Navigation Links
New method identifies genes that can predict prognoses of cancer patients
Date:1/25/2013

ished gene expression profiling studies in ovarian cancer (including data from approximately 1700 patients).

When the investigators used SAPS to analyze these previously identified prognostic signatures in breast and ovarian cancer, they found that only a small subset of the signatures that were considered statistically significant by standard measurements also achieved statistical significance when evaluated by SAPS.

"Our work shows that when using prognostic associations to identify biological signatures that drive cancer progression, it is important to not rely solely on a gene set's association with patient survival," says Beck. "A gene set may appear to be important based on its survival association, when in reality it does not perform significantly better than random genes. This can be a serious problem, as it can lead to false conclusions regarding the biological and clinical significance of a gene set."

By using SAPS, Beck and his colleagues found that they could overcome this problem. "The SAPS procedure ensures that a significant prognostic gene set is not only associated with patient survival but also performs significantly better than random gene sets," says Beck. His team revealed new prognostic signatures in subtypes of breast cancer and ovarian cancer and demonstrated a striking similarity between signatures in estrogen receptor negative breast cancer and ovarian cancer, suggesting new shared therapeutic targets for these aggressive malignancies.

The findings also indicate that the prognostic signatures identified with SAPS will not only help predict patient outcomes but might also help in the development of new anti-cancer drugs. "We hope that markers identified in our analysis will provide new insights into the biological pathways driving cancer progression in breast and ovarian cancer subtypes, and will one day lead to improvements in targeted diagnostics and therapeutics," says Beck. "We also hope the method
'/>"/>

Contact: Bonnie Prescott
bprescot@bidmc.harvard.edu
617-667-7306
Beth Israel Deaconess Medical Center
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. New Book The MELT Method Offers a Breakthrough Self-Treatment System to Eliminate Chronic Pain, Erase the Signs of Aging, and Feel Fantastic in Just 10 Minutes a Day!
2. Kantar Health Further Strengthens Its Advanced Methods and Client Consulting Capabilities in the UK
3. Developed new method to diagnose hereditary breast and ovarian cancer
4. When Can You Get Pregnant? Many Women Don’t Know, But a Simple Family Planning Method Now Available from Cycle Technologies Can Help
5. Research Reveals Which Learning Methods Get an A
6. New Research Survey Indicates That Natural Family Planning Method CycleBeads® Helps Women Planning Pregnancies
7. Targeted gene silencing drugs are more than 500 times more effective with new delivery method
8. Methodist Retirement Communities Set to Open the First Memory Support Community in Huntsville, TX Area
9. Method developed by VTT targets diagnosis of early Alzheimers disease
10. Researchers explore social media as preventative method for infectious diseases
11. New method helps target Parkinsons disease
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/3/2015)... ... August 03, 2015 , ... Catalent Pharma Solutions, the leading ... consumer health products, today welcomed the announcement by OPKO Health that the US ... a new treatment for chronic kidney disease (CKD) and vitamin D insufficiency, which ...
(Date:8/3/2015)... ... August 03, 2015 , ... ... amputation , AUGUST 3, 2015 – Since winning a South by Southwest® (SXSW®) ... Impossible – an organization whose mission is to develop technology for the sake ...
(Date:8/3/2015)... , ... August 03, 2015 , ... ... Leadership ® and Navigant Center for Healthcare Research and Policy Analysis show widespread ... percent of respondents said they agreed or strongly agreed that the controversial law ...
(Date:8/3/2015)... (PRWEB) , ... August 03, 2015 , ... ... Modoc National Forest, to Ahjumawi Lava Springs, California’s northernmost and among its least ... largest untapped ground water aquifers, whose main outflow is at Ahjumawi Lava Springs, ...
(Date:8/3/2015)... ... August 03, 2015 , ... A July 13 article from ... Cells Found to Release Natural Painkiller That Can Last 'For Five Weeks'" discusses ... the report, the new study showed that harvesting stem cell-rich bone marrow from the ...
Breaking Medicine News(10 mins):Health News:Catalent’s OptiShell™ Technology is Delivery Platform for OPKO Health’s New Chronic Kidney Disease Treatment 2Health News:Catalent’s OptiShell™ Technology is Delivery Platform for OPKO Health’s New Chronic Kidney Disease Treatment 3Health News:Not Impossible Earns Top Awards for Technologies Benefiting Humanity 2Health News:Not Impossible Earns Top Awards for Technologies Benefiting Humanity 3Health News:Not Impossible Earns Top Awards for Technologies Benefiting Humanity 4Health News:Survey Finds Support for the Affordable Care Act Among Physician Leaders 2Health News:Survey Finds Support for the Affordable Care Act Among Physician Leaders 3Health News:Medicine Lake Aquifer could ease California drought says fresh water advocate Sharon Kleyne – but is this necessary? 2Health News:Medicine Lake Aquifer could ease California drought says fresh water advocate Sharon Kleyne – but is this necessary? 3Health News:Medicine Lake Aquifer could ease California drought says fresh water advocate Sharon Kleyne – but is this necessary? 4Health News:Los Angeles Spine Surgeon Gives Insight into How Stem Cells Can Relieve Back Pain 2Health News:Los Angeles Spine Surgeon Gives Insight into How Stem Cells Can Relieve Back Pain 3
... , , , ... Translational Research and the California Institute for Quantitative Biomedical ... (UCSF) together with Collaborative Drug Discovery, Inc. (CDD) are ... will present at the 3rd Annual Collaborative Drug Discovery ...
... treatment? Cost versus efficacy? So go two of the ... his fellow researchers in the race to fight HIV ... especially among women and their young children. ... Palumbo, a Dartmouth Medical School professor of medicine and ...
... , BETHPAGE, N.Y., Sept. 15 ... research into better detection and treatment of pancreatic cancer, today ... Patrick Swayze,s life. , , Kerri ... death of beloved actor Patrick Swayze. His courageous, public battle ...
... , ELLICOT CITY, Md., Sept. 15 As ... public, doctors and medical staff are beginning to evaluate their practice ... investing in PC-based medical equipment. , , Medical ... practice. Doctors must use the same precision and care they give ...
... have spent ... since 2007 ... campaign contributions , , WASHINGTON, ... industries spent $126,430,438 over the first half of 2009 and $585,725,712 over the past two and a half years ...
... , , , ... Inc. (Pink Sheets: ASFX) (the Company) today announced the appointment ... as Senior Vice President and Director of Business Development of ... of the intellectual property formerly owned by Safeguard, which produces ...
Cached Medicine News:Health News:3rd Annual Collaborative Drug Discovery - UCSF Community Meeting for Catalyzing Humanitarian and Commercial Research to be Held October 1st 2Health News:3rd Annual Collaborative Drug Discovery - UCSF Community Meeting for Catalyzing Humanitarian and Commercial Research to be Held October 1st 3Health News:3rd Annual Collaborative Drug Discovery - UCSF Community Meeting for Catalyzing Humanitarian and Commercial Research to be Held October 1st 4Health News:Weighing costs, benefits of HIV treatments 2Health News:Weighing costs, benefits of HIV treatments 3Health News:The Lustgarten Foundation Says Patrick Swayze's Death Highlights the Need for Increased Research into Early Diagnosis and Treatment of Pancreatic Cancer 2Health News:More Doctors Diagnose PC as a Winner 2Health News:Insurance and HMO Industries Spend Nearly $700,000 Per Day to Kill Health Care Reform Measures 2Health News:American Scientific Resources, Inc. Welcomes Jason Roth 2
(Date:8/3/2015)... , August 3, 2015 ... 2015 market research with 2020 forecasts as well ... healthcare and medical devices intelligence collection of its ... simulation market with 2020 forecasts spread across 164 ... with 170 tables and figures is now available ...
(Date:8/3/2015)... , Aug. 3, 2015 Par Pharmaceutical ... conference call on Friday, August 7, 2015 at 9:00 ... the second quarter ended June 30, 2015.  Par is ... to the public in its filings with the Securities ... available on its website by following the instructions at ...
(Date:8/3/2015)... Aug. 3, 2015 OmniSeq, LLC today ... to the OmniSeq SM Genomic Network.  Recently, ... Institute (RPCI) and announced it was making available ... physician-driven, collaborative approach to genomic diagnostics that provides ... Institute is a rapidly expanding, multidisciplinary cancer care ...
Breaking Medicine Technology:Medical Simulation Market to see 14% CAGR to 2019 2Medical Simulation Market to see 14% CAGR to 2019 3Medical Simulation Market to see 14% CAGR to 2019 4Medical Simulation Market to see 14% CAGR to 2019 5Medical Simulation Market to see 14% CAGR to 2019 6OmniSeq Adds Wilmot Cancer Institute to its Collaboration-Based Treatment Network 2OmniSeq Adds Wilmot Cancer Institute to its Collaboration-Based Treatment Network 3
... Jan. 10, 2011 CoreLab Partners, Inc , ... Inc and Medifacts International, has launched a new advanced ... are pleased to announce the release of our proprietary ... development continuum by offering sponsors advanced technologies and integrated ...
... Underwriters Laboratories (UL), a world ... release of a white paper that addresses the current ... equipment. The white paper, "Home Healthcare Equipment: An ... highlights the unique challenges for manufacturers with the U.S. ...
Cached Medicine Technology:CoreLab Partners Launches Advanced Imaging Application 2CoreLab Partners Launches Advanced Imaging Application 3UL White Paper Examines Key Implications of Growing Home Healthcare Industry 2
Cobb Curettes, reverse angled, 11"....
Malis Needle Holders, bayonet, titanium. Working distance 2 1/2" (63 mm). Straight tip with width 0.6 mm....
Clinical micro clamps by Acland. Black finish. It provides impressive security in use, both against slippage and against leakage due to controlled closing force and working grip surface....
Medium weight bone cutter....
Medicine Products: