Navigation Links
New methods identify and manipulate 'newborn' cells in animal model of Parkinson's disease
Date:9/3/2008

When cells in the brain are lost through disease or injury, neighboring cells begin to divide and multiply, but only a few areas in the brain are able to produce new neurons. Patients with Parkinson's disease suffer degeneration of certain neurons that reside in an area of the brain called the substantia nigra and project into the striatum. Many of the newborn cells in these areas have not been well described because of limitations of methods used to characterize them.

A research team from Cedars-Sinai Medical Center's Maxine Dunitz Neurosurgical Institute and Lund University in Sweden used an engineered virus to deliver a protein that glows green when exposed to blue light (green fluorescent protein) into newborn cells of the striatum in an animal model (rats) of Parkinson's disease. This revealed that no neurons are formed; most of the cells appear to be glial (structural) cells.

To determine if the newborn cells could be manipulated to generate neurons, the researchers delivered into the cells two genes (neurogenin2 and noggin) that are involved in the genesis of neurons. Neither gene had any effect on the ability of newborn striatal cells to form new neurons, but the insertion of noggin greatly increased the number of oligodendrocytes, cells that support neurons.

Dwain Morris-Irvin, Ph.D., a research scientist at Cedars-Sinai's Maxine Dunitz Neurosurgical Institute and Lund University, is available to describe how scientists are using green fluorescent protein and other new approaches in their effort to find cures for Parkinson's disease and other neurodegenerative brain disorders. Morris-Irvin is the first and corresponding author of a recent cover article in Neurobiology of Disease.

"These results may have great potential for studying the effects of viral gene delivery in the attempt to generate new cells for cell replacement therapy in neurodegenerative diseases or for brain repair after injury," Morris-Irvin said. "The success of a 'self-repair' strategy depends on the continued growth of our understanding of complex signaling patterns governing the development of these newborn cells."


'/>"/>

Contact: Sandy Van
sandy@prpacific.com
800-880-2397
Cedars-Sinai Medical Center
Source:Eurekalert

Related medicine news :

1. Report on patients access to cancer drugs uses flawed methods to reached flawed conclusions
2. Medicare Prescription Drug Benefit, Nonprofit Hospitals, Ambulatory Surgery Centers, Statistical Methods, and Pay-For-Performance Highlighted In the Latest INQUIRY Journal
3. GPS-like technology helps pinpoint best methods for moving injured players
4. New Seminar Series from Activator Methods Teaches Doctors a Unique Approach to Improving Nations Chiropractic Care: Focus on the Patients
5. Manchester researchers announce new methods of beating breast cancer
6. Air Methods Completes Acquisition of FSS Airholdings, Inc., Parent Company of CJ Systems Aviation Group, Inc.
7. Air Methods to Report Third Quarter Financial Results Before Market Open on Thursday, November 8, 2007
8. Air Methods Reports 3Q2007 Results and 4Q2007 Update
9. New Booklet Reveals 12 Proven Methods for Stopping MRSA from Infecting Your Feet and Your Familys Feet
10. Cold Spring Harbor Protocols features innovative methods for embryology research
11. Results promising for computational quantum chemical methods for drug development
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/24/2017)... ... August 24, 2017 , ... Lori ... the development and advances in Desensitization therapy to improve the outcomes of organ ... about his remarkable journey of his 25 years of research in developing therapies ...
(Date:8/24/2017)... ... August 24, 2017 , ... Prime candidates for home ... have a condition that needs further monitoring such as surgery, stroke, heart attack ... stable, such as diabetes, high blood pressure, heart/lung disease, arthritis and stroke. ...
(Date:8/23/2017)... ... 2017 , ... The Arc Mercer, Capitol County’s premier provider of programs and ... community organization for people with special needs. The group, the Special Needs Alliance for ... of New Jersey – but the first in the entire country! , SNAP was ...
(Date:8/23/2017)... ... 2017 , ... Drs. Steven White and Brad Haines are pleased to announce ... of this offer, valued at more than $300 per year, new patients can enjoy ... patients receive a complimentary professional whitening procedure. , Stained or yellowed tooth enamel ...
(Date:8/23/2017)... ... ... Awards have announced the winners of the Best of the IBA Awards in The 2017 ... in the 2017 IBAs were not able to apply for the Best of the IBA ... awards won in the IBAs with a Gold Stevie win counting for three points, a ...
Breaking Medicine News(10 mins):
(Date:8/15/2017)... 2017   Mostyn Law and Gulf Coast Regional Blood ... . The Mostyn Law family has had 3 ... is why Mostyn Law is partnering with Gulf Coast ... its appreciation. Blood supplies are running low. Gulf Coast ... hospital needs in August. That is why the blood center reached ...
(Date:8/15/2017)... , Aug. 15, 2017  AOTI Inc. announced today that ... Therapy Inc., has recently opened a New York City Office in ... usage of its unique Topical Wound Oxygen (TWO 2 ) homecare ... the Accreditation Commission for Health Care (ACHC) under the company,s DMEPOS ... ...
(Date:8/8/2017)... -- BioLineRx Ltd. (NASDAQ/TASE: BLRX), a clinical-stage biopharmaceutical company focused ... for the second quarter ended June 30, 2017. ... and to date: ... Company,s lead project, BL-8040: Announced plans ... novel stem cell mobilization treatment for autologous bone-marrow transplantation ...
Breaking Medicine Technology: