Navigation Links
New method identifies genes that can predict prognoses of cancer patients
Date:1/25/2013

BOSTON In recent years, it has been thought that select sets of genes might reveal cancer patients' prognoses. However, a study published last year examining breast cancer cases found that most of these "prognostic signatures" were no more accurate than random gene sets in determining cancer prognoses. While many saw this as a disappointment, investigators at Beth Israel Deaconess Medical Center (BIDMC), the Dana-Farber Cancer Institute, and the Institut de Recherches Cliniques de Montral (IRCM) saw this as an opportunity to design a new method to identify gene sets that could yield more significant prognostic value.

Led by Andrew Beck, MD, Director of the Molecular Epidemiology Research Laboratory at BIDMC, the team has developed SAPS (Significance Analysis of Prognostic Signatures), a new algorithm that makes use of three specific criteria to more accurately identify prognostic signatures associated with patient survival.

Their results, the largest analysis of its kind ever performed, are reported in the January 24 on-line issue of the journal PLOS Computational Biology.

"SAPS makes use of three specific criteria," explains Beck, who is also an Assistant Professor of Pathology at Harvard Medical School. "First, the gene set must be enriched for genes that are associated with survival. In addition, the gene set must separate patients into groups that show survival differences. Lastly, it must also perform significantly better than sets of random genes at these tasks."

In the new study, the scientific team applied the SAPS algorithm to gene expression profiling data from the study's senior author Benjamin Haibe-Kains, PhD, Director of the Bioinformatics and Computational Genomics Laboratory at IRCM and an Assistant Research Professor at the University of Montreal. The first collection of data was obtained from 19 published breast cancer studies (including approximately 3800 patients), and the second included 12 publ
'/>"/>

Contact: Bonnie Prescott
bprescot@bidmc.harvard.edu
617-667-7306
Beth Israel Deaconess Medical Center
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. New Book The MELT Method Offers a Breakthrough Self-Treatment System to Eliminate Chronic Pain, Erase the Signs of Aging, and Feel Fantastic in Just 10 Minutes a Day!
2. Kantar Health Further Strengthens Its Advanced Methods and Client Consulting Capabilities in the UK
3. Developed new method to diagnose hereditary breast and ovarian cancer
4. When Can You Get Pregnant? Many Women Don’t Know, But a Simple Family Planning Method Now Available from Cycle Technologies Can Help
5. Research Reveals Which Learning Methods Get an A
6. New Research Survey Indicates That Natural Family Planning Method CycleBeads® Helps Women Planning Pregnancies
7. Targeted gene silencing drugs are more than 500 times more effective with new delivery method
8. Methodist Retirement Communities Set to Open the First Memory Support Community in Huntsville, TX Area
9. Method developed by VTT targets diagnosis of early Alzheimers disease
10. Researchers explore social media as preventative method for infectious diseases
11. New method helps target Parkinsons disease
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/30/2015)... ... June 30, 2015 , ... On June 26, 2015, Harper’s Bazaar ... five triggers that most people would not expect to cause acne flare-ups. ... primary causes of acne are clogged pores and bacteria and each of ...
(Date:6/30/2015)... New York, New York (PRWEB) , ... June ... ... Xarelto lawsuits ( http://www.xareltolawsuit2015.com/ ) currently pending in a federal multidistrict litigation now ... when the Court convenes its next monthly Status Conference. According to the Court’s ...
(Date:6/30/2015)... ... ... U.S. Women's National Soccer Team will face the Costa Rica Women's National team in ... at Heinz Field in Pittsburgh at 1:30 p.m. local time. On Wednesday, August 19th, ... The USA WNT previously played at Heinz Field in Pittsburgh and won against Iceland by ...
(Date:6/30/2015)... ... June 30, 2015 , ... An opinion piece published ... transfer procedures had over breast implants when reconstructing breasts after a mastectomy. The ... and feel natural,” have increased sensation, and are less likely than implant reconstructions ...
(Date:6/30/2015)... ... 30, 2015 , ... LifeAID Beverage Company has announced that ... dedicated to raising worldwide awareness of the burgeoning “adaptive” movement, I AM ADAPTIVE ... official charity of FitAID. I AM ADAPTIVE is a non-profit whose goal is ...
Breaking Medicine News(10 mins):Health News:A List of 5 Surprising Acne Triggers and the Latest Acne Treatment Options 2Health News:Progress of Federal Xarelto Lawsuits Pending in Multidistrict Litigation to Be Discussed During July 9th Status Conference 2Health News:Progress of Federal Xarelto Lawsuits Pending in Multidistrict Litigation to Be Discussed During July 9th Status Conference 3Health News:USA vs. Costa Rica Tickets at Heinz Field in Pittsburgh and Finley Stadium in Chattanooga: Ticket Down Slashes Presale Ticket Prices for Costa Rica vs. USA WNT 2Health News:Recent Article Advocating for Breast Reconstruction with Fat Transfers Successfully Outlines the Advantages of Transfer Procedures, Notes Beverly Hills Physicians 2Health News:Recent Article Advocating for Breast Reconstruction with Fat Transfers Successfully Outlines the Advantages of Transfer Procedures, Notes Beverly Hills Physicians 3Health News:LifeAID Beverage Company Partners With The Adaptive Movement 2Health News:LifeAID Beverage Company Partners With The Adaptive Movement 3
... Health authorities in Vietnam confirmed Wednesday the possibility that a ... could have contracted the lethal H5N1 strain of the bird ... ,A fresh outbreak of bird flu has hit ... lethal H5N1 strain after being hospitalized in serious condition. ...
... humanity, Cuban President Fidel Castro called for governments of the ... ,The non-profit exercise of medicine is capable of ... broadcast Tuesday by the island's mass media. ,In ... in Great Britain, which can shoot down lethal Tomahawk missiles ...
... tea is far better than drinking water, researchers said. ... or more cups of tea can reduce the risk of ... Ruxton from King's College London, it is a wrong belief ... than water as it contains antioxidants. It does not dehydrate ...
... to control a new outbreak of avian flu at three ... Wednesday. ,Laboratory tests confirmed the presence of ... humans, at three farms in Chak Shehzad, where about 12,000 ... the Agriculture and Livestock Ministry. ,There were no ...
... has found that combination asthma therapy, SYMBICORT leads ... (HRQL) and greater patient-reported satisfaction with asthma ... placebo). ,SYMBICORT is a recently approved, ... of asthma in patients 12 years of age ...
... the World Conservation Union (IUCN) has said that a sixth ... ,Unless the trend is reversed, conservationists fear that the ... target of halting biodiversity loss by 2010. ,Of ... western Russia, some 15 percent are classed as 'vulnerable' or ...
Cached Medicine News:Health News:Combo Therapy may Be Highly Beneficial in Asthma Control 2Health News:One-sixth of Europe's Mammals Face Extinction, Warns Conservation Experts 2
(Date:6/30/2015)... Millar, Inc. , a leader in catheter-based and wireless ... Craig Thummel , President/CEO and member of the ... the Company. The Company also announced its leadership succession ... Management team as his successors. The Board of Directors ... Sales and Marketing, as President, and also a member ...
(Date:6/30/2015)... CENTER VALLEY, Pa. , June 30, 2015 ... designing and delivering innovative solutions for medical and ... it is guaranteeing next-day replacements for surgical equipment ... surgical product manufacturer to offer this type of ... an Olympus Full Service Agreement earlier this year. ...
(Date:6/30/2015)... , June 30, 2015  Ardelyx, Inc. (NASDAQ: ... gastrointestinal and metabolic diseases, today announced that the Company ... 2015, from 8:00 a.m.- 1:00 pm EDT in ... The Ardelyx senior management team will present an overview ... tenapanor, which has completed Phase 2b clinical trials for ...
Breaking Medicine Technology:Millar, Inc. Announces Leadership Changes 2Millar, Inc. Announces Leadership Changes 3Olympus Introduces Industry-First Next-Day Product Replacement Guarantee for Surgical Business 2Olympus Introduces Industry-First Next-Day Product Replacement Guarantee for Surgical Business 3Ardelyx to Host Inaugural R&D Investor Day in New York City on July 14, 2015 2
... - Novel, ... 15 Carrington,Laboratories, Inc. (Nasdaq: CARN ) today ... toxicology studies of its,GelVac(TM) nasal powder influenza vaccine, incorporating ... a critical step during the vaccine,development and will assess ...
... N.C., Aug. 16 Cancer patients fraught with,flare-ups ... some assistance,in the form of a new easy-to-use ... to quickly deliver pain medication. Cancer patients ... Persistent cancer pain is characterized as continuous pain,present ...
Cached Medicine Technology:Carrington Subsidiary DelSite Initiates Critical Toxicology Studies of Its Nasal Powder Bird Flu Vaccine 2Carrington Subsidiary DelSite Initiates Critical Toxicology Studies of Its Nasal Powder Bird Flu Vaccine 3Novel Technology Breaks Through Cancer Pain 2
... determines osmolality at room temperature with the ... get are cryoscopic artifacts due to high ... interfere with freezing point determinations. The superbly ... Vapro osmometer has a much broader range ...
Rapid assay, results in 1 hours,Range 20-800 ng/mL; sensitivity 2.5 ng/mL,Can be used for animal sera; requires extraction protocol and steroid free serum...
... IMMULITE 2000 assays are ... the IMMULITE 2000, a ... immunoassay analyzer. IMMULITE 2000 ... centralization, and a rapidly ...
... in specimen radiography. The XPERT represents a research ... of gray in every digital x-ray image, thus ... density that heretofore were lost to the human ... x 2 to 8 x 8 in size, ...
Medicine Products: