Navigation Links
New methods identify and manipulate 'newborn' cells in animal model of Parkinson's disease

When cells in the brain are lost through disease or injury, neighboring cells begin to divide and multiply, but only a few areas in the brain are able to produce new neurons. Patients with Parkinson's disease suffer degeneration of certain neurons that reside in an area of the brain called the substantia nigra and project into the striatum. Many of the newborn cells in these areas have not been well described because of limitations of methods used to characterize them.

A research team from Cedars-Sinai Medical Center's Maxine Dunitz Neurosurgical Institute and Lund University in Sweden used an engineered virus to deliver a protein that glows green when exposed to blue light (green fluorescent protein) into newborn cells of the striatum in an animal model (rats) of Parkinson's disease. This revealed that no neurons are formed; most of the cells appear to be glial (structural) cells.

To determine if the newborn cells could be manipulated to generate neurons, the researchers delivered into the cells two genes (neurogenin2 and noggin) that are involved in the genesis of neurons. Neither gene had any effect on the ability of newborn striatal cells to form new neurons, but the insertion of noggin greatly increased the number of oligodendrocytes, cells that support neurons.

Dwain Morris-Irvin, Ph.D., a research scientist at Cedars-Sinai's Maxine Dunitz Neurosurgical Institute and Lund University, is available to describe how scientists are using green fluorescent protein and other new approaches in their effort to find cures for Parkinson's disease and other neurodegenerative brain disorders. Morris-Irvin is the first and corresponding author of a recent cover article in Neurobiology of Disease.

"These results may have great potential for studying the effects of viral gene delivery in the attempt to generate new cells for cell replacement therapy in neurodegenerative diseases or for brain repair after injury," Morris-Irvin said. "The success of a 'self-repair' strategy depends on the continued growth of our understanding of complex signaling patterns governing the development of these newborn cells."


Contact: Sandy Van
Cedars-Sinai Medical Center

Related medicine news :

1. Report on patients access to cancer drugs uses flawed methods to reached flawed conclusions
2. Medicare Prescription Drug Benefit, Nonprofit Hospitals, Ambulatory Surgery Centers, Statistical Methods, and Pay-For-Performance Highlighted In the Latest INQUIRY Journal
3. GPS-like technology helps pinpoint best methods for moving injured players
4. New Seminar Series from Activator Methods Teaches Doctors a Unique Approach to Improving Nations Chiropractic Care: Focus on the Patients
5. Manchester researchers announce new methods of beating breast cancer
6. Air Methods Completes Acquisition of FSS Airholdings, Inc., Parent Company of CJ Systems Aviation Group, Inc.
7. Air Methods to Report Third Quarter Financial Results Before Market Open on Thursday, November 8, 2007
8. Air Methods Reports 3Q2007 Results and 4Q2007 Update
9. New Booklet Reveals 12 Proven Methods for Stopping MRSA from Infecting Your Feet and Your Familys Feet
10. Cold Spring Harbor Protocols features innovative methods for embryology research
11. Results promising for computational quantum chemical methods for drug development
Post Your Comments:
(Date:6/25/2016)... ... 2016 , ... "With 30 hand-drawn hand gesture animations, FCPX users can easily ... of Pixel Film Studios. , ProHand Cartoon’s package transforms over 1,300 hand-drawn pictures ... . Simply select a ProHand generator and drag it above media or text in ...
(Date:6/25/2016)... (PRWEB) , ... June 25, 2016 , ... Conventional wisdom ... of success. In terms of the latter, setting the bar too high can result ... more than just slow progress toward their goal. , Research from ...
(Date:6/24/2016)... , ... June 24, 2016 , ... ... and Scientific Sessions in Dallas that it will receive two significant new grants ... grants came as PHA marked its 25th anniversary by recognizing patients, medical professionals ...
(Date:6/24/2016)... ... 2016 , ... People across the U.S. are sharpening their pencils and honing ... contest in which patients and their families pay tribute to a genetic counselor by ... Society of Genetic Counselors (NSGC) Annual Education Conference (AEC) this September. , In ...
(Date:6/24/2016)... ... June 24, 2016 , ... National recruitment firm ... sciences executive with extensive sequencing and genomics experience, as Vice President of North American ... Hill will be responsible for leading the sales team in the commercialization of the ...
Breaking Medicine News(10 mins):
(Date:6/23/2016)... , June 23, 2016 Any dentist who has ... of the current process. Many of them do not even ... technical difficulties and high laboratory costs involved. And those who ... it at such a high cost that the majority of ... Dr. Parsa Zadeh , founder of Dental Evolutions ...
(Date:6/23/2016)... Research and Markets has announced the ... 2016 - Forecast to 2022" report to their offering. ... up to date financial data derived from varied research sources ... with potential impact on the market during the next five ... comprises of sub markets, regional and country level analysis. The ...
(Date:6/23/2016)... , June 23, 2016 , ... Thursday, July 7, 2016 , , , , LOCATION: , ... , , , , EXPERT PANELISTS:  , , , Frost ... Industry Analyst, Christi Bird; Senior Industry Analyst, Divyaa Ravishankar and Unmesh ... The global pharmaceutical industry is witnessing an exceptional era. Several ...
Breaking Medicine Technology: