Navigation Links
New mechanism of action for PARP inhibitors discovered
Date:11/9/2012

"Critical to this study, is the demonstration that PARP inhibitors are not equivalent with respect to their potency to trap PARP proteins," said Pommier. "Our findings indicate that PARP inhibitors should be categorized according to their potency to trap PARP, in addition to their ability to inhibit DNA repair. This is important because it might explain differences in the results of clinical trials using distinct PARP inhibitors."

In further experiments, the researchers identified several genetic mutations in post-replication repair and Fanconi anemia pathways that, like BRCA1 and BRCA2 mutations, sensitized cultured cells to the toxic effects of trapped PARP protein-DNA complexes.

"These data suggest that patients with cancers deficient in these PARP inhibitor-sensitizing genes might benefit from treatment with PARP inhibitors," said Pommier. "It is clear, however, that this hypothesis will require rigorous testing before being broadly translated to the clinic."


'/>"/>
Contact: Jeremy Moore
Jeremy.Moore@aacr.org
215-446-7109
American Association for Cancer Research
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Mechanism found for destruction of key allergy-inducing complexes, Stanford researchers say
2. Researchers reveal underlying mechanism of powerful chemotherapy for prostate cancer treatment
3. Scientist receives $2.8 Million to study cell signaling mechanism and develop potential therapeutics
4. WSU researchers discover mechanism leading from trichomoniasis to prostate cancer
5. Human Airways Brush Mechanism Gives Clues to Lung Diseases
6. Mechanisms of acquired chemoresistance in ovarian cancer identified
7. Moffitt Cancer Center researchers discover how cancer cells hijack a mechanism to grow
8. New regulatory mechanism discovered in cell system for eliminating unneeded proteins
9. Researchers unfold the mechanisms underlying blood disorders
10. Study reveals new mechanism that might promote cancers growth and spread in the body
11. Zebrafish reveal promising mechanism for healing spinal cord injury
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/27/2015)... The Case Management Society of ... provide CMSA's Career and Knowledge Pathways educational program ... strengthen the case/care management workforce by offering aptitude ... mutually beneficial agreement provides Medix, a workforce solutions ... in the healthcare, scientific and IT industries, access ...
(Date:5/27/2015)... SAN DIEGO, May 27, 2015 – Memorial Hospital, ... provider along the Gulf Coast to pioneer a ... partnership with MD Revolution, a digital care management ... that enables healthcare providers to easily meet Medicare’s ... user-friendly program is designed to improve patient engagement, ...
(Date:5/27/2015)... 2015 CompanionDx announced that ... genomic analysis in personalized cancer therapy: Non-small cell lung ... Society of Clinical Oncology (ASCO) as part of their ... , The molecular and clinical data used for the ... database. The study reports improved patient outcomes from a ...
(Date:5/27/2015)... IL (PRWEB) May 27, 2015 On ... North-based advertising agency, will partner with LifeSource to host ... event will take place in a LifeSource donor coach ... a.m. to 4:00 p.m. , Demand for whole blood ... in Illinois, during the summer months. LifeSource requires approximately ...
(Date:5/27/2015)... Dallas, Texas (PRWEB) May 27, 2015 ... on the current state of the Omega-3 industry. ... industry including definitions, classifications, applications and industry chain ... the international markets including development trends, competitive landscape ... Products, Gc Rieber Oils, Camanchaca Fishing Company, Seadragon ...
Breaking Medicine News(10 mins):Health News:Case Management Society of America Partners with Medix to Offer Career and Knowledge Pathways 2Health News:Case Management Society of America Partners with Medix to Offer Career and Knowledge Pathways 3Health News:Memorial Hospital Selects MD Revolution's Digital Health Platform to Deliver a New Form of Chronic Care Management 2Health News:Memorial Hospital Selects MD Revolution's Digital Health Platform to Deliver a New Form of Chronic Care Management 3Health News:CompanionDx® Analyzes Non-small Cell Lung Cancer Data for Personalized Cancer Therapy 2Health News:CompanionDx® Analyzes Non-small Cell Lung Cancer Data for Personalized Cancer Therapy 3Health News:Donate Your Break and Save Lives at the River North Blood Drive 2Health News:Omega-3 Market: Global 2015 Analysis & 2020 Forecasts on Market Size 2
... The number of heat-related deaths is underestimated and underreported ... study published in Biomedical Market Newsletter//(R). ,A ... of heat-related deaths is actually 54% higher than previously ... hyperthermia as a contributing cause of death increased by ...
... estimate of the repercussions of a potential flu pandemic showed ... the underprivileged nations, could pay// with their life. , ... infamous 1918 Spanish flu, which wiped out nearly 20 million ... of Public Health and the University of Queensland studied the ...
... pain are effective, a new review of studies has ... such as// depression and health-related quality of life, they ... ,“Because this analysis was both more inclusive and more ... to date that these interventions are helpful,” said psychologist ...
... eight year old cancer patient may be forced to undertake ... the painful radiotherapy. Having beaten the condition called Wilm’s Tumour ... been confronted by the tumour after a three year respite. ... attack has left the child with a poor quality of ...
... Journal of Neurology Neurosurgery and Psychiatry published a study which ... for treating wrinkled skin could ease writer’s cramp as well. ... hand, arms or fingers which causes pain. This can also ... with their other hand, but in one in four cases, ...
... recently published a study which proves that fish oil supplements ... ,The trial was done on 98 women who ... from 20th week of their pregnancy till the birth of ... not routinely eat more than two weekly portions of fish ...
Cached Medicine News:Health News:Psychological Treatments Improve Outcomes for Back Pain Sufferers 2Health News:Psychological Treatments Improve Outcomes for Back Pain Sufferers 3Health News:Fish Oil Improves Toddler’s Hand-eye Coordinatio 2
(Date:5/27/2015)... -- Protein purification involves the process of isolating proteins ... properties. The objective of a protein purification process is ... fewest contaminants. The global protein purification and isolation market ... 5% to 6% during the forecast period. This market ... and biotechnological fields, growing need to identify new protein-based ...
(Date:5/27/2015)... 2015  Precision Advisors ( www.precisionadvisors.com ), a Precision ... Digital Trends Study of 145 managed care executives. The ... concepts of big data and predictive analytics, but are ... The Health Information Technology for Economic and Clinical Health ... use of electronic medical records (EMRs) by 2014. While ...
(Date:5/27/2015)... , May 27, 2015 ... announced the addition of the  "US Cancer ... their offering.       (Logo: http://photos.prnewswire.com/prnh/20130307/600769) ... into to two broad categories of prophylactic ... cancer vaccines belong to both of these ...
Breaking Medicine Technology:Protein Purification & Isolation Market by Technology by Product by Application & End User - Global Forecast to 2020 2Protein Purification & Isolation Market by Technology by Product by Application & End User - Global Forecast to 2020 3Precision Advisors Digital Trends Study: Less Than Half of Managed Care Organizations Have Access to Electronic Medical Records Data 2Precision Advisors Digital Trends Study: Less Than Half of Managed Care Organizations Have Access to Electronic Medical Records Data 3US Cancer Vaccine Market Outlook 2020 2US Cancer Vaccine Market Outlook 2020 3
25 mm blunt, double-edged blade. Flat handle....
For use with N4096 R, N4097 R and N4098 R. 18 mm wide x 167 mm long. Ten per package. Designated most popular model or size....
5 mm small, sharp, protected blade. Angled at 105 degrees. Flat handle. Designated most popular model or size....
4 mm blade. Bayonet. Flat handle....
Medicine Products: