Navigation Links
New marker identified for early diagnosis of lung cancer
Date:9/16/2013

PHILADELPHIA A protein called isocitrate dehydrogenase (IDH1) is present at high levels in lung cancers and can be detected in the blood, making it a noninvasive diagnostic marker for lung cancers, according to a study published in Clinical Cancer Research, a journal of the American Association for Cancer Research.

"This study is the first to report identification of IDH1 as a novel biomarker for the diagnosis of non-small cell lung cancers (NSCLC) using a large number of clinical samples," said Jie He, M.D., Ph.D., director of the Laboratory of Thoracic Surgery at the Peking Union Medical College and Chinese Academy of Medical Sciences in Beijing. "Lung cancer has a high mortality rate, mostly because of late diagnosis. With an increase in aging population, we are likely to see an increase in lung cancer incidence and a need for better biomarkers for early diagnosis. We have identified IDH1 as an effective plasma biomarker with high sensitivity and specificity in the diagnosis of NSCLC, especially lung adenocarcinoma."

Lung cancer is the leading cause of cancer deaths in both men and women in the United States and worldwide. To detect lung cancer in blood, currently certain biomarkers including CEA, Cyfra21-1 and CA125 are used, but these markers are not very sensitive, according to He.

He and colleagues found that IDH1 could be detected in the blood of lung cancer patients with 76 percent sensitivity and 77 percent specificity. When they used a mathematical model to combine the detection of IDH1 with the detection of existing markers CEA, Cyfra21-1, and CA125, the sensitivity increased to 86 percent.

"Based on the present data, IDH1 can be used to detect stage 1 lung cancer; however, it is also possible that IDH1 could be used to detect precancer but further studies are required to address that possibility," said He.

He and colleagues used blood samples collected from 943 patients with NSCLC and 479 healthy
'/>"/>

Contact: Jeremy Moore
jeremy.moore@aacr.org
215-446-7109
American Association for Cancer Research
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Immune System Marker Tied to Improved Bone Marrow Transplant Outcomes
2. Researchers identify novel biomarker for diabetes risk
3. Gene-expression-based biomarker predicts long-term risk of breast cancer recurrence
4. Researchers to identify genetic biomarkers for aggressive breast cancer
5. Study identifies fibroblast growth factor 18 as an ovarian cancer biomarker
6. Molecular marker predicts patients most likely to benefit longest from 2 popular cancer drugs
7. Biomarker assessment in suspected ACS could be practice-changing: BIC-8 results
8. Researchers develop specific tests to identify cancer biomarkers in dermatomyositis
9. Brain dopamine may serve as a risk marker for alcohol use disorders
10. Global Oncology Biomarkers Market to Reach US $9.5 Billion by 2014 at a CAGR of 18.1% - New Report by MarketsandMarkets
11. Biomarker Market is Estimated to Grow at a CAGR of 14.40% During the Study Period of 2011-2016 – New Report by MarketsandMarkets
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/31/2014)... New Delhi, India (PRWEB) July 31, 2014 ... company, has launched a new service named ‘Remove Bad ... against which bad reviews are published on various review ... study about the world of internet marketing, the sites ... by its competitors in order to tailor the service. ...
(Date:7/31/2014)... MD (PRWEB) July 31, 2014 FITNESS ... San Francisco, announced that they will upgrade all locations ... MoSo, MyClub, and MoSo Pay. Motionsoft is a leading ... solutions that automate member management and payments services for ... member relationship management suite, which FITNESS SF bundled with ...
(Date:7/31/2014)... India (PRWEB) July 31, 2014 Web ... an ISO 9001:2008 certified internet marketing firm, has recently ... order to make this service affordable for everyone, the ... of the service. , Web Programming Services has ... the world of brochure designing and likely expectations of ...
(Date:7/31/2014)... July 31, 2014 (HealthDay News) -- Recovery time after ... medications known as statins, according to a new study. ... may affect the body,s inflammatory response, reducing the amount ... that seemed to be particularly true among people who ... one of the most widely prescribed medications in the ...
(Date:7/31/2014)... 2014 Ethane Web Technologies, an ... a new service named ‘Java Development’. The service ... has designed the service after doing a serious ... Development service being provided by other web development ... to promise outstanding Java Development service. ...
Breaking Medicine News(10 mins):Health News:Reputation Management India Launches a New Service Called ‘Remove Bad Reviews’ 2Health News:FITNESS SF Upgrades Motionsoft Software to Include Entire Product Lineup: MoSo + MoSo Pay + MyClub 2Health News:Web Programming Services Introduces Affordable Brochure Designing Service 2Health News:Cholesterol Drugs May Speed Healing After Surgery 2Health News:Ethane Web Technologies Announces Java Development Service at Pocket Friendly Cost 2
... start in recent years of intense genetic sequencing, more than ... appearing this week in the journal Science is the first ... poodle named Shadow, the family pet of gene researcher J. ... the canine genes. ,"Shadow is now one of ...
... a greater risk of developing blood clots, but a new ... to prevent the clots from forming.// ,Researchers in ... doctors were aware of the risk of blood clots and ... percent of the doctors who were surveyed treated their patients ...
... basic building blocks of animals, forming in the new embryo and ... grows. Researchers have grown stem cells into many other types ... a sperm cell has been developed, the scientists said. ... with mouse stem cells. The next step would be to see ...
... ancient mosquito-borne disease that was rolled back by medical advances ... ,Strains of the disease are becoming increasingly resistant to treatment, ... as many as 900 million last year, according to estimates ... 1 million people -- and as many as 2.7 million ...
... injecting-drug users who are male and over age 34 are ... need to stress the importance of discontinuing drug-use among older ... help better define different sectors to help them. A study ... drug-users are at the greatest risk of death. Researchers looked ...
... conventional seed with a bright-blooming relative offers the promise of ... oil and other food products with this heart-healthy strain as ... within four years. The breakthrough after 10 years ... varieties such as popcorn and yellow sweet corn. ...
Cached Medicine News:Health News:Dog DNA reveals man's link with best friend, 2Health News:The 'forgotten epidemic' killing millions 2Health News:New heart-healthy corn due in stores by 2007 2
(Date:7/31/2014)... BRUSSEL , 31 juli 2014 De ... van een rekruteringscampagne voor gezonde vrijwilligers van Japanse komaf ... Brussel gevestigde PCRU is één van twee ... met als ideaal levens te verbeteren door de ontdekking ... is de PCRU op zoek naar mannen en vrouwen ...
(Date:7/30/2014)... , July 30, 2014  Cepheid (Nasdaq: ... group purchasing contract with Premier will end on ... Premier GPO will be able to continue their ... Baycare, HPA, MedAssets, Novation, and ROi, in addition ... directly with Cepheid. "Cepheid has always ...
(Date:7/30/2014)... 30, 2014 The Board of Directors ... last evening expressed support for the "Pharmacists, Patient ... of Pharmacy Practitioners (JCPP).  As a JCPP member, ... two-year period to develop a scalable, viable and ... "Pharmacists are fast becoming one of the ...
Breaking Medicine Technology:Gezonde vrijwilligers van Japanse komaf gezocht voor deelname aan Fase I klinisch onderzoek 2Cepheid Updates Status Of Premier Group Purchasing Organization (GPO) Agreement 2Cepheid Updates Status Of Premier Group Purchasing Organization (GPO) Agreement 3AMCP Endorses JCPP "Pharmacists' Patient Care Process" 2
... 3, 2011 Thoratec Corporation (NASDAQ: THOR ... therapies to save, support and restore failing hearts, said ... $111.2 million, a 17 percent increase over revenues of ... Results for all periods of fiscal 2010 exclude ...
... IRVINE, Calif., Aug. 3, 2011 Endologix, Inc. ... of minimally invasive treatments for aortic disorders, announced ... Officer, is scheduled to present at two upcoming ... the 31st Annual Canaccord Genuity Growth Conference in ...
Cached Medicine Technology:Thoratec Reports Second Quarter Revenue Increase of 17 Percent 2Thoratec Reports Second Quarter Revenue Increase of 17 Percent 3Thoratec Reports Second Quarter Revenue Increase of 17 Percent 4Thoratec Reports Second Quarter Revenue Increase of 17 Percent 5Thoratec Reports Second Quarter Revenue Increase of 17 Percent 6Thoratec Reports Second Quarter Revenue Increase of 17 Percent 7Thoratec Reports Second Quarter Revenue Increase of 17 Percent 8Thoratec Reports Second Quarter Revenue Increase of 17 Percent 9Thoratec Reports Second Quarter Revenue Increase of 17 Percent 10Thoratec Reports Second Quarter Revenue Increase of 17 Percent 11Thoratec Reports Second Quarter Revenue Increase of 17 Percent 12Thoratec Reports Second Quarter Revenue Increase of 17 Percent 13Thoratec Reports Second Quarter Revenue Increase of 17 Percent 14Thoratec Reports Second Quarter Revenue Increase of 17 Percent 15Thoratec Reports Second Quarter Revenue Increase of 17 Percent 16Thoratec Reports Second Quarter Revenue Increase of 17 Percent 17Thoratec Reports Second Quarter Revenue Increase of 17 Percent 18Thoratec Reports Second Quarter Revenue Increase of 17 Percent 19Endologix to Present at Two Upcoming Conferences 2
... ReZoom intraocular lens is a second-generation refractive ... with greater independence from glasses than monofocal ... a range of vision that monfocals cannot ... technology distributes light over five optic zones ...
The automated and pivoting M2 hand-piece incorporates two powerful, independent electric motors : one controls the blade oscillation at 15,000 RPM and the second controls the high-torque advance of t...
... Give patients the best potential for ... ACRYSOF IQ IOL compensates for spherical aberration ... the periphery. This is accomplished without increasing ... analyzed to create a design that provides ...
... Optics Aspheric Lens System can revolutionize ... all your cataract patients will want ... and contrast sensitivity. With a revolutionary ... consistently deliver superior optical performance to ...
Medicine Products: