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New model accurately predicts who will develop deadly form of dengue fever
Date:2/16/2012

nalyses using laboratory assays that are commonly available, including in resource-poor clinics, and more complex profiling techniques to identify specific candidate protein biomarkers.

They found that the cytokine IL-10 (a protein involved in the immune response) and reduced platelet and lymphocyte counts were key predictors of DHF. Further investigation showed that the most accurate model for predicting DHF effective in 100 percent of the cases studied was based on IL-10 and seven distinct proteins (tropomyosin, complement 4A, immunoglobin G, fibrinogen and three forms of albumin).

"Until now, biomarkers of the disease have proved elusive. But proteomics technologies are changing the landscape and these studies are the first step toward a personalized approach to treating dengue infection," said Brasier.

For each study, the UTMB Proteomics Center team collaborated with the U.S. Naval Medical Research Unit and practicing physicians in clinics and hospitals in Maracay, Venezuela. Approximately 55 study subjects with acute dengue infection provided blood samples and observed for clinical outcome. The researchers analyzed gender; clinical signs (e.g., days of fever, diarrhea); laboratory measurements (lymphocyte/platelet counts, hemoglobin concentration, red blood cell count); and cytokine concentrations.

Looking first at the most accessible laboratory and clinical data points, they found that increased concentrations of IL-10, reduced platelet counts and, to a slightly lesser extent, reduced lymphocyte counts are major informative features of DHF accurately predicting the disease in 86 percent of cases.

Next, multidimensional protein profiling a more complex and in-depth proteomics analysis was used to measure cytokines that have been associated with DHF in other studies. The researchers again identified IL-10 as a significant determining factor between DF and DHF. Additionally, seven proteins (out of 42 studied) w
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Contact: Olivia Goodman
olivia.goodman@gabbe.com
University of Texas Medical Branch at Galveston
Source:Eurekalert

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