Navigation Links
New model may simplify high-dose radiosurgery planning

COLUMBUS, Ohio There is yet no straightforward way to determine the optimal dose level and treatment schedules for high-dose radiation therapies such as stereotactic radiation therapy, used to treat brain and lung cancer, or for high-dose brachytherapy for prostate and other cancers.

Radiation oncologists at the Ohio State University Comprehensive Cancer Center-Arthur G. James Cancer Hospital and Richard J. Solove Research Institute (OSUCCC-James) may have solved the problem by developing a new mathematical model that encompasses all dose levels.

Typically, radiation therapy for cancer is given in daily, low doses spread over many weeks. Oncologists often calculate the schedules for these fractionated, low-dose treatment courses using a mathematical model called the linear-quadratic (LQ) Model. The same calculation model is used to evaluate radiation response, interpret clinical data and guide clinical trials.

"Unfortunately the LQ Model doesn't work well for high-dose radiation therapy," says co-author Dr. Nina Mayr, professor of radiation oncology at the OSUCCC-James. "Our study resolves this problem by modifying the current method to develop the Generalized LQ (gLQ) Model that covers all dose levels and schedules."

If verified clinically, the Generalized gLQ Model could guide the planning of dose and schedules needed for the newer radiosurgery and stereotactic radiation therapy and high-dose brachytherapy procedures that are increasingly used for cancer patients, she says.

"Developing proper radiation dose schedules for these promising high-dose treatments is very challenging," Mayr says. "Typically, it involves phase I dose-finding studies and a long, cumbersome process that allows only gradual progression from the pre-clinical and clinical trial stages to broader clinical practice."

The new gLQ Model could allow oncologists to design radiation dose schedules more efficiently, help researchers conduct clinical trials for specific cancers more quickly and make these high-dose therapies available to cancer patients much sooner, Mayr says.

Fractionated low-dose therapy causes cumulative damage to tumor cells during the many weeks of exposure, while causing minimal damage to hardier normal cells. Patients, however, must return repeatedly to the hospital for many weeks to complete their treatment.

High-dose therapy has become possible because of advances in computer and radiation technology. It uses multiple beams of radiation that conform tightly to a tumor's shape. They converge on the cancer to deliver higher total radiation levels, while sparing normal tissues. This kills more tumor cells per treatment, so far fewer treatments are needed overall.

The new study, published recently in the journal Science Translational Medicine, tested the gLQ Model in cell and animal models, and is expected to be evaluated soon in clinical trials.

"Our Generalized LQ Model determines appropriate radiation levels across the entire wide spectrum of doses, from low and high, and from many to very few treatments, which is a new approach," Mayr says.


Contact: Darrell E. Ward
Ohio State University Medical Center

Related medicine news :

1. Treatment for S. aureus skin infection works in mouse model
2. Rheumatoid arthritis signaling protein reverses Alzheimers disease in mouse model
3. Scientists develop the first model for investigating the origins of testicular cancer in humans
4. QualEDIx Announces the Launch of the Nation's Only Managed Service Model for HIPAA 5010 and ICD-10 Testing
5. Mathematical models for breast cancer detection with microwave tomography are cheaper and less risky
6. Cancer stem cells are not 1 size fits all, lung cancer models show
7. New research model of human prostate cancer shows cancer development
8. Mona Pearl On Growth Models - Past, Present and Future: Where do Middle Market Companies Go For Global Expansion Expertise?
9. Prize-winning budgeting model aims for more effective marketing spending
10. New model suggests feared side effect of Alzheimers drugs is unlikely
11. University of Pennsylvania: Contrary to popular models, sugar is not burned by self-control tasks
Post Your Comments:
(Date:11/25/2015)... ... November 25, 2015 , ... The ... perfect dish and pleasing the palates of attendees is of the utmost importance. ... to a seasonal get-together, give these recipes a try this holiday season. , ...
(Date:11/25/2015)... Nairobi (PRWEB) , ... November 26, 2015 , ... ... African Union Commission (AUC), European Union (EU), ANDI Pan African Centres of Excellence, ... Nations Office in Nairobi (UNON) for the opening of the 5th African Network ...
(Date:11/25/2015)... ... November 25, 2015 , ... Dental professionals who would like ... , are invited to attend Dr. Mark Iacobelli’s Advanced Implant Mentoring (AIM) CE course. ... OH. , As the co-founders of Advanced Implant Mentoring (AIM), Dr. Iacobelli and ...
(Date:11/25/2015)... (PRWEB) , ... November 25, 2015 , ... Smiles ... of TMJ Disorder, Bruxism, and moderate facial wrinkling. While many patients are aware of ... of the great success Botox® delivers to those suffering with discomfort, soreness, and pain ...
(Date:11/25/2015)... ... , ... “While riding the bus, I saw a passenger in a wheelchair ... to be a convenient and comfortable way to protect them from bad weather, so ... safely travel during cold or inclement weather. In doing so, it ensures that the ...
Breaking Medicine News(10 mins):
(Date:11/25/2015)... , Nov. 25, 2015  Linden Care, LLC, a ... treatment outcomes for patients suffering from chronic pain, said ... a Temporary Restraining Order (TRO) enjoining Express Scripts from ... companies. --> --> ... of its legal options. --> ...
(Date:11/25/2015)... AVIV, Israel , November 25, 2015 ... (NASDAQ: KTOV ) (TASE: KTOV), a biopharmaceutical company ... simultaneous treatment of various clinical conditions, today announced the ... 3,158,900 American Depository Shares ( ADSs ), each representing ... purchase up to 3,158,900 ADSs. The ADSs and warrants ...
(Date:11/25/2015)... , Nov. 25, 2015 Endo International plc (NASDAQ: ... De Silva , President and CEO, will discuss corporate updates ... in New York on Wednesday, December ... . Click on Investor Relations, and then the link to ... the presentation,s start time to visit the site and download ...
Breaking Medicine Technology: