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New medication shows promise as lipid-lowering therapy for rare cholesterol disorder
Date:11/2/2012

PHILADELPHIA An international effort led by researchers at the Perelman School of Medicine at the University of Pennsylvania has resulted in positive phase 3 clinical trial results for a new medicine to treat patients suffering from a rare and deadly cholesterol disorder.

Penn researchers report in The Lancet that lomitapide, a first-in-class microsomal triglyceride transfer protein (MTP) inhibitor, substantially and stably reduced LDL cholesterol (the "bad" cholesterol) in patients with the orphan disease homozygous familial hypercholesterolemia (HoFH). Lomitapide works by inhibiting MTP, which is required for the production of VLDL the precursor to LDL.

HoFH patients have markedly elevated blood levels of cholesterol generally greater than 500 mg/dL due to genetic mutations in the LDL receptor gene that result in impaired ability of the liver to remove LDL from the blood. Heart and vascular disease often develop in childhood, and the average age of death even with current therapies is about 30 years. HoFH patients do not respond well to the usual treatments for elevated cholesterol, such as statins. The only effective therapy for these patients is apheresis, an invasive and time-consuming procedure that involves physically removing excess LDL from the bloodstream and must be repeated every one to two weeks.

The current study was an open-label trial that comprised a six-month phase designed to assess the efficacy of lomitapide when added to standard of care and an additional year-long phase to assess safety and tolerability. Twenty-nine adult HoFH patients from across the world were enrolled, with 23 patients completing both the efficacy and the safety phases. All of the patients received lomitapide along with conventional lipid-lowering therapies including statins and, in some cases, apheresis. The lomitapide dose was gradually increased from five mg to a maximum tolerated dose of up to 60 mg per day. Median do
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Contact: Jessica Mikulski
jessica.mikulski@uphs.upenn.edu
215-349-8369
University of Pennsylvania School of Medicine
Source:Eurekalert

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