Navigation Links
New medication shows promise as lipid-lowering therapy for rare cholesterol disorder
Date:11/2/2012

PHILADELPHIA An international effort led by researchers at the Perelman School of Medicine at the University of Pennsylvania has resulted in positive phase 3 clinical trial results for a new medicine to treat patients suffering from a rare and deadly cholesterol disorder.

Penn researchers report in The Lancet that lomitapide, a first-in-class microsomal triglyceride transfer protein (MTP) inhibitor, substantially and stably reduced LDL cholesterol (the "bad" cholesterol) in patients with the orphan disease homozygous familial hypercholesterolemia (HoFH). Lomitapide works by inhibiting MTP, which is required for the production of VLDL the precursor to LDL.

HoFH patients have markedly elevated blood levels of cholesterol generally greater than 500 mg/dL due to genetic mutations in the LDL receptor gene that result in impaired ability of the liver to remove LDL from the blood. Heart and vascular disease often develop in childhood, and the average age of death even with current therapies is about 30 years. HoFH patients do not respond well to the usual treatments for elevated cholesterol, such as statins. The only effective therapy for these patients is apheresis, an invasive and time-consuming procedure that involves physically removing excess LDL from the bloodstream and must be repeated every one to two weeks.

The current study was an open-label trial that comprised a six-month phase designed to assess the efficacy of lomitapide when added to standard of care and an additional year-long phase to assess safety and tolerability. Twenty-nine adult HoFH patients from across the world were enrolled, with 23 patients completing both the efficacy and the safety phases. All of the patients received lomitapide along with conventional lipid-lowering therapies including statins and, in some cases, apheresis. The lomitapide dose was gradually increased from five mg to a maximum tolerated dose of up to 60 mg per day. Median do
'/>"/>

Contact: Jessica Mikulski
jessica.mikulski@uphs.upenn.edu
215-349-8369
University of Pennsylvania School of Medicine
Source:Eurekalert

0

GOOD

Page: 1 2 3

Related medicine news :

1. Forgoing Medication, for Babys Sake
2. Parents poor math skills may lead to medication errors
3. Reducing off-label use of antipsychotic medications may save money
4. Common acne medication doubles risk of eye infection
5. Misuse of over-the-counter pain medication is potential health threat
6. Genes predict if medication can help you quit smoking
7. Acne Medication May Raise Risk of Eye Infections
8. New delivery method improves efficacy of 2 common Parkinsons disease medications
9. Mount Sinai researcher finds timing of ADHD medication affect academic progress
10. Actos Bladder Cancer Lawsuit Filed in Louisiana Alleging Woman Used Diabetes Medication and Contracted Bladder Cancer, Consumer Justice Foundation Reports
11. Physicians dont adequately monitor patients medication adherence
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/22/2013)... MD (PRWEB) May 22, 2013 According ... is an autoimmune disorder effecting up to 3 million ... causing damage to the small intestine and mal-absorption of ... such as diarrhea, constipation, weight loss and vitamin deficiency, ... diet. While there are many gluten-free foods that celiac ...
(Date:5/22/2013)... research shows that craving drugs such as nicotine ... brain that are implicated in determining the value ... Dr. Alain Dagher, from McGill University, suggests ... underlie addiction. These results were presented at the ... the Canadian Association for Neuroscience - Association Canadienne ...
(Date:5/22/2013)... (HealthDay News) -- Roughly four in 10 uninsured patients ... (COPD) actually do not have the lung disease, a ... were made based on an evaluation of symptoms, rather ... test known as spirometry, which shows how well a ... air they can exhale and how long that takes. ...
(Date:5/22/2013)... Mathews from the University of Melbourne said this small ... undoubted benefits from CT scans in diagnosing and monitoring ... British Medical Journal today and involved researchers ... the International Agency for Research on Cancer in Lyon, ... very useful in providing detailed three dimensional pictures to ...
(Date:5/22/2013)... King of Prussia, PA (PRWEB) May 22, 2013 ... is proud to announce its participation in the Greater Philadelphia ... experienced cyclists and recreational riders who are passionate about stopping ... affects more than 25 million Americans. , The Tour ... Ambler Campus, located at 580 Meetinghouse Road in Ambler, 30 ...
Breaking Medicine News(10 mins):Health News:During Celiac Awareness Month, Nutrition Expert Keri Glassman Encourages People with Celiac Disease to Find a Fiber Alternative like Konsyl Original Formula 2Health News:During Celiac Awareness Month, Nutrition Expert Keri Glassman Encourages People with Celiac Disease to Find a Fiber Alternative like Konsyl Original Formula 3Health News:Addiction as a disorder of decision-making 2Health News:COPD May Be Over-Diagnosed Among Uninsured 2Health News:Small increase in cancer risk following CT scans in childhood and adolescence 2Health News:PreDiabetes Centers to Appear at the Philadelphia Tour de Cure 2Health News:PreDiabetes Centers to Appear at the Philadelphia Tour de Cure 3
... tripled its customer,base in 2008 and now serves more ... part because of economic uncertainty. Vendormate captures,credentials, and ... chain,interruptions. , "With the global ... anxious about their supply chain," said Andy,Monin, Vendormate president ...
... Bureau Chief Lydia Parnes -PALO ALTO, Calif., Jan. 13 ... of legal services to technology, life sciences, and growth ... the firm as a new partner in March. The ... at the Federal Trade Commission (FTC), Parnes is a ...
... Study will begin recruiting volunteers to take part in its comprehensive study ... a briefing, NIH officials announced that the first phase of recruitment for ... York. , ... Washington, DC (PRWEB) January 13, 2009 ...
... BoxTone(R) Inc., the expert in mobile user management, today announced it ... new purchases of its market-leading software solution to manage, monitor and ... ... January 13, 2009 -- BoxTone(R) Inc., the expert in mobile user ...
... PRINCETON, N.J., Jan. 13 Medarex, Inc. (Nasdaq: ... of the company,s strong science-base and strategy for ... provided were recent highlights of Medarex,s record of ... outlook for product pipeline milestones in 2009, underscoring ...
... lost substantially fewer days of work and worked fewer ... the Feb. 1 issue of Clinical Infectious Diseases ... drug resistance among this year,s flu strains, the study ... The burden of influenza-like illnesses during the flu season ...
Cached Medicine News:Health News:Economic Uncertainty Fuels Vendormate Growth in 2008 2Health News:Wilson Sonsini Goodrich & Rosati Expands Consumer Regulatory Practice 2Health News:National Children's Study Begins Recruiting Volunteers 2Health News:National Children's Study Begins Recruiting Volunteers 3Health News:National Children's Study Begins Recruiting Volunteers 4Health News:National Children's Study Begins Recruiting Volunteers 5Health News:BoxTone Presents Mobile Industry with Timely Money Back Software Guarantee for Managing Enterprise BlackBerry Platform 2Health News:BoxTone Presents Mobile Industry with Timely Money Back Software Guarantee for Managing Enterprise BlackBerry Platform 3Health News:BoxTone Presents Mobile Industry with Timely Money Back Software Guarantee for Managing Enterprise BlackBerry Platform 4Health News:Medarex Reviews Recent Highlights and Outlook for 2009 2Health News:Medarex Reviews Recent Highlights and Outlook for 2009 3Health News:Study shows workplace benefits of influenza vaccination in 50-64 year olds 2
(Date:5/22/2013)... CLEVELAND , May 22, 2013 /PRNewswire/ ... Software,s enterprise content management (ECM) ... Meditech,s Hospital Information System .  These organizations ... IT system and will use OnBase to ... corporate initiatives.   (Logo:  ...
(Date:5/22/2013)... 2013 Z-Medica, a leading developer and marketer ... first-ever line of products designed to meet the unique ... ® EMS 4x4 Dressing, QuikClot ® EMS ... Gauze™, all custom-designed to help responders stop bleeding fast ... to a hospital or trauma center. The line includes ...
(Date:5/22/2013)... May 22, 2013 Hemoglobin A1C levels ... with Type 2 diabetes, while modest improvements in ... outcomes and can lead to substantial healthcare cost ... International Society for Pharmacoeconomics and Outcomes Research (ISPOR) ... studies, sponsored by Valeritas, makers of the V-Go ...
Breaking Medicine Technology:Three New Health Systems Integrate Hyland Software's OnBase with Meditech Hospital Information System 2Three New Health Systems Integrate Hyland Software's OnBase with Meditech Hospital Information System 3Z-Medica Launches New Line of Hemostatic Agents for use in Emergency Medical Services 2Type 2 Diabetes Control Worsening, According To Study Of Patients On Commercial Insurance 2Type 2 Diabetes Control Worsening, According To Study Of Patients On Commercial Insurance 3Type 2 Diabetes Control Worsening, According To Study Of Patients On Commercial Insurance 4Type 2 Diabetes Control Worsening, According To Study Of Patients On Commercial Insurance 5Type 2 Diabetes Control Worsening, According To Study Of Patients On Commercial Insurance 6
Intended for the quantitative determination of gammaglutamyl transferase activity in serum or plasma. Single vial, dry powder reagent. Readily soluble at room temperature. Reaction: Kinetic. Waveleng...
For the direct, colorimetric determination of calcium in human serum or urine. Linearity: 20 mg/dl....
Intended for the quantitative determination of calcium in serum. Endpoint Reaction. Reaction complete within one minute, color developed is stable for 30 minutes. Wavelength: 570 nm. Linearity: 16 mg...
For the quantitative determination of alanine aminotransferase in human serum....
Medicine Products: