Navigation Links
New model for studying germ cell tumors in testes enlists embryonic stem cells
Date:7/11/2011

Tampa, Fla. (July 11, 2011) A team of researchers from Spain and Switzerland have developed a new model for studying the development of testicular germ cell tumors by transplanting embryonic stem cells into the seminiferous tubules in mouse models, resulting in the development of testicular germ cell tumors (TGCT) that mimic the early stages of TGCT development. The study, published in Cell Transplantation (20:5), is now freely available on-line at http://www.ingentaconnect.com/content/cog/ct/.

"Over the last fifteen years, cell transplantation into seminiferous tubules has become a valuable tool for studying germinal cell biology," said the study's corresponding author Dr. Juan Arechaga of the University of Basque Country, Spain. "The blood-testes permeability barrier establishes a sealed compartment that protects against influences such as immunological rejection. Thus, our lab has developed a tumor assay to study the cancer invasion process in testicular germ cell tumors using embryonic stem cells injected into the seminiferous tubules."

According to Dr. Arechaga, the tumors generated by the transplantation of early embryos possess gene expressions and differentiation patterns similar to those in testicular germ cell tumors.

The researchers point out that testicular germ cell tumors are uncommon in non-human animals, so there have been no previously suitable animal models for study. However these tumors appear to be genetically regulated and the specific genes related to the development of this kind of tumor have been identified.

"Embryonic stem cell transplantation into mouse seminiferous tubules represents a model with very valuable potential applications because it mimics the pre-invasive state of TGCTs," said Dr. Arechaga. "Donor cells can be transfected with different transgenes before transplantation to evaluate certain genes during the invasive process."

The authors also note that the approach could also be useful in screening novel therapeutic drugs, including inhibitors of angiogenesis and metastasis, to potentially treat TGCTs.

"This study demonstrates the development of an animal model of testicular germ cell tumor formation" said Dr. David Eve, associate editor of Cell Transplantation and Instructor at the Center of Excellence for Aging and Brain Repair, University of South Florida. "Study of this model will further our understanding of how testicular cancers arise and potential ways to treat it."


'/>"/>

Contact: David Eve
celltransplantation@gmail.com
Cell Transplantation Center of Excellence for Aging and Brain Repair
Source:Eurekalert

Related medicine news :

1. Canadas Cancer Risk Management model is an important new health tool for policymakers
2. New breast cancer risk model quantifies the impact of risk reduction
3. Stem cell model offers clues to cause of inherited ALS
4. New book shines light on French versus British models of humanitarian aid
5. Teens look to parents more than friends for sexual role models
6. Internal bleeding higher with popular heart device than earlier model
7. Scientists create humanized mouse model for hepatitis C
8. Using simulation to model the implementation of electronic health records
9. Breaking the fracture cycle through effective and coordinated models of care
10. Pitt researchers build a better mouse model to study depression
11. New model taps tiny, common tropical fish for large-scale drug screening to combat Cushing disease
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/19/2017)... ... February 19, 2017 , ... ... connected home healthcare, will join forces with Healthwise ® at HIMSS ... Healthwise, the industry leader in evidence-based health education, technology and services, will demonstrate ...
(Date:2/18/2017)... ... February 17, 2017 , ... Focused start-ups, not traditional health ... according to the recent NEJM Catalyst Insights Report on the New Marketplace. ... Insights Council, a qualified group of U.S. executives, clinical leaders, and clinicians at ...
(Date:2/18/2017)... ... February 17, 2017 , ... CONTACT:, Glenn ... Beverly Hills plastic surgeon Dr. Glenn Vallecillos experiments SculpSure, the hot, ... "Traditionally, plastic surgery has been centered around that idea that to achieve ones ...
(Date:2/18/2017)... ... February 18, 2017 , ... ProParagraph Fashion Volume 2 features ... ProParagraph Fashion Volume 2 for all multi-line FCPX project needs. Great for ... and choose from hand-crafted trend-setting designs with smooth animations that will add stylistic ...
(Date:2/17/2017)... ... February 17, 2017 , ... Smiles by Seese is a ... Davidson, NC. Dr. Brian Seese leads the practice as a skilled and highly credentialed ... roof. Smiles by Seese serves patients of all ages with excellence in general, restorative, ...
Breaking Medicine News(10 mins):
(Date:2/17/2017)... , Feb. 17, 2017  Perrigo Company plc (NYSE, TASE: ... U.S. Food and Drug Administration for hydrocodone bitartrate and homatropine ... Hydrocodone bitartrate and homatropine methylbromide oral solution ... the symptomatic relief of cough in adults and children 6 ... months ending January 2017 were approximately $16 million.   ...
(Date:2/17/2017)... Feb. 17, 2017   FormFast , the leader ... new partnership with Engage , one of the ... . FormFast will serve as the forms automation ... with MEDITECH .  FormFast is ... to complement and enhance the electronic health record. FormFast,s ...
(Date:2/16/2017)... Pa. , Feb. 16, 2017 Absorption ... biologics, and medical devices, is pleased to announce that ... has been selected as a winner of the 2017 ... SmartCEO Magazine and recognizes driven executives for their ... work ethic. The awards ceremony and celebration is on ...
Breaking Medicine Technology: