Navigation Links
New medication shows promise as lipid-lowering therapy for rare cholesterol disorder
Date:11/2/2012

nd on a study in a rabbit model of the disease, Rader felt it would be effective against HoFH.

A proof of principle study conducted by Drs. Cuchel and Rader at Penn in six HoFH patients confirmed that lomitapide was highly effective in reducing LDL and provided the basis for the international phase 3 study, which was funded in part by the Office of Orphan Product Development at the Food and Drug Administration (FDA). Aegerion Pharmaceuticals in-licensed lomitapide from Penn in 2006, helping fund the completion of the study and the additional work required to submit a new drug application to the FDA.

On October 17, 2012, the FDA's Endocrinologic and Metabolic Drugs Advisory Committee recommended by a vote of 13 to 2 the approval of lomitapide to reduce LDL in patients with HoFH. The FDA is scheduled to make a final decision on approval of the medication by the end of year.

"The more than 15-year story of this therapy is the result of an enormous collaboration between academia, foundation, pharmaceutical and biotech industries, and the government," said Rader. "If lomitapide is approved and is made available to patients with this fatal disease, it will serve as a model for how different sectors can work together to bring new medicines to patients with large unmet medical need."


'/>"/>

Contact: Jessica Mikulski
jessica.mikulski@uphs.upenn.edu
215-349-8369
University of Pennsylvania School of Medicine
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. Forgoing Medication, for Babys Sake
2. Parents poor math skills may lead to medication errors
3. Reducing off-label use of antipsychotic medications may save money
4. Common acne medication doubles risk of eye infection
5. Misuse of over-the-counter pain medication is potential health threat
6. Genes predict if medication can help you quit smoking
7. Acne Medication May Raise Risk of Eye Infections
8. New delivery method improves efficacy of 2 common Parkinsons disease medications
9. Mount Sinai researcher finds timing of ADHD medication affect academic progress
10. Actos Bladder Cancer Lawsuit Filed in Louisiana Alleging Woman Used Diabetes Medication and Contracted Bladder Cancer, Consumer Justice Foundation Reports
11. Physicians dont adequately monitor patients medication adherence
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/25/2015)... Decora Preset 60 Minute Countdown Timer , a ... Hardware City.’ The product helps in automatically switching off any ... the related electronic device is automatically turned off after the ... said, “We are glad that this amazing product is now ... Timer Switch in just a few clicks. The product has ...
(Date:5/24/2015)... Michigan (PRWEB) May 24, 2015 ... them to take pressure measurements in patients’ bladder and ... doctor usually orders it if they have reported symptoms ... , Women’s Excellence in Bladder Control is ... unwanted urinary leakage or problems with overall control of ...
(Date:5/24/2015)... Indianapolis, Indiana (PRWEB) May 24, 2015 ... network service provider announces Midwest Telecom of America, Inc. ... , According to Cory Childs, IFN Enterprise Sales ... to service providers. “IFN’s fiber transport provides MTA ... Operations Center to their Tier 1 Internet and voice ...
(Date:5/23/2015)... 23, 2015 On May 13, Nithyananda ... a youngster's yogic power learned through meditation and initiation ... in Bangalore, India. , Yogamaatha, a nine-year-old girl from ... high profile professionals attending the 2015 Business Advocacy Summit ... -- blindfolded. , In a demonstration that lasted ...
(Date:5/23/2015)... Manufacturers are now required to produce water heaters ... Experts in the field agree that the regulation is aimed ... score is what miles per gallon is to your car. ... the minimum HSPF score has been raised to 8.2, technology ... north of 12. Indeed, the regulation was welcomed by environmentalist, ...
Breaking Medicine News(10 mins):Health News:Leviton's Decora 60 Minute Countdown Timer Available On ‘The Hardware City’ 2Health News:Indiana Fiber Network, LLC Enables Midwest Telecom of America with Fiber Route Diversity 2Health News:Nine-Year-Old Reads Blindfolded at Business Advocacy Summit 2Health News:Nine-Year-Old Reads Blindfolded at Business Advocacy Summit 3Health News:Parker & Sons Welcomes the Department of Energy’s Water Heater Regulation 2
... as Executive Vice President, Managing Director, NEW YORK, ... network, announced that Marcy Leger has joined the firm ... LM&P New,York, as a result of the tremendous growth ... President of Euro RSCG Life LM&P New,York and Chicago., ...
... NASA will release a,report on an astronaut and ... media teleconference to discuss the report at 2 ... an independent external committee,conduct a comprehensive review of ... NASA,s Johnson Space Center, Houston, began an internal,assessment ...
... Resources and National Association of Children of Alcoholics Offer ... Free Training Seminar for Clergy on January 30, 2008, ... and drug treatment agency and the National Association of ... others involved,in pastoral care with a free one-day training ...
... history, is determining factor, study finds , , TUESDAY, Jan. ... radiation treatment for fast-moving prostate cancer can save lives, ... have other serious medical problems, a new study shows. ... there definitely is a difference in outcome, depending on ...
... helps patients shed more pounds than dieting and exercise ... New research suggests that gastric lap-band surgery isn,t only for ... who aren,t severely fat. , Still, the surgery is extremely ... people with diabetes who need alternative ways to shed pounds, ...
... 22 STERIS Corporation,(NYSE: STE ) today announced ... dividend in the amount of $0.06 per common share. ... record at the close,of business on February 12, 2008., ... is to provide a healthier today and,safer tomorrow through ...
Cached Medicine News:Health News:Euro RSCG Life LM&P Announces Growth of Leadership Team 2Health News:Hormone Therapy Only Helps Some Older Men With Prostate Cancer 2Health News:Gastric Lap-Band Surgery Can Send Diabetes Into Remission 2Health News:Gastric Lap-Band Surgery Can Send Diabetes Into Remission 3Health News:STERIS Corporation Declares Regular Quarterly Dividend 2Health News:STERIS Corporation Declares Regular Quarterly Dividend 3
(Date:5/22/2015)... May 22, 2015 The North American ... and is estimated to reach $90.7 million by 2019, at ... Browse through the TOC of North America Dental Lasers Market ... help of various tables and figures. http://www.micromarketmonitor.com/market/north-america-dental-lasers-1771208223.html ... on this report.   Dental lasers are ...
(Date:5/22/2015)...  RegeneRx Biopharmaceuticals, Inc. (OTCQB: RGRX) ("the Company" ... the results of the Company,s 72-patient, placebo-controlled Phase ... for the treatment of dry eye patients using ... model.  The exploratory study was completed in late ... by the Company in a press release, identify ...
(Date:5/22/2015)... --  InspireMD, Inc. (NYSE MKT: NSPR) ("InspireMD" or the ... announced that its CGuard TM Embolic Prevention System reported ... Piotr Musialek , at the EuroPCR conference on ... PARADIGM, an investigator-initiated P rospective evaluation of ... revascularization I n symptomatic and increased-risk asymptomatic carotid ...
Breaking Medicine Technology:North America Dental Lasers Market is Expected to Reach $90.7 Million by 2019, at a CAGR of 9.2% From 2014 to 2019 2North America Dental Lasers Market is Expected to Reach $90.7 Million by 2019, at a CAGR of 9.2% From 2014 to 2019 3Complete Data from RegeneRx Phase II Dry Eye Trial Published in Current Issue of Clinical Ophthalmology 2Complete Data from RegeneRx Phase II Dry Eye Trial Published in Current Issue of Clinical Ophthalmology 3Complete Data from RegeneRx Phase II Dry Eye Trial Published in Current Issue of Clinical Ophthalmology 4InspireMD's CGuardTM Highlighted at Clinical Presentation at EuroPCR 2015 Conference 2InspireMD's CGuardTM Highlighted at Clinical Presentation at EuroPCR 2015 Conference 3InspireMD's CGuardTM Highlighted at Clinical Presentation at EuroPCR 2015 Conference 4
... Findings Include 80% SVR12 Rate with Nitazoxanide-Based Combination Therapy ... into Mechanism of Action of Nitazoxanide, MILAN, Italy, ... today announced that data from studies of,nitazoxanide in chronic ... presentations made at the 43rd Annual Meeting of the,European ...
... Award of a National Institutes of Health Small, ... Phase 2 Trial, HOUSTON, April 22 Agennix, ... placebo-controlled Phase 2 study,of oral talactoferrin alfa in patients ... talactoferrin in sepsis and is based on both the,mechanism ...
Cached Medicine Technology:Romark Announces Presentation of New Data for Nitazoxanide in Chronic Hepatitis C at EASL 2008 2Romark Announces Presentation of New Data for Nitazoxanide in Chronic Hepatitis C at EASL 2008 3Romark Announces Presentation of New Data for Nitazoxanide in Chronic Hepatitis C at EASL 2008 4Romark Announces Presentation of New Data for Nitazoxanide in Chronic Hepatitis C at EASL 2008 5Romark Announces Presentation of New Data for Nitazoxanide in Chronic Hepatitis C at EASL 2008 6Romark Announces Presentation of New Data for Nitazoxanide in Chronic Hepatitis C at EASL 2008 7Agennix Initiates A Randomized Double-Blind, Placebo-Controlled Phase 2 Study of Oral Talactoferrin in Severe Sepsis 2Agennix Initiates A Randomized Double-Blind, Placebo-Controlled Phase 2 Study of Oral Talactoferrin in Severe Sepsis 3Agennix Initiates A Randomized Double-Blind, Placebo-Controlled Phase 2 Study of Oral Talactoferrin in Severe Sepsis 4Agennix Initiates A Randomized Double-Blind, Placebo-Controlled Phase 2 Study of Oral Talactoferrin in Severe Sepsis 5
... are becoming very popular only a few ... the pack. Explore why MediTalk is rapidly ... and practice administrators. An EMR designed by ... doctors see patients quickly and efficiently while ...
Transfer your exams to AltaPoint with our EMR Exam Word Lists. Document systems as normal and annotate exceptions to the systems in the exam. AltaPoint EMR is configured to allow a specialty to cust...
MediNotes e is an EMR design which utilizes a "tab concept for navigation. MediNotes e can display multiple patients, encounter notes, workflow items, patient flow, messages, alerts, and more, all in...
... Software developed a touchscreen EHR and is ... a user can choose to use a ... maintain eye contact while recording encounter results. ... EHR also runs on a pen tablet ...
Medicine Products: