Navigation Links
New model for studying germ cell tumors in testes enlists embryonic stem cells
Date:7/11/2011

Tampa, Fla. (July 11, 2011) A team of researchers from Spain and Switzerland have developed a new model for studying the development of testicular germ cell tumors by transplanting embryonic stem cells into the seminiferous tubules in mouse models, resulting in the development of testicular germ cell tumors (TGCT) that mimic the early stages of TGCT development. The study, published in Cell Transplantation (20:5), is now freely available on-line at http://www.ingentaconnect.com/content/cog/ct/.

"Over the last fifteen years, cell transplantation into seminiferous tubules has become a valuable tool for studying germinal cell biology," said the study's corresponding author Dr. Juan Arechaga of the University of Basque Country, Spain. "The blood-testes permeability barrier establishes a sealed compartment that protects against influences such as immunological rejection. Thus, our lab has developed a tumor assay to study the cancer invasion process in testicular germ cell tumors using embryonic stem cells injected into the seminiferous tubules."

According to Dr. Arechaga, the tumors generated by the transplantation of early embryos possess gene expressions and differentiation patterns similar to those in testicular germ cell tumors.

The researchers point out that testicular germ cell tumors are uncommon in non-human animals, so there have been no previously suitable animal models for study. However these tumors appear to be genetically regulated and the specific genes related to the development of this kind of tumor have been identified.

"Embryonic stem cell transplantation into mouse seminiferous tubules represents a model with very valuable potential applications because it mimics the pre-invasive state of TGCTs," said Dr. Arechaga. "Donor cells can be transfected with different transgenes before transplantation to evaluate certain genes during the invasive process."

The authors also note that the approach could also be useful in screening novel therapeutic drugs, including inhibitors of angiogenesis and metastasis, to potentially treat TGCTs.

"This study demonstrates the development of an animal model of testicular germ cell tumor formation" said Dr. David Eve, associate editor of Cell Transplantation and Instructor at the Center of Excellence for Aging and Brain Repair, University of South Florida. "Study of this model will further our understanding of how testicular cancers arise and potential ways to treat it."


'/>"/>

Contact: David Eve
celltransplantation@gmail.com
Cell Transplantation Center of Excellence for Aging and Brain Repair
Source:Eurekalert

Related medicine news :

1. Canadas Cancer Risk Management model is an important new health tool for policymakers
2. New breast cancer risk model quantifies the impact of risk reduction
3. Stem cell model offers clues to cause of inherited ALS
4. New book shines light on French versus British models of humanitarian aid
5. Teens look to parents more than friends for sexual role models
6. Internal bleeding higher with popular heart device than earlier model
7. Scientists create humanized mouse model for hepatitis C
8. Using simulation to model the implementation of electronic health records
9. Breaking the fracture cycle through effective and coordinated models of care
10. Pitt researchers build a better mouse model to study depression
11. New model taps tiny, common tropical fish for large-scale drug screening to combat Cushing disease
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/13/2017)... (PRWEB) , ... October 13, 2017 , ... “The Journey: ... faced every danger possible to save lost souls in the Philippines. “The Journey: From ... Carole is a dedicated teacher of the Bible. She has taught all ages and ...
(Date:10/12/2017)... ... October 12, 2017 , ... CitiDent ... sleep apnea using cutting-edge Oventus O2Vent technology. As many as 18 million ... by frequent cessation in breathing. Oral appliances can offer significant relief to about ...
(Date:10/12/2017)... Fla. (PRWEB) , ... October 12, 2017 , ... IsoComforter, ... therapy products, announced today the introduction of an innovative new design of the shoulder ... pad so you get maximum comfort while controlling your pain while using cold therapy. ...
(Date:10/12/2017)... ... October 12, 2017 , ... Information about the ... to develop to enable prevention of a major side effect of chemotherapy in ... in pediatric patients. For cisplatin, hearing loss is FDA listed on-label as a ...
(Date:10/12/2017)... , ... October 12, 2017 , ... Leading pediatric oncology ... in Washington, D.C., for the 49th Congress of the International Society of Paediatric ... President of the Center for Cancer and Blood Disorders at Children’s National, ...
Breaking Medicine News(10 mins):
(Date:10/4/2017)... Oct. 4, 2017  South Korean-based healthcare product Development ... aide "cprCUBE" on Kickstarter. The device will educate the ... arrests with better efficiency compared to the dated and ... feedback on efficacy of the compression for a more ... a goal to raise $5,000. ...
(Date:10/2/2017)... Oct. 2, 2017  AllianceRx Walgreens Prime, the combined ... Walgreens and pharmacy benefit manager Prime Therapeutics LLC (Prime), ... which included the unveiling of new signage at its ... well as at a few other company-owned facilities across ... to patients, some of whom will begin to see ...
(Date:9/27/2017)... their devotion to personalized service, SMP Pharmacy Solutions announces their ... South Florida Business Journal,s 50 Fastest-Growing Companies, and listed for ... specialty pharmacy has found its niche.  To that end, the ... by SFBJ as the 2017 Power Leader in Health Care. ... award in October, Bardisa said of the three achievements, "It,s ...
Breaking Medicine Technology: