Navigation Links
New marker for Alzheimer's discovered
Date:9/14/2009

Gothenburg researchers have discovered a previously unknown substance in spinal fluid that can be used to diagnose Alzheimer's disease. The findings, described in a thesis from the Sahlgrenska Academy at the University of Gothenburg, Sweden, will also be useful in research on new medications.

The substance is a beta-amyloid protein called Abeta16. The thesis shows in two independent studies that Alzheimer's patients have higher levels of the protein in their spinal fluid than do healthy individuals.

'The discovery of the new protein could be used to diagnose patients with Alzheimer's and also help determine which medications are most effective for the disease', says biochemist Erik Portelius, the author of the thesis.

Alzheimer's disease includes the formation of plaque on the brain. Neurons and other cell types form around 20 different beta-amyloid proteins, and these are excreted into the spinal fluid around the brain.

'These types of beta-amyloid proteins can be analysed with great precision, and our research team has also shown that the analyses can be used to distinguish between Alzheimer's patients and healthy individuals with a high degree of accuracy', says Portelius.

The beta-amyloid protein Abeta42 is particularly prevalent in the plaque. Abeta42 is created when a larger protein is cut into pieces by certain enzymes. The new Alzheimer's drugs that are currently being tested aim to reduce the production of Abeta42 by blocking these enzymes. Portelius found that these drugs increase the level of the newly discovered Abeta16.

'Abeta42 and Abeta16 are formed from the same precursor molecule, but the enzymatic process is different and Abeta16 is not harmful. The finding that Abeta16 is a very sensitive biomarker for the effect of these drugs may become very useful in future treatment studies', says Portelius.


'/>"/>

Contact: Erik Portelius
erik.portelius@neuro.gu.se
46-031-343-2390
University of Gothenburg
Source:Eurekalert  

Page: 1

Related medicine news :

1. UCLA researchers develop biomarker for rapid relief of major depression
2. Reportlinker Adds World Cardiac Biomarkers Market Report
3. MicroRNAs circulating in blood show promise as biomarkers to detect pancreatic cancer
4. Scientists from University of Hawaii at Manoa find genetic marker
5. MarketsandMarkets: Global Biomarker Market Worth US$ 20.5 Billion by 2014
6. New biomarker predicts response to hepatitis C treatment
7. Biomarker Could Predict Severe Osteoarthritis
8. SNMs Clinical Trials Network expands European membership of PET biomarker manufacturers
9. New Diagnostic Biomarker Test Shows Promise in Monitoring Ovarian Cancer
10. Biomarkers May Predict Alzheimers
11. JNCI news brief: Improving the biomarker pipeline for early cancer detection
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
New marker for Alzheimer's discovered
(Date:9/17/2014)... (PRWEB) September 17, 2014 Holon ... (DHCHD) has implemented its CollaborNet™ Health Information ... of patients’ health information between Coon Memorial Hospital, ... and physicians in the community. , Coon ... to enable electronic referrals by physicians to the ...
(Date:9/17/2014)... NY (PRWEB) September 17, 2014 ... sports, concussion prevention is top of mind for ... five facts to remember about concussions and an ... developed for kids, parents, coaches and teachers to ... , "As a pediatric orthopedic surgeon, ...
(Date:9/17/2014)... 2014 On October 1-2, Voom will ... lineup at Techmanity, a celebration of the intersection of ... tech events,” Techmanity will host the best and brightest ... the ranks of Cisco, PayPal, Samsung, Silicon Valley Bank, ... Technology Conference. , Voom was created to address the ...
(Date:9/17/2014)... 1st-Dress.com, one of the most distinguished dress companies, ... dresses recently. All the fresh items provided in ... they are offered at deeply discounted rates at the ... firm is striving to provide a nice shopping experience ... compromises on style, quality and customer service. Currently, similar ...
(Date:9/16/2014)... September 17, 2014 Dog Food Secrets ... owners the true poisonous ingredients in most commercial dog food ... has caught the attention of Shane Michaels, prompting an investigative ... as much of a family member as any other human ... dies earlier than it should due to poor diet” reports ...
Breaking Medicine News(10 mins):Health News:Dallam-Hartley Counties Hospital District Deploys Holon's Health Information Exchange (HIE) Solution to Facilitate Improved Patient Care 2Health News:Dallam-Hartley Counties Hospital District Deploys Holon's Health Information Exchange (HIE) Solution to Facilitate Improved Patient Care 3Health News:Video Helps Kids and Adults Talk About Concussion Recognition and Treatment 2Health News:Health and Wellness Startup Voom Announces Sponsorship at Techmanity 2Health News:2014 Long Bridesmaid Dresses Available Online At 1st-Dress.com 2Health News:Dog Food Secrets: Review Exposes Andrew Lewis’ Guide to Happier, Healthier Dogs with Homemade Dog Food 2
... ... In 20 Minutes Twice A Week , ... Bunker Hill Village, Houston (Vocus) August 17, 2009 -- SuperSlow® Zone of ... SuperSlow® Zone at 9738 Katy Freeway, Suite 200 provides a one-on-one efficient, effective workout ...
... HOUSTON, Aug. 17 After nearly four years of joint ... and NASA / Johnson Space Center (JSC), a senior NASA medical officer ... and tested in space by the astronauts of mission STS-125 of May ... now in use and testing aboard the International Space Station. , ...
... , , , , ... Hospital scientists lead survey of genome that identifies new genes ... MEMPHIS, Tenn., Aug. 16 Scientists at St. Jude Children,s Research ... percent of childhood acute lymphoblastic leukemia (ALL), including a gene that may ...
... online interventions now await , SUNDAY, Aug. 16 (HealthDay ... games and gossip, news and entertainment, essential information and ... as well. , A number of successful online medical ... quit smoking, lower their blood pressure and deal with ...
... Escape ... to freedom from addiction to drugs and alcohol. This service is provided in ... the convenience of the client,s personal/professional schedule. , ... Monticello, Minnesota (PRWEB) August 15, 2009 -- Jeanie Cooke, ...
... KUNMING, China, Aug. 14 /PRNewswire-Asia-FirstCall/ -- ... Shenghuo" or,the "Company"), which is engaged in the research, ... products,in the People,s Republic of China ("PRC"), today reported ... 2009. , , Second Quarter 2009 ...
Cached Medicine News:Health News:SuperSlow Zone Opens in Bunker Hill Village 2Health News:Astronauts Test Use of Nutritional Supplements in Space 2Health News:Inherited Risk Factors Increase Odds of Developing Childhood Acute Lymphoblastic Leukemia 2Health News:Inherited Risk Factors Increase Odds of Developing Childhood Acute Lymphoblastic Leukemia 3Health News:Inherited Risk Factors Increase Odds of Developing Childhood Acute Lymphoblastic Leukemia 4Health News:Web Is Becoming One-Stop Shopping for Health Help 2Health News:Web Is Becoming One-Stop Shopping for Health Help 3Health News:Licensed Drug and Alcohol Counselor Offers Minimal Cost On-Line Guidance to Freedom from Addiction 2Health News:China Shenghuo Reports Unaudited Financial Results for the Second Quarter of 2009 2Health News:China Shenghuo Reports Unaudited Financial Results for the Second Quarter of 2009 3Health News:China Shenghuo Reports Unaudited Financial Results for the Second Quarter of 2009 4Health News:China Shenghuo Reports Unaudited Financial Results for the Second Quarter of 2009 5Health News:China Shenghuo Reports Unaudited Financial Results for the Second Quarter of 2009 6Health News:China Shenghuo Reports Unaudited Financial Results for the Second Quarter of 2009 7Health News:China Shenghuo Reports Unaudited Financial Results for the Second Quarter of 2009 8Health News:China Shenghuo Reports Unaudited Financial Results for the Second Quarter of 2009 9Health News:China Shenghuo Reports Unaudited Financial Results for the Second Quarter of 2009 10
(Date:9/16/2014)... -- Chindex International, Inc. ("Chindex" or the "Company") (Nasdaq: ... meeting of stockholders held today, the Company,s stockholders adopted ... and among the Company, Healthy Harmony Holdings, L.P. ("Parent"), ... an affiliate of TPG, Shanghai Fosun Pharmaceutical (Group) Co., ... CEO of the Company. The Merger Agreement ...
(Date:9/16/2014)... NEW YORK , Sept. 16, 2014  This report ... and Units, The report provides separate comprehensive analytics for the ... , Europe , Asia-Pacific ... America , and Rest of World. Annual estimates and ... a seven-year historic analysis is provided for these markets. Market ...
(Date:9/16/2014)... , Sept. 16, 2014 This report analyzes the ... following Product Segments: Devices, and Medication. The report provides separate ... Japan , Europe , ... , and Rest of World. Annual estimates and forecasts are ... historic analysis is provided for these markets. Market data and ...
Breaking Medicine Technology:Chindex Stockholders Approve Merger 2Chindex Stockholders Approve Merger 3Global Digital Radiography Industry 2Global Digital Radiography Industry 3Global Digital Radiography Industry 4Global Digital Radiography Industry 5Global Digital Radiography Industry 6Global Digital Radiography Industry 7Global Digital Radiography Industry 8Global Digital Radiography Industry 9Global Digital Radiography Industry 10Global Digital Radiography Industry 11Global Digital Radiography Industry 12Global Digital Radiography Industry 13Global Digital Radiography Industry 14Global Digital Radiography Industry 15Global Digital Radiography Industry 16Global Digital Radiography Industry 17Global Digital Radiography Industry 18Global Digital Radiography Industry 19Global Digital Radiography Industry 20Global Digital Radiography Industry 21Global Digital Radiography Industry 22Global Foot Care Products Industry 2Global Foot Care Products Industry 3Global Foot Care Products Industry 4Global Foot Care Products Industry 5Global Foot Care Products Industry 6Global Foot Care Products Industry 7Global Foot Care Products Industry 8Global Foot Care Products Industry 9Global Foot Care Products Industry 10Global Foot Care Products Industry 11Global Foot Care Products Industry 12Global Foot Care Products Industry 13
... Calif., Aug. 31, 2011 The healthcare professionals at ... of orthopaedic surgeries on children each year, are using ... (NASDAQ: MASI ) to noninvasively monitor patient ... needles, the innovative technology instantly lets the healthcare team ...
... AVIV, Israel, August 31, 2011 Elbit Imaging ... results for the second quarter of 2011. Consolidated ... amounted to NIS 241 million (US$ 71 million) compared to NIS ... The decrease is mainly attributable to: (i) we reported non-recurring gain ...
Cached Medicine Technology:Shriners Hospitals for Children® - Honolulu: First in Hawaii to Implement Masimo Noninvasive Hemoglobin Monitoring Technology 2Shriners Hospitals for Children® - Honolulu: First in Hawaii to Implement Masimo Noninvasive Hemoglobin Monitoring Technology 3Shriners Hospitals for Children® - Honolulu: First in Hawaii to Implement Masimo Noninvasive Hemoglobin Monitoring Technology 4Shriners Hospitals for Children® - Honolulu: First in Hawaii to Implement Masimo Noninvasive Hemoglobin Monitoring Technology 5Elbit Imaging Ltd. Announces Second Quarter Results for 2011 2Elbit Imaging Ltd. Announces Second Quarter Results for 2011 3Elbit Imaging Ltd. Announces Second Quarter Results for 2011 4Elbit Imaging Ltd. Announces Second Quarter Results for 2011 5Elbit Imaging Ltd. Announces Second Quarter Results for 2011 6Elbit Imaging Ltd. Announces Second Quarter Results for 2011 7Elbit Imaging Ltd. Announces Second Quarter Results for 2011 8Elbit Imaging Ltd. Announces Second Quarter Results for 2011 9Elbit Imaging Ltd. Announces Second Quarter Results for 2011 10
Welch Allyn quality in a convenient pocket size. The PocketScope fits into your pocket! Easy to use, lightweight, and perfect for general and specialist use. Take your PocketScope with you everywhere...
... processing system assures a perfect fit of ... the convenience of complete automatic operation. The ... advanced processing unit and large LCD display. ... feature (ALE-3700 PC) or a polishing feature ...
... The new ULTIMA SG and ULTIMA ... todays progressive optical environments. These new products ... a host of innovative new features at ... features all-material edging, a large color LCD ...
... all the features of the FR-20 Frame Reader ... you no longer need to connect the frame ... is capable of receiving data via a cable ... you to streamline your edging operations. It stores ...
Medicine Products: