Navigation Links
New model for studying germ cell tumors in testes enlists embryonic stem cells
Date:7/11/2011

Tampa, Fla. (July 11, 2011) A team of researchers from Spain and Switzerland have developed a new model for studying the development of testicular germ cell tumors by transplanting embryonic stem cells into the seminiferous tubules in mouse models, resulting in the development of testicular germ cell tumors (TGCT) that mimic the early stages of TGCT development. The study, published in Cell Transplantation (20:5), is now freely available on-line at http://www.ingentaconnect.com/content/cog/ct/.

"Over the last fifteen years, cell transplantation into seminiferous tubules has become a valuable tool for studying germinal cell biology," said the study's corresponding author Dr. Juan Arechaga of the University of Basque Country, Spain. "The blood-testes permeability barrier establishes a sealed compartment that protects against influences such as immunological rejection. Thus, our lab has developed a tumor assay to study the cancer invasion process in testicular germ cell tumors using embryonic stem cells injected into the seminiferous tubules."

According to Dr. Arechaga, the tumors generated by the transplantation of early embryos possess gene expressions and differentiation patterns similar to those in testicular germ cell tumors.

The researchers point out that testicular germ cell tumors are uncommon in non-human animals, so there have been no previously suitable animal models for study. However these tumors appear to be genetically regulated and the specific genes related to the development of this kind of tumor have been identified.

"Embryonic stem cell transplantation into mouse seminiferous tubules represents a model with very valuable potential applications because it mimics the pre-invasive state of TGCTs," said Dr. Arechaga. "Donor cells can be transfected with different transgenes before transplantation to evaluate certain genes during the invasive process."

The authors also note that the approach could also be useful in screening novel therapeutic drugs, including inhibitors of angiogenesis and metastasis, to potentially treat TGCTs.

"This study demonstrates the development of an animal model of testicular germ cell tumor formation" said Dr. David Eve, associate editor of Cell Transplantation and Instructor at the Center of Excellence for Aging and Brain Repair, University of South Florida. "Study of this model will further our understanding of how testicular cancers arise and potential ways to treat it."


'/>"/>

Contact: David Eve
celltransplantation@gmail.com
Cell Transplantation Center of Excellence for Aging and Brain Repair
Source:Eurekalert

Related medicine news :

1. Canadas Cancer Risk Management model is an important new health tool for policymakers
2. New breast cancer risk model quantifies the impact of risk reduction
3. Stem cell model offers clues to cause of inherited ALS
4. New book shines light on French versus British models of humanitarian aid
5. Teens look to parents more than friends for sexual role models
6. Internal bleeding higher with popular heart device than earlier model
7. Scientists create humanized mouse model for hepatitis C
8. Using simulation to model the implementation of electronic health records
9. Breaking the fracture cycle through effective and coordinated models of care
10. Pitt researchers build a better mouse model to study depression
11. New model taps tiny, common tropical fish for large-scale drug screening to combat Cushing disease
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/29/2016)... ... April 29, 2016 , ... World Patent Marketing ... an exercise invention which aids in proper muscle development. , "The Gym & ... Creative Director of World Patent Marketing. "Globalization has threatened the future growth of ...
(Date:4/29/2016)... , ... April 29, 2016 , ... Dr. Robert Mondavi, ... treatments to improve smiles. Cosmetic dentistry is a fast-growing field as more patients are ... allows patients to learn more about the options currently available to them and which ...
(Date:4/29/2016)... ... April 29, 2016 , ... For those who skip meals occasionally (which ... That was among the many new lifestyle diet tips offered by nutritionists Pam Bonney ... Power of Water® radio show. Bonny and Lawrence noted that because proper nutrition, including ...
(Date:4/29/2016)... Fla. (PRWEB) , ... April 29, 2016 , ... ... Journal’s Best Places to Work employee satisfaction survey, earning them second place for Tampa’s ... businesses with 25-49 employees. , “This is a great accomplishment for our team,” ...
(Date:4/29/2016)... CA (PRWEB) , ... April 29, 2016 , ... Nike ... long softball camp from July 24th – 27th for girls aged 10-18. All facets ... is held at the beautiful Clark V. Whited Complex, one of the finest softball ...
Breaking Medicine News(10 mins):
(Date:4/29/2016)... 29, 2016 Glycotope GmbH, a ... announces the appointment of Dr. Alfredo Zurlo ... an oncologist with many years clinical experience and a ... His last role was at Mologen AG where he ... Board. Previously Dr. Zurlo held various positions at F ...
(Date:4/28/2016)... 2016  While Abbott,s announced purchase of St. ... repair and stent business, healthcare research firm Kalorama ... firmly into patient monitoring.  Kalorama said that patient ... areas, with double-digit growth expected the next 5 ... Remote Patient Monitoring . Abbott Laboratories agreed ...
(Date:4/28/2016)... TOKYO , April 28, 2016 /PRNewswire/ ... Ahuja , George Phillips und ... wachsenden Unternehmens    ArisGlobal®, ein ... Life Sciences, gab heute bekannt, dass neue ... wachsenden Unternehmens gestoßen sind, die vielfältige Erfahrungen ...
Breaking Medicine Technology: