Navigation Links
New method manipulates particles for sensors, crime scene testing

WEST LAFAYETTE, Ind. - Researchers at Purdue University have developed a potential new tool for medical diagnostics, testing food and water for contamination, and crime-scene forensics.

The technique uses a combination of light and electric fields to position droplets and tiny particles, such as bacteria, viruses and DNA, which are contained inside the drops.

Other methods using either light or electric fields separately are able to position droplets or the particles they contain, but the new "hybrid optoelectric" device is able to do both, making it potentially practical for sensors and industrial processes, said mechanical engineering doctoral student Aloke Kumar.

Ordinarily, the particles inside droplets are detected when they randomly fall on a sensor's surface. However, the new method could improve sensor efficiency by actively moving particles to specific regions on an electronic chip for detection or analysis.

"This new hybrid technique is universal in the sense that we can manipulate a range of droplet and particle sizes, going all the way from microliter drops to particles a few nanometers long," said Steven T. Wereley, a professor of mechanical engineering who is working with Kumar.

The method offers promise for future "lab-on-a-chip" technology, using electronic chips to analyze biological samples for medical and environmental applications. Sensors based on the technique could make possible a new class of chemical analyses, or assays, with point-of-care devices in a doctor's office or hospitals.

Such sensors might be used to quickly analyze blood, urine and other bodily fluids for a range of applications, including drug screening; paternity testing; detecting coronary artery disease, tumors and various inherited diseases including cystic fibrosis; and detecting infectious diseases and bacteria, viruses and fungi that are difficult to culture using conventional laboratory methods.

"This technique also would be good for DNA tests, such as those used on the TV program 'CSI,' to identify crime suspects using only a small blood sample," Wereley said. "The idea is to use a chip to quickly carry out laboratory procedures called polymerase chain reaction and capillary electrophoresis. The new technology also should be good for testing food and water for pathogens such as E. coli or salmonella."

Critical to the technology are electrodes made of indium tin oxide, a transparent and electrically conductive material commonly used in consumer electronics for touch-screen displays. Liquid drops are positioned on the electrodes, and the infrared laser heats up both the electrodes and the droplets. Then electric fields in the electrodes cause the heated liquid to produce a "microfluidic vortex" of circulating liquid. This vortex enables researchers to position the particles in the circulating liquid by moving the infrared laser. The particles accumulate only where the laser is shined.

"Sensors are one of the immediate applications of this technology," said Kumar, who may continue the work as a postdoctoral researcher at the Oak Ridge National Laboratories, where he will complete a two-year Eugene Wigner Fellowship starting this month. "We should be able to improve the efficiency of sensors at least 10 times."

Findings were detailed in a research paper appearing June 1 in the journal Langmuir. The paper was written by Kumar, Wereley and former Purdue doctoral student Han-Sheng Chuang, now a postdoctoral researcher at the University of Pennsylvania. The research is based at the Birck Nanotechnology Center at Purdue's Discovery Park.

Purdue has filed a U.S. patent application on the design.

The technique might be used to manufacture sensors and other devices by modifying a phenomenon called the coffee-ring effect, which causes residue to form when liquid evaporates. Because the particles in the residue form only where the infrared laser shines, the procedure might be used to precisely position particles to create structures and circuits for biosensors and electronics.

"We have successfully used this technique to create spatially controlled microassemblies, and we hope that this would interest other research groups looking into the coffee-ring effect," Kumar said.


Contact: Emil Venere
Purdue University

Related medicine news :

1. New treatment method safe, effective for advanced melanoma patients
2. Color-coded tracking method helps scientists analyze outcomes of newly transplanted tissue
3. OHM Cheers End of the "Build it Bigger" Directive: Metropolitan Communities Look to New Methods to Evaluate, Rehabilitate Aging Sewer Systems
4. PMSI Advocacy Efforts Prompt CMS to Improve MSA Review Methodology
5. Investigators examine colorectal cancer screening methods among diverse populations
6. Allsup Outlines Quick-Processing Methods for Social Security Disability Claims
7. Breakthrough method predicts risk of invasive breast cancer
8. New reliable method based on patients gait helps to diagnose fibromyalgia
9. MU researchers show potential for new cancer detection and therapy method
10. Association of fiber and colorectal cancer risk differs depending on dietary assessment method
11. University of Miami College of Engineering to develop new methods for data analysis
Post Your Comments:
Related Image:
New method manipulates particles for sensors, crime scene testing
(Date:11/24/2015)... , ... November 24, 2015 , ... It takes only ... a business, it is critical that the first impression be positive and reflects business ... not likely to buy anything or want to return. They will also share their ...
(Date:11/24/2015)... ... 24, 2015 , ... United Benefit Advisors (UBA), the nation’s ... as its newest Partner Firm. Based in Jefferson City, Missouri, their core philosophy ... regardless of whether that client is a business, a family, or an individual. ...
(Date:11/24/2015)... , ... November 24, 2015 , ... Serenity Point Rehabilitation, ... series of recent video interviews with some of the staff members at their recovery ... residential treatment facility, as well as some of the things that make their recovery ...
(Date:11/24/2015)... ... 2015 , ... Abington Hospital – Jefferson Health is pleased ... Surgery Facility for treating individuals living with morbid or extreme obesity. , Aetna ... its members to help them make informed decisions about their healthcare needs. In ...
(Date:11/24/2015)... ... November 24, 2015 , ... American Specialty ... Program have announced their endorsement of the Medical Fitness Network (MFN), a ... proud to have the MFN as one of our endorsed organizations,” said ASH ...
Breaking Medicine News(10 mins):
(Date:11/24/2015)... Nov. 24, 2015 iRhythm Technologies, Inc. , a ... today announced that it will participate in the 27th Annual Piper ... New York, NY . Kevin King , ... December 1, 2015 at 8:50am ET. --> ... . --> . --> iRhythm ...
(Date:11/24/2015)... Ontario , Nov. 24, 2015 Teledyne ... digital X-Ray image sensing technology, will introduce its CMOS ... Technical Exhibition , November 29 to December 3, at McCormick ... of dynamic detectors for diagnostic and interventional imaging will be ... Xineos family of advanced CMOS X-Ray detectors is ...
(Date:11/24/2015)... The uptake of recently approved and pipeline premium products for ... growth to 2021, says GBI Research . ... Type 1 Diabetes Mellitus (T1DM), will be a key driver of market ... --> The uptake of recently approved and pipeline premium products ... market growth to 2021, says GBI Research . ...
Breaking Medicine Technology: