Navigation Links
New method to test breast lesions could better detect cancer, save money by reducing repeat biopsies
Date:5/30/2013

PHILADELPHIA A newly developed, single-step Raman spectroscopy algorithm has the potential to simultaneously detect microcalcifications and enable diagnosis of the associated breast lesions with high precision, according to data published in Cancer Research, a journal of the American Association for Cancer Research.

"Nearly 1.6 million breast biopsies are performed and roughly 250,000 new breast cancers are diagnosed in the Unites States each year," said Ishan Barman, Ph.D., postdoctoral fellow at the Massachusetts Institute of Technology in Cambridge and the study's lead author. "If 200,000 repeat biopsies were avoided, even by a conservative estimate, the U.S. health care system could save $1 billion per year."

X-ray mammography is currently the only accepted routine screening method for early detection of breast cancer, but it cannot accurately distinguish whether microcalcifications (microscopic areas of calcium accumulation) are associated with benign or malignant breast lesions, according to Barman. Most patients, therefore, undergo core needle biopsy to determine if the microcalcifications are associated with malignancy, but the technique fails to retrieve microcalcifications in about 15 to 25 percent of patients. This results in nondiagnostic or false-negative biopsies, requiring the patient to undergo repeat, often surgical biopsy.

According to the researchers, the newly developed algorithm exhibited positive and negative predictive values of 100 percent and 96 percent, respectively, for the diagnosis of breast cancer with or without microcalcifications. The algorithm also showed an overall accuracy of 82 percent for classification of the samples into normal, benign or malignant lesions.

"There is an unmet clinical need for a tool that could minimize the number of X-rays and biopsy procedures. This tool could shorten procedure time; reduce patient anxiety, distress and discomfort; and prevent complications such as bleeding into the biopsy site after multiple biopsy passes," said Barman. "Our study demonstrates the potential of Raman spectroscopy to simultaneously detect microcalcifications and diagnose associated lesions with a high degree of accuracy, providing real-time feedback to radiologists during the biopsy procedures."

The researchers used a portable clinical Raman spectroscopy system to obtain Raman spectra from breast tissue biopsy specimens of 33 women. They collected Raman spectra from 146 tissue sites within the samples, including 50 normal tissue sites, 77 lesions with microcalcifications and 19 lesions without microcalcifications. Notably, they acquired all spectra within 30 minutes of sample removal.

Barman and colleagues fitted the obtained spectra into a model that identifies the different type and texture of various components of the breast tissue. They then developed a single-step Raman algorithm to distinguish normal breast tissue, breast cancer with and without microcalcifications, and other benign breast lesions including fibrocystic change and fibroadenoma.

In addition, the majority of breast cancers diagnosed using the one-step Raman algorithm were ductal carcinoma in situ, the most common lesion associated with microcalcifications, which is a challenge to diagnose using existing methods, according to Barman.


'/>"/>

Contact: Jeremy Moore
jeremy.moore@aacr.org
215-446-7155
American Association for Cancer Research
Source:Eurekalert

Related medicine news :

1. New gene delivery method: magnetic nanoparticles
2. Jennifer Nicole Lee Makes a Special Celebrity Appearance to the Hamptons Aug 9-11th for Celebrity Author Night and to Showcase Her JNL Fusion Workout Method
3. Atlanta Vision Clinic Acquires the Latest in Blade-Free Lasik Technology Bringing Dubai Patients the Intralase Method
4. AOAC International Approves ORAC as First Action Official Method
5. Mobile health app developed at UCLA simplifies process of choosing birth control method
6. Da Vinci Robotic Surgery Lawsuit News: Bernstein Liebhard LLP Comments on New Study Evaluating Robotic Surgery Training Methods
7. Truth About Cellulite Review Explores Joey Atlas' Naked Beauty "Symulast" Method
8. NYU and NYU Langone researchers devise method for enhancing CEST MRI
9. Method makes it easier to separate useful stem cells from problem ones for therapies
10. New Method May Help Pinpoint Womans Final Menstrual Period
11. Arlington, VA Cosmetic Dentist, Dr. Duke Kim Now Offers Modern Alternatives to Traditional Braces with the Invisalign and Six Month Smiles Teeth Straightening Methods
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/6/2016)... (PRWEB) , ... February 06, 2016 , ... With the ... easily add warm color grades to their footage. A LUT is a Lookup Table ... color to the corresponding color indicated by the table. By manipulating each pixel, LUT's ...
(Date:2/6/2016)... ... February 06, 2016 , ... Research ... treatment helps to reduce the frequency and level of relapse. , ... Healthy Identity and Purpose,” will explore the critical tasks of the recovery phase ...
(Date:2/5/2016)... ... ... Love is in the air at King Kullen! The local grocer is offering ... for Valentine’s Day is a must-have, and can be picked up with all other ... long-stem roses available, but also other flower bouquets, elegantly wrapped and ready to go. ...
(Date:2/5/2016)... ... February 05, 2016 , ... Today, the Whole-Food Warrior ... that the much-anticipated feature with author Jahnavi Foster, specialist in healthy vegetarian cuisine, will ... , Each week, on his weekly Whole-Food Warrior TV show, Frank Davis highlights Whole-Food ...
(Date:2/5/2016)... ... February 05, 2016 , ... The event is being held on ... Center in Minneapolis, Minn. Triumph Over Parkinson’s will fund nearly $100,000 for research for ... Furniture, lives with Parkinson’s disease and is the architect of this informative event to ...
Breaking Medicine News(10 mins):
(Date:2/5/2016)... Aethlon Medical, Inc. (Nasdaq: AEMD ), today announced that ... at Source Capital Group,s 2016 Disruptive Growth & Healthcare Conference ... p.m. ET on Wednesday, February 10, 2016.  Mr. Joyce will ... 3:15 p.m. ET. http://www.aethlonmedical.com .  The webcast will ... of the live event. The panel discussion will not be ...
(Date:2/5/2016)... 5, 2016 Dehaier Medical Systems Ltd. ... "Company"), which develops, markets and sells medical devices ... China and international markets, today announced ... to concentrate the Company,s resources to develop its ... and to focus more on its major businesses. ...
(Date:2/5/2016)... Feb. 5, 2016  Henry Schein, Inc. (NASDAQ: HSIC ... and services to office-based dental, animal health and medical ... agreement to acquire a majority ownership interest in Dental ... in Brazil . ... Dental Cremer is the dental distribution business of Cremer ...
Breaking Medicine Technology: