests feared side effect of Alzheimers drugs is unlikely
11. University of Pennsylvania: Contrary to popular models, sugar is not burned by self-control tasks
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/25/2016)... ... June 25, 2016 , ... Dr. Calvin Johnson has ... he has implemented orthobiologic procedures as a method for treating his patients. The ... first doctors to perform the treatment. Orthobiologics are substances that orthopaedic surgeons use ...
(Date:6/24/2016)... ... ... Those who have experienced traumatic events may suffer from a complex set of ... or alcohol abuse, as a coping mechanism. To avoid this pain and suffering, Serenity ... event. , Trauma sufferers tend to feel a range of emotions, from depression, guilt, ...
(Date:6/24/2016)... , ... June 24, 2016 , ... Global law firm ... 2016 Legal Elite. The attorneys chosen by their peers for this recognition are considered ... Seven Greenberg Traurig Shareholders received special honors as members of this year’s Legal Elite ...
(Date:6/24/2016)... Plano, TX (PRWEB) , ... June 24, 2016 , ... ... taking part in Genome magazine’s Code Talker Award, an essay contest in which patients ... for an award to be presented at the 2016 National Society of Genetic Counselors ...
(Date:6/24/2016)... Maryland (PRWEB) , ... June 24, 2016 , ... ... Angels is actively feeding the Frederick area economy by obtaining investment capital for ... over the past 2½ years that have already resulted in more than a ...
Breaking Medicine News(10 mins):
(Date:6/24/2016)... Research and Markets has announced the addition of ... report to their offering. ... The World Market for Companion Diagnostics covers the world market ... the report includes the following: , World ... Region (N. America, EU, ROW), 2015-2020 , World IVD ...
(Date:6/24/2016)... Tenn. , June 24, 2016  Arkis ... providing less invasive and more durable cerebrospinal fluid ... in funding.  The Series-A funding is led by ... Lighthouse Fund, and other private investors.  Arkis, new ... neurosurgical instrumentation and the market release of its ...
(Date:6/23/2016)... Research and Markets has announced ... Type (Organic Chemical (Sugar, Petrochemical, Glycerin), Inorganic Chemical), Functionality ... - Global Forecast to 2021" report to their ... global pharmaceutical excipients market is projected to reach USD ... in the forecast period 2016 to 2021. ...
Breaking Medicine Technology: