Navigation Links
New mechanism for long-term memory formation discovered
Date:3/25/2013

Irvine, Calif., March 25, 2013 UC Irvine neurobiologists have found a novel molecular mechanism that helps trigger the formation of long-term memory. The researchers believe the discovery of this mechanism adds another piece to the puzzle in the ongoing effort to uncover the mysteries of memory and, potentially, certain intellectual disabilities.

In a study led by Marcelo Wood of UC Irvine's Center for the Neurobiology of Learning & Memory, the team investigated the role of this mechanism a gene designated Baf53b in long-term memory formation. Baf53b is one of several proteins making up a molecular complex called nBAF.

Mutations in the proteins of the nBAF complex have been linked to several intellectual disorders, including Coffin-Siris syndrome, Nicolaides-Baraitser syndrome and sporadic autism. One of the key questions the researchers addressed is how mutations in components of the nBAF complex lead to cognitive impairments.

In their study, Wood and his colleagues used mice bred with mutations in Baf53b. While this genetic modification did not affect the mice's ability to learn, it did notably inhibit long-term memories from forming and severely impaired synaptic function.

"These findings present a whole new way to look at how long-term memories form," said Wood, associate professor of neurobiology & behavior. "They also provide a mechanism by which mutations in the proteins of the nBAF complex may underlie the development of intellectual disability disorders characterized by significant cognitive impairments."

How does this mechanism regulate gene expression required for long-term memory formation? Most genes are tightly packaged by a chromatin structure chromatin being what compacts DNA so that it fits inside the nucleus of a cell. That compaction mechanism represses gene expression. Baf53b, and the nBAF complex, physically open the chromatin structure so specific genes required for long-term memory formation are turned on. The mutated forms of Baf53b did not allow for this necessary gene expression.

"The results from this study reveal a powerful new mechanism that increases our understanding of how genes are regulated for memory formation," Wood said. "Our next step is to identify the key genes the nBAF complex regulates. With that information, we can begin to understand what can go wrong in intellectual disability disorders, which paves a path toward possible therapeutics."


'/>"/>
Contact: Tom Vasich
tmvasich@uci.edu
949-824-6455
University of California - Irvine
Source:Eurekalert

Related medicine news :

1. Fungus uses copper detoxification as crafty defense mechanism
2. BUSM authors propose potential epigenetic mechanisms for improved cancer therapy
3. A new mechanism that contributes to the evolution of cancer
4. Singapore scientists led by A*STARs GIS identify 4 mechanisms that contribute to gastric cancers
5. Cancer scientists determine mechanism of 1 of the most powerful tumor-suppressor proteins, Chd5
6. Research sheds new light on mechanisms of T-ALL, a form of leukemia that primarily affects children
7. Scientists discover mechanism that could reduce obesity
8. New mechanism for cancer progression discovered by UNC and Harvard researchers
9. Novel mechanism through which normal stromal cells become cancer-promoting cells identified
10. Mechanism of breathing muscle paralysis in dreaming sleep identified
11. New mechanism of action for PARP inhibitors discovered
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/9/2016)... ... February 09, 2016 , ... Cirracore Enterprise ... enterprises move workloads to the cloud. Cirracore provides a secure VMware® vCloud ... traversing the Internet. Transformation Solutions (TSL Partners) provides a full range of ...
(Date:2/9/2016)... (PRWEB) , ... February 09, 2016 , ... ... specialty pharmacies, announces today the continuation of the ‘Pay It Forward’ program into ... prescription referral received at our specialty pharmacy. , “Since our Pay It ...
(Date:2/9/2016)... ... February 09, 2016 , ... On January 12, 2016 Paul ... appointment after they noticed their furnace not producing any heat. Shortly after entering the ... cracked heat exchanger was leaking dangerous levels of carbon monoxide into the home, at ...
(Date:2/9/2016)... ... February 09, 2016 , ... The ... Herberger’s and Younkers department stores, announced it has raised $176,000 to benefit the ... Holden Comprehensive Cancer Center at the University of Iowa, The Lynn Sage Cancer ...
(Date:2/9/2016)... ... 09, 2016 , ... ZipHearing.com is proud to ... hearing aids , increase industry transparency, and promote awareness of hearing solutions ... “For the average consumer, the hearing aid industry is esoteric and difficult to ...
Breaking Medicine News(10 mins):
(Date:2/9/2016)... -- Axovant Sciences Ltd. (NYSE:  AXON), a leading clinical-stage ... today announced further details of three new clinical ... of Lewy body dementia, a disease affecting approximately ... of the three studies were recently initiated and ... quarter. In addition, the Company reported financial results ...
(Date:2/9/2016)... The new report "Global Diagnostic Ultrasound Devices Market Assessment ... reveals that global diagnostic ultrasound devices market was valued at US$ ... million by 2019 at a CAGR of 6.8% from 2015 to ... has been analyzed for six geographies of North America ... , Latin America , Middle-East ...
(Date:2/9/2016)... 2016 The new report "Global Blood Monitoring & Cardiac Monitoring Devices ... Consulting group reveals that global market for blood monitoring & cardiac ... expected to grow to US$ 24,830.1 million by 2019 at a ... America , Europe , Asia-Pacific ... and Africa . The three major ...
Breaking Medicine Technology: