Navigation Links
New method to overcome multiple drug resistant diseases developed by Stanford researchers
Date:8/18/2008

Many drugs once considered Charles Atlases of the pharmaceutical realm have been reduced to the therapeutic equivalent of 97-pound weaklings as the diseases they once dispatched with ease have developed resistance to them.

The problem is well documented for antibiotics, although not confined to them. Chemotherapy drugs that were once highly effective when first used against a particular cancer now are often rendered near powerless when a patient's cancer resurges.

Even more devastating, when an organism develops resistance to one drug, it often becomes resistant to other drugs (known as multi-drug resistance), rendering not just one medication but a whole class of therapeutics useless against it.

But researchers at Stanford University have developed a method to get around one of the most common forms of resistance, thereby opening up some if not many resistant diseases to the reinvigorated fury of the medications that once laid them low. To do it, they took a tip from nature.

"Nature has developed all of this firepower for getting things into cells, and one of the ways is to create entities that are arginine-rich," said Paul Wender, the Bergstrom Professor of Chemistry at Stanford University. Arginine is an amino acid, the building block of proteins, and as such is found in virtually every cell in the human body, as well as other mammalian bodies.

Using such a common transporter to ferry a potent medication inside a resistant cell is a bit like recruiting your grandmother to cart a load of switchblade knives through customs. Indeed, Wender said, "Arginine-rich sequences appear to figure in the mechanisms by which many pathogens invade cells." Wender's team used a necklace of eight arginine molecules to surround the medication they worked with.

Wender and his colleagues figured out that a particular molecular subunit within arginine, called a guanidinium group, was what nature actually exploits to get foreign
'/>"/>

Contact: Louis Bergeron
louisb3@stanford.edu
650-725-1944
Stanford University
Source:Eurekalert

0

GOOD

Page: 1 2 3 4 5

Related medicine news :

1. Stanford study highlights cost-effective method of lowering heart disease risks
2. Different method of evaluating the urinary tract system reduces radiation dose
3. Report on patients access to cancer drugs uses flawed methods to reached flawed conclusions
4. A classic method for modeling skin cancer is featured in Cold Spring Harbor Protocols
5. Researcher developing new method for hearing loss assessment
6. Medicare Prescription Drug Benefit, Nonprofit Hospitals, Ambulatory Surgery Centers, Statistical Methods, and Pay-For-Performance Highlighted In the Latest INQUIRY Journal
7. GPS-like technology helps pinpoint best methods for moving injured players
8. New Seminar Series from Activator Methods Teaches Doctors a Unique Approach to Improving Nations Chiropractic Care: Focus on the Patients
9. Less invasive lymph node biopsy method could spare thousands unnecessary operations
10. 454 Sequencing(TM): Science Paper Describes a Novel, Highly Efficient Method of Sequencing Ancient DNA; Sequences the Mitochondria of 10 Individual Mammoths to Prove It
11. Manchester researchers announce new methods of beating breast cancer
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/25/2013)... New York, NY (PRWEB) May 25, 2013 Country ... was Jason Aldean's opening act in 2012. Due to overwhelming ... countless venues during 2013. , Luke Bryan has written ... a songwriter nearly a decade ago back in the mid-2000 era. ... Billy Currington and Travis Tritt. , When Luke was 14, ...
(Date:5/25/2013)... Park City, Utah (PRWEB) May 25, 2013 ... on health insurance marketplaces . Zane Benefits, which ... health benefits, is the leader in defined contribution ... Zane Benefits’ website, the October 1, 2013 open enrollment ... corner. The mantra of the Marketplaces is "Choice, Competition ...
(Date:5/25/2013)... This week idcloak Technologies releases a list of IP port ... site is blocked. When IP proxies are used for ... compatibility problems associated with regular proxy sites. Gill-Chris Welles, senior ... apply IP Port proxies to create a proxy web ... , “When a user takes an IP address and port ...
(Date:5/25/2013)... Angeles, California (PRWEB) May 25, 2013 According ... Magazine titled “Hooked on a Feeling,” nearly 30 million Americans ... beach to tan despite knowing the health risks. ... relaxing, seductive and even addictive effect on the brains of ... data included in the article so I can’t say that ...
(Date:5/25/2013)... Imagine running the air conditioner with the ... air and wasted energy! If the home has a folding ... clothes dryer, that may be just what is occurring in ... holes waste energy in the form of higher energy bills. ... in the home. , Drafts occur through the small cracks ...
Breaking Medicine News(10 mins):Health News:Luke Bryan Tickets: Prices Slashed on Luke Bryan Tickets in Raleigh, Bethel, Camden, Peoria, Nashville, Hartford, Chicago, Boston, Atlanta, Indianapolis & SaratogaSprings 2Health News:Zane Benefits Publishes New Information on the Health Insurance Marketplaces 2Health News:Zane Benefits Publishes New Information on the Health Insurance Marketplaces 3Health News:idcloak Launches Proxy Web Browser for Blocked Facebook Users 2Health News:Sun Damage – Are UV Rays Addictive? 2Health News:How To Stop Drafts and Save On Home Energy Bills This Summer - New Draft Stoppers Now Available From Battic Door Energy Conservation 2Health News:How To Stop Drafts and Save On Home Energy Bills This Summer - New Draft Stoppers Now Available From Battic Door Energy Conservation 3Health News:How To Stop Drafts and Save On Home Energy Bills This Summer - New Draft Stoppers Now Available From Battic Door Energy Conservation 4
... can be more vindictive than women when it comes to ... slighted, men are more bent upon revenge. The results of ... College researchers conducted the study, which proves that the sex ... to seeking revenge. ,Volunteers who were offended ...
... who give birth naturally may be better than those who ... both prospective mothers and healthcare// professionals to think again. This ... lesser problems to mothers. ,Some women believe ... life after they have their baby. But the researchers say ...
... higher risk of cardiovascular disease or diabetes can be reduced ... by Nadine Sahyoun of the University of Maryland. //The American ... study. The study has revealed that elders who ate three ... of metabolic syndrome than people who ate less than one ...
... FMD infection is reported in two Chinese province of Ningxia Hui ... Asia which is already facing outbreaks of bird flu infection. Though ... immense economic loss to cattle industry and it would increase the ... poultry loss due to bird flu infection. ,FMD is ...
... encouraged by a school in Scotland with the object of ... proposed to be conducted in schools by Fake Bake, // ... number of skin cancer cases rising. ,Many ... be going in for sun-beds sessions, prompting the school authorities ...
... highly potent formulation for combating the virulent forms of the ... review by the Food and Drug Administration. // ... can be injected intravenously. Promising results have been obtained from ... and approved we could soon have a new form of ...
Cached Medicine News:
(Date:5/23/2013)... Calif. , May 23, 2013 More ... cancer may not benefit from chemotherapy and still have ... the launch of one of the largest sources of ... new website and interactive Facebook page provide recently diagnosed ... they can safely avoid chemotherapy. "We anticipate ...
(Date:5/23/2013)... 2013  Every day, their baby stopped breathing, his collapsed ... April and Bryan Gionfriddo watched helplessly, ... "Quite a few doctors said he had a good ... April Gionfriddo , about her now 20-month-old son, Kaiba. ... we would take it and run with it." ...
(Date:5/23/2013)... MILFORD, Mass. , May 23, 2013  Spring ... for the treatment of viral infections, today announced that ... of SB 9200, its investigational, once daily, oral therapy ... conducted in healthy, HCV-infected patients and is designed to ... 9200. SB 9200 is a first-in-class drug for the ...
Breaking Medicine Technology:Agendia Launches Social Media Campaigns to Help Breast Cancer Patients with Chemotherapy Decisions 2Agendia Launches Social Media Campaigns to Help Breast Cancer Patients with Chemotherapy Decisions 3Baby's life saved with groundbreaking 3D printed device from U-M that restored his breathing 2Baby's life saved with groundbreaking 3D printed device from U-M that restored his breathing 3Baby's life saved with groundbreaking 3D printed device from U-M that restored his breathing 4Spring Bank Pharmaceuticals Initiates a Phase I Clinical Trial for SB 9200 in HCV-infected Patients 2Spring Bank Pharmaceuticals Initiates a Phase I Clinical Trial for SB 9200 in HCV-infected Patients 3
... real-time PCR analysis of gene expression ... LightCycler 480 System combines amazing speed ... the needs of a broad range ... including array validation, gene-knockdown studies, and ...
... broad menu clinical chemistry analyzer designed for ... Care givers can now perform routine multi-chemistry ... minute of hands-on time. Complete panel results ... expensive laboratory analyzers are available in under ...
A simple solution to hand assisted laparoscopic surgery....
... non-adhesive sealing method maintains the ... (HALS) procedures, allowing the surgeon ... throughout. Because HALS requires incisions ... patients experience less trauma compared ...
Medicine Products: