Navigation Links
New method to overcome multiple drug resistant diseases developed by Stanford researchers
Date:8/18/2008

e pumps are occupied with the decoy molecule. But if any of the molecules make their way into healthy cells, they can gum up the proper functioning of the pumps in those cells, too, adding to the litany of undesirable side effects that generally accompany chemotherapy.

Wender's group decided to see if they could take drugs to which diseases had become resistant and, by combining them with what they call "molecular transporters," get them in around the pump.

"If we think of the pump as being a bouncer for the cellular club, then effectively what we're doing is disguising one of these therapeutic agents to get it in through the back door or the side door," Wender said. "We're not even going to deal with the bouncer."

Therein lies what may be the greatest value of the work. The basic approach of bonding a medication to an arginine-rich transporter to slip it past the cellular sentries could, in theory, be used to get any of a host of medications into any cell that has developed the type of resistance involving increased numbers of export pumps.

"This could potentially be used with any drug which is effective but has a delivery problem," Teng said. "Not just Taxol."

That could include medications for diseases caused by antibiotic resistant bacteria, such as multi-drug resistant tuberculosis, or by drug resistant parasites such as malaria, as well as other types of cancer.

The arginine transporter manages to avoid ejection by slipping through the membrane of the cell in between the pumps. The key is the ability of arginine to form weak, temporary bonds with some of the molecules that reside in the membrane.

"As the transporter, with all these arginine guanidinium groups, approaches the cell, it basically does a handshake using hydrogen bonds with cell surface constituents that are in the membrane," Wender said. "In essence, it changes its physical properties by shaking hands with all these cell membrane com
'/>"/>

Contact: Louis Bergeron
louisb3@stanford.edu
650-725-1944
Stanford University
Source:Eurekalert

0

GOOD

Page: 1 2 3 4 5

Related medicine news :

1. Stanford study highlights cost-effective method of lowering heart disease risks
2. Different method of evaluating the urinary tract system reduces radiation dose
3. Report on patients access to cancer drugs uses flawed methods to reached flawed conclusions
4. A classic method for modeling skin cancer is featured in Cold Spring Harbor Protocols
5. Researcher developing new method for hearing loss assessment
6. Medicare Prescription Drug Benefit, Nonprofit Hospitals, Ambulatory Surgery Centers, Statistical Methods, and Pay-For-Performance Highlighted In the Latest INQUIRY Journal
7. GPS-like technology helps pinpoint best methods for moving injured players
8. New Seminar Series from Activator Methods Teaches Doctors a Unique Approach to Improving Nations Chiropractic Care: Focus on the Patients
9. Less invasive lymph node biopsy method could spare thousands unnecessary operations
10. 454 Sequencing(TM): Science Paper Describes a Novel, Highly Efficient Method of Sequencing Ancient DNA; Sequences the Mitochondria of 10 Individual Mammoths to Prove It
11. Manchester researchers announce new methods of beating breast cancer
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/19/2013)... spring arrived late this year in parts of the ... strong, according to a sinus expert at the University ... professor in the university,s division of otolaryngology, said a ... season. However, some simple strategies can help people manage ... "Tree pollen has been bad for several weeks ...
(Date:5/19/2013)... Louis, MO (PRWEB) May 19, 2013 ... Conference, May 19-22, 2013, at the Walt Disney World ... latest trends in supply chain innovation, care delivery and ... much different dynamic in all healthcare markets, ... part of the conversation,” said Todd Ebert, Amerinet president ...
(Date:5/19/2013)... May 19, 2013 Actos lawsuit ... litigation now underway in U.S. District Court, Western District ... dated May 3rd, the Court has modified the litigation’s ... eight cases rather than four. The next Status Conference ... May 23rd. (In re: Actos Product Liability Litigation, MDL ...
(Date:5/19/2013)... 19, 2013 According to a ... and Forecast (2013 – 2018): By Applications (Healthcare ... Technology (CCD, CMOS, Contact IS, Infrared, X-Ray) And ... sensor market was $8.00 billion in 2012 and ... at an estimated CAGR of 3.84% from 2013 ...
(Date:5/19/2013)... (PRWEB) May 19, 2013 Fat Burning ... loss program that provides people with fat burning ... people order this Fat Burning Furnace package, people will ... that they can download quickly. The Fat Burning Furnace ... helps people build lean muscle mass. In addition, this ...
Breaking Medicine News(10 mins):Health News:Managing Seasonal Allergies 2Health News:Healthcare Leaders Gather at 2013 Amerinet Member Conference to Share New Ways to Reduce Costs and Enhance Care Delivery 2Health News:Actos Lawyers at Bernstein Liebhard LLP Note Issuance of New Case Management Order in Federal Actos Bladder Cancer Litigation 2Health News:Actos Lawyers at Bernstein Liebhard LLP Note Issuance of New Case Management Order in Federal Actos Bladder Cancer Litigation 3Health News:Image Sensors Market to Reach $10.75 Billion by 2018 at a CAGR of 3.84% - New Report by MarketandMarkets 2Health News:Image Sensors Market to Reach $10.75 Billion by 2018 at a CAGR of 3.84% - New Report by MarketandMarkets 3Health News:Fat Burning Diet | How “Fat Burning Furnace” Helps People Lose Their Weight Naturally And Fast – V-kool 2
... element in making U.S. medical care more effective and efficient, ... the Stanford University School of Medicine shows that electronic records ... in 2003 and 2004. ,Of 17 quality indicators ... in 14 measures. In two areas, better quality was associated ...
... backed by sturdy cardboard it shows in neat, printed script ... ,Next to it, propped up against one of the ancient ... the 28-year-old bachelor proudly donning his military uniform. ... dozens of other parents amble past and take a look ...
... claims they can soon release the worlds first blood test that ... of UK will stand to save billions of pounds per year, ... in the western world, costs the NHS up to 17 billion ... a series of proteins, which are most commonly found in those ...
... London are long overdue but it is unclear how the ... patient care in the capital , BMA leaders claim. ... said: There is a case for changing how some services ... these proposals may not be in the best interests of ...
... to help dialysis patients ,One of the ... to live a better quality life, dialysis-dependent patients, needs ... is a very significant part of the dialysis process. ... production of red blood cells in bone marrow is ...
... The U.S. obesity prevalence increased from 13 percent to ... researchers at the Johns Hopkins Bloomberg School of Public ... obesity and overweight has increased at an average rate ... the past three decades. , Some minority ...
Cached Medicine News:Health News:Electronic Health Records Shows No Improvement in Quality of Outpatient Care 2Health News:Electronic Health Records Shows No Improvement in Quality of Outpatient Care 3Health News:Parental Match-making Blossoms in a Beijing Park 2Health News:Parental Match-making Blossoms in a Beijing Park 3Health News:Simple Blood Test May Predict Alzheimers Disease 2Health News:Polyclinics Could Threaten NHS Services, Warns BMA 2Health News:Analysis of Hemoglobin Level Control in Dialysis Patients 2Health News:Analysis of Hemoglobin Level Control in Dialysis Patients 3Health News:U.S Shows Increased Obesity Rate 2
(Date:5/17/2013)... , May 17, 2013  TechAtlas Group has ... their competitive landscape map for the Chronic Kidney ... 90 international companies with drugs and devices currently ... and its sequelae. (Logo:  ... , hypertension - renal denervation , ...
(Date:5/17/2013)... 17, 2013  Boehringer Ingelheim will contribute to ... the American Thoracic Society International Conference (ATS 2013) ... 17 – 22. Data will highlight ... treatment of chronic obstructive pulmonary disease (COPD) [Spiriva® ... investigational compounds for asthma, idiopathic pulmonary fibrosis (IPF) ...
(Date:5/17/2013)... 2013 Sinovac Biotech Ltd. (Nasdaq: SVA ... , today announced that it will release its unaudited ... before market on Tuesday, May 28, 2013.  The Company will ... 8:00 a.m. EDT (May 28, 2013 at 8:00 p.m. China ... an update on recent corporate developments. To access ...
Breaking Medicine Technology:TechAtlas Group Releases Innovative Chronic Kidney Disease Landscape Map 2Boehringer Ingelheim to Present 17 Abstracts at the Annual American Thoracic Society International Conference 2Boehringer Ingelheim to Present 17 Abstracts at the Annual American Thoracic Society International Conference 3Boehringer Ingelheim to Present 17 Abstracts at the Annual American Thoracic Society International Conference 4Boehringer Ingelheim to Present 17 Abstracts at the Annual American Thoracic Society International Conference 5Boehringer Ingelheim to Present 17 Abstracts at the Annual American Thoracic Society International Conference 6Boehringer Ingelheim to Present 17 Abstracts at the Annual American Thoracic Society International Conference 7Boehringer Ingelheim to Present 17 Abstracts at the Annual American Thoracic Society International Conference 8Sinovac to Host Conference Call to Report First Quarter 2013 Unaudited Financial Results 2Sinovac to Host Conference Call to Report First Quarter 2013 Unaudited Financial Results 3
... 22, 2011 /PRNewswire-Asia/ -- Sinovac Biotech Ltd. (NASDAQ: ... announced today it has filed its Annual Report on Form ... year ended December 31, 2010 on April 22, 2011.  The ... www.sec.gov . The Company will provide a hard ...
... One hundred and eighty miles — Houston to Austin, ... MS 150 overcame on April 16 and 17 in a ... sponsored by The SCOOTER Store , the nation,s leading ... ride and raised nearly $20,000 toward the cause. ...
Cached Medicine Technology:Sinovac Files Annual Report on Form 20-F 2The SCOOTER Store Supports Fight Against Multiple Sclerosis 2
... reference laboratory and a worldwide leader in ... an extensive test menu of highly complex ... anatomic pathology. Owned by the University of ... half of the nation's university teaching hospitals ...
... national reference laboratory and a worldwide leader ... offers an extensive test menu of highly ... and anatomic pathology. Owned by the University ... than half of the nation's university teaching ...
... a national reference laboratory and a worldwide ... ARUP offers an extensive test menu of ... clinical and anatomic pathology. Owned by the ... more than half of the nation's university ...
... a national reference laboratory and a worldwide ... ARUP offers an extensive test menu of ... clinical and anatomic pathology. Owned by the ... more than half of the nation's university ...
Medicine Products: