Navigation Links
New method to find novel connections from gene to gene, drug to drug and between scientists
Date:7/24/2012

Researchers from Mount Sinai School of Medicine have developed a new computational method that will make it easier for scientists to identify and prioritize genes, drug targets, and strategies for repositioning drugs that are already on the market. By mining large datasets more simply and efficiently, researchers will be able to better understand gene-gene, protein-protein, and drug/side-effect interactions. The new algorithm will also help scientists identify fellow researchers with whom they can collaborate.

Led by Avi Ma'ayan, PhD, Assistant Professor of Pharmacology and Systems Therapeutics at Mount Sinai School of Medicine, and Neil Clark, PhD a postdoctoral fellow in the Ma'ayan laboratory, the team of investigators used the new algorithm to create 15 different types of gene-gene networks. They also discovered novel connections between drugs and side effects, and built a collaboration network that connected Mount Sinai investigators based on their past publications.

"The algorithm makes it simple to build networks from data," said Dr. Ma'ayan. "Once high dimensional and complex data is converted to networks, we can understand the data better and discover new and significant relationships, and focus on the important features of the data."

The group analyzed one million medical records of patients to build a network that connects commonly co-prescribed drugs, commonly co-occurring side effects, and the relationships between side effects and combinations of drugs. They found that reported side effects may not be caused by the drugs, but by a separate condition of the patient that may be unrelated to the drugs. They also looked at 53 cancer drugs and connected them to 32 severe side effects. When chemotherapy was combined with cancer drugs that work through cell signaling, there was a strong link to cardiovascular related adverse events. These findings can assist in post-marketing surveillance safety of approved drugs.

Th
'/>"/>

Contact: Mount Sinai Press Office
newsmedia@mssm.edu
212-241-9200
The Mount Sinai Hospital / Mount Sinai School of Medicine
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Newer technology to control blood sugar works better than conventional methods
2. Study suggests new screening method for sudden death in athletes
3. Meditation Method a Matter of Taste
4. New Stanford method enables sequencing of fetal genomes using only maternal blood sample
5. Electronic data methods research seeks to build a learning health care system
6. New delivery method improves efficacy of 2 common Parkinsons disease medications
7. Quick-Reversal Method May Be at Hand for New Blood Thinner
8. Safer Grilling Methods Might Cut Cancer Risk
9. Hear to see: New method for the treatment of visual field defects
10. OHSU Oregon National Primate Research Center develops new, safer method for making vaccines
11. Advanced genetic screening method may speed vaccine development
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/24/2014)... NC (PRWEB) July 24, 2014 ... minorities, and low-income households are disproportionately affected by ... food safety net in the United States, according ... Under Section 743 of the Consolidated Appropriations Act, ... of Agriculture's Food and Nutrition Service (FNS) to ...
(Date:7/24/2014)... New York (PRWEB) July 24, 2014 ... lawsuits ( http://www.injurybeacon.com/granuflo-dialysis/lawsuit/ ) in the U.S. ... qualified protective order for plaintiff medical information covered ... Act. According to the July 16th Order, U.S. ... attorneys for Fresenius Medical Care the right ...
(Date:7/24/2014)... By Amy Norton HealthDay ... stereotype of the sex-crazed teenage boy may be dead wrong, according ... from romantic relationships. In interviews with 33 boys between the ... wanted a relationship with a girl for the closeness and trust. ... "main goal" in starting a relationship with a girl. "In ...
(Date:7/24/2014)... HealthDay Reporter THURSDAY, July 24, 2014 (HealthDay ... kids as unhealthy or recognize the health consequences of excess ... children of the families surveyed for the new research were ... Providence, R.I. "A third categorized their child,s health as ... now an assistant professor of pediatrics at the University of ...
(Date:7/24/2014)... may have found a way to delay or even ... neurons with the anti-aging protein Klotho can prevent neuron ... and glutamate. These findings currently appear in the ... is the most frequent age-related dementia affecting 5.4 million ... older and more than 40 percent of people over ...
Breaking Medicine News(10 mins):Health News:Report: Vulnerable Populations Disproportionately Affected by Food Security, Despite Public Programs 2Health News:Report: Vulnerable Populations Disproportionately Affected by Food Security, Despite Public Programs 3Health News:GranuFlo Lawsuits Move Forward in Federal Court, With Issuance of Protective Order for HIPAA Information, Bernstein Liebhard LLP Reports 2Health News:GranuFlo Lawsuits Move Forward in Federal Court, With Issuance of Protective Order for HIPAA Information, Bernstein Liebhard LLP Reports 3Health News:GranuFlo Lawsuits Move Forward in Federal Court, With Issuance of Protective Order for HIPAA Information, Bernstein Liebhard LLP Reports 4Health News:Teenage Boys Want Intimacy, Not Just Sex, Survey Finds 2Health News:Teenage Boys Want Intimacy, Not Just Sex, Survey Finds 3Health News:Parents of Obese Kids Often View Them as Healthy 2Health News:Parents of Obese Kids Often View Them as Healthy 3Health News:BU researchers discover that Klotho is neuroprotective against Alzheimer's disease 2
... ... numerous prominent politicians along with TV stars and sports heroes have made headline news ... cannot seem to get enough of the tawdry details of the betrayers, the spotlight ... The true heroes are left standing in the shadows of their betrayers. , ...
... ... aftershave, beard inhibitor, and SPF29 sun block spray. , ... (PRWEB) January 27, 2010 -- Hey Dude Skin Care ™, ... an outstanding array of premium skin care products targeted at the unique protection, repair and ...
... CHAIRMAN , NEW YORK , Jan. 27 ... University announced today that William H. Foster , PhD, Dean ... Service, will become President and Chief Executive Officer of CASA on ... former U.S. Secretary of Health, Education, and Welfare who founded CASA in ...
... , , ... Remuda Ranch, Programs for Eating and Anxiety Disorders ( ... partnered to help educate parents, teachers and students about eating ... "MASK is excited to be trained by an organization of ...
... Jan. 27 The Ford Foundation today ... Initiative (CHAI), a global health-focused non-profit started by former President ... continuation of HIV/AIDS treatment and prevention services in Haiti ... , Haiti has one of the highest HIV ...
... , , LOS ANGELES , Jan. 27 ... information about the IDEAL breast implants on his blog. He discussed the ... be available to the public for a clinical trial. , Board-certified Dr. ... the new IDEAL breast implants. These implants are known to have the ...
Cached Medicine News:Health News:The True Hero Stands in the Shadow of the Betrayer 2Health News:Hey Dude Skin Care™ Rolls Out Line of Premium Men's Skin Care Products 2Health News:William H. Foster Succeeds Califano as President and CEO of CASA* 2Health News:William H. Foster Succeeds Califano as President and CEO of CASA* 3Health News:William H. Foster Succeeds Califano as President and CEO of CASA* 4Health News:Remuda Ranch, Programs for Eating and Anxiety Disorders, and MASK (Mothers Awareness on School-Age Kids), Partner to Help Educate Parents, Teachers and Students About Eating Disorders 2Health News:Remuda Ranch, Programs for Eating and Anxiety Disorders, and MASK (Mothers Awareness on School-Age Kids), Partner to Help Educate Parents, Teachers and Students About Eating Disorders 3Health News:Ford Foundation Commits $250,000 to Support HIV/AIDS Services in Haiti 2Health News:Dr. Jay Calvert MD Announces Details on New Patent-Protected Investigational Breast Implants 2Health News:Dr. Jay Calvert MD Announces Details on New Patent-Protected Investigational Breast Implants 3
(Date:7/24/2014)... -- IGI Laboratories, Inc. (NYSE MKT: IG), a New Jersey based ... results for the second quarter ended June 30, 2014. ... of $6.5 million in the second quarter of 2014, an ... , Total revenues of $13.3 million for the six months ... same period in 2013 , Total revenues generated from ...
(Date:7/24/2014)... RALEIGH-DURHAM, N.C. , July 24, 2014 /PRNewswire/ ... company has signed an Agreement with Kineticos, a ... sciences consulting company. Kineticos will support LSI Medience ... in sepsis management, to demonstrate utility in clinical ... has shown potential utility in diagnosis of sepsis, ...
(Date:7/24/2014)...  The American Association for Homecare (AAHomecare) yesterday ... help address audit issues in the HME industry ... the information technology lead in shaping its HME ... billing and business management solutions for nearly 3,000 ... support this important initiative on behalf of all ...
Breaking Medicine Technology:IGI Laboratories Announces Second Quarter 2014 Results 2IGI Laboratories Announces Second Quarter 2014 Results 3IGI Laboratories Announces Second Quarter 2014 Results 4IGI Laboratories Announces Second Quarter 2014 Results 5IGI Laboratories Announces Second Quarter 2014 Results 6IGI Laboratories Announces Second Quarter 2014 Results 7LSI Medience Corporation and Kineticos Sign Agreement Related to the Presepsin Biomarker in Sepsis Management and Treatment 2Brightree Joins AAHomecare as Corporate Partner and IT Lead on HME Audit Key 2
... China , July 22 /PRNewswire-Asia-FirstCall/ -- ... developing and producing botanical extracts and other raw ... receipt of its,European order for approximately 80 metric ... pharmaceutical company. This order is valued at,approximately ...
... A total joint replacement registry based on carefully designed and ... according to a paper published online in Clinical Orthopaedics and Related ... , , ... Permanente,s Total Joint Replacement Registry -- the nation,s largest such registry -- ...
Cached Medicine Technology:Huifeng Bio-Pharmaceutical Technology Announces a New Spain Order 2Huifeng Bio-Pharmaceutical Technology Announces a New Spain Order 3Kaiser Permanente Demonstrates Success of Large-Scale Total Joint Replacement Registry 2Kaiser Permanente Demonstrates Success of Large-Scale Total Joint Replacement Registry 3Kaiser Permanente Demonstrates Success of Large-Scale Total Joint Replacement Registry 4
... Genesis Total Knee System provides the adaptability ... each patient. Not the other way around. ... articular inserts and patellar components allow surgeons ... And you do it all with one ...
... Total Knee System will define the state ... possible with less - reducing inventory requirements ... both clinical and cost situations. The GENESIS ... giving surgeons creative solutions tomeet todays surgical ...
... MJS anatomic knee system ... durability, minimize polyethylene wear ... to minimize contact stress ... to achieve a well ...
The Balanced Knee™ system provides instrumentation designed to achieve proper tissue balancing and alignment with user-friendly instrumentation that provides reproducible results....
Medicine Products: