Navigation Links
New model for studying germ cell tumors in testes enlists embryonic stem cells
Date:7/11/2011

Tampa, Fla. (July 11, 2011) A team of researchers from Spain and Switzerland have developed a new model for studying the development of testicular germ cell tumors by transplanting embryonic stem cells into the seminiferous tubules in mouse models, resulting in the development of testicular germ cell tumors (TGCT) that mimic the early stages of TGCT development. The study, published in Cell Transplantation (20:5), is now freely available on-line at http://www.ingentaconnect.com/content/cog/ct/.

"Over the last fifteen years, cell transplantation into seminiferous tubules has become a valuable tool for studying germinal cell biology," said the study's corresponding author Dr. Juan Arechaga of the University of Basque Country, Spain. "The blood-testes permeability barrier establishes a sealed compartment that protects against influences such as immunological rejection. Thus, our lab has developed a tumor assay to study the cancer invasion process in testicular germ cell tumors using embryonic stem cells injected into the seminiferous tubules."

According to Dr. Arechaga, the tumors generated by the transplantation of early embryos possess gene expressions and differentiation patterns similar to those in testicular germ cell tumors.

The researchers point out that testicular germ cell tumors are uncommon in non-human animals, so there have been no previously suitable animal models for study. However these tumors appear to be genetically regulated and the specific genes related to the development of this kind of tumor have been identified.

"Embryonic stem cell transplantation into mouse seminiferous tubules represents a model with very valuable potential applications because it mimics the pre-invasive state of TGCTs," said Dr. Arechaga. "Donor cells can be transfected with different transgenes before transplantation to evaluate certain genes during the invasive proce
'/>"/>

Contact: David Eve
celltransplantation@gmail.com
Cell Transplantation Center of Excellence for Aging and Brain Repair
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Canadas Cancer Risk Management model is an important new health tool for policymakers
2. New breast cancer risk model quantifies the impact of risk reduction
3. Stem cell model offers clues to cause of inherited ALS
4. New book shines light on French versus British models of humanitarian aid
5. Teens look to parents more than friends for sexual role models
6. Internal bleeding higher with popular heart device than earlier model
7. Scientists create humanized mouse model for hepatitis C
8. Using simulation to model the implementation of electronic health records
9. Breaking the fracture cycle through effective and coordinated models of care
10. Pitt researchers build a better mouse model to study depression
11. New model taps tiny, common tropical fish for large-scale drug screening to combat Cushing disease
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/30/2014)... As the economy continues to recover ... style bathrooms and in-home fitness centers, the North ... in interest not only in designing and installing saunas ... benefits of sauna. Through working with manufacturers across ... Sauna Society provides a strong knowledge base of Finnish ...
(Date:8/30/2014)... 2014 UWDress.com, a distinguished wedding dress supplier, ... first range of fashionable outfits. Recently, the company has unveiled ... As an autumn special offer, all these brand new products ... , “We are excited to unveil the new and ... high quality products are available at low prices now. The ...
(Date:8/30/2014)... 2014 Recently, Skmen.com, a well-known clothing ... casual dresses . Before the middle of September, all ... discounted price, from 15 to 30 percent off. ... long casual outfits are carefully made and come with ... for the wearers. Skmen.com is popular for its fashionable, ...
(Date:8/30/2014)... Patients suffering from vitiligo can now discover a ... published by Daily Gossip. , Vitiligo is a ... no wonder that numerous sufferers search for an alternative ... one of the most appreciated such methods at the ... the spread of this disorder immediately, while completely curing ...
(Date:8/30/2014)... 30, 2014 The term nutraceuticals ... Pharameuticals. Nutraceuticals is a source of healthy-dietary supplements ... natural food sources. Nutraceutical ingredients have certain curative ... human body. Nutraceutical health products include factors such ... and more. Although nature is the most bountiful ...
Breaking Medicine News(10 mins):Health News:As Interest in Saunas Increases, the North American Sauna Society Increases Outreach to Provide Education on History, Design, and Culture 2Health News:UWDress.com’s Beautiful Collection Of “Flowy Bridesmaid Dresses” Released 2Health News:Huge Deals On 2014 Long Casual Dresses Unveiled By Skmen.com 2Health News:Natural Vitiligo Treatment Review Exposes Fast Method for Skin Repigmentation 2Health News:A Granular Analysis of the Nutraceutical Ingredients Market by Transparency Market Research 2Health News:A Granular Analysis of the Nutraceutical Ingredients Market by Transparency Market Research 3Health News:A Granular Analysis of the Nutraceutical Ingredients Market by Transparency Market Research 4
... SHENZHEN, China, Feb. 13 /PRNewswire-Asia/ -- Winner Medical Group Inc.,(OTC ... financial results for the first quarter ended December 31,2008. The ... with,the United States Securities and Exchange Commission. , , ... Total net sales revenue increased by 33.14% over the first ...
... the University of Brighton Medical School has chosen a Mecmesin MultiTest ... orthopaedic prosthesis for shoulder reconstruction. , ... Slinfold, West ... orthopaedic surgeon at the University of Brighton Medical School has chosen ...
... share most of their genes, including 70 percent of ... remarkable evolutionary conservation, researchers at the Salk Institute for ... model for an innovative study of gliomas, the most ... disease but we still know very little about the ...
... 44%, researchers say , , THURSDAY, Feb. 12 (HealthDay News) ... much as a 44 percent increased risk of developing ... has established a connection between smoking and increased risk ... the largest review to date showing a link between ...
... Feb. 12 Biotel Inc.,(OTC Bulletin Board: BTEL) announced ... net earnings of $289,000, or $0.10 per diluted share,on ... $206,000, or $0.07,per diluted share, on revenues of $2,859,000 ... months ended December 31, 2008, Biotel had net earnings ...
... The Pennsylvania Department of Health has reviewed and ... Hospital in Brownsville, Fayette County, which ceased operations ... have been relocated to other facilities. All hospital ... work, assisted with the patient transfer.Local ambulances and ...
Cached Medicine News:Health News:Winner Medical Reports First Quarter Fiscal 2009 Results 2Health News:Winner Medical Reports First Quarter Fiscal 2009 Results 3Health News:Winner Medical Reports First Quarter Fiscal 2009 Results 4Health News:Winner Medical Reports First Quarter Fiscal 2009 Results 5Health News:Winner Medical Reports First Quarter Fiscal 2009 Results 6Health News:Winner Medical Reports First Quarter Fiscal 2009 Results 7Health News:Winner Medical Reports First Quarter Fiscal 2009 Results 8Health News:Winner Medical Reports First Quarter Fiscal 2009 Results 9Health News:Winner Medical Reports First Quarter Fiscal 2009 Results 10Health News:Force Tester Shoulders The Burden 2Health News:Fruit flies soar as lab model, drug screen for the deadliest of human brain cancers 2Health News:Fruit flies soar as lab model, drug screen for the deadliest of human brain cancers 3Health News:Secondhand Smoke Linked to Dementia 2Health News:Biotel Announces Profitable Second Quarter Ended December 31, 2008 2
(Date:8/29/2014)... , Aug. 29, 2014 Research ... "Global Multiple Sclerosis Drugs Market 2014-2018" report ... a chronic, inflammatory medical condition that results in demyelination, ... because of an abnormal response by the immune system, ... It is a potentially debilitating disease in which the ...
(Date:8/29/2014)... -- Pixcelldata, the innovative Irish developer of ... major new deal with Dutch based eX-Path, global providers ... Marius Nap . The announcement was ... Pathology which is taking placing between August 30th and ... where Pixcelldata will demonstrate its innovative solution. ...
(Date:8/28/2014)...  Rigrodsky & Long, P.A.: , Do you, ... LCI )? , Did you purchase your shares before ... 2014, inclusive? , Did you lose money in your ... to discuss your rights? Rigrodsky & ... Timothy J. MacFall , announces that a complaint has been filed ...
Breaking Medicine Technology:Global Multiple Sclerosis Drugs Market 2014-2018: Key Vendors are Bayer, Biogen Idec, Merck Serono, Novartis and Teva Pharmaceutical 2Global Multiple Sclerosis Drugs Market 2014-2018: Key Vendors are Bayer, Biogen Idec, Merck Serono, Novartis and Teva Pharmaceutical 3Pixcelldata Announces New Deal with Dutch Tele-Pathology Specialists eX-Path Ahead of ECP 2014 2Rigrodsky & Long, P.A. Announces A Securities Fraud Class Action Lawsuit Has Been Filed Against Lannett Company, Inc. 2Rigrodsky & Long, P.A. Announces A Securities Fraud Class Action Lawsuit Has Been Filed Against Lannett Company, Inc. 3
... is based on SIREMOBIL Iso-C, the first ... the intra-operative 3D-Mode, the 3D-dataset is immediately ... orbital movement. This allows the surgeon to ... during the procedure. This 3D capability is ...
... Humphrey Field Analyzer II-i series is a ... the patient's visual field. ,By using SITA, ... is reduced by up to 70%. ,A ... ergonomic design to increase patient comfort while ...
... an innovative device designed to be a ... abdominal aortic aneurysms (AAA). It is constructed ... an outer self-expanding Nitinol support structure to ... The function of the endoprosthesis is to ...
... a cast from an arm or leg can ... cut or burned by the cast saw blade. ... remove any cast with confidence. This innovative, cut-resistant ... burns from the cast saw and can be ...
Medicine Products: