Navigation Links
New medication shows promise as lipid-lowering therapy for rare cholesterol disorder
Date:11/2/2012

PHILADELPHIA An international effort led by researchers at the Perelman School of Medicine at the University of Pennsylvania has resulted in positive phase 3 clinical trial results for a new medicine to treat patients suffering from a rare and deadly cholesterol disorder.

Penn researchers report in The Lancet that lomitapide, a first-in-class microsomal triglyceride transfer protein (MTP) inhibitor, substantially and stably reduced LDL cholesterol (the "bad" cholesterol) in patients with the orphan disease homozygous familial hypercholesterolemia (HoFH). Lomitapide works by inhibiting MTP, which is required for the production of VLDL the precursor to LDL.

HoFH patients have markedly elevated blood levels of cholesterol generally greater than 500 mg/dL due to genetic mutations in the LDL receptor gene that result in impaired ability of the liver to remove LDL from the blood. Heart and vascular disease often develop in childhood, and the average age of death even with current therapies is about 30 years. HoFH patients do not respond well to the usual treatments for elevated cholesterol, such as statins. The only effective therapy for these patients is apheresis, an invasive and time-consuming procedure that involves physically removing excess LDL from the bloodstream and must be repeated every one to two weeks.

The current study was an open-label trial that comprised a six-month phase designed to assess the efficacy of lomitapide when added to standard of care and an additional year-long phase to assess safety and tolerability. Twenty-nine adult HoFH patients from across the world were enrolled, with 23 patients completing both the efficacy and the safety phases. All of the patients received lomitapide along with conventional lipid-lowering therapies including statins and, in some cases, apheresis. The lomitapide dose was gradually increased from five mg to a maximum tolerated dose of up to 60 mg per day. Median do
'/>"/>

Contact: Jessica Mikulski
jessica.mikulski@uphs.upenn.edu
215-349-8369
University of Pennsylvania School of Medicine
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. Forgoing Medication, for Babys Sake
2. Parents poor math skills may lead to medication errors
3. Reducing off-label use of antipsychotic medications may save money
4. Common acne medication doubles risk of eye infection
5. Misuse of over-the-counter pain medication is potential health threat
6. Genes predict if medication can help you quit smoking
7. Acne Medication May Raise Risk of Eye Infections
8. New delivery method improves efficacy of 2 common Parkinsons disease medications
9. Mount Sinai researcher finds timing of ADHD medication affect academic progress
10. Actos Bladder Cancer Lawsuit Filed in Louisiana Alleging Woman Used Diabetes Medication and Contracted Bladder Cancer, Consumer Justice Foundation Reports
11. Physicians dont adequately monitor patients medication adherence
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/31/2014)... Daily Gossip writes in its Xtreme Fat ... the fastest fat loss program ever developed. It promises to ... , There is no wonder after all that this has ... The new nutrition and workout fat loss program was created ... , According to the author of this fat loss system, ...
(Date:10/31/2014)... 2014 This Method to get ... effects for practitioners. , The Hypopresive (aka ... Science and Movement specializing in physical rehabilitation. Dr. ... floor reeducation that traditional abdominal exercises after pregnancy ... Prolepses, etc. , The Hipopressives exercises pull back ...
(Date:10/31/2014)... (PRWEB) October 31, 2014 With all ... one Midwest optometrist feels they may overlook one critical ... affect areas like concentration, school performance and even behavior. ... too brief to identify progressive vision problems, and to ... Mo., announces a new initiative: The Awesome Eyes Student ...
(Date:10/31/2014)... FL (PRWEB) October 31, 2014 Energy ... compression gear. The new gear is now available online, ... on the benefits of Celliant infrared-active athletic gear over ... reported that another contract has been signed for Under ... speedskaters for the next eight years. In light of ...
(Date:10/31/2014)... Oct. 31, 2014 (HealthDay News) -- Sleep apnea may make ... where you parked your car or left your house keys, ... severe sleep apnea showed that this ability -- called spatial ... movement (REM) sleep, even when other stages of sleep weren,t ... which dreams typically occur. "We,ve shown for the first ...
Breaking Medicine News(10 mins):Health News:Xtreme Fat Loss Diet Review Reveals How to Transform Your Body in 25 Days 2Health News:Super Models and European Celebrities’ Secret Flat Tummy System Comes to America 2Health News:Super Models and European Celebrities’ Secret Flat Tummy System Comes to America 3Health News:New School Vision Initiative Announced by Dr. Rosenak’s Optical Options; Program Aims to Help Recognize Unseen Vision Problems That Impact School Success 2Health News:New School Vision Initiative Announced by Dr. Rosenak’s Optical Options; Program Aims to Help Recognize Unseen Vision Problems That Impact School Success 3Health News:Compression Gear--Is There a Better Alternative? 2Health News:Compression Gear--Is There a Better Alternative? 3Health News:Compression Gear--Is There a Better Alternative? 4Health News:Sleep Apnea May Steal Some of Your Memory: Study 2
... 16 In this tough economy many,Americans are losing ... looking,at alternative health insurance options. Not only ... for most individuals and families, the loss of,health care ... the mortgage and,banking crisis, medical bills remain the leading ...
... Medical,International Limited (NYSE: MR ), a leading ... that it will present at,the 27th Annual J.P. Morgan ... The conference will ... Ronald Ede, Group Vice President of International,Operations and May ...
... can no longer be ignored. Treadmill desks offer a unique solution that ... ... America,s fixation on low carb diets has been shown to be ineffective ... it may have harmful effects on brain function as well. The study ...
... the unrivaled success of the diabetes pill DBCare®, Healing Power has ... alleviate physical and mental ailments such as blood pressure, allergies and ... ... December 16, 2008 - Healing Power Inc., a leader in all-natural ...
... large, multicenter clinical trial has shown that a diet ... in fat compared to standard federal dietary recommendations cuts ... breast cancer survivors women who didn,t have hot ... have higher recurrence and lower survival rates than breast ...
... Dec. 15 /PRNewswire-FirstCall/ - Labopharm Inc. (TSX: DDS; NASDAQ: ... on, Tuesday, December 16, 2008, at 10:00 am (ET) ... the product profile, clinical and regulatory progress and the ... (DDS-04A), a serotonin antagonist reuptake inhibitor (SARI), for the ...
Cached Medicine News:Health News:HealthInsuranceFinders.com Publishes Health Insurance Guide for the Recently Unemployed 2Health News:HealthInsuranceFinders.com Publishes Health Insurance Guide for the Recently Unemployed 3Health News:HealthInsuranceFinders.com Publishes Health Insurance Guide for the Recently Unemployed 4Health News:Mindray Medical to Present at the 27th Annual J.P. Morgan Healthcare Conference 2Health News:Low Carb Diets Shown to Impair Cognitive Function, Treadmill Desks Improve It 2Health News:Low Carb Diets Shown to Impair Cognitive Function, Treadmill Desks Improve It 3Health News:Healing Power Inc. Introduces New Web Site with 14 New Ayurvedic Products to Promote a Healthier Life 2Health News:Healing Power Inc. Introduces New Web Site with 14 New Ayurvedic Products to Promote a Healthier Life 3Health News:Diet may cut risk of breast cancer recurrence in women without hot flashes 2Health News:Diet may cut risk of breast cancer recurrence in women without hot flashes 3Health News:Labopharm to host webcast presentation on novel trazodone formulation - tomorrow (Dec.16/08) at 10:00 a.m. ET 2Health News:Labopharm to host webcast presentation on novel trazodone formulation - tomorrow (Dec.16/08) at 10:00 a.m. ET 3Health News:Labopharm to host webcast presentation on novel trazodone formulation - tomorrow (Dec.16/08) at 10:00 a.m. ET 4
(Date:10/31/2014)... 30, 2014 Migranade, Inc. announced today the ... to the 36 million U.S. migraine sufferers November, 2014. ... targets the actual cause of migraines and not just ... not the source Migranade is assured to be a ... Relief is available at http://www.migranade.com and will ...
(Date:10/31/2014)... 31, 2014  Isis Pharmaceuticals, Inc. (NASDAQ: ... , Isis Pharmaceuticals, Third Quarter 2014 Financial Results ... at 11:30 a.m. ET / 8:30 a.m. PTWhere: ... Internet. Simply log onto our website listed above. If ... a replay of the webcast will be available for ...
(Date:10/30/2014)... CHARLOTTETOWN , Oct. 30, 2014 /CNW/ - Atlantic ... three-year agreement reached between Canada,s ... Jim Keon , President of the Canadian Generic Pharmaceutical ... made the comments while speaking at the Atlantic Summit ... Charlottetown , which is being hosted by the ...
Breaking Medicine Technology:Game Changing Migraine Medication To Be Available November 2014 2Webcast Alert: Isis Pharmaceuticals' Third Quarter 2014 Financial Results Conference Call 2Webcast Alert: Isis Pharmaceuticals' Third Quarter 2014 Financial Results Conference Call 3Atlantic Canadians to Save $560-Million Through Unprecedented Three-Year Pan-Canadian Agreement on Generic Prescription Medicines 2Atlantic Canadians to Save $560-Million Through Unprecedented Three-Year Pan-Canadian Agreement on Generic Prescription Medicines 3
... N.J., Aug. 1, 2011 Social stigma is the ... care physicians, according to a survey commissioned by Janssen ... the National Medical Association (NMA).(1) Despite the belief by ... very serious or a crisis in the African-American community, ...
... Reportlinker.com announces that a new market research ... Prefilled Syringes: Devices, Therapeutics, Players, ... http://www.reportlinker.com/p0581168/Prefilled-Syringes-Devices-Therapeutics-Players-Markets-and-Prospects .html#utm_source=prnewswire&utm_medium=pr&utm_campaign=In_Vitro_Diagnostic ... continues to grow, the issue of prefilled ...
Cached Medicine Technology:Stigma Remains a Significant Barrier to Routine HIV Testing by African-American Physicians, Survey Finds 2Stigma Remains a Significant Barrier to Routine HIV Testing by African-American Physicians, Survey Finds 3Stigma Remains a Significant Barrier to Routine HIV Testing by African-American Physicians, Survey Finds 4Prefilled Syringes: Devices, Therapeutics, Players, Markets and Prospects 2Prefilled Syringes: Devices, Therapeutics, Players, Markets and Prospects 3
... ARUP Laboratories is a national reference laboratory ... research and development. ARUP offers an extensive ... medical tests in clinical and anatomic pathology. ... Laboratories' clients include more than half of ...
... national reference laboratory and a worldwide leader ... offers an extensive test menu of highly ... and anatomic pathology. Owned by the University ... than half of the nation's university teaching ...
... a national reference laboratory and a worldwide ... ARUP offers an extensive test menu of ... clinical and anatomic pathology. Owned by the ... more than half of the nation's university ...
... Laboratories is a national reference laboratory and ... and development. ARUP offers an extensive test ... tests in clinical and anatomic pathology. Owned ... clients include more than half of the ...
Medicine Products: