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New microscopy tracks molecules in live tissue at video rate
Date:12/2/2010

CAMBRIDGE, Mass. -- A novel type of biomedical imaging, made possible by new advances in microscopy from scientists at Harvard University, is so fast and sensitive it can capture "video" of blood cells squeezing through capillaries.

Researchers led by Harvard's Brian G. Saar, Christian W. Freudiger, and X. Sunney Xie describe the work this week in the journal Science.

The new technique, based on stimulated Raman scattering (SRS), makes a complementary partner to MRI, widely used to capture static images of organs, tumors, and other large structures. For the first time, SRS microscopy makes possible label-free chemical movies, with streaming footage at the subcellular level, catching video of proteins, lipids, and water within cells.

"When we started this project 11 years ago, we never imagined we'd have an amazing result like this," says Xie, professor of chemistry and chemical biology at Harvard. "It took MRI more than 30 years to reach patients, but we're already looking forward with great anticipation to applications of SRS microscopy in hospitals. It's now clear that stimulated Raman scattering will play an important role in the future of biological imaging and medical diagnostics."

Xie says SRS microscopy could aid, and speed, surgery to remove tumors and other lesions. Surgeons must now send excised samples for histological analysis -- a process that takes about 20 minutes -- while a patient waits on the operating table. SRS microscopy provides equivalent insights through real-time scanning.

Xie's team has already used SRS microscopy to track migration of medications in skin, shedding new light on the absorption of topical drugs. In conjunction with endoscopy, the technique can also view three-dimensional sections of tissue, layer by layer.

"Previous SRS microscopy captured only about one image per minute, far too slow for use in live animals or humans," Xie says. "We were able to speed the
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Contact: Steve Bradt
steve_bradt@harvard.edu
617-496-8070
Harvard University
Source:Eurekalert  

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