Navigation Links
New method to overcome multiple drug resistant diseases developed by Stanford researchers
Date:8/18/2008

substances through cell membranes. Working with Taxol(r), a widely used chemotherapeutic agent, they attached a series of arginines with their associated guanidinium groups and tried it out against Taxol-resistant ovarian cancer cells implanted in mice. It worked.

"It's an exciting result to be able to take a drug known to work against cancer, but stymied by resistant cells, and restore it to effectiveness using an arginine transporter," Wender said. "This bodes well for use with other drugs that succumb to resistance."

A paper describing the work is scheduled to be published next week in the online Early Edition of the Proceedings of the National Academy of Sciences. Wender's group collaborated with that of Chris Contag, a professor of pediatrics and of microbiology and immunology at Stanford's School of Medicine, who is a co-author on the paper.

"Overcoming Taxol resistance is big. It's huge," said Nelson Teng, professor of obstetrics and gynecology at the Medical School. "In essence, the technology can be used to overcome one of the most challenging types of problems of drug resistance."

The type of drug resistance that Wender's work has overcome develops when pumps located in the membrane that encloses a cell become sensitized to a medication. It is one of the most common ways in which resistance manifests. The pumps, which normally capture and eject foreign material from a cell, are produced at higher levels in certain resistant cells and, because of their increased number, become more effective at tossing the drug molecules out.

"It is kind of like a bouncer," Wender said. "If you're not recognized as being part of the club, then you're kicked out." Resistant cells also create a lot more of the pumps than a normal cell would have.

Some researchers have tried dealing with this situation by adding another molecule to the mix to inhibit the pump, keeping it busy so the medication can slip in while th
'/>"/>

Contact: Louis Bergeron
louisb3@stanford.edu
650-725-1944
Stanford University
Source:Eurekalert

Page: 1 2 3 4 5

Related medicine news :

1. Stanford study highlights cost-effective method of lowering heart disease risks
2. Different method of evaluating the urinary tract system reduces radiation dose
3. Report on patients access to cancer drugs uses flawed methods to reached flawed conclusions
4. A classic method for modeling skin cancer is featured in Cold Spring Harbor Protocols
5. Researcher developing new method for hearing loss assessment
6. Medicare Prescription Drug Benefit, Nonprofit Hospitals, Ambulatory Surgery Centers, Statistical Methods, and Pay-For-Performance Highlighted In the Latest INQUIRY Journal
7. GPS-like technology helps pinpoint best methods for moving injured players
8. New Seminar Series from Activator Methods Teaches Doctors a Unique Approach to Improving Nations Chiropractic Care: Focus on the Patients
9. Less invasive lymph node biopsy method could spare thousands unnecessary operations
10. 454 Sequencing(TM): Science Paper Describes a Novel, Highly Efficient Method of Sequencing Ancient DNA; Sequences the Mitochondria of 10 Individual Mammoths to Prove It
11. Manchester researchers announce new methods of beating breast cancer
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/31/2015)... York, NY (PRWEB) , ... July 31, 2015 , ... ... Rodgers Theatre . Those looking to catch a new and refreshing show on ... won numerous awards and achievements including an Obie Award, Outer Critics Circle Award, Drama ...
(Date:7/31/2015)... Los Angeles, CA (PRWEB) , ... July 31, 2015 , ... ... of surgeons and cosmetic experts gathered to see if they could reach a consensus ... procedures, including breast augmentation and facelifts. Overall, the group reached 90 percent consensus on ...
(Date:7/31/2015)... ... July 31, 2015 , ... ... pharmaceutical negligence is now available online at ( http://www.lawline.com/cle/course/its-a-wonderful-life-if-you-receive-the-right-meds-a-discussion-of-pharmaceutical-negligence ). Mr. ... approval rating from the nationwide audience. The course focused on the ...
(Date:7/31/2015)... ... 2015 , ... As part of their company mission, Dallas pet sitting ... organizations is essential to the longevity of their business. It is for that ... Professional Pet Sitters (NAPPS) annual Presents 4 Pets supply drive. Presents 4 ...
(Date:7/31/2015)... (PRWEB) , ... July 31, 2015 , ... Transfinder, a ... 2015. , Total sales were up 16 percent year-over-year for the first six months ... Antonio Civitella said he expected Transfinder to beat last year’s record-revenue mark of $10.4 ...
Breaking Medicine News(10 mins):Health News:Cheap Hamilton Tickets at Richard Rodgers Theatre: Ticket Down Slashes Ticket Prices for Hamilton in New York City at the Richard Rodgers Theatre 2Health News:Cheap Hamilton Tickets at Richard Rodgers Theatre: Ticket Down Slashes Ticket Prices for Hamilton in New York City at the Richard Rodgers Theatre 3Health News:Cheap Hamilton Tickets at Richard Rodgers Theatre: Ticket Down Slashes Ticket Prices for Hamilton in New York City at the Richard Rodgers Theatre 4Health News:Cheap Hamilton Tickets at Richard Rodgers Theatre: Ticket Down Slashes Ticket Prices for Hamilton in New York City at the Richard Rodgers Theatre 5Health News:Cheap Hamilton Tickets at Richard Rodgers Theatre: Ticket Down Slashes Ticket Prices for Hamilton in New York City at the Richard Rodgers Theatre 6Health News:Cheap Hamilton Tickets at Richard Rodgers Theatre: Ticket Down Slashes Ticket Prices for Hamilton in New York City at the Richard Rodgers Theatre 7Health News:Article on Plastic Surgery Consensus Highlights the Duties of Veteran Plastic Surgeons, says Beverly Hills Physicians 2Health News:Article on Plastic Surgery Consensus Highlights the Duties of Veteran Plastic Surgeons, says Beverly Hills Physicians 3Health News:Re-Broadcast of Nationally Renowned Trial Attorney Jason T. Brown's Lecture on Pharmaceutical Negligence Now Available 2Health News:Dallas-based Park Cities Pet Sitter Selects Non-Profit Animal Welfare Organization “Angie’s Friends” as this Year’s Recipient of their Presents 4 Pets Supply Drive. 2Health News:Dallas-based Park Cities Pet Sitter Selects Non-Profit Animal Welfare Organization “Angie’s Friends” as this Year’s Recipient of their Presents 4 Pets Supply Drive. 3Health News:Dallas-based Park Cities Pet Sitter Selects Non-Profit Animal Welfare Organization “Angie’s Friends” as this Year’s Recipient of their Presents 4 Pets Supply Drive. 4Health News:Transfinder Closes First Half of 2015 with Record Revenue 2
... City Marathon 2007 and be Recognized for ... Runners and Avis, NEW YORK, Oct. 30 New ... today that Vincent Corso and Daniel Trush have,won the fourth-annual ... York City Marathon 2007. The award celebrates people who endeavor,to ...
... Conference Call and Webcast to Follow, ROCKVILLE, ... VNDA ), a biopharmaceutical company focused on the ... system disorders, today announced it will release results ... November 8, 2007, before the,market opens. A full ...
... a,statement of William V. Corr, executive director, Campaign ... has taken an important step,forward by recommending that ... health threats posed by secondhand smoke, while,preserving the ... as well. We,urge the Legislature to enact a ...
... Vote on Measure Thursday, WASHINGTON, Oct. 30 ... mouth are actually composed of 50% MERCURY, a,known neurotoxin? ... currently is not. Councilwoman Blondell Reynolds Brown wants to ... which ensures that patients are,given the opportunity to know ...
... preliminary, experts caution, , , TUESDAY, Oct. 30 (HealthDay News) ... a new study suggests that at least one virus ... treat some metastatic cancers. , Reporting in the ... Cancer Institute , researchers explained that the virus, Seneca ...
... post-traumatic stress disorder had a ,protective, effect , , TUESDAY, ... veterans suffering from depression finds that their risk factors ... other depressed Americans. , Specifically, the risk for suicide ... what,s seen in the general population. , And even ...
Cached Medicine News:Health News:Vincent Corso and Daniel Trush Win 2007 Avis 'We Try Harder' Awards 2Health News:Vincent Corso and Daniel Trush Win 2007 Avis 'We Try Harder' Awards 3Health News:Vanda Pharmaceuticals to Announce Third Quarter 2007 Financial Results on November 8, 2007 2Health News:Indiana Legislature Should Protect All Workers from Secondhand Smoke 2Health News:A Patients Right to Know: 'Silver Fillings' are 50% Mercury 2Health News:Virus Shows Some Cancer-Killing Abilities 2Health News:Virus Shows Some Cancer-Killing Abilities 3Health News:Younger Veterans at Greater Suicide Risk 2Health News:Younger Veterans at Greater Suicide Risk 3Health News:Younger Veterans at Greater Suicide Risk 4
(Date:7/30/2015)... VIEW, Calif. , July 30, 2015 ... it will release its second quarter 2015 financial results ... 2015.   In conjunction with the release, the Company ... at 5:00 p.m. Eastern Time on ... of the quarter and other business developments. ...
(Date:7/30/2015)... SAN DIEGO , July 30, 2015 /PRNewswire/ ... a medical device company and manufacturer of the ... it has entered into non-exclusive Development Agreements with ... generation Tandem insulin pumps with the Dexcom G5 ... "Integrating Tandem,s next generation pump platform with ...
(Date:7/30/2015)... WASHINGTON , July 30, 2015  Today we bring you a special edition ... wanted to remind you about some of our Medicare resources and continue highlighting the ... Check out our latest infographics and videos ... ... ...
Breaking Medicine Technology:IRIDEX Announces Second Quarter 2015 Conference Call and Release Date 2Tandem Diabetes Care Announces Development Agreement with Dexcom for Integration of Future Generation CGM Systems 2Tandem Diabetes Care Announces Development Agreement with Dexcom for Integration of Future Generation CGM Systems 3Happy 50th Anniversary Medicare! 2Happy 50th Anniversary Medicare! 3