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New method enables design, production of extremely novel drugs
Date:1/23/2008

ts to synthesize a compound now in clinical trials.

Demand for our catalysts has gone from gram to kilogram quantities, from fractions of an ounce to multiple pounds, said Davies.

So far, the new synthesis strategy has generated compounds that have potential activity against a broad range of disease states, from cancer to central nervous system disorders, such as depression, to inflammatory and microbial diseases and medications for treating cocaine addiction.

This method is like an enabling technology, making available new targets and materials that previously were out of range, said Davies.

Its ability to result in never-before-seen chemical structures is making Davies collaborations with scientists in partner institutions on the Buffalo Niagara Medical Campus especially fruitful.

Were using this as a platform for drug discovery, collaborating through the Center of Excellence with biologists at UB, Roswell Park and Hauptman Woodward Medical Research Institute, said Davies.

Davies company is one of 10 life sciences spinoffs based in the Center of Excellence, which has the dual mission of promoting life sciences research while facilitating economic development in Upstate New York.

In addition to helping drug companies design novel leads for new products, the new chemistry also allows pharmaceutical companies to synthesize efficiently and economically large quantities of novel compounds.

Through catalysis, the chemical synthesis method the UB researchers developed allows for highly unusual functionalizations of carbon-hydrogen bonds, Davies explained.

The method allows you to transform a molecule from a simple structure to a much more elaborate, drug-like material, he said, so it goes from a cheap building block to a potential drug-like candidate. Without a catalyst, it wont happen.

A major advantage of Davies chemical strategy is that the resulting compounds are produced selectively as
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Contact: Ellen Goldbaum
goldbaum@buffalo.edu
716-645-5000 x1415
University at Buffalo
Source:Eurekalert

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