Navigation Links
New method developed to expand blood stem cells for bone marrow transplant
Date:3/21/2013

es are thus far the most efficient means to deliver therapeutic genes into HSCs in the laboratory setting. In the past, scientists used a virus as a vehicle to deliver a therapeutic gene into patients with severe combined immunodeficiency disease (SCID) to correct their immune deficiency. However, four children receiving SCID gene therapy developed treatment-related leukemia due to the inability to control where the virus inserts itself in the genome, often on the so-called "hot spots" that activate oncogenes or inactivate tumor suppressor genes. Also, other investigators have shown that it is possible to directly insert HOXB4 protein into extracted bone marrow stem cells. "All you do is add a little tag to the protein, which acts like a vehicle, driving the proteins through the cell membrane, directly into the nucleus," Dr. Zhou says. "But the half-life of the natural protein is very short -- about one hour. So that means that in order to expand blood stem cells, these HOXB4 proteins have to be added all the time. Because the proteins are very costly, this process is both expensive and impractical."

Dr. Zhou and his team, in collaboration with Dr. Malcolm A. S. Moore's group from Memorial Sloan-Kettering Cancer Center, took a different approach. They examined why HOXB4 protein doesn't last long in HSCs, once these cells are removed from the protective stem cell niche that they nest quietly in. They found that HOXB4 is targeted for degradation so that stem cells can start differentiating -- that is, turn into different kinds of adult blood cells. "HOXB4 prevents blood stem cells from differentiating, while, at the same time, allows them to renew themselves," Dr. Zhou says.

The researchers found that a protein, CUL4, is tasked with recognizing HOXB4 and tagging it for destruction by the cell's protein destruction apparatus. They discovered that CUL4 recognizes HOXB4 because it "sees" a set of four amino acids on the protein. "HOXB4 carries a destru
'/>"/>

Contact: Lauren Woods
Law2014@med.cornell.edu
646-317-7401
Weill Cornell Medical College
Source:Eurekalert

Page: 1 2 3 4

Related medicine news :

1. Nonsurgical Method to Measure Brain Pressure Shows Promise
2. New Method to Reveal Alzheimers Marker Shows Promise
3. New method to measure work addiction
4. Advanced genetic screening method may speed vaccine development
5. OHSU Oregon National Primate Research Center develops new, safer method for making vaccines
6. Hear to see: New method for the treatment of visual field defects
7. Safer Grilling Methods Might Cut Cancer Risk
8. Quick-Reversal Method May Be at Hand for New Blood Thinner
9. New delivery method improves efficacy of 2 common Parkinsons disease medications
10. Electronic data methods research seeks to build a learning health care system
11. New Stanford method enables sequencing of fetal genomes using only maternal blood sample
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/8/2015)... ... July 08, 2015 , ... ... has been recognized as a Gold-Level Fit-Friendly Worksite by the American Heart Association ... its employees to eat better and stay active through its Swellness Program, which ...
(Date:7/8/2015)... ... July 08, 2015 , ... The Fertility Centers of New England recently ... Hill Office Park, Suite 107. , "We are delighted to offer our patient-centered ... President and CEO, Joseph A. Hill, MD. “Both Dr. Beth Plante and Dr. Robert ...
(Date:7/7/2015)... ... July 08, 2015 , ... The OR Business Management Conference ... business managers increase efficiency, reduce supply chain costs, optimize throughput, and improve patient ... Phoenix Glendale, February 21-24, 2016. The agenda has been announced and includes four ...
(Date:7/7/2015)... ... July 07, 2015 , ... World Patent Marketing, ... apparel invention that merges kid's clothing and footwear for maximum comfort and benefit. ... 2017 and is one of the most lucrative segments in the global apparel ...
(Date:7/7/2015)... ... 07, 2015 , ... Researchers at UC Davis have reviewed ... didn’t) and how similar programs can be improved. , Interviewing staff, clinicians and ... of Practice (HEALTH COP) program, the team identified four factors that helped clinicians ...
Breaking Medicine News(10 mins):Health News:LaunchPoint Recognized with Second Consecutive American Heart Association Fit-Friendly Worksite Award 2Health News:New Braintree, MA Location for the Fertility Centers of New England 2Health News:Agenda, Pre-Conference Workshop, and More Announced for OR Business Management Conference 2Health News:Agenda, Pre-Conference Workshop, and More Announced for OR Business Management Conference 3Health News:Mom Creates Clothing Line and Footwear Product In One For World Patent Marketing's Trendy Selection Of New Apparel Inventions 2Health News:Mom Creates Clothing Line and Footwear Product In One For World Patent Marketing's Trendy Selection Of New Apparel Inventions 3Health News:Mom Creates Clothing Line and Footwear Product In One For World Patent Marketing's Trendy Selection Of New Apparel Inventions 4Health News:Mom Creates Clothing Line and Footwear Product In One For World Patent Marketing's Trendy Selection Of New Apparel Inventions 5Health News:UC Davis Study Identifies Tools, Strategies for Enhancing Obesity Prevention in Rural Communities 2Health News:UC Davis Study Identifies Tools, Strategies for Enhancing Obesity Prevention in Rural Communities 3
... 5 Cell Therapeutics, Inc. (CTI),(Nasdaq: CTIC ; ... Investor Forum next week. The conference will be ... Francisco. CTI will present on Wednesday, October 10 at ... slides and available for,replay after the presentation. The webcast ...
... Oct. 5 "The good news is,that there ... Terry D. Hashey,Medical Director of First Coast Family ... Corral Flu Campaign. "The bad news,is that despite ... still,ranked below the national average of 69.3% for ...
... Health, NGOs, Sports, Academic, and Business Leaders Issue a, Call ... ... Disabilities, ... non-governmental organizations (NGOs), sports,academic and business representing 60 countries gathered ...
... SOUTH SAN FRANCISCO, Calif., Oct. 4 Sunesis,Pharmaceuticals, Inc. ... inducement stock options awards in accordance with NASDAQ,Marketplace Rule ... stock options cover an aggregate of 48,000 shares of,common ... an,exercise price equal to the fair market value of ...
... 125 leaders,from throughout the state, led by Governor ... statewide campaign to Make Delaware,s Kids the,Healthiest in ... and,Prevention Services (NHPS), encourages and celebrates the efforts ... and other leaders to improve the motivation, opportunity ...
... Strike Force Since March, WASHINGTON, Oct. 4 ... operator of Direct Nursing Assistance Inc. of,Medicare fraud, Assistant ... U.S. Attorney R. Alexander Acosta of the Southern District ... Rodolfo Aenlle, 47, was found guilty on all,counts of ...
Cached Medicine News:Health News:Florida Health Care Community Stepping Up for the 2007-2008 Flu Season 2Health News:Global Leaders Converge for Special Olympics Global Policy Summit 2Health News:Global Leaders Converge for Special Olympics Global Policy Summit 3Health News:Global Leaders Converge for Special Olympics Global Policy Summit 4Health News:Sunesis Pharmaceuticals Reports New Option Grants Under NASDAQ Marketplace Rule 4350 2Health News:Governor Ruth Ann Minner, U.S. Senator Tom Carper, U.S. Representative Mike Castle and Lt. Governor John Carney Join 125 Delaware Community Leaders Endorsing the Campaign to Make Delaware's Kids the Healthiest in the Nation 2Health News:Governor Ruth Ann Minner, U.S. Senator Tom Carper, U.S. Representative Mike Castle and Lt. Governor John Carney Join 125 Delaware Community Leaders Endorsing the Campaign to Make Delaware's Kids the Healthiest in the Nation 3Health News:Miami Jury Convicts Medical Company Owner of Medicare Fraud 2
(Date:7/7/2015)... FREMONT, Calif. , July 7, 2015  The ... and Velos, Inc. have entered into a seven year ... research nationally throughout South Korea and ... signing was accompanied by a two day joint workshop between ... Korea.  National Cancer Center President Dr. Lee ...
(Date:7/7/2015)... , Kalifornien, 7. Juli 2015 /PRNewswire/ ... Medizintechnikunternehmen, das sich der Entwicklung innovativer Geräte ... heute den Zugang von R. Michael ... Herr Kleine verfügt über eine ... Medizintechnik und Gesundheitsfürsorge. Er hat verschiedene globale ...
(Date:7/7/2015)... Md. , July 7, 2015 ... (CRO) focusing in Oncology, Vaccines, and General Medicine ... the final locked database to Heron Therapeutics, Inc. ... 3 receptor antagonist product candidate SUSTOL® (granisetron ... regimen with the IV NK 1 receptor ...
Breaking Medicine Technology:National Cancer Center of South Korea and Velos Sign Long-Term Velos eResearch Agreement 2National Cancer Center of South Korea and Velos Sign Long-Term Velos eResearch Agreement 3Sequent Medical beruft Mike Kleine in den Aufsichtsrat 2Sequent Medical beruft Mike Kleine in den Aufsichtsrat 3Accelovance Completes Trial Enrollment and Delivery of Clinical Data for Heron Therapeutics' Phase 3 Trial 2
... ALTO, Calif., Jan. 10, 2012 Varian Medical Systems (NYSE: ... a new radiotherapy treatment planning tool designed to work with ... the amount of time needed for planning advanced treatments. ... clinician must take the patient,s anatomical images and identify and ...
... Agreement allows development for potential treatment of chronic constipation ... SHPGY ), the global specialty biopharmaceutical company, announced today ... market Resolor ® (prucalopride) in the United States ... of the agreement have not been disclosed. ...
Cached Medicine Technology:Varian Medical Systems Receives FDA 510(k) Clearance for Software that Speeds Up Radiotherapy Treatment Planning 2Shire Acquires US Rights to Resolor(R) (prucalopride) 2Shire Acquires US Rights to Resolor(R) (prucalopride) 3Shire Acquires US Rights to Resolor(R) (prucalopride) 4
... false signals and contamination caused by ... Barrier Tips offer performance and economy ... (PCR(a)), radioactive isotopes, tissue culture fluids, ... , ,Promega Barrier Tips are made ...
... eliminate false signals and contamination caused ... Promega Barrier Tips offer performance and ... acids (PCR(a)), radioactive isotopes, tissue culture ... specimens. , ,Promega Barrier Tips are ...
... a safe alternative to using positive displacement ... such as PCR(a), pipetting radioactive materials and ... excellent for tissue culture, gel loading, serological ... aerosol contaminants and liquids from reaching the ...
Diamond Filter Tips play a critical role in preventing aerosol-borne contamination. Also available sterilized (no need to autoclave) and certified free of detectable RNase, DNase, DNA, RNA, and prote...
Medicine Products: