Navigation Links
New method developed to expand blood stem cells for bone marrow transplant
Date:3/21/2013

ction signal that CUL4 recognizes and acts on," Dr. Zhou says.

The research team engineered a synthetic HOXB4 protein with a scrambled destruction signal. They produced large quantities of the protein in bacteria, and then delivered the protein into human blood stem cells in the laboratory. "When you mask the CUL4 degradation signal, HOXB4's half-life expands for up to 10 hours," Dr. Zhou says. "The engineered HOXB4 did its job to expand the stem cell, while keeping all its stem cell properties intact. As a result, cells receiving the engineered HOXB4 demonstrated superior expansion capacity than those given natural HOXB4 protein. Animal studies demonstrated that the transplanted engineered human stem cells can retain their stem cell-like qualities in mouse bone marrow."

Dr. Zhou says the engineered protein HOXB4 can potentially be administered every 10 hours or so to make the quantity of blood stem cells necessary for patient transplant and for banking.

"This is the ultimate goal for what we are trying to achieve," he says. "There are likely many roadblocks ahead to reach our goals, but we appear to have found ways to deal with one major hurdle of adult hematopoietic stem cell expansion."

Cornell Center for Technology Enterprise and Commercialization (CCTEC), on behalf of Cornell University, has filed a patent application that covers the work described here.


'/>"/>

Contact: Lauren Woods
Law2014@med.cornell.edu
646-317-7401
Weill Cornell Medical College
Source:Eurekalert

Page: 1 2 3 4

Related medicine news :

1. Nonsurgical Method to Measure Brain Pressure Shows Promise
2. New Method to Reveal Alzheimers Marker Shows Promise
3. New method to measure work addiction
4. Advanced genetic screening method may speed vaccine development
5. OHSU Oregon National Primate Research Center develops new, safer method for making vaccines
6. Hear to see: New method for the treatment of visual field defects
7. Safer Grilling Methods Might Cut Cancer Risk
8. Quick-Reversal Method May Be at Hand for New Blood Thinner
9. New delivery method improves efficacy of 2 common Parkinsons disease medications
10. Electronic data methods research seeks to build a learning health care system
11. New Stanford method enables sequencing of fetal genomes using only maternal blood sample
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/31/2015)... ... August 31, 2015 , ... MeYou Health ®, a social well-being company ... app, Walkadoo , by including an in-app step tracker. , Walkadoo is a ... walking habits. Rather than broadly assign every Walkadoo member 10,000 steps a day (as ...
(Date:8/31/2015)... ... August 31, 2015 , ... The ... the use of health IT to create efficiencies in healthcare information exchange, announces ... . Taking place at the Hyatt Regency Reston in Reston, Va. from October ...
(Date:8/31/2015)... ... August 31, 2015 , ... It’s a lot like ... director of GreenFields of Geneva. During his first days on the job, he’s run ... nice seeing them, and I like knowing that they’re living in such a wonderful ...
(Date:8/31/2015)... ... August 31, 2015 , ... The ... Talent Management Division , a department devoted to helping organizations identify and keep ... goes beyond selection, and The Brooks Group believes in offering a solution that ...
(Date:8/31/2015)... , ... August 31, 2015 , ... ... Commerce Exchange and Organization Supporting Business Owners and provided a tour of their ... Georgia, represents the success possible to international companies expanding business in the U.S. ...
Breaking Medicine News(10 mins):Health News:Walkadoo™ Walking Program Now Includes In-app Step Tracker 2Health News:WEDI Announces Program for Annual Fall Conference: WEDI-Con 2015 2Health News:WEDI Announces Program for Annual Fall Conference: WEDI-Con 2015 3Health News:Friendship Senior Options Welcomes New Executive Director for GreenFields of Geneva 2Health News:The Brooks Group Introduces Talent Management Division 2Health News:The Brooks Group Introduces Talent Management Division 3Health News:PartnerTech Supports Economic Growth as Host 2
... HealthDay Reporter , TUESDAY, Oct. 25 (HealthDay News) ... cantaloupes produced at a Colorado farm has reached 28, with ... late Tuesday. Officials said last week that the outbreak ... farm. Inspections on Sept. 22 and 23 ...
... potential leukemia therapy targets only cancer cells, while leaving ... cancer cells and healthy cells, causing significant side effects, ... This research is being presented at the 2011 ... Exposition in Washington, D.C., Oct. 23 27. ...
... both men and women, yet men remain underrepresented in research. A ... has found that the medical impact of the disorder is ... research has shown that the number of men seeking treatment is ... is closely linked to obesity and excessive weight gain as well ...
... high proportion of dense breast tissue, as seen with a ... But the role of non-dense fat tissue in the breast ... access journal Breast Cancer Research separates the breast ... shows that large areas of either are independently associated with ...
... TUESDAY, Oct. 25 (HealthDay News) -- Men with a history ... for lung cancer could benefit from a simultaneous check for ... estimated that smoking will cause more than 8 million deaths ... addition to cardiovascular disease and cancer, COPD is a major ...
... activity and cancer prevention, treatment recovery and survivorship have ... component in the treatment of a disease that claims ... to the American Cancer Society,s Global Facts and Figures. ... and Cancer, Dr. Kerry Courneya, is one of the ...
Cached Medicine News:Health News:Death Toll From Listeria Outbreak Hits 28 2Health News:Death Toll From Listeria Outbreak Hits 28 3Health News:Study shows why underrepresented men should be included in binge eating research 2Health News:CT Scans May Pick Up COPD Early in Smokers 2Health News:CT Scans May Pick Up COPD Early in Smokers 3Health News:Canada Research Chair renewal for Kerry Courneya 2Health News:Canada Research Chair renewal for Kerry Courneya 3
(Date:8/31/2015)... -- Regen BioPharma, Inc. (OTCBB: RGBP) and (PINK: ... of delivering its patented (US Patent 8,263,571) gene ... a clinically approved formulation as delivery system.  The ... silencing therapeutics in which the gene silencing drug ... By utilizing a local delivery system, potential toxicities ...
(Date:8/31/2015)... , Aug. 31, 2015  Soligenix, ... late-stage biopharmaceutical company developing products that address unmet ... and biodefense, announced today it has completed enrollment ... Data Review Committee (DRC) earlier this year, into ... is a first-in-class innate defense regulator (IDR) and ...
(Date:8/31/2015)... , Aug. 31, 2015  QT Vascular Ltd., together with ... together with its subsidiaries, the "Group"), a global ... of advanced therapeutic solutions for the minimally invasive ... results of the below-the-knee ("BTK") cohort of patients ... were presented on August 15, 2015 at the ...
Breaking Medicine Technology:Regen BioPharma, Inc. Develops BORIS Gene Silencing Based Treatment for Unresectable Liver Cancer 2Regen BioPharma, Inc. Develops BORIS Gene Silencing Based Treatment for Unresectable Liver Cancer 3Soligenix Announces Completion of Patient Enrollment into its Phase 2 Clinical Trial of SGX942 for the Treatment of Oral Mucositis in Head and Neck Cancer Patients 2Soligenix Announces Completion of Patient Enrollment into its Phase 2 Clinical Trial of SGX942 for the Treatment of Oral Mucositis in Head and Neck Cancer Patients 3Soligenix Announces Completion of Patient Enrollment into its Phase 2 Clinical Trial of SGX942 for the Treatment of Oral Mucositis in Head and Neck Cancer Patients 4Soligenix Announces Completion of Patient Enrollment into its Phase 2 Clinical Trial of SGX942 for the Treatment of Oral Mucositis in Head and Neck Cancer Patients 5Soligenix Announces Completion of Patient Enrollment into its Phase 2 Clinical Trial of SGX942 for the Treatment of Oral Mucositis in Head and Neck Cancer Patients 6Final Results From Below-The-Knee Cohort In Chocolate Registry Presented At The 5th Annual Amputation Prevention Conference 2Final Results From Below-The-Knee Cohort In Chocolate Registry Presented At The 5th Annual Amputation Prevention Conference 3Final Results From Below-The-Knee Cohort In Chocolate Registry Presented At The 5th Annual Amputation Prevention Conference 4
... levels were significantly higher in patients with osteosarcoma than ... Biological Trace Element Research (April 2009). Osteosarcoma, ... young adults.Randhu and colleagues measured serum fluoride levels in ... one had osteosarcoma, group two had non-osteosarcoma bone tumors, ...
... U.S. Agency for International Development (USAID) is convening a ... Ethiopia, in a regional exercise that will kick off ... The three-day exercise seeks to advance global capacity ... a pandemic. As recently emphasized by outbreaks of swine ...
Cached Medicine Technology:Another Study Links Fluoride to Bone Cancer 2USAID Cooperates in Pandemic Preparedness Initiative 2USAID Cooperates in Pandemic Preparedness Initiative 3
The Genesis Camera meets the needs of those with specific requirements that cannot be met by a conventional 'chinrest' type camera....
Eye Q PRO is the optimum choice for ophthalmologists and clinicians specializing in advanced pathology and research....
Auto Lensmeter LM-970...
... designed to eliminate the subjective nature of ... providing repeatable, objective measurements every time. The ... icon-based operating system ensure fast and simple ... optimal lens positioning and, in auto mode, ...
Medicine Products: