Navigation Links
New method to find novel connections from gene to gene, drug to drug and between scientists
Date:7/24/2012

Researchers from Mount Sinai School of Medicine have developed a new computational method that will make it easier for scientists to identify and prioritize genes, drug targets, and strategies for repositioning drugs that are already on the market. By mining large datasets more simply and efficiently, researchers will be able to better understand gene-gene, protein-protein, and drug/side-effect interactions. The new algorithm will also help scientists identify fellow researchers with whom they can collaborate.

Led by Avi Ma'ayan, PhD, Assistant Professor of Pharmacology and Systems Therapeutics at Mount Sinai School of Medicine, and Neil Clark, PhD a postdoctoral fellow in the Ma'ayan laboratory, the team of investigators used the new algorithm to create 15 different types of gene-gene networks. They also discovered novel connections between drugs and side effects, and built a collaboration network that connected Mount Sinai investigators based on their past publications.

"The algorithm makes it simple to build networks from data," said Dr. Ma'ayan. "Once high dimensional and complex data is converted to networks, we can understand the data better and discover new and significant relationships, and focus on the important features of the data."

The group analyzed one million medical records of patients to build a network that connects commonly co-prescribed drugs, commonly co-occurring side effects, and the relationships between side effects and combinations of drugs. They found that reported side effects may not be caused by the drugs, but by a separate condition of the patient that may be unrelated to the drugs. They also looked at 53 cancer drugs and connected them to 32 severe side effects. When chemotherapy was combined with cancer drugs that work through cell signaling, there was a strong link to cardiovascular related adverse events. These findings can assist in post-marketing surveillance safety of approved drugs.

The approach is presented in two separate publications in the journals BMC Bioinformatics and BMC Systems Biology. The tools that implement the approach Genes2FANs and Sets2Networks can be found online at http://actin.pharm.mssm.edu/genes2FANs and http://www.maayanlab.net/S2N.


'/>"/>

Contact: Mount Sinai Press Office
newsmedia@mssm.edu
212-241-9200
The Mount Sinai Hospital / Mount Sinai School of Medicine
Source:Eurekalert

Related medicine news :

1. Newer technology to control blood sugar works better than conventional methods
2. Study suggests new screening method for sudden death in athletes
3. Meditation Method a Matter of Taste
4. New Stanford method enables sequencing of fetal genomes using only maternal blood sample
5. Electronic data methods research seeks to build a learning health care system
6. New delivery method improves efficacy of 2 common Parkinsons disease medications
7. Quick-Reversal Method May Be at Hand for New Blood Thinner
8. Safer Grilling Methods Might Cut Cancer Risk
9. Hear to see: New method for the treatment of visual field defects
10. OHSU Oregon National Primate Research Center develops new, safer method for making vaccines
11. Advanced genetic screening method may speed vaccine development
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/4/2016)... , ... May 04, 2016 , ... Natalie Jill ... with local company MitoXcell in preparation of the launch of her new book: Natalie ... plan is a nutritional guide designed to jump start a new healthy lifestyle featuring ...
(Date:5/4/2016)... (PRWEB) , ... May 04, 2016 , ... ... all-LED multi-function small and compact tactical (6.7 inch) dual-light flashlights in models ... Vegas, model NSP-9842XL (average retail starting at $59.95) uses 2 included CR-123 batteries ...
(Date:5/4/2016)... Wisconsin (PRWEB) , ... May ... ... delivers next-level compression and support for knees, ankles, and elbows. Engineered with ... , Innovative 3D flat-bed manufacturing (opposed to ineffective circular knitting, common in ...
(Date:5/4/2016)... , ... May 04, 2016 , ... ... 2016, a powerful cellular therapy software application that helps blood and marrow ... patients. , Since Transtem’s initial launch, Mediware has continued to enhance core application ...
(Date:5/4/2016)... ... ... Over 40 athletic trainer’s (ATs) and athletic training students (ATSs) from across ... advocacy day. The annual lobbying effort is a collaboration between the Pennsylvania Athletic ... the day was to educate the elected legislators and the public about the profession ...
Breaking Medicine News(10 mins):
(Date:5/4/2016)... 4, 2016  It,s time for an upgrade. There are many medical recorders on ... inch LCD, the illustrious DVMAXX HD  offers unparalleled connectivity and functionality.  Ampronix  is ... world class manufacturer of innovative technology.  Photo - http://photos.prnewswire.com/prnh/20160503/363416 ... ... ...
(Date:5/4/2016)... May 4, 2016 Valeritas Holdings, ... an alternative public offering (APO). This was accomplished via ... Valeritas, Inc. and a private placement of approximately 5 ... per share. Under the terms of the ... Valeritas Holdings, Inc. will trade on the OTC Markets ...
(Date:5/4/2016)... , May 4, 2016 ... addition of the  "Global Acute lymphocytic Leukemia ...  report to their offering.       ... Global Acute Lymphocytic Leukemia Market and Competitive ... Acute Lymphocytic Leukemia pipeline products, Acute Lymphocytic ...
Breaking Medicine Technology: