Navigation Links
New marker offers hope for more reliable detection of prostate cancer
Date:5/9/2011

A new, promising marker for diagnosing prostate cancer has been discovered by Uppsala researchers with the aid of a unique method developed at the Department of Immunology, Genetics and Pathology. The study, being published this week in the journal Proceedings of the National Academy of Sciences, PNAS, can lead to more reliable diagnoses and fewer unnecessary operations.

The PSA marker used for diagnosing prostate cancer today has been criticized for false positive responses, leading to unnecessary operations. There is therefore great interest in finding new and better biomarkers.

- In the limited patient material examined in our study, blood levels of so-called prostasomes seem to correlate more closely with the severity of the disease than do PSA levels, says Masood Kamali-Moghaddam, a scientist in Professor Ulf Landegren's research team at the Department of Immunology, Genetics, and Pathology.

The team has previously developed a uniquely specific and sensitive method, called proximity ligation, for effective determination of proteins, and the method has now been adapted for detecting prostasomes.

One of the co-authors of the present study, Professor Gunnar Ronquist, showed 30 years ago that prostate cells pump out large quantities of a tiny membrane-coated particle in semen, which he named prostasomes. The hypothesis is that, in cancer, rather than winding up in semen, prostasomes are pumped out into the surrounding cancer tissue in invasive cancer. Therefore, prostasomes could be expected to occur at elevated levels in blood in cases of prostate cancer.

It has not been possible earlier to detect prostasomes in blood, but the researchers devised a unique test that requires several different antibodies to simultaneously recognize proteins on the surface of the prostasomes, and this allowed them to detect elevated levels of prostasomes in the blood of patients with prostate cancer.

"We are hope
'/>"/>

Contact: Masood Kamali- Moghaddam
masood.kamali@igp.uu.se
46-070-745-4366
Uppsala University
Source:Eurekalert

Page: 1 2

Related medicine news :

1. A cancer marker and treatment in 1?
2. Predicting premature birth possible through markers in mothers blood
3. Mans best friend: A joint tumor marker in man and dog
4. New potential atherosclerosis risk marker discovered
5. Blood Marker Suggests Severity of Alzheimers Disease
6. BATTLE researchers identify new biomarkers for EGFR inhibition
7. University of Colorado team identifies new colon cancer marker
8. Biomarker-driven science at the heart of new ACRIN-ECOG structure
9. Validation of salivary-biomarkers for Sjogrens syndrome detection in US population
10. Scientists ID possible biomarker to gauge Alzheimers prognosis, effect of therapies
11. Researchers discover possible biomarker and therapeutic target for melanoma
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/5/2015)... Doylestown, PA (PRWEB) May 05, 2015 The ... , raised $110,000 to benefit their global research, outreach and ... and silent auction, and awards ceremony that attracted hundreds of ... anniversary of the discovery of the hepatitis B virus (HBV) ... Dr. Blumberg received the Nobel Prize in Medicine for his ...
(Date:5/5/2015)... (PRWEB) May 05, 2015 Viverae®, ... C.R. Bard Inc., a leading multinational developer, manufacturer ... the fields of vascular, urology, oncology and surgical ... Vanguard Award. The Vanguard Award recognizes outstanding ... wellness programs among Viverae’s significant client base. , ...
(Date:5/5/2015)... Sunny skies and cool temperatures made for great conditions ... and walkers participated in Global Lyme Alliance’s (GLA) inaugural ... The 5K and 10K runs and 1-and 3-mile walks were ... funds for tick-borne disease research. The “Lyme Walk and Run” ... of Lyme Research Alliance (LRA) and Tick-Borne Disease Alliance ...
(Date:5/5/2015)... Skedans Systems a division of ... Sensor Collaboration Platform at AUVSI's Unmanned Systems 2015 ... provides tooling to deliver real time information for decision ... Sensor Collaboration Platform is a single unified cloud software ... Web Real Time Communications (WebRTC), and commercial Unmanned Autonomous ...
(Date:5/5/2015)... This year, PolyU researchers garnered two Grand Prizes, two ... Medals and four Silver Medals at the world-renowned event. ... Grand Prize and Gold Medal with the Congratulations of ... Principal Investigator: Dr Allan Chee-kooi CHAN, Institute of Textiles ... on the “mannequin” for many tasks involved in apparel ...
Breaking Medicine News(10 mins):Health News:Hepatitis B Foundation Marks 50th Anniversary of HBV Discovery at its Crystal Ball Gala 2Health News:Hepatitis B Foundation Marks 50th Anniversary of HBV Discovery at its Crystal Ball Gala 3Health News:Viverae® Honors C. R. Bard, Inc. with 2015 Vanguard Award 2Health News:1st Annual “Lyme Walk & Run” Event a Huge Success 2Health News:1st Annual “Lyme Walk & Run” Event a Huge Success 3Health News:Skedans Systems Announces Skedans Sensor Collaboration Platform at AUVSI's Unmanned Systems 2015 in Atlanta 2Health News:PolyU wins top prizes in Geneva’s Invention Expo 2Health News:PolyU wins top prizes in Geneva’s Invention Expo 3Health News:PolyU wins top prizes in Geneva’s Invention Expo 4Health News:PolyU wins top prizes in Geneva’s Invention Expo 5
... Targets and Cancer Therapeutics will be held from Nov. ... Francisco. This unique conference combines the efforts ... Cancer Institute and the European Organisation for the Research ... of its kind to focus exclusively on issues of ...
... are the typical excuses one might expect when medical ... error-reporting systems designed to improve patient safety and the ... that the most common reason among radiation oncologists was ... e-mailed an anonymous survey to physicians, nurses, radiation physicists ...
... the 5th Annual Osteoporosis Symposium, the announcement was made ... for the diagnosis of osteoporosis in Armenia. This brings ... to Armenia to 5 over the past 4 years. ... advanced of the technologies used to measure bone mineral ...
... , WEDNESDAY, Oct. 5 (HealthDay News) -- Three hours ... attack risk by 22 percent, a new study suggests. ... about 38 percent of that decreased risk was due to ... "good" high-density lipoprotein (HDL) cholesterol. The findings were published ...
... , TUESDAY, Oct. 4 (HealthDay News) -- As scientists continue ... appears that kids unlucky enough to get a "downer" personality ... in a warm, positive manner. A new study on ... variation predisposing them to lower serotonin levels in the brain ...
... we travel for sport -- whether to play it or ... place we visited to do that. Sport tourism is a ... youth. And, because it,s become a leisure phenomenon with increasingly ... the more timely that Hinch and his New Zealand co-author, ...
Cached Medicine News:Health News:Survey reveals reasons doctors avoid online error-reporting tools 2Health News:Capacity to diagnose osteoporosis doubles in Armenia 2Health News:Capacity to diagnose osteoporosis doubles in Armenia 3Health News:Happy Kids a Product of Genes, Parenting, Study Finds 2Health News:Happy Kids a Product of Genes, Parenting, Study Finds 3Health News:Sport tourism development book reveals new insights on growing leisure activity 2Health News:Sport tourism development book reveals new insights on growing leisure activity 3
(Date:5/5/2015)... MISSION, Kan. , May 5, 2015 ... priorities for you? If you,re like most adults, monitoring ... of your health care routine. But what about vision ... When adults reach their 40s, they ... which can impact their daily lives and job performance. ...
(Date:5/5/2015)... Research and Markets ( http://www.researchandmarkets.com/research/74vlb2/electro_surgical ... "Electro Surgical Market" report to their offering. ... to achieve a CAGR of 7% for the ... for patients as well as surgeons such as ... marks, bleeding control and improved accuracy are some ...
(Date:5/5/2015)... Isis Pharmaceuticals, Inc. (Nasdaq: ISIS ) ... for the three months ended March 31, 2015 compared ... million for the same period in 2014.  Isis, significantly ... milestone payments earned from its partners compared to the ... reported a loss from operations of $9.3 million for ...
Breaking Medicine Technology:Eye Care as You Age 2Eye Care as You Age 3Eye Care as You Age 4Global Electro Surgical Market 2015 2Isis Reports Financial Results and Highlights for First Quarter 2015 2Isis Reports Financial Results and Highlights for First Quarter 2015 3Isis Reports Financial Results and Highlights for First Quarter 2015 4Isis Reports Financial Results and Highlights for First Quarter 2015 5Isis Reports Financial Results and Highlights for First Quarter 2015 6Isis Reports Financial Results and Highlights for First Quarter 2015 7Isis Reports Financial Results and Highlights for First Quarter 2015 8Isis Reports Financial Results and Highlights for First Quarter 2015 9Isis Reports Financial Results and Highlights for First Quarter 2015 10Isis Reports Financial Results and Highlights for First Quarter 2015 11Isis Reports Financial Results and Highlights for First Quarter 2015 12Isis Reports Financial Results and Highlights for First Quarter 2015 13
... qualitative detection of Group A Streptococcal antigen ... is,self-contained and features all the necessary components ... including the throat swabs,and a pictorial procedure ... detection of Group A Streptococcal antigen directly ...
This One-step Ovulation Predicting Test is a lateral flow,chromatographic immunoassay for the rapid semi-quantitative,detection of human luteinizing hormone (hLH) in human urine to,predict the...
... Medical Ovulation Test Kits help you plan your ... sticks to help you predict your most fertile ... and accurately detect the increase in luteinizing hormone ... 24 to 48 hours before ovulation. You are ...
...
Medicine Products: