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New method powerfully boosts efficiency of RNA interference (RNAi) in shutting down genes
Date:2/24/2011

As against that gene could shut down its activity efficiently. The success of their approach also means that scientists might no longer have to rely on current algorithms that are often not accurate in predicting which shRNA would work best at shutting down any given gene.

"There is still very little that is known about small RNA biogenesis," says Hannon. "But this assay has now allowed us to explore this process at a scale that wasn't feasible before." The scientists' analysis of the 20,000 small hairpin RNAs, and especially those recovered from cells in which the target gene had been efficiently shut off has revealed new insights into this process and drastically improved the recipe for creating a potent RNAi trigger. "Our assay has given us a strong framework for rational design of small hairpin RNAs," says Lowe.


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Contact: Hema Bashyam
bashyam@cshl.edu
516-367-6822
Cold Spring Harbor Laboratory
Source:Eurekalert

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