Navigation Links
New marker for Alzheimer's discovered
Date:9/14/2009

Gothenburg researchers have discovered a previously unknown substance in spinal fluid that can be used to diagnose Alzheimer's disease. The findings, described in a thesis from the Sahlgrenska Academy at the University of Gothenburg, Sweden, will also be useful in research on new medications.

The substance is a beta-amyloid protein called Abeta16. The thesis shows in two independent studies that Alzheimer's patients have higher levels of the protein in their spinal fluid than do healthy individuals.

'The discovery of the new protein could be used to diagnose patients with Alzheimer's and also help determine which medications are most effective for the disease', says biochemist Erik Portelius, the author of the thesis.

Alzheimer's disease includes the formation of plaque on the brain. Neurons and other cell types form around 20 different beta-amyloid proteins, and these are excreted into the spinal fluid around the brain.

'These types of beta-amyloid proteins can be analysed with great precision, and our research team has also shown that the analyses can be used to distinguish between Alzheimer's patients and healthy individuals with a high degree of accuracy', says Portelius.

The beta-amyloid protein Abeta42 is particularly prevalent in the plaque. Abeta42 is created when a larger protein is cut into pieces by certain enzymes. The new Alzheimer's drugs that are currently being tested aim to reduce the production of Abeta42 by blocking these enzymes. Portelius found that these drugs increase the level of the newly discovered Abeta16.

'Abeta42 and Abeta16 are formed from the same precursor molecule, but the enzymatic process is different and Abeta16 is not harmful. The finding that Abeta16 is a very sensitive biomarker for the effect of these drugs may become very useful in future treatment studies', says Portelius.


'/>"/>

Contact: Erik Portelius
erik.portelius@neuro.gu.se
46-031-343-2390
University of Gothenburg
Source:Eurekalert  

Page: 1

Related medicine news :

1. UCLA researchers develop biomarker for rapid relief of major depression
2. Reportlinker Adds World Cardiac Biomarkers Market Report
3. MicroRNAs circulating in blood show promise as biomarkers to detect pancreatic cancer
4. Scientists from University of Hawaii at Manoa find genetic marker
5. MarketsandMarkets: Global Biomarker Market Worth US$ 20.5 Billion by 2014
6. New biomarker predicts response to hepatitis C treatment
7. Biomarker Could Predict Severe Osteoarthritis
8. SNMs Clinical Trials Network expands European membership of PET biomarker manufacturers
9. New Diagnostic Biomarker Test Shows Promise in Monitoring Ovarian Cancer
10. Biomarkers May Predict Alzheimers
11. JNCI news brief: Improving the biomarker pipeline for early cancer detection
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
New marker for Alzheimer's discovered
(Date:8/21/2014)... 21, 2014Popular fiction that normalizes and glamorizes violence against ... be associated with a greater risk of potentially harmful ... new study are presented in the article " Fiction ... in Adolescent and Young Adult Females ," published in ... from Mary Ann Liebert, Inc., publishers . The ...
(Date:8/21/2014)... Individuals with schizophrenia often have trouble engaging in daily ... study from San Francisco State University suggests the reason ... effort required to complete tasks. , The research, detailed ... Journal of Abnormal Psychology , can assist health professionals ... help those patients function normally by breaking up larger, ...
(Date:8/21/2014)... August 21, 2014 Entries are now ... the only comprehensive national awards program totally dedicated to ... development and executive leadership. The entry deadline is Oct. ... Real Estate Insights™, the first and only national magazine ... and investment. , “We launched the HREI Insights Awards ...
(Date:8/21/2014)... York, New York (PRWEB) August 21, 2014 ... Medical Cannabis Network that a company located in Massachusetts ... be the only marijuana patient verification system ... to welcome this new entity to our growing and ... to our belief that these claims are inaccurate. ...
(Date:8/21/2014)... Steven Reinberg HealthDay Reporter ... shows promise in treating respiratory syncytial virus (RSV), a leading ... finally making major progress in being able to treat human ... viral pneumonia, second only to influenza virus," said study author ... of Tennessee College of Medicine in Memphis. "There ...
Breaking Medicine News(10 mins):Health News:Women's health and Fifty Shades: Increased risks for young adult readers? 2Health News:Difficulty assessing effort drives motivation deficits in schizophrenia, study finds 2Health News:Entries Open for 2014 HREI Insights Awards™ 2Health News:Entries Open for 2014 HREI Insights Awards™ 3Health News:Entries Open for 2014 HREI Insights Awards™ 4Health News:MarijuanaDoctors.com Responds to Massachusetts Company's Claim 2Health News:New Drug May Fight Serious Respiratory Virus in Infants 2Health News:New Drug May Fight Serious Respiratory Virus in Infants 3
... Denmark, Thursday 11 June 2009: Nulliparous women (those who ... chronic arthritides (including ankylosing spondylitis, psoriatic arthritis and rheumatoid ... women (those who have given birth to children), according ... the Annual Congress of the European League Against Rheumatism ...
... As Congress prepares to debate a major overhaul of the ... support of several proposals to expand coverage that have been ... Health Confidence Survey released today. But attitudes could change as ... , Between 68 percent and 88 percent of Americans either ...
... SYK ) announced today that it will host a conference ... to discuss the Company,s operating results for the quarter ended June ... quarter ended June 30, 2009 will be released at 4:00 p.m. ... dial 866-700-0133 (domestic) or 617-213-8831 (international) and ...
... in whether women decide to go for cancer screening or not, ... wrongly assume that they will ask for information if they want ... study published in the June issue of the UK-based Journal ... and Dr Stephanie Preston reviewed 19 studies that between them explored ...
... Quality of Life of Injured Veterans , , ... by Kessler Foundation Research Center published in Brain ... Injury Association, uncovered the possible cause of cognitive fatigue ... fatigue has been shown to be one of the ...
... at August Luncheon , , DENVER, June 11 ... of kidney care services for those diagnosed with chronic kidney ... the Los Angeles Business Journal ,s 2009 "Best Places ... 67 companies chosen for their impact on the region,s economy, ...
Cached Medicine News:Health News:Diagnosis of arthritis 5 years earlier in childless women compared to those with children 2Health News:12th Annual Health Confidence Survey: Americans Show Support for Several Health Coverage Options, But Their Views Could Change as More Details Emerge 2Health News:12th Annual Health Confidence Survey: Americans Show Support for Several Health Coverage Options, But Their Views Could Change as More Details Emerge 3Health News:Stryker to Host Conference Call on July 21, 2009 2Health News:Cancer screening fear is fueled by lack of information says review covering nearly 6,000 women 2Health News:Kessler Foundation Research Center Study Provides Insight into One of the Most Challenging Symptoms Following a Traumatic Brain Injury 2Health News:Kessler Foundation Research Center Study Provides Insight into One of the Most Challenging Symptoms Following a Traumatic Brain Injury 3Health News:DaVita Named to List of 'Best Places to Work in Los Angeles' by the Los Angeles Business Journal 2
(Date:8/21/2014)... , Aug. 21, 2014 /CNW/ - Eisai Limited is ... introduction of the first-of-its-kind comic book available in ... has been designed specifically to educate children and their parents ... Canada affecting more than 300,000 Canadians. Eisai is ... care (hhc) , in which the patient is central – ...
(Date:8/21/2014)... Germany , Aug. 21, 2014  IBM (NYSE: ... Elektronen-Synchrotron ( DESY ), a leading national research center ... management and storage of massive volumes of x-ray data. ... based on IBM software defined technology can handle more ... performance and help scientists worldwide gain faster insights into ...
(Date:8/21/2014)... August 21, 2014 BreedIT ... Ltd., the exclusive worldwide license holder and distributor ... breeders and researchers, today is pleased to announce ... with Seach Ltd, a leading Israeli medical Cannabis ... and develop new breeds of medical Cannabis to ...
Breaking Medicine Technology:Eisai Pleased to Support Canadian Epilepsy Alliance Comic Book that Teaches Children About Epilepsy 2DESY and IBM Develop Big Data Architecture for Science 2DESY and IBM Develop Big Data Architecture for Science 3BreedIT Ltd. and Seach Ltd. Form KanaboSeed to Develop New Medical Cannabis Varieties 2BreedIT Ltd. and Seach Ltd. Form KanaboSeed to Develop New Medical Cannabis Varieties 3BreedIT Ltd. and Seach Ltd. Form KanaboSeed to Develop New Medical Cannabis Varieties 4
... Sept. 2, 2011 SimonMed and Cox Business have ... called tomosynthesis available to patients in the Valley and ... traditional digital mammogram. This is the first dedicated outpatient ... offered at SimonMed,s office in Scottsdale. Sub-specialty ...
... Pharmaceuticals International, Inc. (NYSE: VRX ) (TSX: VRX) ... will be participating at the following conferences: ... a presentation at the Bank of America Merrill Lynch Global ... at 10:35 a.m. BT (5:35 a.m. ET). ...
Cached Medicine Technology:SimonMed and Cox Business Bring Breast Tomosynthesis to Arizona 2
... ARUP Laboratories is a national reference ... laboratory research and development. ARUP offers an ... unique medical tests in clinical and anatomic ... ARUP Laboratories' clients include more than half ...
... reference laboratory and a worldwide leader in ... an extensive test menu of highly complex ... anatomic pathology. Owned by the University of ... half of the nation's university teaching hospitals ...
... is a national reference laboratory and a ... development. ARUP offers an extensive test menu ... in clinical and anatomic pathology. Owned by ... include more than half of the nation's ...
... Laboratories is a national reference laboratory and ... and development. ARUP offers an extensive test ... tests in clinical and anatomic pathology. Owned ... clients include more than half of the ...
Medicine Products: