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New medication treats drug-resistant prostate cancer in the laboratory
Date:6/17/2013

utations that enable them to spread, or metastasize, without the influence of androgens. For this reason, these aggressive prostate cancers are called castration-resistant.

In contrast, the study drug binds to a different part of the AR that does not require androgen, according to Jones. "Our new lead compound, pyrvinium pamoate, works by a unique mechanism that involves binding to a different site on the AR and inhibiting its activity without preventing androgen binding," he said. "We are hopeful that an optimized derivative of pyrvinium will be able to inhibit all AR activity and inhibit the growth of human prostate cancers that become resistant to other AR-targeted therapies and perhaps result in a curative metastatic prostate cancer therapy."

Investigators conducted this pre-clinical study using prostate-cancer cells in an animal model.

The National Institutes of Health's National Cancer Institute supported part of this study.


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Contact: Aaron Lohr
alohr@endocrine.org
240-482-1380
The Endocrine Society
Source:Eurekalert

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