Navigation Links
New mechanism of bacterial pathogenesis discovered
Date:6/27/2012

Scientists have identified a new mechanism of bacterial pathogenesis. The results of the research project, partly funded by the Academy of Finland, have been published in the journal Proceedings of the National Academy of Sciences of the United States of America (PNAS).

Bacteria that cause chronic infections have an amazing but yet poorly known ability to subvert immune response, live and produce offspring, enter and wake up from a dormant phase to cause, in some instances, deadly complications.

Bartonella bacteria cause chronic infections in mammals (incl. humans), and are typically transmitted to new hosts mainly by arthropod vectors such as fleas, lice and ticks, but also via direct tissue trauma (e.g. cat scratches).

One very notable feature of these bacteria is their ability to cause vasoproliferative tumours that resemble Kaposi's sarcoma in patients suffering from immunodeficiency (e.g. AIDS, aggressive cancer treatments, organ transplantation). If left untreated, these foci of inflammation maintain a chronic infection and contribute to transmitting bacteria to new hosts.

In his research, biologist Arto Pulliainen (University of Turku) has demonstrated that Bartonella henselae injects a protein called BepA into vascular endothelial cells and that this protein manipulates cAMP-mediated cell signalling using a previously unknown mechanism.

BepA directly binds the host cell adenylyl cyclase, which is an enzyme responsible for the production of cAMP. However, the binding of BepA to the adenylyl cyclase does not activate cAMP production per se, but the adenylyl cyclase rather becomes more sensitive to its natural activator, stimulatory G-protein (Gαs). The cellular concentration of cAMP increases and prevents the death of the host cell. BepA significantly prolongs the lifespan of the host cell and partly contributes to the formation of vasoproliferative tumours.

Several bacterial species are known to manipulate host cell functions via cAMP-mediated cell signalling. The symptoms are typically very strong and may even be deadly. The best-known example is Vibrio cholerae and its cholera toxin, which modifies Gαs into a permanently adenylyl cyclase-stimulating form. BepA, in turn, manipulates host cell signalling in a subtle sophisticated manner, which is ideal for chronic persistence of Bartonella henselae in the infected vascular endothelium.

The research has been carried out at the Universities of Basel and Turku.


'/>"/>

Contact: Arto Pulliainen, Ph.D.
arto.pulliainen@utu.fi
358-233-37238
Academy of Finland
Source:Eurekalert

Related medicine news :

1. Abnormal gene product associated with prostate cancer generated by unusual mechanism
2. Scientists discover mechanism that promotes lung cancer growth and survival
3. Fruit flies reveal mechanism behind ALS-like disease
4. Probing the mechanism of ADAM28-mediated cancer metastasis
5. Study supports urate protection against Parkinsons disease, hints at novel mechanism
6. Aggregating instead of stabilizing: New insights into the mechanisms of heart disease
7. Researchers gain better understanding of mechanism behind tau spreading in the brain
8. Joslin scientists identify important mechanism that affects the aging process
9. Bacterial Vaginosis Increases Female-to-Male HIV Transmission Risk
10. Study Ties Kids Allergy Risks to Antibacterials, Preservatives
11. Killer stainless steel: New process gives icon of cleanliness antibacterial coating
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/23/2017)... ... August 23, 2017 , ... This week the The Voss ... Texas. Founded by Bill Voss, the firm grew quickly and has built a reputation ... of helping clients get the money they deserve from their insurance companies. , ...
(Date:8/23/2017)... ... August 23, 2017 , ... Based on ... safety and efficacy of HBOT in treating and helping to heal addictions and ... research showing the similarities of the wounds to the brain from traumatic brain ...
(Date:8/23/2017)... ... 23, 2017 , ... PreCheck, Inc., a background screening and ... with a three-year sales growth of 49 percent . The Inc. 5000 is ... comprehensive look at America’s independent entrepreneurs. This represents PreCheck’s fifth consecutive entry on ...
(Date:8/23/2017)... ... August 23, 2017 , ... MobilityWorks ®, the ... to the 2017 Inc. 500|5000, an exclusive ranking of America’s fastest-growing private companies. ... 139 percent, marking the twelfth year that the company has been included on ...
(Date:8/23/2017)... ... August 23, 2017 , ... ... American Academy of Orthopaedic Surgeons , points out that therapeutic modalities (physical ... pain or injury. According to the report, a wider scope of physical therapy ...
Breaking Medicine News(10 mins):
(Date:8/15/2017)... Inc. announced today that its fully owned USA ... York City Office in Yonkers, New York ... (TWO 2 ) homecare therapy. This new East Coast location has ... under the company,s DMEPOS accreditation for Home/Durable Medical Equipment Services. ... Advanced Oxygen Therapy Inc. New ...
(Date:8/11/2017)... 11, 2017 DarioHealth Corp. (NASDAQ: DRIO), a ... big data solutions, today announced that it will release ... and host a conference call at 9:00am ET. The ... financial results and its strategy and outlook for the ... Erez Raphael , Chief Executive Officer, and ...
(Date:8/8/2017)... Aug. 8, 2017  BioLineRx Ltd. (NASDAQ/TASE: BLRX), a ... reports its financial results for the second quarter ended ... the second quarter 2017 and to date: ... development programs for the Company,s lead project, BL-8040: ... study with BL-8040 as novel stem cell mobilization treatment ...
Breaking Medicine Technology: