Navigation Links
New method to overcome multiple drug resistant diseases developed by Stanford researchers
Date:8/18/2008

ponents."

That change in physical properties effectively cloaks the arginine-Taxol complex, allowing it to slip past the sentries and into the cell. As it passes into the cell, the weak bonds it formed with the membrane components break and the transporter, with its therapeutic load, is free to roam inside the cell.

But after getting into the cell, the arginine-Taxol complex still has to break apart for the Taxol to do its job against the cancer cell. Wender's group achieved this by taking advantage of the presence of a molecule called glutathione, which is generally abundant inside cells and which in cancer cells tends to be present in higher levels than usual.

Glutathione is predisposed to attacking sulphur-sulphur bonds, so that is the bond the researchers used to hold the arginine and Taxol together. Once the arginine-Taxol complex is inside the cell, the glutathione can get to work hacking away at the sulphur bonds, and in the process, unwittingly release the compound that will spell its doom.

Because glutathione is relatively scarce outside of cells, the arginine transporter is effectively inert in that environment, so there are no side effects from having the arginine-Taxol complex moving through the patient's body. This is in stark contrast to the present situation, as many patients are extremely sensitive to the molecular vehicle that is currently used to administer ferried Taxol to the cancer cells.

The researchers achieved another breakthrough by tinkering with the form of the arginine used in their transporter. By altering certain aspects of the arginine, the researchers were able to control the rate at which glutathione slices and dices the arginine-Taxol complex.

This gives them an unprecedented ability to regulate the amount of medication that is active inside the patient at any point in time. To date, doctors have had to be content with injecting as high a dose of medication as patients can tole
'/>"/>

Contact: Louis Bergeron
louisb3@stanford.edu
650-725-1944
Stanford University
Source:Eurekalert

Page: 1 2 3 4 5

Related medicine news :

1. Stanford study highlights cost-effective method of lowering heart disease risks
2. Different method of evaluating the urinary tract system reduces radiation dose
3. Report on patients access to cancer drugs uses flawed methods to reached flawed conclusions
4. A classic method for modeling skin cancer is featured in Cold Spring Harbor Protocols
5. Researcher developing new method for hearing loss assessment
6. Medicare Prescription Drug Benefit, Nonprofit Hospitals, Ambulatory Surgery Centers, Statistical Methods, and Pay-For-Performance Highlighted In the Latest INQUIRY Journal
7. GPS-like technology helps pinpoint best methods for moving injured players
8. New Seminar Series from Activator Methods Teaches Doctors a Unique Approach to Improving Nations Chiropractic Care: Focus on the Patients
9. Less invasive lymph node biopsy method could spare thousands unnecessary operations
10. 454 Sequencing(TM): Science Paper Describes a Novel, Highly Efficient Method of Sequencing Ancient DNA; Sequences the Mitochondria of 10 Individual Mammoths to Prove It
11. Manchester researchers announce new methods of beating breast cancer
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/22/2015)... Combination therapy, or polytherapy, will ... obstructive pulmonary disorder (COPD) as the dominant companies ... as well as Germany’s Boehringer Ingelheim compete with ... will market payers, clinicians and patients be disposed ... completely new ones? , In spite of recently ...
(Date:5/22/2015)... 22, 2015 Coordinating care for ... process. Historically providers have not been reimbursed or ... in 2015, Medicare has paved the way by ... to the launch of Oculus Health , ... systems using the platform will now be able ...
(Date:5/22/2015)... ZH Healthcare (ZH), a ... that Bill Lane, joins ZH’s Advisory Board. ... first of its kind, Freemium SaaS, Electronic Health ... Records (EHR) with an integrated practice management system ... portal, and more. Combined with its Revenue Cycle ...
(Date:5/22/2015)... 22, 2015 sweetFrog Enterprises, LLC. is pleased ... Texas. Jacksonville is now the 16th sweetFrog store located in ... listed as #22 on the Inc. 500 list of fastest ... and worked in East Texas for 20 years and love ... of the Jacksonville, and nearby Palestine, sweetFrog locations. “We are ...
(Date:5/22/2015)... AZ (PRWEB) May 22, 2015 In ... Olympics, Parker and Sons is offering to donate $5 ... installing an AC unit or water softening system. Customers ... behalf; Parker and Sons gets business; and the Special ... , The Special Olympics helps over 4.4 million athletes, ...
Breaking Medicine News(10 mins):Health News:Chronic Obstructive Pulmonary Disorder Therapeutics Market Discussed in In-demand FirstWord Report Published at MarketPublishers.com 2Health News:Oculus Health Care Coordination Platform Officially Launched 2Health News:Oculus Health Care Coordination Platform Officially Launched 3Health News:Oculus Health Care Coordination Platform Officially Launched 4Health News:ZH Healthcare Adds Bill Lane to Advisory Board 2Health News:sweetFrog Opens New Location in Jacksonville, Texas 2Health News:Parker and Sons is Proud to Support the Special Olympics with Their Everybody Wins Program 2
... at-risk patient groups , FRIDAY, Dec. 4 (HealthDay News) ... nervous system tumors, carry the risk of late recurrence, ... data from 12,795 five-year survivors of the most common ... Survivor Study. , The researchers found that the overall ...
... inhaled through hookah, research shows , FRIDAY, Dec. 4 (HealthDay ... smoking tobacco, researchers say. , A new study found that ... monoxide and nicotine, which puts them at risk for heart ... aged 18 to 50, who smoked tobacco using a water ...
... ... ... garnering national attention with an invention proven to help individuals lose weight, prevent disease, ... Technology Fair located at the Civic Center Gallery., , , , , TrekDesk ...
... , BOULDER, ... TEACHER, ON LOVE , Kathryn Budig, a prominent yoga teacher, ... viewing of Twilight,s New Moon along the way. , To ... KING AND BREAST CANCER , elephantjournal.com takes a ...
... N.J., Dec. 4 Movado Group Inc. (NYSE: ... Georgia, shared in a tribute on December 3, 2009, to ... performance in the tournament. Melanie became the youngest American quarterfinalist ... http://www.newscom.com/cgi-bin/prnh/20091204/NY21184 ) , At a celebratory reception held at Brown ...
... , PACIFIC PALISADES, Calif., Dec. 4 Forget the ... something they can be proud of - beautiful, younger-appearing ... and men will love the ultimate youthful appearance made ... and neck combined. , Dermagenics Ultra-Intensive Anti-Wrinkle Beauty Moisturizer ...
Cached Medicine News:Health News:Water Pipes No Safer Than Cigarettes 2Health News:Valley Health Invention Making National Splash Showcased at Scottsdale Civic Center Gallery 2Health News:Give the Gift of Beautiful Skin for the Holiday Season 2
(Date:5/22/2015)... 2015 Research and Markets( http://www.researchandmarkets.com/research/28m7nx/guide_to_prepare ) ... to Prepare Application Dossiers for Oversea Medical device ... report to their offering. The ... market of the most growth potentiality, which is ... and producers to penetrate such market. It is ...
(Date:5/22/2015)... 22, 2015 Research and Markets ... the "Latest Regulations on Pharmaceutical International Multi-Center ... offering. This is first time in ... on international multi-center clinical trials of drugs in ... to be implemented on March 1, 2015. The ...
(Date:5/22/2015)... a sweeping analysis assessing the current state of diabetes ... conclude that there remains considerable room for improving treatment ... but especially for adolescents and young adults. The analysis ... the need to address barriers to care and implement ... patients achieve optimal metabolic control. The ...
Breaking Medicine Technology:China Guide to Prepare Application Dossiers for Oversea Medical Device Registration and Recordation 2China Guide to Prepare Application Dossiers for Oversea Medical Device Registration and Recordation 32015 Regulations on Pharmaceutical International Multi-Center Clinical Trials in China 2Study Reveals Poor Disease Control Among Adolescents and Young Adults with Type 1 Diabetes 2Study Reveals Poor Disease Control Among Adolescents and Young Adults with Type 1 Diabetes 3Study Reveals Poor Disease Control Among Adolescents and Young Adults with Type 1 Diabetes 4Study Reveals Poor Disease Control Among Adolescents and Young Adults with Type 1 Diabetes 5
... , WAYNE, N.J., Nov. 24 MAQUET Cardiovascular ... that it has signed a guaranteed two-year contract with ... to be the sole source provider of surgical devices ... of the agreement, which runs through October 31, 2012, ...
... , , MOUNTAIN VIEW, Calif., ... and leading providers of kidney dialysis services and a major ... Renal Disease survivor and chef Elias Nasrallah in his effort ... Elias Nasrallah built a successful career as a chef for ...
Cached Medicine Technology:MAQUET Cardiovascular Receives Guaranteed Two-Year Sole Source Contract From Novation for Beating Heart Surgical Devices 2MAQUET Cardiovascular Receives Guaranteed Two-Year Sole Source Contract From Novation for Beating Heart Surgical Devices 3Satellite Healthcare and Renal Disease Survivor Elias Nasrallah Join Forces to Support the Homeless This Holiday Season 2
Inquire...
The essence of fluorescence analysis is sensitivity. The high throughput optical system in the RF-5301PC employs a blazed holographic grating, photomultiplier and digital signal processing to provide...
The Fluoroskan Ascent, a dedicated microplate fluorometer, offers high sensitivity for a wide variety of fluorometric applications....
... 200 is a fixed wavelength fluorometer ... nm emission. The spectral characteristics are ... double-stranded DNA using the standard Hoechst ... interference from the presence of protein, ...
Medicine Products: