Navigation Links
New metabolite-based diagnostic test could help detect pancreatic cancer early
Date:3/29/2013

PHILADELPHIA A new diagnostic test that uses a scientific technique known as metabolomic analysis may be a safe and easy screening method that could improve the prognosis of patients with pancreatic cancer through earlier detection.

Researchers examined the utility of metabolomic analysis as a diagnostic method for pancreatic cancer and then validated the new approach, according to study results published in Cancer Epidemiology, Biomarkers & Prevention, a journal of the American Association for Cancer Research.

"Although surgical resection can be a curative treatment for pancreatic cancer, more than 80 percent of patients with pancreatic cancer have a locally advanced or metastatic tumor that is unresectable at the time of detection," said Masaru Yoshida, M.D., Ph.D., associate professor and chief of the Division of Metabolomics Research at Kobe University Graduate School of Medicine in Kobe, Japan. "Conventional examinations using blood, imaging and endoscopy are not appropriate for pancreatic cancer screening and early detection, so a novel screening and diagnostic method for pancreatic cancer is urgently required."

Using gas chromatography mass spectrometry, the researchers measured the levels of metabolites in the blood of patients with pancreatic cancer, patients with chronic pancreatitis and healthy volunteers. They randomly assigned 43 patients with pancreatic cancer and 42 healthy volunteers to a training set and 42 patients with pancreatic cancer and 41 healthy volunteers to a validation set. They included all 23 patients with chronic pancreatitis in the validation set.

Analysis of the metabolomic data generated from the training set indicated that levels of 18 metabolites were significantly different in the blood of patients with pancreatic cancer compared with the healthy volunteers. Further investigation led the researchers to develop a method to predict a pancreatic cancer diagnosis using assessment of the levels of just four metabolites. In the training set, the approach demonstrated 86 percent sensitivity and 88.1 percent specificity. When tested again in the validation set, which included patients with chronic pancreatitis, the method demonstrated 71.4 percent sensitivity and 78.1 percent specificity.

"Our diagnostic approach using serum metabolomics possessed higher accuracy than conventional tumor markers, especially at detecting the patients with pancreatic cancer in the cohort that included the patients with chronic pancreatitis," Yoshida said. "This novel diagnostic approach, which is safe and easy to apply as a screening method, is expected to improve the prognosis of patients with pancreatic cancer by detecting their cancers early, when still in a resectable and curable state."


'/>"/>

Contact: Jeremy Moore
jeremy.moore@aacr.org
215-446-7155
American Association for Cancer Research
Source:Eurekalert

Related medicine news :

1. Diagnostic Marketing Association Names Siemens Healthcare Diagnostics its 2012 Marketer of the Year
2. Notre Dame researchers scoring a win-win with novel set of concussion diagnostic tools
3. Members of University Services Sleep Diagnostic & Treatment Centers Wake Up Industries and Communities to the Importance of Sleep for Sleep Awareness Week
4. About 15 percent of patients with Wolfram syndrome do not meet current diagnostic criteria
5. Combining plasma screening methods better identifies diagnostic and therapeutic targets
6. Dental Diagnostic & Surgical Equipment Market is expected to grow at a CAGR of 5.8% & to reach $6,073.7 Million by 2016 - by MarketsandMarkets
7. Fast, low-cost device uses the cloud to speed up diagnostic testing for HIV and more
8. Digital diagnostic tools lead to patient dissatisfaction, says MU expert
9. Mayo Clinic and SV Bio enter strategic relationship on genome diagnostics and interpretation
10. Canada In Vitro Diagnostics Market Analysis and Forecasts to 2017 in New Research Report at RnRMarketResearch.com
11. Combining diagnostic tests more accurate at predicting Alzheimers
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/26/2017)... ... June 26, 2017 , ... Dr. ... Medicine Specialists, in collaboration with the Fertility Center of California, is pleased to ... (percutaneous epidydimal sperm aspiration) and TESA (percutaneous testicular sperm extraction). These minimally invasive ...
(Date:6/26/2017)... ... 2017 , ... Maryland’s soybean farmers have improved the sustainability ... the United Soybean Board. , Thanks to the responsible use of technology ... on less land per bushel, the report says. The United Soybean Board’s “Soy ...
(Date:6/26/2017)... ... June 26, 2017 , ... LARKR™ , an innovative ... in every state across the country to join its online treatment platform. , ... therapists to reach a substantially greater number of people in need nationwide, and to ...
(Date:6/26/2017)... ... ... KICKICO , a protocol built on Ethereum for more transparent ICO and ... funding campaigns. KICKICO developers are testing the platform, which will launch for the public ... through the power of many - has been around for about ten years as ...
(Date:6/25/2017)... ... , ... FCPX LUT Vintage Volume 2 for Final Cut Pro X allows ... 2 contains 60 different color-grade presets, giving editors multiple options for adding different color ... out subjects, plus much more. FCPX LUT Vintage Volume 2 is designed for any ...
Breaking Medicine News(10 mins):
(Date:6/9/2017)... INDIANAPOLIS , June 9, 2017 More ... a further effort to help spread lessons learned from ... the International Diabetes Federation (IDF) and Eli Lilly and ... for the second phase of the Bringing Research in ... reaffirming their commitment to helping people with diabetes effectively ...
(Date:6/8/2017)... June 8, 2017   Responding to Heath Ledger,s ... the death of singer Chris Cornell in May, ... International offers a free online psychiatric drug ... and families about psychotropic drug risks. The ... died from an accidental overdose, has called for tighter rules ...
(Date:6/7/2017)... , June 7, 2017 Endo International ... June 7, 2017, the Hon. Joseph R. Goodwin ... of West Virginia , entered a ... Inc. Pelvic Repair System Products Liability Litigation (the "MDL") ... MDL cases to provide expert disclosures on specific causation ...
Breaking Medicine Technology: