Navigation Links
New marker offers hope for more reliable detection of prostate cancer
Date:5/9/2011

A new, promising marker for diagnosing prostate cancer has been discovered by Uppsala researchers with the aid of a unique method developed at the Department of Immunology, Genetics and Pathology. The study, being published this week in the journal Proceedings of the National Academy of Sciences, PNAS, can lead to more reliable diagnoses and fewer unnecessary operations.

The PSA marker used for diagnosing prostate cancer today has been criticized for false positive responses, leading to unnecessary operations. There is therefore great interest in finding new and better biomarkers.

- In the limited patient material examined in our study, blood levels of so-called prostasomes seem to correlate more closely with the severity of the disease than do PSA levels, says Masood Kamali-Moghaddam, a scientist in Professor Ulf Landegren's research team at the Department of Immunology, Genetics, and Pathology.

The team has previously developed a uniquely specific and sensitive method, called proximity ligation, for effective determination of proteins, and the method has now been adapted for detecting prostasomes.

One of the co-authors of the present study, Professor Gunnar Ronquist, showed 30 years ago that prostate cells pump out large quantities of a tiny membrane-coated particle in semen, which he named prostasomes. The hypothesis is that, in cancer, rather than winding up in semen, prostasomes are pumped out into the surrounding cancer tissue in invasive cancer. Therefore, prostasomes could be expected to occur at elevated levels in blood in cases of prostate cancer.

It has not been possible earlier to detect prostasomes in blood, but the researchers devised a unique test that requires several different antibodies to simultaneously recognize proteins on the surface of the prostasomes, and this allowed them to detect elevated levels of prostasomes in the blood of patients with prostate cancer.

"We are hopeful that this type of marker will prove valuable not only for prostate cancer but also in several other common tumor types," says Masood Kamali- Moghaddam.


'/>"/>

Contact: Masood Kamali- Moghaddam
masood.kamali@igp.uu.se
46-070-745-4366
Uppsala University
Source:Eurekalert

Related medicine news :

1. A cancer marker and treatment in 1?
2. Predicting premature birth possible through markers in mothers blood
3. Mans best friend: A joint tumor marker in man and dog
4. New potential atherosclerosis risk marker discovered
5. Blood Marker Suggests Severity of Alzheimers Disease
6. BATTLE researchers identify new biomarkers for EGFR inhibition
7. University of Colorado team identifies new colon cancer marker
8. Biomarker-driven science at the heart of new ACRIN-ECOG structure
9. Validation of salivary-biomarkers for Sjogrens syndrome detection in US population
10. Scientists ID possible biomarker to gauge Alzheimers prognosis, effect of therapies
11. Researchers discover possible biomarker and therapeutic target for melanoma
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/28/2017)... ... March 28, 2017 , ... ... advancing the science and clinical practice of radiosurgery, announced today the publication ... multi-institutional, observational registry established to standardize data collection from patients treated with ...
(Date:3/28/2017)... , ... March 28, 2017 , ... ... today that the University of Pittsburgh Medical Center (UPMC) will acquire QuikClot® Bleeding ... Pennsylvania. , The program, developed in association with efforts by the American College ...
(Date:3/28/2017)... ... , ... The Radiology Business Management Association (RBMA) is pleased to ... executive director. Mr. Still was selected through a careful months-long search by the RBMA ... known to our members, has been a part of building the RBMA since 1992,” ...
(Date:3/28/2017)... , ... March 28, 2017 , ... ... Wethersfield, Conn., has relocated its corporate headquarters to a new, more expansive office ... , In October 2016, Qualidigm purchased a distressed office building in Wethersfield, Conn. ...
(Date:3/28/2017)... ... March 28, 2017 , ... METTLER ... ions found in power plant water and steam. , Chlorides and sulfates cause ... boilers, leading to extensive maintenance and unplanned shutdowns. Monitoring these ions at low ...
Breaking Medicine News(10 mins):
(Date:3/28/2017)... March 28, 2017  Medeon Biodesign, Inc., a ... is pleased to announce that the Company led ... Panther Orthopedics, Inc., a San Jose, ... solutions for orthopedic extremity applications.  ... rapidly, primarily due to procedure volume growth, lifestyle ...
(Date:3/28/2017)... , Va. and PHOENIX , March 28, ... Avella Specialty Pharmacy released a new white ... allergies and the use of latex in healthcare. Specifically, there ... in healthcare. In fact, the FDA has urged manufacturers to ... latex" claim from labels, because of the challenge to ensure ...
(Date:3/28/2017)... Kingdom and  BOSTON , March 28, 2017 ... Linguamatics today announced a partnership with premium ... agreement allows pharmaceutical companies to extract key insights ... text mining technology. The Linguamatics ... the top 20 global pharmaceutical companies. The Linguamatics-Dow ...
Breaking Medicine Technology: