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New model accurately predicts who will develop deadly form of dengue fever
Date:2/16/2012

ere shown to be predictive of DHF: tropomysin, complement 4A, immunoglobin G, fibrinogen and three forms of albumin.

Further analysis indicated that any single protein would be a poor differentiator between DF and DHF, but together the proteins were 100 percent accurate in classifying the infection.

"We've proved it is feasible to identify predictive proteins associated with DHF," said Brasier. "If future research bears out these candidate proteins as firm predictors of DHF, doctors can act early to save lives the highest hope for personalized medicine."

He added that larger validation studies will be needed to verify these findings and analyze the biological pathways affected in DHF. Most of the candidate proteins identified can be linked to the biological processes underlying DHF, including cytokine storm, capillary leakage, hepatic injury and antibody consumption, suggesting that these predictors may have biological relevance.


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Contact: Olivia Goodman
olivia.goodman@gabbe.com
University of Texas Medical Branch at Galveston
Source:Eurekalert

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